Article
Immunology
John G. Noel, Seth W. Ramser, Lori Pitstick, Holly S. Goetzman, Elizabeth L. Dale, Andrew Potter, Mike Adam, S. Steven Potter, Jason C. Gardner
Summary: This study demonstrates that the burn wound is the primary source of G-CSF and IL-6 secretion, and their secretion is independent through an IL-1/MyD88-dependent mechanism. IL-1/MyD88 signaling mediates postburn anemia by inducing G-CSF and IL-6 secretion, leading to impaired medullary erythropoiesis and limiting the access of erythroid cells to iron. Neutralizing IL-1a/b antibodies attenuate features of postburn anemia and restore deficits caused by burn injury.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Sarah Rehou, Abdikarim Abdullahi, Marc G. Jeschke
Summary: This study aimed to investigate the role of sIL-6R in burn injury. The results showed that patients with a higher IL-6/sIL-6R ratio had significantly higher mortality. This suggests that IL-6 signaling via its membrane-bound receptor with an anti-inflammatory function is important.
Article
Orthopedics
R. Wiegertjes, N. G. M. Thielen, A. P. M. van Caam, M. van Laar, H. M. van Beuningen, M. I. Koenders, P. L. E. M. van Lent, P. M. van der Kraan, F. A. J. van de Loo, E. N. Blaney Davidson
Summary: The study indicates that aging leads to increased expression of IL-6 receptor and enhanced IL-6-induced p-STAT3 signaling in articular cartilage, which may be caused by age-related loss of protective TGF-β3 signaling and suppression of IL-6R. This mechanism could contribute to age-related osteoarthritis development.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Vilotic, Mirjana Nacka-Aleksic, Andrea Pirkovic, Zanka Bojic-Trbojevic, Dragana Dekanski, Milica Jovanovic Krivokuca
Summary: This review summarizes the role of interleukin-6 (IL-6) and interleukin-8 (IL-8) in healthy and pathological pregnancies. The authors provide an overview of the expression of these cytokines during pregnancy and discuss their involvement in pregnancy establishment, parturition, and various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Radoslaw Grebowski, Joanna Saluk, Michal Bijak, Janusz Szemraj, Paulina Wigner
Summary: Bladder cancer is the 10th most common form of cancer globally, and chronic inflammation may play a role in its development and progression. This study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) in IL-6 and IL-8 genes and bladder cancer development, as well as the impact of bladder cancer on the expression and methylation of IL-6 and IL-8 promoters in PBMCs. The study found no association between the studied SNPs and bladder cancer occurrence. However, bladder cancer patients had decreased IL-6 and IL-8 mRNA expression levels and higher methylation status of the IL-6 promoter compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xiaoli Ren, Yuying Fan, Dongmei Shi, Yun Liu
Summary: Mammary gland tumors are a common malignant disease that poses a serious threat to women and female dogs. The lack of an effective tumor marker hinders the early diagnosis and prognosis of these tumors in veterinary clinical medicine. This study investigated the expression of IL-6, IL-8, and IL-10 in canine mammary gland tumors to determine their association with tumor progression. The results suggest that IL-6 and IL-8 could potentially serve as diagnostic or biomarkers for canine mammary gland tumors.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Orthopedics
Tzu-Hao Tseng, Chien-Lin Chen, Chung-Hsun Chang, Jyh-Horng Wang, Tai-Horng Young
Summary: IL-6 induces ACL remnants to produce POSTN, and this effect can be attenuated by the PI3K/Akt blocker. The coexistence of IL-6 and ACL remnants may accelerate the development of post-traumatic arthritis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: GzmK and GzmA can activate PAR1 and PAR2, influencing cell signaling cascades and leading to the release of inflammatory cytokines. This suggests that GzmK acts as a pro-inflammatory regulator during immune responses.
Article
Biochemistry & Molecular Biology
Hanna Sternby, Hannes Hartman, Henrik Thorlacius, Sara Regner
Summary: The study found that selected biomarkers in patients with acute pancreatitis underwent significant changes within 48 hours of onset, with IL-1 beta and IL-6 showing associations with severe disease. IL-6 had the ability to differentiate severe cases of acute pancreatitis, while the prognostic capacity of the investigated biomarkers was low.
Article
Medicine, Research & Experimental
Roxana Serban, Cristiana Filip, Luminita Radulescu, Minerva Badescu, Magda Badescu, Bogdan Diaconescu, Mihail Cobzeanu, Bogdan Cobzeanu
Summary: Inflammatory mediators play a crucial role in the pathogenesis of otitis media, potentially leading to the transformation from acute otitis media to chronic otitis media. Inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: Granzyme K (GzmK) and GzmA can activate PAR1 and PAR2, and are involved in inflammatory response and cell signaling cascade. Despite cleaving PAR2 at the same point as trypsin, GzmK activates a distinct signaling pathway instead of the classical Ca2+ flux. In epithelial cells, GzmK induces the release of inflammatory cytokines through the activation of PAR2.
