Article
Biochemistry & Molecular Biology
Mi Joung Kim, Daun Jung, Joo Youn Park, Seung Min Lee, Hee Jung An
Summary: This study identified that CAFs in ovarian serous carcinomas support migration and metastasis of ovarian cancer cells through the overexpression of GLIS1. Knockdown of GLIS1 in CAFs significantly inhibited the migration and invasion abilities of OC cells, indicating GLIS1 in CAFs may be a potential therapeutic target to inhibit OC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xin Ning, Guangyue Shi, Sujing Ren, Shuang Liu, Jing Ding, Ruichun Zhang, Lianwei Li, Qin Xie, Wei Xu, Fanling Meng, Rong Ma
Summary: GBAS is a newly identified gene that is amplified in approximately 40% of glioblastomas. This article investigates the expression, prognostic significance, and possible pathways of GBAS in ovarian cancer. The study found that GBAS is overexpressed in ovarian cancer and is associated with lymph node metastasis. Inhibition of GBAS expression reduces cell proliferation and migration and promotes apoptosis in ovarian cancer cells. Further research suggests that GBAS may regulate cancer progression through mitochondria-associated pathways and can be targeted by specific microRNAs.
Article
Biochemistry & Molecular Biology
Martha B. Alvarez-Elizondo, Daphne Weihs
Summary: In this study, the invasiveness of CD44(+)ALDH(+) cancer stem-like cells (CSCs) was investigated using a rapid mechanobiology-based assay. It was found that CD44(+)ALDH(+) cells showed higher invasiveness and migratory capacity, suggesting their potential role in disease progression and as prognostic markers for recurrence and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Michael W. Caminear, Brittney S. Harrington, Rahul D. Kamdar, Michael J. Kruhlak, Christina M. Annunziata
Summary: The study found that disulfiram was more effective in reducing the viability of TICs compared to NCTs, affecting NF kappa B signaling, and was more suitable as a therapeutic to prevent EOC relapse.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Biochemistry & Molecular Biology
Francesco Meghini, Torcato Martins, Qian Zhang, Nicolas Loyer, Michelle Trickey, Yusanjiang Abula, Hiroyuki Yamano, Jens Januschke, Yuu Kimata
Summary: A functional centrosome is crucial for animal development and physiology. In addition to regulating centriole duplication, ubiquitin-mediated proteolysis plays a vital role in controlling the precise regulation of centrosome. The research conducted on Drosophila demonstrates that APC/C-Fzr controls the levels of Spd2 to affect neural stem cell-specific asymmetric PCM recruitment and microtubule nucleation at interphase centrosomes. Furthermore, APC/C-Fzr-dependent Spd2 degradation facilitates the accumulation of Polo-dependent Spd2 phosphorylation for PCM recruitment.
Article
Biochemistry & Molecular Biology
Jiadi Lv, Yaoping Liu, Feiran Cheng, Jiping Li, Yabo Zhou, Tianzhen Zhang, Nannan Zhou, Cong Li, Zhenfeng Wang, Longfei Ma, Mengyu Liu, Qiang Zhu, Xiaohan Liu, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Yi Fang, Haizeng Zhang, Ning Wang, Yuying Liu, Bo Huang
Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.
Article
Cell Biology
Lingling Gao, Xin Nie, Rui Gou, Yuexin Hu, Hui Dong, Xiao Li, Bei Lin
Summary: This study found that ANXA2 from ovarian cancer cells can be transferred to HMrSV5 cells through exosomes. Exosomal ANXA2 not only promotes migration, invasion and apoptosis of HMrSV5 cells, but also regulates morphological changes and fibrosis of HMrSV5 cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Huijuan Tang, Adetunji P. Fayomi, Shoumei Bai, Navneet Gupta, Sandra Cascio, Dongli Yang, Ronald J. Buckanovich
Summary: The study aims to create and validate humanized affinity-matured EGFL6 neutralizing antibodies for clinical development. The results demonstrate that these antibodies have high affinity for EGFL6 and can effectively neutralize it, inhibiting cancer cell proliferation and metastasis, suppressing angiogenesis, and promoting tumor cell apoptosis.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xu Feng, Zhaodong Ji, Gong Yang
Summary: Ovarian cancer is a serious and deadly disease for females, and effective screening approaches are still lacking. Immunotherapy may revolutionize the treatment of this disease by revealing the interactions between ovarian cancer cells and immune molecules in the microenvironment, potentially leading to new therapeutic targets.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Reproductive Biology
Xiameng Shen, Conghui Wang, Huihui Zhu, Yaping Wang, Xinyu Wang, Xiaodong Cheng, Wanzhong Ge, Weiguo Lu
Summary: Tumor-derived exosomes play important roles in promoting migration and invasion of ovarian cancer cells. CD44, transferred through exosomes, influences the metastatic phenotype of cancer cells and may be a potential therapeutic target for ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Dhrishya Dharmapal, Athira Jyothy, Amrutha Mohan, P. G. Balagopal, Nebu Abraham George, Paul Sebastian, Tessy Thomas Maliekal, Suparna Sengupta
Summary: Recent cancer research has highlighted the importance of cancer stem cell (CSC) niches in tumor progression and treatment outcomes. The role of TUBB4B, a membrane trafficking protein, in sustaining CSCs in oral cancer has been investigated. It was found that TUBB4B may play a crucial role in constituting the CSC niche, potentially through its cooperation with signaling protein Ephrin-B1, which affects the self-renewal of oral cancer stem cells and leads to a poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhi Chen, Jie Chen, Xiaohong Xu, Qiuli Li, Caihua Zhang, Shuai Li, Lianlian Liu, Congyuan Cao, Demeng Chen, Qianting He
Summary: This study investigated the effect and mechanism of methyltransferase-like 3 (METTL3) on cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). The analysis of scRNA-seq and TCGA datasets revealed that METTL3 regulates the malignant behavior of BMI1(+) HNSCC CSCs through the cell division pathway. Knockout or overexpression models of Mettl3 were used, along with tracing and staining technologies, flow cytometry sorting, sphere formation assays, cell transfection, western blotting, and MeRIP-seq and MeRIP-qPCR techniques to validate the findings.
