Review
Pharmacology & Pharmacy
Sian Chen, Chenbin Chen, Yuanbo Hu, Gendi Song, Xian Shen
Summary: Pancreatic cancer is a type of malignant tumor with poor prognosis, and the molecular mechanisms behind its development are not fully understood. In addition to key signaling pathways, noncoding RNAs like circRNAs have been found to be involved in pancreatic cancer progression. Compounds that regulate circRNA expression could potentially be beneficial in treating pancreatic cancer.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Nutrition & Dietetics
Cho-Won Kim, Kyung-Chul Choi
Summary: Iridoid glycosides play an important role in anti-cancer by inhibiting cancer cell growth and metastasis through multiple mechanisms. They can influence cancer cell growth by regulating the cell cycle and apoptosis-related signaling pathways, while also suppressing the activity of matrix metalloproteinases and reducing cancer cell invasiveness.
Review
Biochemistry & Molecular Biology
Wanglong Qiu, Chia-Yu Kuo, Yu Tian, Gloria H. Su
Summary: Activin, a member of the TGF-beta superfamily, is involved in various physiological processes and human diseases, particularly in tumorigenesis where it plays both tumor-suppressor and tumor-promoter roles. Understanding the mechanisms of activin signaling in tumorigenesis could lead to potential therapeutic targets for human cancers and other diseases.
Article
Nanoscience & Nanotechnology
Muhammad R. Haque, Caitlin R. Wessel, Daniel D. Leary, Chengyao Wang, Abhinav Bhushan, Faraz Bishehsari
Summary: Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, which hampers treatment and clinical trials. Patient-derived organoids (PDOs) have opened the door for personalized medicine. This study developed a tumor-chip device that replicates the PDAC tumor microenvironment and validated its application in drug testing.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Oncology
Adam L. Burrack, Ellen J. Spartz, Meagan R. Rollins, Ebony A. Miller, Maria Firulyova, Eduardo Cruz, Michael F. Goldberg, Iris X. Wang, Hezkiel Nanda, Steven Shen, Konstantin Zaitsev, Ingunn M. Stromnes
Summary: Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to therapy. Understanding the differentiation and maintenance of tumor-specific T cells in vivo can lead to innovative therapeutic strategies. The spleen harbors tumor-specific CD8 T cells that can be functionally distinguished based on Cxcr3 and Klrg1 expression. Cxcr3+ Klrg1- T cells possess stem cell-like properties, while Cxcr3-Klrg1+ T cells display characteristics of terminal differentiation. Intermediate Cxcr3+ Klrg1+ T cells in the spleen are highly enriched for tumor specificity. However, tumor-specific T cells infiltrating primary tumors lose Cxcr3 and Klrg1 expression and upregulate exhaustion markers PD-1 and Lag-3. The absence of Cxcr3 enhances IFN gamma production in primary tumors but facilitates cancer cell dissemination, emphasizing the importance of Cxcr3 in controlling metastasis. Intratumoral myeloid cells and splenic DC subsets differentially produce chemokines Cxcl10 and Cxcl9 following immunotherapy, influencing T cell differentiation. Overall, Cxcr3 influences peripheral T cell fate rather than intratumoral T cell trafficking, thereby mitigating tumor cell dissemination.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Engineering, Biomedical
Ozlem Sen, Melis Emanet, Gianni Ciofani
Summary: This review examines the use of nanomaterials in the detection and treatment of cancer metastasis, focusing on the impact of nanostructures on cell migration, invasion, and angiogenesis in the tumor microenvironment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Genetics & Heredity
Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, Francois Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse
Summary: There is an urgent need for new and improved biomarker modalities to estimate the risk of recurrence in breast cancer patients. This study provides proof of concept that various liquid biopsy read-outs could be used to build a multi-modal biomarker model that can distinguish between early metastasizing and non-metastasizing patients.
