Review
Pharmacology & Pharmacy
Diana Duarte, Nuno Vale
Summary: Drug repurposing and drug combination have emerged as alternatives to costly and ineffective de novo drug development. These strategies offer benefits of lower cost, quicker development, and ease of application, while also enabling increased efficacy, reduced toxicity, and overcoming drug resistance. The potential for combining repurposed drugs in cancer therapy, particularly for colorectal cancer, remains an under-explored area in pre-clinical and clinical development.
DRUG DISCOVERY TODAY
(2022)
Article
Otorhinolaryngology
Chih-Wen Twu, Po-Ju Lin, Hsiao-Hui Tsou, Yi-Chun Liu, Rong-San Jiang, Kai-Li Liang, Tian-Yun Lin, Wen-Yi Wang, Jin-Ching Lin
Summary: This study investigated the survival impact and toxicity of maintenance metronomic chemotherapy in patients with metastatic/recurrent nasopharyngeal carcinoma. The results showed that maintenance chemotherapy significantly improved overall and progression-free survivals while demonstrating low toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biology
Yurun Huang, Hang Jiang, Linwei Xu, Xitian Wu, Jia Wu, Yuhua Zhang
Summary: The aim of this study was to investigate the optimal timing of surgery after neoadjuvant chemotherapy (NAC) for liver metastasis of colorectal cancer (CRLM). The results showed that patients who underwent surgery within a short interval (<=4 weeks) had better recurrence-free survival and no significant difference in overall survival compared to those in the long interval (>4 weeks) group. The postoperative complication rate was slightly higher in the 1-2 weeks subgroup. Overall, performing surgery within 2-4 weeks of NAC was feasible and safe, and it did not increase the incidence of postoperative complications but it did prolong recurrence-free survival.
Article
Oncology
Carmen Garcia-Duran, Francisco Grau, Guillermo Villacampa, Ana Oaknin
Summary: The study aims to evaluate the effect of dostarlimab as maintenance therapy on progression-free survival in high-risk locally advanced cervical cancer patients. A total of 132 patients are expected to be recruited, and recruitment is estimated to be completed in the third quarter of 2022. Results are expected to be released in the third quarter of 2024.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Eluri Pavitra, Begum Dariya, Gowru Srivani, Sung-Min Kang, Afroz Alam, Putty-Reddy Sudhir, Mohammad Amjad Kamal, Ganji Seeta Rama Raju, Young-Kyu Han, Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Ganji Purnachandra Nagaraju, Yun Suk Huh
Summary: Colorectal cancer is one of the deadliest diseases worldwide due to a lack of early detection methods and appropriate drug delivery strategies. New screening tools and nanotechnology can improve accuracy and reduce harm to healthy tissues.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Frederic Dumont, Vahan Kepenekian, Valeria De Franco, Clarisse Eveno, Patrick Rat, Charles Sabbagh, Jean-Jacques Tuech, Jean-Marc Bereder, Maxime Gerard, Cecile Loaec, Elodie Martin, Loic Campion, Olivier Glehen
Summary: Multimodal treatment, including perioperative chemotherapy and complete resection, improves survival in patients with peritoneal metastases from colorectal cancer. However, the impact of treatment delays on oncologic outcomes remains uncertain.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Said Moshawih, Ai Fern Lim, Chrismawan Ardianto, Khang Wen Goh, Nurolaini Kifli, Hui Poh Goh, Qais Jarrar, Long Chiau Ming
Summary: This article summarizes the molecular mechanisms, driver genes, and advancements in treatment of colorectal cancer. A better understanding of colorectal cancer contributes to the development of more targeted and safer treatment methods. Protein kinases play a crucial role in the treatment of colorectal cancer. In silico studies have shown promising improvements in colorectal cancer treatment and enhanced selectivity for specific targets.
Review
Oncology
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K-Y Lam, Vinod Gopalan, Farhadul Islam
Summary: This study highlights the significant role of estrogens and their receptors, particularly ERβ, in the pathogenesis of colorectal carcinoma (CRC). Understanding the underlying mechanisms of estrogen and its receptors in CRC pathogenesis could offer new insights for therapeutic development.
Article
Endocrinology & Metabolism
Xinxin Zeng, Liyue Sun, Xiaomei Ling, Yuying Jiang, Ju Shen, Lei Liang, Xuhui Zhang
Summary: Based on the analysis of the Genomics of Drug sensitivity in Cancer database and The Cancer Genome Atlas, CALB2 and GPX3 were identified as potential action targets for gemcitabine treatment in colorectal cancer patients. The study also suggested that CALB2 and GPX3 could serve as prognostic biomarkers for colorectal cancer and could potentially enhance the efficacy of certain drugs when used in combination with gemcitabine.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Svea Becker, Jeffrey Momoh, Ilaria Biancacci, Diana Moeckel, Qingbi Wang, Jan-Niklas May, Huan Su, Lena Susanna Candels, Marie-Luise Berres, Fabian Kiessling, Maximilian Hatting, Twan Lammers, Christian Trautwein
Summary: Fasting has a positive impact on tumor microenvironment and drug delivery, with intermittent fasting slowing down tumor growth and improving liposome delivery. Fasting also promotes tumor cell uptake of liposomes. Combining fasting with liposomal doxorubicin treatment increases antitumor efficacy and reduces systemic side effects.