Article
Medicine, Research & Experimental
Jin Qian, Bauer L. LeSavage, Kelsea M. Hubka, Chenkai Ma, Suchitra Natarajan, Joshua T. Eggold, Yiren Xiao, Katherine C. Fuh, Venkatesh Krishnan, Annika Enejder, Sarah C. Heilshorn, Oliver Dorigo, Erinn B. Rankin
Summary: Ovarian cancer-associated mesothelial cells play a critical role in promoting chemoresistance and stemness in ovarian cancer. The secreted factor osteopontin drives mesothelial-mediated chemoresistance and stemness, and therapeutic targeting of osteopontin may enhance platinum sensitivity in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding
Summary: The study found that n-butylidenephthalide (BP) can kill cancer stem cells (CSCs) of high-grade serous ovarian cancer (HGSOC) by inducing apoptosis, providing a new therapeutic approach for treating HGSOC.
Article
Peripheral Vascular Disease
Timothy D. Le Cras, Jillian Goines, Nora Lakes, Patricia Pastura, Adrienne M. Hammill, Denise M. Adams, Elisa Boscolo
Article
Oncology
Janet Crane, Jackie Manfredo, Elisa Boscolo, Mara Coyan, Clifford Takemoto, Maxim Itkin, Denise M. Adams, Timothy D. Le Cras
PEDIATRIC BLOOD & CANCER
(2020)
Article
Medicine, General & Internal
Shruti Gupta, Salim S. Hayek, Wei Wang, Lili Chan, Kusum S. Mathews, Michal L. Melamed, Samantha K. Brenner, Amanda Leonberg-Yoo, Edward J. Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Anand Srivastava, Yan Zhou, Anne Sutherland, Adam Green, Alexandre M. Shehata, Nitender Goyal, Anitha Vijayan, Juan Carlos Q. Velez, Shahzad Shaefi, Chirag R. Parikh, Justin Arunthamakun, Ambarish M. Athavale, Allon N. Friedman, Samuel A. P. Short, Zoe A. Kibbelaar, Samah Abu Omar, Andrew J. Admon, John P. Donnelly, Hayley B. Gershengorn, Miguel A. Hernan, Matthew W. Semler, David E. Leaf
JAMA INTERNAL MEDICINE
(2020)
Article
Urology & Nephrology
Shruti Gupta, Steven G. Coca, Lili Chan, Michal L. Melamed, Samantha K. Brenner, Salim S. Hayek, Anne Sutherland, Sonika Puri, Anand Srivastava, Amanda Leonberg-Yoo, Alexandre M. Shehata, Jennifer E. Flythe, Arash Rashidi, Edward J. Schenck, Nitender Goyal, S. Susan Hedayati, Rajany Dy, Anip Bansal, Ambarish Athavale, H. Bryant Nguyen, Anitha Vijayan, David M. Charytan, Carl E. Schulze, Min J. Joo, Allon N. Friedman, Jingjing Zhang, Marie Anne Sosa, Eric Judd, Juan Carlos Q. Velez, Mary Mallappallil, Roberta E. Redfern, Amar D. Bansal, Javier A. Neyra, Kathleen D. Liu, Amanda D. Renaghan, Marta Christov, Miklos Z. Molnar, Shreyak Sharma, Omer Kamal, Jeffery Owusu Boateng, Samuel A. P. Short, Andrew J. Admon, Meghan E. Sise, Wei Wang, Chirag R. Parikh, David E. Leaf
Summary: The study found that AKI-RRT is common among critically ill patients with COVID-19, with a mortality rate of over 50%. For patients with AKI-RRT, older age, severe oliguria, and admission to a hospital with fewer ICU beds or higher density of COVID-19 were associated with higher 28-day mortality rates.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Tariq U. Azam, Husam R. Shadid, Pennelope Blakely, Patrick O'Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A. Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H. Loosen, Evangelos J. Giamarellos-Bourboulis, Jesper Eugen-Olsen, Jochen Reiser, Salim S. Hayek
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Medicine, General & Internal
Salim S. Hayek, Samantha K. Brenner, Tariq U. Azam, Husam R. Shadid, Elizabeth Anderson, Hanna Berlin, Michael Pan, Chelsea Meloche, Rafey Feroz, Patrick O'Hayer, Rayan Kaakati, Abbas Bitar, Kishan Padalia, Daniel Perry, Pennelope Blakely, Shruti Gupta, Shahzad Shaefi, Anand Srivastava, David M. Charytan, Anip Bansal, Mary Mallappallil, Michal L. Melamed, Alexandre M. Shehata, Jag Sunderram, Kusum S. Mathews, Anne K. Sutherland, Brahmajee K. Nallamothu, David E. Leaf
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Article
Medicine, General & Internal
