Article
Biochemistry & Molecular Biology
Ivan Sammir Aranda-Uribe, Julian Ramirez-Bello, Georgina Victoria-Acosta, Felipe Munoz-Gonzalez, Rosa Elda Barbosa-Cobos, Jose Moreno
Summary: The study found that the evaluated TNFAIP3 SNVs are not risk factors for rheumatoid arthritis in Mexican patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ana Triguero-Martinez, Emilia Roy-Vallejo, Nuria Montes, Hortensia de la Fuente, Ana Maria Ortiz, Santos Castaneda, Isidoro Gonzalez-Alvaro, Amalia Lamana
Summary: A study found that genetic variants in the LGALS1 gene are associated with Gal1 serum levels, and these genetic variants can explain the differences in Gal1 levels among patients, with higher levels of Gal1 being associated with lower levels of IL-6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Shicheng Guo, Yehua Jin, Jieru Zhou, Qi Zhu, Ting Jiang, Yanqin Bian, Runrun Zhang, Cen Chang, Lingxia Xu, Jie Shen, Xinchun Zheng, Yi Shen, Yingying Qin, Jihong Chen, Xiaorong Tang, Peng Cheng, Qin Ding, Yuanyuan Zhang, Jia Liu, Qingqing Cheng, Mengru Guo, Zhaoyi Liu, Weifang Qiu, Yi Qian, Yang Sun, Yu Shen, Hong Nie, Steven J. Schrodi, Dongyi He
Summary: Genome-wide association studies have identified over 100 genetic risk factors for rheumatoid arthritis, but they can only explain less than 40% of its heritability. To address the missing heritability, novel functional SNPs were identified through genotyping HLA SNPs and common SNPs located in miRNA. The study discovered new SNPs significantly associated with rheumatoid arthritis and demonstrated significant epistasis effects between certain SNPs.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Xiaoli Liu, Linna Peng, Dandan Li, Chunjuan He, Shishi Xing, Yuhe Wang, Yongjun He
Summary: Certain genetic variants of IL1R1 and IL1R2 were found to be associated with the susceptibility to rheumatoid arthritis (RA) in the Chinese Han population in this study.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Immunology
Ding-Ping Chen, Ying-Hao Wen, Wei-Tzu Lin, Fang-Ping Hsu, Kuang-Hui Yu
Summary: This study investigated the association between RA and single-nucleotide polymorphisms (SNPs) of co-stimulatory or co-inhibitory molecules. The results showed that there were 13 SNPs associated with RA, which may play an important role in immune regulation and require further research into the pathogenesis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Fengzhen Liu, Yahang Liang, Yu Zhao, Lili Chen, Xiaolin Wang, Chunquan Zhang
Summary: This meta-analysis examined the association between miRNA polymorphisms and susceptibility to RA and SLE. The study found that miR-146a rs2910164 and miR-499 rs3746444 may be associated with RA susceptibility in Caucasians, while miR-146a rs2431697 may increase the risk of SLE. Other miRNA polymorphisms were not found to be significantly associated with RA or SLE.
Article
Rheumatology
Mariya Blagoeva Kosturkova, Galya Mihaylova Mihaylova, Tanya Kirilova Shivacheva, Maria Atanasova Radanova
Summary: This study evaluated the associations of five SNPs in the C1q gene cluster with rheumatoid arthritis (RA) and its clinical and immunologic characteristics. The results showed significant associations between rs172378 and rs292001 with RA, while rs665691, rs682658, and rs294179 did not show significant associations. RA patients had lower C1q levels compared to healthy controls.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Lin-Lin Zhang, Xiao-Xiao Wu, Xu-Fan Wang, Dong-Sheng Di, Qian Huang, Rui-Shan Liu, Zong-Wen Shuai, Dong-Qing Ye, Rui-Xue Leng
Summary: The study investigated the association between SNPs in the miR-146a gene and susceptibility of RA, finding that the SNP rs2431697 in miR-146a gene is associated with RA risk. The effect size of this SNP was larger in Asian population compared to European population. Plasma TNF-alpha levels in healthy controls were inversely associated with the risk allele T of the SNP rs2431697.
