Article
Environmental Sciences
Yanru Sang, Jingjing Zhang, Kaiyong Liu, Qunan Wang, Sufang Wang, Jie Sheng, Li Wang, Dongmei Zhang, Xiude Li, Hongjuan Cao, Annuo Liu, Fangbiao Tao
Summary: The study found that elderly individuals exposed to specific types of antibiotics, potentially from the food chain, may contribute to obesity. Specifically, norfloxacin concentrations were associated with body mass index, waist circumference, and body fat percentage. Women were found to have a higher risk of obesity compared to men.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Infectious Diseases
Yingying Wang, Xinping Zhao, Jinxin Zang, Yurong Li, Xiaolian Dong, Feng Jiang, Na Wang, Lufang Jiang, Qingwu Jiang, Chaowei Fu
Summary: This study aimed to evaluate the total intake level of antibiotics in humans via foods and drinking water in an East China community population. The study found that the community population was extensively exposed to multiple antibiotics via dietary routes, with long-term exposure potentially posing risks of chronic toxicity and the spread of antibiotic resistance.
Article
Environmental Sciences
Bao-Trong Dang, Xuan-Thanh Bui, Tomoaki Itayama, Huu Hao Ngo, Deokjin Jahng, Chitsan Lin, Shiao-Shing Chen, Kun-Yi Andrew Lin, Thanh-Tin Nguyen, Dinh Duc Nguyen, Todd Saunders
Summary: This study reveals the impact of CIP on bacterial community structures in the Sponge-MBR process, reducing the richness of critical phylotypes and affecting the removal efficiency of nitrogen and ammonia in wastewater treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Tiffany Fitzpatrick, William Malcolm, Jim McMenamin, Arlene Reynolds, Astrid Guttmann, Pia Hardelid
Summary: This study estimated the proportion of antibiotics prescribed to children in Scotland aged less than 5 years that were attributable to common respiratory viruses, with RSV consistently associated with the highest proportion of prescribed antibiotics. A future RSV vaccine could substantially reduce unnecessary antibiotic prescribing among children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Jeremiah Laktabai, Alyssa C. Platt, Elizabeth Turner, Indrani Saran, Joseph Kipkoech, Diana Menya, Wendy Prudhomme O'Meara
Summary: Diagnostic testing for malaria reduces dual consumption of ACTs and antibiotics, especially among those testing outside the formal healthcare sector.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Ecology
Benedikt R. Schmidt, Raluca I. Bancila, Tibor Hartel, Kurt Grossenbacher, Michael Schaub
Summary: Predation can have significant effects on the dynamics of amphibian populations in lentic freshwater ecosystems, with fish predators known to reduce prey abundance and restrict species distribution. The study revealed that changes in fish predator communities had varying impacts on different pond-breeding amphibian populations, and that fish predation can result in alterations to species dynamics.
Article
Engineering, Environmental
Filip Gamon, Anna Banach-Wisniewska, Jaspreet Jandoo Kaur, Grzegorz Cema, Aleksandra Ziembinska-Buczynska
Summary: This study investigated the impact of three common antibiotics (oxytetracycline, ciprofloxacin, and clarithromycin) on the anammox process in wastewater. The results showed that these antibiotics did not significantly affect the nitrogen removal rate and specific anammox activity, but had an impact on the abundance of functional genes and antibiotic resistance genes.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Fisheries
Wenfang Dai, Jing Ye, Sheng Liu, Hongqiang Xu, Minhai Liu, Zhihua Lin, Qinggang Xue
Summary: This study investigated the effects of antibiotic exposure on the microbial community of Kumamoto oyster larvae. The results showed that antibiotic treatment altered the structure of the larval microbiome, increasing the diversity of prokaryotic microbes but decreasing the diversity of eukaryotic microbes. These findings suggest that antibiotic treatment may cause a shift in the larval microbiome, which can in turn affect the health of oysters.
Article
Microbiology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: Our study found that despite heavy and sustained antibiotic pressure, microbial communities within the same patient remained more similar to each other than to those from other patients. We identified 6 taxa within the pre-treatment microbiota that predicted the extent of antibiotic-induced perturbations. Our results suggest that specific species in the pre-treatment microbiota play a key role in determining personalized microbiota responses to antibiotics in humans, which could lead to precision interventions to prevent antibiotic-induced dysbiosis and its adverse clinical consequences.
Article
Mathematics
Dennis Ridley, Pierre Ngnepieba
Summary: Monte Carlo simulation is used with uniformly distributed U(0,1) pseudo-random numbers, which may contain some serial correlation. This paper illustrates how this correlation affects the response variable, which becomes an asynchronous time series. It also presents a method to correct this issue by deriving the correlation between an exponential random variable and its antithetic counterpart.
