Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Povilas Ignatavicius, Albertas Dauksa, Justas Zilinskas, Mintaute Kazokaite, Romualdas Riauka, Giedrius Barauskas
Summary: The study suggests that the HOXA11 gene may serve as a potential prognostic molecular marker in patients with gastric adenocarcinoma, showing longer survival associated with unmethylated HOXA11 promoter.
Article
Oncology
Alicia Eckhardt, Richard Drexler, Melanie Schoof, Nina Struve, David Capper, Claudius Jelgersma, Julia Onken, Patrick N. Harter, Katharina J. Weber, Iris Dive, Kai Rothkamm, Konstantin Hoffer, Lukas Klumpp, Katrin Ganser, Cordula Petersen, Franz Ricklefs, Malte Kriegs, Ulrich Schueller
Summary: Mean global DNA methylation is independently associated with outcome in glioblastoma. Higher DNA methylation is associated with better radiotherapy response and less aggressive phenotype.
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Zonglei Zhao, Xixiu Wang, Yan Ding, Xuefeng Cao, Xingyuan Zhang
Summary: SMC4 is a member of the ATPase family of chromosomes and is involved in various biological functions such as compression and dissociation of sister chromatids, DNA damage repair, and transcription. It also plays a role in embryonic cell division cycle, immune response regulation, and tumor development. High expression of SMC4 is consistently associated with worse overall survival in tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang, Zizhen Wu, Yinping Dong, Fenglin Cai, Liqiao Chen, Huifang Liu, Han Liang, Jingyu Deng
Summary: ADAMTS9 in gastric cancer cells exerts inhibitory effects, with its decreased expression associated with malignant phenotypes and poor prognosis. Restoration of ADAMTS9 significantly suppressed the viability and motility of GC cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A. Kim, Wooram Choi, Chae Young Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang, Han Gyung Kim, Young-Jun Jeon, Bokyoung Kim, Younghoon Kim, Kyung-Hee Kim, Byong Chul Yoo, Jeung-Whan Han, Narayana Parameswaran, Ji Hye Kim, Hoon Hur, Jae Youl Cho
Summary: The study explored the pathological role of a nonhistone methyltransferase in gastric cancer (GC), identified EEF1AKMT3 as a novel tumor suppressive methyltransferase, and revealed its mechanism of action through regulating the methylation of MAP2K7 and the degradation of TP53. The findings suggest potential targeted therapy in GC by manipulating the dysregulated EEF1AKMT3/MAP2K7/TP53 signaling axis.
Article
Oncology
Xiaoji Chen, Zhao Dong, Earl Hubbell, Kathryn N. Kurtzman, Geoffrey R. Oxnard, Oliver Venn, Collin Melton, Christina A. Clarke, Rita Shaknovich, Ting Ma, Gerry Meixiong, Michael V. Seiden, Eric A. Klein, Eric T. Fung, Minetta C. Liu
Summary: The study evaluated the prognostic significance of cancer detection by the MCED test using longitudinal follow-up data, finding that cancers detected by the test had lower overall survival rates and could differentiate more aggressive cancers. Cancers not detected by the test had better prognosis, and the MCED test results were predictive of their outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Javier Freire, Pilar Garcia-Berbel, Belen Caramelo, Lucia Garcia-Berbel, Victor J. Ovejero, Nuria Cadenas, Ainara Azueta, Javier Gomez-Roman
Summary: This study demonstrates that COL11A1 immunostaining is an accurate predictive marker of tumor infiltration in small biopsies of breast, colon, bladder, and ovarian cancer.