GENES AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Dongdong Yan, Di Cui, Yun Zhu, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi, Tengfei Liu, Nikki P. Y. Lee, Simon Law, Sai Wah Tsao, Stephanie Ma, Annie Lai Man Cheung
Summary: This study found that the expression of Cation-dependent mannose-6-phosphate receptor (M6PR) and ephrin type-B receptor 4 (EphB4) was significantly upregulated in exosomes derived from serglycin (SRGN)-overexpressing esophageal squamous cell carcinoma (ESCC) cells (SRGN Exo). SRGN Exo promoted ESCC cell invasion and tumor angiogenesis by upregulating M6PR, and enhanced ESCC cell invasion through upregulating EphB4. The expression levels of M6PR and EphB4 in the serum were positively correlated with SRGN expression levels in ESCC patients, and high serum M6PR levels were associated with poor overall survival rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Lihua Wang, Nv Mu, Nina Qu
Summary: This study investigated the impact of miR-29b-3p gene promoter methylation on angiogenesis, invasion, and migration in human pancreatic cancer. The results showed a negative correlation between miR-29b expression and its promoter methylation level. Inhibiting DNMT1 had a suppressive effect on pancreatic cancer cell migration and invasion, while miR-29b reversed the promotive effect of DNMT1 on tumor cell properties.
Review
Endocrinology & Metabolism
Carmen Clapp, Georgina Ortiz, Jose F. Garcia-Rodrigo, Maria G. Ledesma-Colunga, Oscar F. Martinez-Diaz, Norma Adan, Gonzalo Martinez de la Escalera
Summary: Inflammatory arthritis is a group of diseases caused by an overactive immune system, influenced by host factors, such as sex and stress. Prolactin (PRL), a hormone associated with rheumatoid arthritis (RA), has both positive and negative effects on the disease. This review focuses on the PRL/vasoinhibin axis, discussing its role in joint inflammation and the pathophysiology of RA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Michael Brandon Ware, Maggie Phillips, Christopher McQuinn, Mohammad Y. Zaidi, Hannah M. Knochelmann, Emily Greene, Brian Robinson, Cameron J. Herting, Thomas A. Mace, Zhengjia Chen, Chao Zhang, Matthew R. Farren, Amanda N. Ruggieri, Jacob S. Bowers, Reena Shakya, Alton B. Farris, Gregory Young, William E. Carson III, Bassel El-Rayes, Chrystal M. Paulos, Gregory B. Lesinski
Summary: This study demonstrates that anti-IL-6 and anti-CTLA-4 antibodies can enhance antitumor immune responses to pancreatic cancer. Dual blockade of IL-6 and CTLA-4 inhibits tumor growth by inducing T cell infiltrations and secretion of IFN-gamma by CD4+ T cells. The efficacy of this combination therapy is dependent on the CXCR3 axis and the presence of both CD4+ and CD8+ T cells.
Review
Cell Biology
Devi Satarkar, Chinmoy Patra
Summary: This review provides a comprehensive description of the role of CXCR3 and its ligands in the immune system and diseases, highlighting the potential of CXCR3 as a therapeutic target and an early diagnostic biomarker.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Masaya Yamanaka, Masamichi Hayashi, Fuminori Sonohara, Suguru Yamada, Haruyoshi Tanaka, Akihiro Sakai, Shinji Mii, Daigo Kobayashi, Keisuke Kurimoto, Nobutake Tanaka, Yoshikuni Inokawa, Hideki Takami, Norifumi Hattori, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Summary: Decreased ROBO4 expression is associated with malignant phenotypes and poor survival outcomes in pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Cecilia Bica, Alexandru Tirpe, Andreea Nutu, Cristina Ciocan, Sergiu Chira, Eugen S. Gurzau, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: This article presents an integrative review on the implications of semaphorins in cancer, specifically discussing their role in cell proliferation/survival, angiogenesis, invasion, metastasis, stemness, and chemo-resistance/response. It highlights the heterogeneity of semaphorins as a family and their interaction with the tumor microenvironment components in driving cancer progression. The differences observed in the biological structure of semaphorins and the specificities of each cancer type necessitate viewing each semaphorin as a unique entity and conducting research accordingly. A deeper understanding of the molecular mechanisms promoting and sustaining the malignant behavior of cancer cells is crucial.
