Patient-Derived Colorectal Cancer Organoids Upregulate Revival Stem Cell Marker Genes following Chemotherapeutic Treatment

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

(2019) Arshad Ayyaz et al.   NATURE

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Identification, isolation and characterization of human LGR5-positive colon adenoma cells

(2018) Michael K. Dame et al.   DEVELOPMENT

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

(2018) Julie G Grossman et al.   OncoImmunology

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Chemotherapy outcome predictive effectiveness by the Oncogramme: pilot trial on stage-IV colorectal cancer

(2016) Christophe Bounaix Morand du Puch et al.   Journal of Translational Medicine

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

(2015) Samuel Asfaha et al.   Cell Stem Cell

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

(2015) K. Horvay et al.   EMBO JOURNAL

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer

(2015) Melissa R. Junttila et al.   Science Translational Medicine

ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer

(2015) Thierry Jardé et al.   PLoS One

The First 1000 Patients on an Internet-based Colorectal Neoplasia Database Across Private and Public Medicine in Australia

(2014) P. J. McMurrick et al.   DISEASES OF THE COLON & RECTUM

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

(2013) Raul Aguirre-Gamboa et al.   PLoS One

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Clusterin expression is associated with decreased disease-free survival of patients with colorectal carcinomas

(2010) Maximino Redondo et al.   HISTOPATHOLOGY

High Clusterin Expression Correlates with a Poor Outcome in Stage II Colorectal Cancers

(2009) D. Kevans et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer

(2009) Da-wei Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY