Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Andrology
Jason Zhu, Chad Livasy, Erin E. Donahue, James T. Symanowski, Claud M. Grigg, Landon C. Brown, Justin T. Matulay, James T. Kearns, Derek Raghavan, Earle F. Burgess, Peter E. Clark
Summary: This study assessed the relationship between the expression of Galectin-1 and Galectin-3 proteins and the progression of urothelial carcinoma (UC). The results showed that the expression of Gal-1 and Gal-3 proteins is associated with the depth of tumor invasion in UC, but they cannot independently predict recurrence-free survival or overall survival. Additionally, the intratumoral heterogeneity of Gal-1 and Gal-3 complicates their use as prognostic biomarkers.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Oncology
Christina Guo, Rucha Trivedi, Amit K. Tripathi, Rajesh R. Nandy, Diana C. Wagner, Kalyani Narra, Pankaj Chaudhary
Summary: This study investigated the correlation between Annexin A2 (AnxA2) and bladder urothelial carcinoma (BLCA) using data from the Cancer Genome Atlas (TCGA). The results showed that AnxA2 mRNA expression was significantly higher in BLCA tumors and associated with high pathological grades and stages, non-papillary tumor histology, and poor survival outcomes. Furthermore, AnxA2 expression was higher in high-grade metastatic bladder cancer cells and correlated with plasmin generation and secretion. Downregulation of AnxA2 inhibited the proliferation, migration, and invasion of bladder cancer cells. These findings suggest that AnxA2 could serve as a potential biomarker and therapeutic target for high-grade BLCA.
Article
Oncology
Hong-Lin He, Hong-Yue Lai, Ti-Chun Chan, Chung-Hsi Hsing, Steven K. Huang, Kun-Lin Hsieh, Tzu-Ju Chen, Wan-Shan Li, Yu-Hsuan Kuo, Yow-Ling Shiue, Chien-Feng Li
Summary: Zinc finger and SCAN domain containing 4 (ZSCAN4) is downregulated in muscle-invasive bladder cancer and its low expression is significantly correlated with tumor progression, metastasis, and vascular invasion in both upper urinary tract urothelial carcinoma (UTUC) and urinary bladder urothelial carcinoma (UBUC). Furthermore, low expression of ZSCAN4 serves as an independent negative prognostic factor for both diseases. Gene ontology analysis reveals that ZSCAN4 and its co-downregulated genes are associated with the mitotic cell cycle.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Michele J. Hoffmann, Wolfgang A. Schulz
Summary: Urinary bladder cancer is among the top ten major cancers worldwide, with higher incidences in males, smokers, and highly industrialized countries. Gene mutations play a crucial role in the development of bladder cancer, particularly in a group of proteins regulating chromatin state and gene expression that are discovered to be frequently affected.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Vamsi Mohan Meka, Baphiralyne Wankhar, Vijayanadh Ojili, Prem P. Batchala
Summary: F-18-fluciclovine is a radiolabeled synthetic amino acid used for evaluating recurrent prostate cancer, but it is not specific to prostate cancer and can also show uptake in non-prostate conditions. We present a case of an 87-year-old male with a bladder wall mass detected on F-18-fluciclovine PET/CT, ultimately diagnosed as papillary urothelial carcinoma.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shinsuke Oda, Masayoshi Fujisawa, Li Chunning, Toshihiro Ito, Takahiro Yamaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: Aberrant activation of the Ras/Raf/ERK-MAPK pathway is involved in cancer progression, but the negative regulation by Spred2 may counter this progression in non-invasive bladder carcinoma. The loss of Spred2 regulation is associated with increased ERK activation and Ki67 index in more malignant cancers. Spred2 appears to be a key regulator in the progression of non-invasive bladder carcinoma.
Article
Agriculture, Dairy & Animal Science
Leonore Kuechler, Caroline Posthaus, Kathrin Jaeger, Franco Guscetti, Louise van der Weyden, Wolf von Bomhard, Jarno M. M. Schmidt, Dima Farra, Heike Aupperle-Lellbach, Alexandra Kehl, Sven Rottenberg, Simone de Brot
Summary: AI histology can predict BRAF gene mutation in canine urothelial carcinoma, offering new opportunities in diagnostic and predictive tumour marker detection.
Article
Pathology
Christina M. Gutierrez, Bradley C. Carthon, Shreyas Joshi, Adeboye O. Osunkoya
Summary: Primary urothelial carcinoma of the ureter is a relatively rare type of urinary tract tumor, often found in association with other urinary tract tumors. Our understanding of this type of cancer is limited due to the lack of comprehensive studies, highlighting the need for further research to explore its clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, General & Internal
Bin Zheng, Qiquan Wu, Ren Wang, Gang Wang, Yu Ren, Guobin Wing
Summary: shRNA interference of B7-H3 gene expression can significantly inhibit the proliferation and invasion of bladder urothelial carcinoma T24 cells.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Urology & Nephrology
David D'Andrea, Surena Matin, Peter C. Black, Firas G. Petros, Homayoun Zargar, Colin P. Dinney, Michael S. Cookson, Wassim Kassouf, Marc A. Dall'Era, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeffrey M. Holzbeierlein, Trinity J. Bivalacqua, Srikala S. Sridhar, Scott North, Daniel A. Barocas, Yair Lotan, Andrew J. Stephenson, Bas W. van Rhijn, Philippe E. Spiess, Siamak Daneshmand, Shahrokh F. Shariat
Summary: The study found that patients with UTUC had a lower rate of pathological complete response but a higher rate of pathological objective response after NAC treatment. Cox regression analysis revealed that UTUC patients had better overall survival and cancer-specific survival outcomes.
Article
Medicine, Research & Experimental
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
Summary: This study aimed to explore the clinical significance of galectin-3 in the development of bladder cancer by examining its expression in urothelial carcinomas and normal tissues, and its correlation with clinicopathological factors. The results showed that galectin-3 was downregulated in bladder cancer and was not a useful marker for diagnosing or predicting the prognosis of bladder cancer.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Oncology
Ning Xu, Zhenmei Yao, Guoguo Shang, Dingwei Ye, Haixing Wang, Hailiang Zhang, Yuanyuan Qu, Fujiang Xu, Yunzhi Wang, Zhaoyu Qin, Jiajun Zhu, Fan Zhang, Jinwen Feng, Sha Tian, Yang Liu, Jianyuan Zhao, Jun Hou, Jianming Guo, Yingyong Hou, Chen Ding
Summary: This study provides an integrated multi-omics analysis of Chinese UC patients, revealing the association between SND1 and CDK5 amplifications and the activation of STAT3 in tumor proliferation. It also identifies chromosome 5p gain as a high-risk factor in NMIBC patients through actin cytoskeleton modulation. Phosphoproteomic analysis identifies UC-associated activated kinases, and proteomic analysis groups UC patients into distinct prognostic and molecular signature categories. Immune subtypes of UC tumors demonstrate a complex immune landscape with the amplification of TRAF2 related to increased PD-L1 expression. Lastly, GARS is validated to promote the pentose phosphate pathway by inhibiting activities of PGK1 and PKM2 in U-II subtype.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
Article
Oncology
Kaiwei Yang, Wei Yu, Huanhuan Liu, Feng Ding, Yanrui Zhang, Yun Zhang, Wang Wang, Feng Lou, Shanbo Cao, Huina Wang, Zhisong He
Summary: The study revealed significant genomic differences and carcinogenesis prevalence between UTUC and UCB, with differences in mutational landscape and driver genes. This suggests the necessity for site-specific management of patients with urothelial carcinoma. Mutational signatures could serve as screening tools for clinical differential diagnosis between UTUC and UCB.