Article
Biochemistry & Molecular Biology
Zhengcheng Wang, Xiang Ao, Zhilin Shen, Luoquan Ao, Xiaofeng Wu, Chengxiu Pu, Wei Guo, Wei Xing, Min He, Hongfeng Yuan, Jianhua Yu, Ling Li, Xiang Xu
Summary: Chronic inflammation-induced metastases in cancer have been a significant obstacle in treatment. Recent studies have shown that TNF-alpha activates PI3K/Akt and p38 MAPK pathways to enhance CXCL10 transcription, promoting metastases in colon cancer cells. CXCL10, in turn, regulates EMT in colon cancer cells via the PI3K/Akt pathway, offering a new potential target for inhibiting colon cancer metastases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Tra Ly Nguyen, Marie-Julie Nokin, Silvia Teres, Mercedes Tome, Clement Bodineau, Oriane Galmar, Jean-Max Pasquet, Benoit Rousseau, Sebastian van Liempd, Juan Manuel Falcon-Perez, Elodie Richard, Elodie Muzotte, Hamid-Reza Rezvani, Muriel Priault, Marion Bouchecareilh, Isabelle Redonnet-Vernhet, Julien Calvo, Benjamin Uzan, Francoise Pflumio, Patricia Fuentes, Maria L. Toribio, Abdel-Majid Khatib, Pierre Soubeyran, Piedad Del Socorro Murdoch, Raul Duran
Summary: Upregulation of Notch1 in T-ALL induces metabolic changes in glutamine, leading to increased glutamine addiction. Notch1 also activates the mTORC1 pathway through increased glutaminolysis, promoting cell growth. Combined treatment targeting mTORC1 and limiting glutamine availability has a synergistic effect in inducing apoptosis and preventing Notch1-driven leukemia progression.
MOLECULAR ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Marie-Louise F. Van Velthuysen, Anne Couvelard, Guido Rindi, Nicola Fazio, Dieter Hoersch, Els J. Nieveen van Dijkum, Gunter Kloeppel, Aurel Perren
Summary: In recent years, there have been changes in the WHO classification of neuroendocrine neoplasms (NEN), leading to the establishment of a working group by ENETS to develop standardized reporting templates. These templates allow for recording of essential information and help distinguish between different types of neuroendocrine tumors.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zongsheng He, Abdel-Majid Khatib, John W. M. Creemers
Summary: Furin, as the first discovered proprotein convertase member, plays diverse roles in cancer by regulating the maturation of various protein precursors. Understanding the functions and regulations of Furin in cancer cells is crucial for developing effective strategies in cancer treatment.
Review
Pathology
Anne Couvelard, Jerome Cros
Summary: This review examines the classification and recent advancements in molecular understanding of digestive neuroendocrine neoplasms (NENs), and discusses important issues in diagnosis and the use of biomarkers.
Article
Multidisciplinary Sciences
Kevin Boye, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L. Ackerman, Anne Eichmann
Summary: The authors demonstrate that Netrin-1-Unc5B signaling is crucial for maintaining blood-brain barrier integrity by regulating Wnt/b-catenin signaling, and blocking Netrin-1 binding to Unc5B with antibodies leads to temporary BBB breakdown. These findings provide new insights into the understanding and treatment of CNS diseases.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Simon Pernot, Serge Evrard, Abdel-Majid Khatib
Summary: This article discusses the importance of the reciprocal interactions between tumor cells and stromal cells in the evolution and survival of cancer cells, as well as the impact of immune cells and other cells on tumor progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jean Descarpentrie, Marcos J. Arauzo-Bravo, Zongsheng He, Alexia Francois, Alvaro Gonzalez, Patricia Garcia-Gallastegi, Iker Badiola, Serge Evrard, Simon Pernot, John W. M. Creemers, Abdel-Majid Khatib
Summary: This study reveals that the malignant phenotype of colorectal cancer stem cells can be repressed by inhibition of the proprotein convertase Furin, leading to reduced expression of stem cell markers LGR5 and Nanog, as well as dysregulated expression of several calcium regulators. Targeting Furin may provide a potential therapeutic approach for colorectal cancer stem cells.
Article
Microbiology
Noemie Pied, Coralie F. Daussy, Zoe Denis, Jessica Ragues, Muriel Faure, Richard Iggo, Mario P. Tschan, Benoit Roger, Fabienne Rayne, Harald Wodrich
Summary: Intracellular pathogens cause membrane damage and cells respond by activating autophagy. The mechanism of autophagy induction during viral infections is rarely studied. This study investigates the cellular response to membrane damage during adenoviral entry and demonstrates that TBK1 kinase plays a crucial role in promoting autophagy in response to membrane penetration by adenoviruses. TBK1 is rapidly activated and recruited to the penetration sites, and its recruitment depends on damage recognition via galectin 8. This work highlights the importance of TBK1 in the cellular response to membrane damage and the activation of autophagy.