Shruti Gupta, Wei Wang, Salim S. Hayek, Lili Chan, Kusum S. Mathews, Michal L. Melamed, Samantha K. Brenner, Amanda Leonberg-Yoo, Edward J. Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Anand Srivastava, Yan Zhou, Diana Finkel, Adam Green, Mary Mallappallil, Anthony J. Faugno, Jingjing Zhang, Juan Carlos Q. Velez, Shahzad Shaefi, Chirag R. Parikh, David M. Charytan, Ambarish M. Athavale, Allon N. Friedman, Roberta E. Redfern, Samuel A. P. Short, Simon Correa, Kapil K. Pokharel, Andrew J. Admon, John P. Donnelly, Hayley B. Gershengorn, David J. Douin, Matthew W. Semler, Miguel A. Hernan, David E. Leaf
Summary: A multicenter cohort study found that early treatment with tocilizumab may reduce mortality among critically ill patients with COVID-19. Further research from randomized clinical trials is needed to confirm these findings.
JAMA INTERNAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wenquan Hu, Zhong Liu, Valerie Salato, Paula E. North, Joyce Bischoff, Suresh N. Kumar, Zhi Fang, Sujith Rajan, M. Mahmood Hussain, Qing R. Miao
Summary: Infantile hemangioma is characterized by rapid growth and slow involution of disorganized blood vessels. NGBR was found to be highly expressed in the proliferating phase of hemangioma but decreased in the involuting phase. Knockdown of NGBR in HemSCs attenuated RAS activation and inhibited cell migration and proliferation, suggesting its role in controlling growth and differentiation of hemangioma stem cells.
Article
Hematology
Zahra Alvandi, Joyce Bischoff
Summary: Endothelial-to-mesenchymal transition is a dynamic process where endothelial cells transition to mesenchymal cells, starting with loosening and migration, ultimately leading to decreased endothelial functions. This process plays a critical role in inflammation, angiogenesis, and cardiovascular diseases, affecting cell function and tissue integrity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Peripheral Vascular Disease
Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras
Summary: This study demonstrates that somatic mutations in NRAS can drive abnormal angiogenesis in human endothelial cells. The researchers developed in vitro and in vivo models to identify disease-causing pathways and test inhibitors. Treatment with a MAP kinase inhibitor prevented the abnormal changes caused by the NRAS(Q61R) mutation.
Article
Medicine, General & Internal
Patrick J. O'Hayer, Alexi Vasbinder, Elizabeth Anderson, Tonimarie Catalan, Brayden Bitterman, Ibrahim Khaleel, Grace Erne, Annika Tekumulla, Caroline Tilley, Feriel Presswalla, Namratha Nelapudi, Jiazi Chen, Medha Tripathi, Matthew Rochlen, Loni Rambo, Noor Sulaiman, Pennelope Blakely, Yiyuan Huang, Lili Zhao, Rodica Pop-Busui, Salim S. Hayek
Summary: The study found that COVID-19 patients in different stages had different characteristics and treatment approaches. The burden of comorbidities and inflammation decreased over time, leading to improved clinical outcomes.
AMERICAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Hematology
Joyce Bischoff
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Sana Nasim, Jill Wylie-Sears, Xinlei Gao, Qianman Peng, Bo Zhu, Kaifu Chen, Hong Chen, Joyce Bischoff
Summary: Endothelial-to-mesenchymal transition (EndMT) is a dynamic process in which endothelial cells acquire mesenchymal properties and contribute to tissue remodeling and growth. CD45 is identified as a potential regulator of EndMT, as its inhibition blocks TGF-beta-induced EndMT. Activation of CD45 induces the EndMT phenotype and acquisition of mesenchymal cell properties in normal human endothelial cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Jacquelyn Manfredo, Clifford Takemoto, Elisa Boscolo, Denise Adams, Timothy LeCras, Janet Crane
HORMONE RESEARCH IN PAEDIATRICS
(2020)
Article
Medicine, Research & Experimental
Alexander J. Cole, Mangala Iyengar, Santiago Panesso-Gomez, Patrick O'Hayer, Daniel Chan, Greg M. Delgoffe, Katherine M. Aird, Euisik Yoon, Shoumei Bai, Ronald J. Buckanovich