Article
Oncology
Jing-Yi Chen, Chien-Feng Li, You-Syuan Lai, Wen-Chun Hung
Summary: The study found that increased stromal KDM2A in breast cancer is associated with advanced tumor stage and poor clinical outcome. KDM2A induces p53-dependent senescence and promotes the release of cytokines in fibroblasts, thereby promoting cancer cell proliferation. Inhibition of KDM2A reduces fibroblast senescence and suppresses tumor growth.
BRITISH JOURNAL OF CANCER
(2021)
Article
Peripheral Vascular Disease
Chien-Feng Li, Ti-Chen Chan, Cheng-I. Wang, Fu-Min Fang, Po-Chun Lin, Shih-Chen Yu, Hsuan-Ying Huang
Summary: Myxofibrosarcoma is genetically complex and lacks effective treatment strategies, but the overexpression of RSF1 and its interactions with the IL-1 beta signaling pathway may provide potential therapeutic targets for this type of cancer. Both in vitro and in vivo studies have demonstrated the oncogenic mechanisms of RSF1 and its association with angiogenesis, suggesting its prognostic and pathogenetic relevance in myxofibrosarcomas.
Article
Cell Biology
Hong-Yue Lai, Hsin-Hwa Tsai, Chia-Jui Yen, Liang-Yi Hung, Ching-Chieh Yang, Chung-Han Ho, Hsin-Yin Liang, Feng-Wei Chen, Chien-Feng Li, Ju-Ming Wang
Summary: This study found that HCC patients receiving sorafenib with HBV were at higher risk of mortality, and high EGFR expression was linked to HBV-induced sorafenib resistance. Additionally, AMPK/CEBPD-activated autophagy could be a potent strategy for improving the efficacy of sorafenib in HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiabei He, Chien-Feng Li, Hong-Jen Lee, Dong-Hui Shin, Yi-Jye Chern, Bruno Pereira De Carvalho, Chia-Hsin Chan
Summary: MIG-6 is upregulated in TNBC and associated with poor clinical outcomes, playing a role in reprogramming glucose metabolism and driving tumor growth. This study identifies MIG-6 as a novel prognostic biomarker, metabolism regulator, and molecular driver in triple-negative breast cancer.
Article
Oncology
Chien-Feng Li, Ti-Chun Chan, Cheng-Tang Pan, Pichpisith Pierre Vejvisithsakul, Jia-Chen Lai, Szu-Yu Chen, Ya-Wen Hsu, Meng-Shin Shiao, Yow-Ling Shiue
Summary: The study identified that EMP2 induces cytostasis through the TGF beta/SMAD/SP1 axis and recruits P2RX7 to enhance apoptosis in UBUC. These findings provide new insights for the design of UBUC targeting therapies.
Article
Genetics & Heredity
Tzu-Ju Chen, Ti-Chun Chan, Wan-Shan Li, Chien-Feng Li, Hung-Lung Ke, Yu-Ching Wei, Wen-Jeng Wu, Wei-Ming Li
Summary: The study identified EFEMP1 as a key player in the development and prognosis of UC, with high levels of EFEMP1 expression associated with adverse pathological features and predicting worse clinical outcomes.
Article
Medicine, General & Internal
Chia-Lin Chou, Tzu-Ju Chen, Yu-Feng Tian, Ti-Chun Chan, Cheng-Fa Yeh, Wan-Shan Li, Hsin-Hwa Tsai, Chien-Feng Li, Hong-Yue Lai
Summary: In this study, upregulated MUC2 immunoexpression in rectal cancer patients undergoing CCRT was found to be significantly associated with treatment resistance and worse prognosis, suggesting its potential as a prognostic marker.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pathology
Pei-Hang Lee, Yu-Chien Kao, Tsung-Han Hsieh, Jia-Bin Liao, Chien-Feng Li, Jen-Chieh Lee, Yi-Ming Chang, Ching-Di Chang, Shih-Chiang Huang, Tzu-Ju Chen, Ting-Ting Liu, Shih-Chen Yu, Hsuan-Ying Huang
Summary: Studying the clinicopathologic and genetic spectrum of extracranial myxoid mesenchymal tumors with fusions between EWSR1/FUS and CREB transcription factors revealed similarities and differences among groups, highlighting the morphologic overlap with myxoid angiomatoid fibrous histiocytoma and myoepithelial tumor/carcinoma. The relationships between fusion types and histology, immunoprofile, and outcome remain unclear.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Ti-Chun Chan, Chung-Hsi Hsing, Yow-Ling Shiue, Steven K. Huang, Kun-Lin Hsieh, Yu-Hsuan Kuo, Chien-Feng Li
Summary: This study uncovers the biological significance of the CEBPD/hsa-miR-429/VEGFA axis in angiogenesis and tumor growth in urothelial carcinoma (UC). By inhibiting hsa-miR-429, CEBPD stabilizes the expression of VEGFA, leading to the progression of UC.