Article
Oncology
Susan F. Slovin, Karen Knudsen, Susan Halabi, Renee de Leeuw, Ayesha Shafi, Praneet Kang, Steven Wolf, Bin Luo, Anuradha Gopalan, Tracy Curley, Mark Fleming, Ana Molina, Celina Fernandez, Kevin Kelly
Summary: Upfront combination therapy in chemotherapy/ARSI-naive mCRPC patients showed improved radiographic progression-free survival and may benefit some men, but further research is needed to identify the specific population that would benefit from this treatment.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi, Hai Wang
Summary: Our study found that TMEFF2 expression is lower in glioma tumor tissues, and its DNA methylation might be associated with tumor progression, serving as a valuable prognostic marker for adult diffuse gliomas.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc-Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Summary: This study used methylome sequencing to investigate the DNA methylation patterns in prostate cancer patients, and identified methylation patterns associated with prostate cancer-specific mortality, as well as prognostic biomarkers. The combination of DNA methylation biomarkers and clinicopathological measures improved the prognostic models for prostate cancer mortality.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Li Liu, Jiangtu He, Guifeng Sun, Nan Huang, Zhixuan Bian, Chang Xu, Yue Zhang, Zhongqi Cui, Wenqiang Xu, Fenyong Sun, Chengle Zhuang, Qiuhong Man, Song Gu
Summary: In this study, the researchers found that METTL3-mediated SLC7A11 m6A modification enhanced resistance to ferroptosis in hepatoblastoma (HB). Mechanistically, SLC7A11 mRNA exhibited abnormal METTL3-mediated m6A modification, which enhanced its stability and expression. IGF2 mRNA-binding protein 1 (IGF2BP1) was identified as the m6A reader of SLC7A11, enhancing SLC7A11 mRNA stability and expression by inhibiting SLC7A11 mRNA deadenylation in an m6A-dependent manner. The study highlights the critical role of the m6A modification in SLC7A11-mediated ferroptosis and provides a potential strategy for HB therapy through blockade of the m6A-SLC7A11 axis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Article
Pediatrics
Daisuke Ishii, Kazutoshi Miyamoto, Masatoshi Hirasawa, Hisayuki Miyagi
Summary: TF is an effective and simple treatment for GERD, with low recurrence rates and minimal complications. Further studies comparing TF with other techniques are needed to confirm its efficacy.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Article
Pediatrics
Daisuke Ishii, Hisayuki Miyagi, Masatoshi Hirasawa
Summary: This study found that the postoperative GERD recurrence rate after TF was 5.8%. Univariate analysis showed that the presence of convulsive seizures and the absence of a tracheostomy at the time of TF were significantly associated with recurrence. Multivariate analysis revealed that the presence of convulsive seizures at the time of TF was the only factor significantly associated with recurrence.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Review
Pediatrics
Tomoro Hishiki, Shohei Honda, Yuichi Takama, Yukihiro Inomata, Hideaki Okajima, Ken Hoshino, Tatsuya Suzuki, Ryota Souzaki, Motoshi Wada, Mureo Kasahara, Koichi Mizuta, Takaharu Oue, Akiko Yokoi, Takuro Kazama, Shugo Komatsu, Isamu Saeki, Osamu Miyazaki, Tetsuya Takimoto, Kohmei Ida, Kenichiro Watanabe, Eiso Hiyama
Summary: The study involved using a real-time central surgical reviewing system to facilitate early referral of liver transplantation candidates, leading to prompt surgical decisions and procedures.
Article
Surgery
Jun Soma, Daisuke Ishii, Hisayuki Miyagi, Seiya Ishii, Keita Motoki, Hidemasa Kawabata, Shunta Ishitoya, Masahiro Hagiwara, Naohiro Kokita, Masatoshi Hirasawa
Summary: In this case report, an 8-year-old boy with grade IV blunt hepatic injury was successfully treated using damage control surgery and the ABTHERA Open Abdomen Negative Pressure Therapy System. The boy recovered without neurological sequelae and was discharged after 102 days in the hospital. The use of a damage control strategy in pediatric patients with severe blunt hepatic injury is effective and can help improve outcomes.
SURGICAL CASE REPORTS
(2021)
Editorial Material
Pediatrics
Shinsuke Fukui, Hisayuki Miyagi, Daisuke Ishii, Masatoshi Hirasawa, Yoshiki Hirano
PEDIATRICS INTERNATIONAL
(2022)
Article
Oncology
Takahiro Fukazawa, Keiji Tanimoto, Emi Yamaoka, Masato Kojima, Masami Kanawa, Nobuyuki Hirohashi, Eiso Hiyama
Summary: Hepatoblastoma (HBL) is a rare liver malignancy that occurs mainly in early childhood. Although treatment regimens have improved the prognosis, there are still refractory cases and the current treatment often leads to severe side effects. This study demonstrates that ADAM32, a protein involved in various cancer types, is highly expressed in HBL and is associated with poor prognosis. ADAM32 plays a role in cancer cell proliferation, stemness, migration, invasion, and chemotherapy resistance. This suggests that ADAM32 could be a promising target for therapy and provides insights into the molecular mechanisms of HBL carcinogenesis.
Article
Cell Biology
Yoko Hiyama, Emi Yamaoka, Takahiro Fukazawa, Masato Kojima, Yusuke Sotomaru, Eiso Hiyama
Summary: In this study, we investigated the association between the expression of DHRS3, NROB1, and CYP26A1 genes and the suppression of neuroblastoma cell growth. The overexpression of these genes led to a reduction in cell growth and induced morphological senescence, mainly through pathways related to cellular senescence and cell adhesion. DHRS3 and NROB1 also arrested the cell cycle and induced differentiation and senescence. These findings suggest that the induction of these genes could be a potential therapeutic strategy for suppressing high-risk neuroblastoma growth.