Article
Critical Care Medicine
David Malorey, Fleur Lorton, Martin Chalumeau, Pierre Bourgoin, Gerald Boussicault, Julie Chantreuil, Theophile Gaillot, Jean-Michel Roue, Alain Martinot, Remy Assathiany, Jean-Pascal Saulnier, Jocelyne Caillon, Audrey Grain, Christele Gras-Le Guen, Elise Launay
Summary: This study describes the distribution, consequences, and potential determinants of time to antibiotics administration in children with COSBIs. The results showed no significant association between medical interval and mortality or severe sequelae.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Michael K. Tu, Samantha H. Chiang, Richard A. Bender, David T. W. Wong, Charles M. Strom
Summary: This study investigated the kinetics of IgG antibodies to SARS-CoV-2 S1 antigen in saliva using a noninvasive electrochemical assay. The results showed a sharp rise in antibody levels in the two weeks after the second vaccination, with peak levels observed at 10-20 days after vaccination. Some individuals experienced a decrease in antibody levels during the monitoring period.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Environmental Sciences
Kena Qin, Qingliang Zhao, Hang Yu, JianJu Li, Junqiu Jiang, Kun Wang, Liangliang Wei
Summary: The study found that in groundwater recharging systems, aerobic biodegradation, abiotic processes, and anoxic/anaerobic microorganisms are the main mechanisms for the removal of antibiotics. Different antibiotics have varying degradation efficiencies under different redox conditions.
Article
Cell Biology
Cecile Apel, Marceau Levasseur, Clara Lejeune, Shaleen B. Korch, Florence Guerard, Michelle David, Ahmed Askora, Marc Litaudon, Fanny Roussi, Bertrand Gakiere, John Chaput, Marie-Joelle Virolle
Summary: ATP spilling, mediated by the DX protein, enhances the metabolism and productivity of Streptomyces species. The introduction of the DX protein resulted in increased biomass and a regulation of metabolic pathways, leading to the production of antibiotics and bioactive molecules by Streptomyces.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel R. Amor, Jeff Gore
Summary: Microbial communities face limitations in predicting community transitions based on individual species' susceptibility to antibiotics. This study demonstrates that bacterial growth dynamics play a dominant role in determining community resilience following antibiotic exposure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Matteo Saponati, Jordi Garcia-Ojalvo, Enrico Cataldo, Alberto Mazzoni
Summary: In a feedforward network between the thalamus and primary sensory cortex, thalamic oscillations in the alpha range do not entrain cortical activity due to weaker oscillations in neurons projecting to the cortex and gamma resonance dynamics in the cortical networks hampering alpha range oscillations. This highlights the importance of corticothalamic feedback in sustaining alpha range oscillations for an integrated understanding of sensory stream transmission.
Article
Environmental Sciences
Xuejie Wang, Carmen Villa, Yadira Dobarganes, Casilda Olveira, Rosa Giron, Marta Garcia-Clemente, Luis Maiz, Oriol Sibila, Rafael Golpe, Rosario Menendez, Juan Rodriguez-Lopez, Concepcion Prados, Miguel Angel Martinez-Garcia, Juan Luis Rodriguez, David de la Rosa, Xavier Duran, Jordi Garcia-Ojalvo, Esther Barreiro
Summary: This study investigated whether high blood eosinophil counts could define a better phenotype in bronchiectasis patients and identified two distinct clinical phenotypes based on blood eosinophil counts. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammation levels. These results contribute to better characterizing bronchiectasis patients into phenotypic profiles with clinical implications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Kwang-Tao Chou, Dong-Yeon D. Lee, Jian-Geng Chiou, Leticia Galera-Laporta, San Ly, Jordi Garcia-Ojalvo, Gurol M. Suel
Summary: This study reveals a ring-like pattern in gene expression underlying the nitrogen stress response of a developing Bacillus subtilis biofilm. Mathematical modeling and experiments show that this pattern is generated by a clock and wavefront mechanism. The study also confirms that this mechanism is driven by cell-autonomous oscillations and is responsible for spatial patterning of sporulation within the biofilm.
Article
Multidisciplinary Sciences
Ronghui Zhu, Jesus M. del Rio-Salgado, Jordi Garcia-Ojalvo, Michael B. Elowitz
Summary: This study explores synthetic circuits that generate multiple stable states, providing insights into natural cell fate control circuit structures and enabling engineering of multicellular programs requiring interactions among distinct cell types.
Editorial Material
Biochemistry & Molecular Biology
Jordi Garcia-Ojalvo
Summary: This is a snapshot of the peer review process for a study on a synthetic gene circuit for imaging-free detection of signaling pulses (Ravindran et al., 2022).