Review
Oncology
Alexia Francois, Jean Descarpentrie, Iker Badiola, Geraldine Siegfried, Serge Evrard, Simon Pernot, Abdel-Majid Khatib
Summary: Immunotherapy is an advanced clinical management for various cancers, achieved by rebuilding aberrant immune surveillance on cancers through in vivo or ex vivo engineering of efficient immune cells. The programming of immune cells using different strategies has improved their therapeutic influence and specificity. However, effective immunotherapy must consider the complete complexity of immune cell function.
BRITISH JOURNAL OF CANCER
(2023)
Review
Neurosciences
Elise Drape, Typhaine Anquetil, Bruno Larrivee, Alexandre Dubrac
Summary: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by vessel dilatation and arteriovenous malformations (AVM). Recent studies have found that brain AVMs in HHT patients are associated with abnormalities in vascular endothelial cells, with the PI3K/AKT signaling pathway being a key factor in disease progression.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Cell Biology
Malak Alannan, Hala Fatrouni, Veronique Trezeguet, Franziska Dittrich-Domergue, Patrick Moreau, Geraldine Siegfried, Benjamin Liet, Abdel-Majid Khatib, Christophe F. Grosset, Bassam Badran, Hussein Fayyad-Kazan, Aksam J. Merched
Summary: The inhibition of PCSK9 in liver cancer cells can effectively suppress cell proliferation and enhance vulnerability to iron-triggered lipid peroxidation. Targeting the key metabolic player PCSK9 may be a potential therapeutic approach for treating liver cancers.
Article
Cell Biology
Celine Gounou, Flora Bouvet, Benjamin Liet, Valerie Prouzet-Mauleon, Lena d'Agata, Etienne Harte, Francoise Argoul, Geraldine Siegfried, Richard Iggo, Abdel-Majid Khatib, Anthony Bouter
Summary: ANXA5 and ANXA6 are crucial components of the membrane repair machinery in MDA-MB-231 cells and are correlated with the invasiveness of breast cancer cells. High expression of ANXA5 and ANXA6 predicts poor prognosis in high-grade lung, gastric, and breast cancers. Genetic inhibition of ANXA5 and ANXA6 in zebrafish significantly reduces tumor cell dissemination.
BIOLOGY OF THE CELL
(2023)
Article
Biochemistry & Molecular Biology
Steffen E. Kuenzel, Leonie T. M. Flesch, Dominik P. Frentzel, Vitus A. Knecht, Anne Ruebsam, Felix Dreher, Moritz Schuette, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Antonia M. Joussen, Oliver Zeitz
Summary: The BIOMAC study investigates the link between systemic proteomic signals and macular disease in neovascular age-related macular degeneration (nAMD) under anti-VEGF therapy. By analyzing proteomic profiles and clinical features, the study identifies underlying health conditions, biomarkers for disease control, and complex molecular patterns determining disease expression. These findings highlight the importance of considering systemic signals in understanding and treating nAMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marta Martin-Bornez, Debora Falcon, Rosario Morrugares, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. A. Rosado, Isabel Galeano-Otero, Tarik Smani
Summary: Myocardial infarction (MI) leads to the loss of cardiac myocytes and damage to the coronary microcirculation, which exceeds the regenerative capacity of the heart. The repair process after MI involves angiogenesis, fibroblast proliferation, and scar formation. Various signaling pathways, including Notch, Wnt, PI3K, and modulation of intracellular Ca2+ concentration, regulate angiogenesis in the infarcted heart. Additionally, cell-to-cell communication through extracellular vesicles containing pro-angiogenic proteins and miRNAs plays a role in cardiac repair after MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Floriane Lagadec, Irene Carlon-Andres, Jessica Ragues, Sarah Port, Harald Wodrich, Ralph H. Kehlenbach
Summary: After receptor-mediated endocytosis, adenoviral capsids travel to the nuclear envelope via microtubule organizing centers. Capsid disassembly and viral genome import into nuclei involve nuclear pore complexes and the nucleoporins Nup214 and Nup358. The nuclear export receptor CRM1 is required for this process and can promote capsid disassembly even in mitotic cells, indicating an export-independent role. Additionally, inhibition of CRM1 by leptomycin B leads to a blockage of capsid movement, and a mutant CRM1 variant, W142A P143A, shows deficiency in capsid disassembly but is still capable of nuclear export of cargo proteins.
JOURNAL OF VIROLOGY
(2022)