Article
Oncology
Angela D. Trobaugh-Lotrario, Rudolf Maibach, Daniel C. Aronson, Arun Rangaswami, Beate Haeberle, Allison F. O'Neill, Irene Schmid, Marc Ansari, Tomoro Hishiki, Sarangarajan Ranganathan, Rita Alaggio, Ronald R. de Krijger, Yukichi Tanaka, Soo-Jin Cho, Christian Vokuhl, Rebecca Maxwell, Mark Krailo, Eiso Hiyama, Piotr Czauderna, Milton Finegold, James H. Feusner, Marcio H. Malogolowkin, Rebecka L. Meyers, Dolores Lopez-Terrada
Summary: Hepatoblastoma is the most common malignant liver tumor in children, and small cell undifferentiated histology and low alpha-fetoprotein levels have been associated with poor prognosis. It is important to differentiate rhabdoid tumors from hepatoblastoma with small cell undifferentiated component or low alpha-fetoprotein levels, as the treatment differs significantly. When rhabdoid tumors are correctly diagnosed, neither the presence of small cell undifferentiated component nor low alpha-fetoprotein levels are associated with poor prognosis.
Article
Biology
Sungmin Yang, Kyungsik Ha, Woojeung Song, Masashi Fujita, Kirsten Kuebler, Paz Polak, Eiso Hiyama, Hidewaki Nakagawa, Hong-Gee Kim, Hwajin Lee
Summary: We have developed COOBoostR, a computational method that can predict the tissue or cell of origin for various types of cancer. COOBoostR uses regional somatic mutation density information and chromatin mark features in an extreme gradient boosting-based machine-learning algorithm. By ranking chromatin marks from different tissue and cell types, COOBoostR can determine the most likely tissue or cell of origin based on the somatic mutation density landscape of a sample.
Meeting Abstract
Oncology
Hisayuki Miyagi, Daisuke Ishii, Seiya Ishii, Keita Motoki, Shinsuke Fukui, Yukari Sakurai, Naohisa Toriumi, Sayaka Yuzawa, Mishie Tanino, Takeo Sarashina
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Hitoshi Ono, Shohei Honda, Hisayuki Miyagi, Masashi Minato, Momoko Ara, Takafumi Kondo, Kazuyoshi Okumura, Tadao Okada, Akinobu Taketomi
Summary: Various treatment strategies have been explored for patients with severe symptomatic abdominal lymphatic malformation (ALM) and emphasis is placed on the importance of surgical management.
ANNALS OF PEDIATRIC SURGERY
(2022)
Article
Medicine, General & Internal
Hideki Isa, Hisayuki Miyagi, Daisuke Ishii, Masatoshi Hirasawa
Summary: This report introduces a novel three-stage laparoscopic surgery for high anorectal malformation, which includes temporary loop colostomy to minimize invasive wounds. The procedure was proven to be effective and safe in practice.
Article
Surgery
Hisayuki Miyagi, Daisuke Ishii, Masatoshi Hirasawa, Tatsuya Shonaka, Yasuo Sumi, Nobuyoshi Azuma
Summary: Kasai portoenterostomy (KPE) is the first-line treatment for biliary atresia, with dissecting fibrous remnants at the porta hepatis being crucial. Laparoscopic surgery allows for easier identification of microbiliary ducts, while using an 8K ultra-high-definition television system during open KPE enhances visualization and surgical success at the porta hepatis.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY REPORTS
(2021)
Article
Oncology
Shohei Honda, Aniruddha Chatterjee, Anna L. Leichter, Hisayuki Miyagi, Masashi Minato, Sunao Fujiyoshi, Momoko Ara, Norihiko Kitagawa, Mio Tanaka, Yukichi Tanaka, Masato Shinkai, Kanako C. Hatanaka, Akinobu Taketomi, Michael R. Eccles
FRONTIERS IN ONCOLOGY
(2020)
Article
Surgery
Hisayuki Miyagi, Daisuke Ishii, Masatoshi Hirasawa, Shunsuke Yasuda, Naohisa Toriumi, Takeo Sarashina, Mishie Tanino, Mio Tanaka, Yukichi Tanaka, Kazutoshi Miyamoto
SURGICAL CASE REPORTS
(2020)