ANNALS OF MEDICINE
(2021)
Article
Genetics & Heredity
Takashi Higuchi, Shomi Oka, Hiroshi Furukawa, Kota Shimada, Shinichiro Tsunoda, Satoshi Ito, Akira Okamoto, Misuzu Fujimori, Tadashi Nakamura, Masao Katayama, Koichiro Saisho, Satoshi Shinohara, Toshihiro Matsui, Kiyoshi Migita, Shouhei Nagaoka, Shigeto Tohma
Summary: This study found an association between rs2736100 and AD in RA patients, as well as an association between ATP11A rs1278769 and NSIP in older RA patients.
Article
Medical Laboratory Technology
Milena Despotovic, Tatjana Jevtovic Stoimenov, Sonja Stojanovic, Jelena Basic, Jasen Kundalic, Branka Dordevic, Milica Randelovic, Dusica Pavlovic
Summary: This study found significant differences in FokI genotypes among rheumatoid arthritis patients, with a higher susceptibility to RA in f allele carriers and to RA-OSTP in BsmI/ApaI Ba (AC) haplotype carriers.
CLINICAL BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
M. Shri Preethi, Asha Devi
Summary: This study found a significant association between the rs1738074 SNP in the TAGAP gene and RA, with the AG heterozygous genotype showing a stronger association. The novel candidate nsSNP rs759674898 only had the G allele, with no detection of the A allele in the studied population. This study emphasizes the importance of the rs1738074 SNP in the TAGAP gene in relation to RA in the Indian population.
Article
Virology
Shuyi Fang, Sheng Liu, Jikui Shen, Alex Z. Lu, Audrey K. Y. Wang, Yucheng Zhang, Kailing Li, Juli Liu, Lei Yang, Chang-Deng Hu, Jun Wan
Summary: Recent analysis of SARS-CoV-2 genomes revealed significant changes in SNV clustering since June 2020, with some SNV groups becoming dominant. Additionally, emerging groups of SNVs with sharply increased monthly incidence ratios of up to 70% were observed in November 2020. Further investigation identified sets of SNVs specific to patients' ages and/or gender, or strongly associated with mortality.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Maha Daghestani, Nashwa Othman, Mohammed A. Omair, Fahidah Alenzi, Maha A. Omair, Eman Alqurtas, Shireen Amin, Arjumand Warsy
Summary: This study conducted an investigation on the Saudi population and found that 6 single nucleotide polymorphisms (SNPs) were significantly associated with rheumatoid arthritis (RA), with 4 of them having a protective effect. Two SNPs showed significantly higher heterozygote frequencies in the control group compared to the patients. This indicates considerable heterogeneity in the genetics of RA in different populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Charity Masilela, Brendon Pearce, Joven Jebio Ongole, Oladele Vincent Adeniyi, Rabia Johnson, Mongi Benjeddou
Summary: This study investigated the association of 5 single nucleotide polymorphisms (SNPs) in selected genes with blood pressure (BP) response to enalapril treatment among South African adults with hypertension. The study found that certain variants in ADRB2 and BDKRB2 genes were independently associated with controlled hypertension, while there was a significant interaction observed between VEGFA, ABO, and NOS3 genes in blood pressure response to enalapril. The findings suggest that SNPs can be predictive markers for enalapril response in South African adults with hypertension.