Article
Biochemistry & Molecular Biology
Piotr Fiedorczuk, Ewa Olszewska, Agnieszka Polecka, Marzena Walasek, Barbara Mroczko, Agnieszka Kulczynska-Przybik
Summary: In this single-center, case-control study, the concentrations of CRP, S100B, IL-6, TNF-α, and IL-8 were found to be elevated in patients with Obstructive Sleep Apnea (OSA), and positively correlated with disease severity, age, and BMI. These results support the potential role of these biomarkers in diagnosing OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Juwon Park, Malina J. Ivey, Yanik Deana, Kara L. Riggsbee, Emelie Sorensen, Veronika Schwabl, Caroline Sjoberg, Tilda Hjertberg, Ga Young Park, Jessica M. Swonger, Taylor Rosengreen, Rory E. Morty, Ekatrin Ahlbrecht, Michelle D. Tallquist
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Malina J. Ivey, Jill T. Kuwabara, Kara L. Riggsbee, Michelle D. Tallquist
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Perwez Alam, Bryan D. Maliken, Malina J. Ivey, Shannon M. Jones, Onur Kanisicak
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Review
Medicine, Research & Experimental
Zhichao Wu, Jialiang Liang, Wei Huang, Lin Jiang, Christian Paul, Xiang Gao, Perwez Alam, Onur Kanisicak, Meifeng Xu, Yigang Wang
Summary: Heart transplantation is the gold standard treatment for end-stage heart failure, but complications such as allograft rejection and infections are common. Recent studies have shown the potential of mesenchymal stem cells in alleviating allograft rejection during heart transplantation.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Adrienne R. Guarnieri, Sarah R. Anthony, Anamarie Gozdiff, Lisa C. Green, Salma M. Fleifil, Sam Slone, Michelle L. Nieman, Perwez Alam, Joshua B. Benoit, A. Phillip Owens, Onur Kanisicak, Michael Tranter
Summary: Adipose tissue homeostasis is crucial for cardiovascular health, with the presence of thermogenically active brown adipose tissue (BAT) associated with cardiometabolic health. Deletion of the RNA binding protein HuR in adipose tissue leads to spontaneous development of cardiac hypertrophy and fibrosis, suggesting a direct role of adipose tissue homeostasis in cardiovascular disease. This study demonstrates the intricate relationship between adipose tissue function and cardiovascular pathology, providing insights into potential mechanisms underlying cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Perwez Alam, Bryan D. Maliken, Shannon M. Jones, Malina J. Ivey, Zhichao Wu, Yigang Wang, Onur Kanisicak
Summary: Mammalian adult cardiomyocytes have limited ability to proliferate following heart injury, leading to adverse fibrotic and myocardial remodeling that ultimately results in heart failure. Various strategies to induce myocardial regeneration after cardiac injury have shown promising results, but still face challenges for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Lin Jiang, Jialiang Liang, Wei Huang, Jianyong Ma, Ki Ho Park, Zhichao Wu, Peng Chen, Hua Zhu, Jian-Jie Ma, Wenfeng Cai, Christian Paul, Liang Niu, Guo-Chang Fan, Hong-Sheng Wang, Onur Kanisicak, Meifeng Xu, Yigang Wang
Summary: Using the CRISPR activation system, fibroblasts were reprogrammed into CPCs by activating endogenous genes. These induced CPCs showed cardiac characteristics and were able to generate functional cardio-myocytes and vascular cells in vitro. The transcriptomic analysis revealed important gene regulatory mechanisms during the early stage of CPC formation.
Meeting Abstract
Cardiac & Cardiovascular Systems
Hadi Khalil, Shannon M. Jones, Perwez Alam, Bruce J. Aronow, Jeffery D. Molkentin, Onur Kanisicak
CIRCULATION RESEARCH
(2019)
Article
Medicine, Research & Experimental
Hadi Khalil, Onur Kanisicak, Ronald J. Vagnozzi, Anne Katrine Johansen, Bryan D. Maliken, Vikram Prasad, Justin G. Boyer, Matthew J. Brody, Tobias Schips, Katja K. Kilian, Robert N. Correll, Kunito Kawasaki, Kazuhiro Nagata, Jeffery D. Molkentin
Meeting Abstract
Cell Biology
Alexander Evdokiou, Stephanie Gierek, Onur Kanisicak, Richard Bodnar, Latha Satish
WOUND REPAIR AND REGENERATION
(2019)