4.7 Article

Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 9, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/jcm9010005

Keywords

cerebral palsy; premature infants; general movement assessment; machine learning

Funding

  1. Central Norway Regional Health Authority, Trondheim, Norway [SO: 90056100]
  2. Norwegian University of Science and Technology, Trondheim, Norway [SO: 90056100]
  3. St. Olavs hospital, NTNU, Trondheim, Norway
  4. Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway
  5. Friends of Prentice, Chicago, USA
  6. Shaw research grant in nursing and allied health professions, Chicago, USA

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Background: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based on infant video recordings. Methods: The CIMA model was designed to assess the proportion (%) of CP risk-related movements using a time-frequency decomposition of the movement trajectories of the infant's body parts. The CIMA model was developed and tested on video recordings from a cohort of 377 high-risk infants at 9-15 weeks corrected age to predict CP status and motor function (ambulatory vs. non-ambulatory) at mean 3.7 years age. The performance of the model was compared with results of the general movement assessment (GMA) and neonatal imaging. Results: The CIMA model had sensitivity (92.7%) and specificity (81.6%), which was comparable to observational GMA or neonatal cerebral imaging for the prediction of CP. Infants later found to have non-ambulatory CP had significantly more CP risk-related movements (median: 92.8%, p = 0.02) compared with those with ambulatory CP (median: 72.7%). Conclusion: The CIMA model may be a clinically feasible alternative to observational GMA.

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