Article
Biochemistry & Molecular Biology
Jeong Yong Lee, Eun Hee Ahn, Hyeon Woo Park, Ji Hyang Kim, Young Ran Kim, Woo Sik Lee, Nam Keun Kim
Summary: Recurrent implantation failure (RIF) may be related to embryo characteristics, immune factors, coagulation factors, and genetics. This study found significant differences in HOTAIR SNVs between RIF patients and healthy controls, which are associated with blood biochemical indicators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Araceli Hernandez-Zavala, Fernando Cortes-Camacho, Icela Palma-Lara, Ricardo Godinez-Aguilar, Ana Maria Espinosa, Javier Perez-Duran, Patricia Villanueva-Ocampo, Carlos Ugarte-Briones, Carlos Alberto Serrano-Bello, Paula Jesus Sanchez-Santiago, Jose Bonilla-Delgado, Marco Antonio Yanez-Lopez, Georgina Victoria-Acosta, Adolfo Lopez-Ornelas, Patricia Garcia Alonso-Themann, Jose Moreno, Carmen Palacios-Reyes
Article
Rheumatology
Mario Adan Moreno-Eutimio, Carmen Estefania Martinez-Aleman, Ivan Sammir Aranda-Uribe, Guillermo Aquino-Jarquin, Carlos Cabello-Gutierrez, Jose Manuel Fragoso, Rosa Elda Barbosa-Cobos, Miguel A. Saavedra, Julian Ramirez-Bello
Summary: This study investigates the association of three TNFSF4 single nucleotide variants with SLE susceptibility in Mexican patients. The results indicate that TNFSF4 rs1234315T/C, rs2205960G/T, and rs704840T/G are risk factors for SLE in Mexicans. Additionally, meta-analysis suggests that TNFSF4 rs2205960G/T is a risk factor for SLE in Latin Americans and Asians.
CLINICAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ivan Sammir Aranda-Uribe, Juan Carlos Lopez-Vazquez, Rosa Elda Barbosa-Cobos, Julian Ramirez-Bello
Summary: The study investigated the association between TLR4 and TLR9 gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Mexican patients, and found that these variants are not risk factors for RA or SLE in this population.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Icela Palma-Lara, Monserrat Perez-Ramirez, Patricia Garcia Alonso-Themann, Ana Maria Espinosa-Garcia, Ricardo Godinez-Aguilar, Jose Bonilla-Delgado, Adolfo Lopez-Ornelas, Georgina Victoria-Acosta, Maria Guadalupe Olguin-Garcia, Jose Moreno, Carmen Palacios-Reyes
Summary: FAM20C gene codes for a protein kinase that targets specific motifs on phosphoproteins in diverse tissues. Pathogenic variants of FAM20C cause Raine syndrome, characterized by atherosclerosis, bone formation, facial dysmorphisms and intracerebral calcifications. This review provides an overview of FAM20C targets and variants, as well as the clinical aspects of lethal and non-lethal RS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Hector Gonzalez-Pacheco, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Galileo Escobedo, Jose Manuel Fragoso
Summary: Genetic variants of the PCSK7 gene are significantly associated with the development of ACS and dyslipidemia, potentially increasing the risk of ACS.
Article
Immunology
Guillermo Valencia Pacheco, Yumi E. Nakazawa Ueji, Julian Ramirez Bello, Rosa E. Barbosa Cobos, Eduardo D. Jimenez Becerra, Lizbeth J. Gonzalez Herrera, Gerardo J. Perez Mendoza, Nubia A. Rivero Cardenas, Angelica Angulo Ramirez, Ricardo F. Lopez Villanueva
Summary: Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which genetic factors play a role in the susceptibility to develop it. The genetic differences between and within Mexican mestizo populations and the role of the TLR7 gene in the pathogenesis of SLE are important factors contributing to the complexity of LES.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Gustavo Rojas-Velasco, Alberto Lopez-Reyes, Laura Martinez-Gomez, Silvestre Ortega-Pena, Isela Montufar-Robles, Rosa Elda Barbosa-Cobos, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: In a case-control study, ABO gene polymorphisms were found to be associated with a higher risk of developing COVID-19. Specific genotypes and haplotypes were also related to the risk of disease development and platelet concentration in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Jose Manuel Fragoso, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez
Summary: FOXA3 polymorphisms are not associated with subclinical atherosclerosis, but they are related to cardiometabolic parameters in individuals with and without SA.