Article
Biochemistry & Molecular Biology
Joris van de Haar, Xuhui Ma, Salo N. Ooft, Pim W. van der Helm, Louisa R. Hoes, Sara Mainardi, David J. Pinato, Kristi Sun, Lisa Salvatore, Giampaolo Tortora, Ina Valeria Zurlo, Silvana Leo, Riccardo Giampieri, Rossana Berardi, Fabio Gelsomino, Valeria Merz, Federica Mazzuca, Lorenzo Antonuzzo, Gerardo Rosati, Chara Stavraka, Paul Ross, Maria Grazia Rodriquenz, Michele Pavarana, Carlo Messina, Timothy Iveson, Federica Zoratto, Anne Thomas, Elisabetta Fenocchio, Margherita Ratti, Ilaria Depetris, Massimiliano Cergnul, Cristina Morelli, Michela Libertini, Alessandro Parisi, Michele De Tursi, Nicoletta Zanaletti, Ornella Garrone, Janet Graham, Raffaella Longarini, Stefania Maria Gobba, Angelica Petrillo, Emiliano Tamburini, Nicla La Verde, Fausto Petrelli, Vincenzo Ricci, Lodewyk F. A. Wessels, Michele Ghidini, Alessio Cortellini, Emile E. Voest, Nicola Valeri
Summary: Genomic analysis identified KRAS(G12) mutations as potential biomarkers of resistance to trifluridine/tipiracil treatment in metastatic colorectal cancer. Real-world data and phase 3 clinical trial data confirmed the significant association between KRAS(G12) mutations and reduced overall survival. These findings provide important implications for precision medicine in approximately 28% of patients with metastatic colorectal cancer.
Article
Pharmacology & Pharmacy
Ya-Nan Li, Xiaoju Shi, Dandan Sun, Shulan Han, Yifang Zou, Lingzhi Wang, Leilei Yang, Yutong Li, Ying Shi, Jianfeng Guo, Caitriona M. O'Driscoll
Summary: In this study, the potential of melarsoprol (MEL) for hepatocellular carcinoma (HCC) therapy was investigated for the first time using in vitro and in vivo experimental approaches. A folate-targeted polyethylene glycol-modified amphiphilic cyclodextrin nanoparticle was developed for safe, efficient and specific delivery of MEL. The targeted nanoformulation achieved cell-specific uptake, cytotoxicity, apoptosis and migration inhibition in HCC cells, and significantly prolonged the survival of mice with orthotopic tumor without causing toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Computer Science, Information Systems
Sheng Dong, Jibiao Zhou, Shuichao Zhang, Lin Guo, Zhijian Wang
Summary: This study analyzed the decision-making behavior and process of e-bike riders using high-precision trajectory data collected at two similar intersections in Shanghai. The results showed that different decision types influenced riders' decision-making behavior during the signal change interval, with green countdown providing an early decision opportunity. These findings can be applied to enhance the design of traffic signals.
JOURNAL OF INTERNET TECHNOLOGY
(2021)
Article
Oncology
Hao-Yun Tao, Fang He, Qi-Yun Shi, Ran Liu, Zhi-Long Wang, Kun-Peng Du, Jian-Feng Li, Hui Liu, Zhi-Qiang Lu, Jing-Jing Zhang, Yu-Hai Bai
Summary: This study aims to explore the clinical value of adjuvant chemotherapy or maintenance chemotherapy in patients with locally advanced nasopharyngeal carcinoma after induction chemotherapy and concurrent chemoradiotherapy. The results demonstrate that the addition of AC/MC can improve the distant metastasis-free survival and prolong the overall survival of high-risk patients.
Review
Gastroenterology & Hepatology
Zaynab Fatfat, Maamoun Fatfat, Hala Gali-Muhtasib
Summary: Colorectal cancer is still one of the most fatal malignancies worldwide despite significant progress in cancer therapy. The long-term effectiveness of chemotherapy drugs has been hindered by various limitations. In recent years, nanotechnology-based drug delivery systems, particularly polymeric micelles, have emerged as a promising approach to overcome these limitations. Polymeric micelles have shown great potential in improving the pharmacokinetic properties and safety profile of chemotherapeutic drugs, as well as achieving synergistic therapeutic outcomes through combination therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)