Article
Oncology
Hong-Yue Lai, Li-Ching Wu, Po-Hsin Kong, Hsin-Hwa Tsai, Yen-Ta Chen, Yuan-Tso Cheng, Hao-Lun Luo, Chien-Feng Li
Summary: The high prevalence of dialysis and incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan may be related to aristolochic acid (AA) exposure. This study developed a fast and cost-effective AA detection platform and found correlations between AA detection and clinical outcomes, suggesting it as a predictive and prognostic biomarker.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yu-Wei Hsiao, Jhih-Ying Chi, Chien-Feng Li, Lei-Yi Chen, Yi-Ting Chen, Hsin-Yin Liang, Yu-Chih Lo, Jhen-Yi Hong, Chin-Pin Chuu, Liang-Yi Hung, Jyun-Yi Du, Wen-Chang Chang, Ju-Ming Wang
Summary: Targeting vital protumour factors found in stromal cells in the tumour microenvironment may be an effective strategy in cancer therapy. Loss of PTX3 in stromal cells has been shown to decrease the metastasis and growth of cancer cells. Clinically, stromal PTX3 expression is associated with adverse prognostic features and worse survival outcomes in TNBC. Furthermore, TGF-beta 1 induces PTX3 expression by activating CEBPD in stromal fibroblasts, leading to the metastasis and invasion of TNBC MDA-MB-231 cells.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Meng-Ta Sung, Yeh-Han Wang, Chien-Feng Li
Summary: This review emphasizes the importance of harmonization and standardization of tumor mutational burden (TMB) panels in clinical applications, and summarizes the various factors that affect the estimation of TMB, such as preanalytic, sequencing, bioinformatics, and interpretative factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ting-Ting Liu, Chien-Feng Li, Kien-Thiam Tan, Yi-Hua Jan, Pei-Hang Lee, Chih-Hao Huang, Shih-Chen Yu, Cheng-Feng Tsao, Jui-Chu Wang, Hsuan-Ying Huang
Summary: Genetic aberrations involving DNA damage repair in gastrointestinal stromal tumors (GISTs) have not been well studied. This study characterized DDR abnormalities using sequencing and amplification techniques, and validated the findings using immunofluorescence and immunohistochemistry. The results showed that heterozygous deletions frequently targeted DNA damage-sensing genes and were associated with age, risk levels, and biomarker expression. These findings are important for identifying potential DDR-defective GISTs and assessing prognosis.
Article
Microbiology
Po-Hsin Kong, Cheng-Hsiung Chiang, Ting-Chia Lin, Shu-Chen Kuo, Chien-Feng Li, Chao A. Hsiung, Yow-Ling Shiue, Hung-Yi Chiou, Li-Ching Wu, Hsiao-Hui Tsou
Summary: This study explores a machine learning-based mass spectrometry analysis method for rapid discrimination of methicillin-resistant Staphylococcus aureus (MRSA) in Staphylococcus aureus bacteremia (SAB). By establishing and calibrating the model, this method can identify MRSA 24 hours earlier and adjust the treatment accordingly.
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