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Julian Ramirez-Bello, Marco Antonio Pena-Duque, Marco Antonio Martinez-Rios, Hilda Delgadillo-Rodriguez, Jose Manuel Fragoso
Summary: In this study, the association of BAT1, NFKBIL, LTA, and CASP1 single nucleotide polymorphisms and their gene-gene interactions with restenosis risk after coronary stenting was evaluated. The results showed that rs501192 A/G and rs580253 A/G polymorphisms, as well as the gene-gene interactions between BAT1-NFKBIL1-LTA-CASP1, were associated with an increased restenosis risk.
Article
Medicine, General & Internal
Gilberto Vargas-Alarcon, Maria del Carmen Gonzalez-Salazar, Adrian Hernandez-Diaz Couder, Fausto Sanchez-Munoz, Julian Ramirez-Bello, Jose Manuel Rodriguez-Perez, Rosalinda Posadas-Sanchez
Summary: This study found that the rs17574 polymorphism is associated with a lower risk of pCAD in diabetic patients. DPP4 concentrations were lower in diabetic pCAD patients, and carriers of the rs17574 GG genotype had the lowest protein levels.
Article
Biochemistry & Molecular Biology
Ivan Sammir Aranda-Uribe, Julian Ramirez-Bello, Georgina Victoria-Acosta, Felipe Munoz-Gonzalez, Rosa Elda Barbosa-Cobos, Jose Moreno
Summary: The study found that the evaluated TNFAIP3 SNVs are not risk factors for rheumatoid arthritis in Mexican patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Virology
Rosalinda Posadas-Sanchez, Jose Manuel Fragoso, Fausto Sanchez-Munoz, Gustavo Rojas-Velasco, Julian Ramirez-Bello, Alberto Lopez-Reyes, Laura E. Martinez-Gomez, Carlos Sierra-Fernandez, Tatiana Rodriguez-Reyna, Nora Elemi Regino-Zamarripa, Gustavo Ramirez-Martinez, Joaquin Zuniga-Ramos, Gilberto Vargas-Alarcon
Summary: This study found that TMPRSS2 gene polymorphisms are associated with the risk of COVID-19, with rs2298659, rs456298, and rs462574 polymorphisms being associated with a higher risk of developing the disease. Additionally, the rs456298 and rs462574 genotypes are related to higher levels of LDH and heart rate.
Review
Biochemistry & Molecular Biology
Diana Karen Mendiola-Soto, Diego Alberto Barcenas-Lopez, Carlos Jhovani Perez-Amado, Gabriela Marisol Cruz-Miranda, Juan Manuel Mejia-Arangure, Julian Ramirez-Bello, Alfredo Hidalgo-Miranda, Silvia Jimenez-Morales
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and although cure rates have increased, a significant number of patients still relapse. The role of microRNAs (miRNAs) as non-coding RNA genes in ALL has gained interest in terms of understanding the disease's molecular mechanisms and identifying clinical biomarkers. Consistent findings suggest that miRNAs can be useful in distinguishing between different types of leukemia and predicting chemotherapy response. However, there is limited research on the molecular interplay between miRNAs and their targeted genes. This review aims to discuss the various ways miRNAs could be involved in ALL and their clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Luis M. Amezcua-Guerra, Carlos A. Guzman-Martin, Isela Montufar-Robles, Rashidi Springall, Adrian Hernandez-Diazcouder, Rosa Elda Barbosa-Cobos, Fausto Sanchez-Munoz, Julian Ramirez-Bello
Summary: This study investigated the impact of the CD147 gene rs8259T>A single nucleotide variant on individuals with COVID-19 in Mexico. The results suggest that the CD147 rs8259T>A variant is significantly associated with susceptibility to COVID-19, acting as a risk factor.