Article
Biochemistry & Molecular Biology
Xuejie Wang, Casilda Olveira, Rosa Giron, Marta Garcia-Clemente, Luis Maiz, Oriol Sibila, Rafael Golpe, Rosario Menendez, Juan Rodriguez-Lopez, Concepcion Prados, Miguel Angel Martinez-Garcia, Juan Luis Rodriguez, David de la Rosa, Liyun Qin, Xavier Duran, Jordi Garcia-Ojalvo, Esther Barreiro
Summary: This study investigated different phenotypic characteristics in bronchiectasis patients based on neutrophil counts through biostatistics analysis, identifying two distinct clinical phenotypes. Patients with neutrophil counts above a certain threshold exhibited more severe lung function impairment, poorer nutritional status, and higher systemic inflammation compared to those below the threshold. Cluster analysis of combined systemic and respiratory variables defined well-distinguished phenotypic profiles in bronchiectasis patients.
Article
Multidisciplinary Sciences
Kaito Kikuchi, Leticia Galera-Laporta, Colleen Weatherwax, Jamie Y. Lam, Eun Chae Moon, Emmanuel A. Theodorakis, Jordi Garcia-Ojalvo, Gurol M. Suel
Summary: Despite their dormant state, bacterial spores are able to sense environmental signals through a preexisting electrochemical potential and integrate these signals over time, affecting their decision to exit dormancy.
Article
Biochemistry & Molecular Biology
Sheng Wang, Jordi Garcia-Ojalvo, Michael B. Elowitz
Summary: This article demonstrates that a single morphogen is sufficient to generate stable spatial patterns in multicellular development and identifies key factors for robust pattern formation.
Article
Computer Science, Cybernetics
Pau Clusella, Elif Koksal-Ersoz, Jordi Garcia-Ojalvo, Giulio Ruffini
Summary: Neural mass models (NMMs) aim to replicate the collective dynamics of neuronal populations. A common framework assumes that the firing rate of a population can be described by a static nonlinear transfer function. However, a recent theory challenges this view by showing that the firing rate follows nonlinear differential equations. This study analyzes and compares these two descriptions in the presence of second-order synaptic dynamics.
BIOLOGICAL CYBERNETICS
(2023)
Article
Clinical Neurology
Ruben Molina-Fernandez, Pol Picon-Pages, Alejandro Barranco-Almohalla, Giulia Crepin, Victor Herrera-Fernandez, Anna Garcia-Elias, Hugo Fanlo-Ucar, Xavier Fernandez-Busquets, Jordi Garcia-Ojalvo, Baldomero Oliva, Francisco J. Munoz
Summary: Alzheimer's disease and Type 2 diabetes are linked to aging, and there is a connection between Alzheimer's disease and insulin resistance. The aggregation of amyloid beta-peptide into beta-sheets is the main characteristic of Alzheimer's disease. In this study, it was found that monomeric amyloid beta-peptide 1-40 shares a similar structure to insulin and can activate insulin receptor. However, the accumulation and oligomerization of amyloid beta-peptide can block the insulin receptor, leading to insulin resistance and compromising neuronal metabolism and protective pathways.
BRAIN COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xuejie Wang, Carmen Villa, Yadira Dobarganes, Casilda Olveira, Rosa Giron, Marta Garcia-Clemente, Luis Maiz, Oriol Sibila, Rafael Golpe, Rosario Menendez, Juan Rodriguez-Lopez, Concepcion Prados, Miguel Angel Martinez-Garcia, Juan Luis Rodriguez, David de la Rosa, Xavier Duran, Jordi Garcia-Ojalvo, Esther Barreiro
Summary: Differential phenotypic clusters were identified in a large cohort of bronchiectasis patients using data mining approaches. The three clusters were classified as mild, moderate, and severe based on systemic biomarkers, with severe cluster exhibiting worse disease severity and poorer outcomes. Clustering analysis proved to be a powerful tool in characterizing the complexity and heterogeneity of bronchiectasis patients.
Meeting Abstract
Clinical Neurology
K. Kennedy, N. Kerlero de Rosbo, A. Uccelli, M. Cellerino, H. Flinstad Harbo, T. Berge, S. Bos, E. Hogestol, F. Paul, A. Brandt, P. Baecker-Koduah, J. Behrens, J. Saez-Rodriguez, M. Rinas, S. Llufriu, A. Saiz, I. Pulido-Valdeolivas, E. Martinez-Lapiscina, J. Garcia-Ojalvo, P. Villoslada
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriel Torregrosa, Jordi Garcia-Ojalvo
Summary: Our understanding of how individual cells self-organize to form complex multicellular systems is being revolutionized by a data outburst, machine-learning approaches, and mathematical modeling, shedding light on the impact of single-cell behavior on the formation of multicellular organisms.
CURRENT OPINION IN SYSTEMS BIOLOGY
(2021)
