Journal
CANCER SCIENCE
Volume 107, Issue 9, Pages 1215-1222Publisher
WILEY-BLACKWELL
DOI: 10.1111/cas.12989
Keywords
Chemoresistance; lncRNA-ROR; metastasis; nasopharyngeal carcinoma; proliferation
Categories
Funding
- Chinese National Natural Science Foundation [81172841, 81202368, 81471603]
- China Postdoctoral Science Foundation [2013M541708]
- 333 Natural Science Foundation of Jiangsu Grant [BRA2013286]
- Jiangsu Provincial Health Department [Z201005]
- Nantong University Postgraduate Students [13025043]
- Jiangsu Province's Outstanding Medical Academic Leader Program [LJ201136]
- Natural Science Foundation of Jiangsu Province [SBK2015022581]
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Nasopharyngeal carcinoma (NPC) is one of the most common malignancies of the head and neck. It arises from the nasopharynx epithelium and is associated with high morbidity and mortality. Long non-coding RNA (lncRNA) have been reported to regulate gene interaction and play critical roles in carcinogenesis and progression. LncRNA-ROR, a recently identified lncRNA, has been shown to be involved in initiation, progression and metastasis of several tumors, including hepatocellular carcinoma, breast cancer and glioma. However, whether lncRNA-ROR is associated with the progression of NPC remains unknown. Resistance to radiotherapy and chemotherapy is the primary cause of NPC patients' death. In this study, we found that lncRNA-ROR was significantly upregulated in NPC tissues compared with normal tissues. Next, our study proved that lncRNA-ROR was highly associated with the proliferation, metastasis and apoptosis of NPC. The enrichment of lncRNA-ROR played a critucal functional role in chemoresistance. The mechanism by which NPC resists chemotherapy might be that lncRNA-ROR suppress p53 signal pathway. Taken together, these data suggested that lncRNA-ROR played an important role in the progression of NPC; thereby it might become a therapeutic target and reduce chemoresistance for NPC.
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