Article
Cell Biology
Xiaoping Zhang, Dan Li, Chengyou Jia, Haidong Cai, Zhongwei Lv, Bo Wu
Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Quan Lin, Yan Jia, Duo Zhang, Hongjuan Jin
Summary: The study reveals that NCK1-AS1 is overexpressed in melanoma cell lines, and its knockdown inhibits the proliferation and migration of melanoma cells. Additionally, miR-526b-5p binds to NCK1-AS1 in melanoma, with ADAM15 validated as its downstream target.
CANCER CELL INTERNATIONAL
(2021)
Article
Genetics & Heredity
Jianhua Zhu, Yan Huang, Yong Zhang, Rongfu Huang, Chunmei Huang
Summary: In this study, we found that lncRNA KCNMB2-AS1 is significantly upregulated in bladder cancer tissues and cell lines, promoting the progression of bladder cancer. Mechanistically, lncRNA KCNMB2-AS1 functions as a competitive endogenous RNA (ceRNA) by sponging miR-374a-3p and regulating the expression of S100A10, contributing to bladder cancer progression.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Wei Zhang, Jingyu Zhang, Zhi Hu, Wei Sun, Lv Xu, Hao Chu, Xiao Wang, Qiao Fu
Summary: This study elucidates the impact of long non-coding RNA ARAP1-AS1 on bladder cancer cell function. ARAP1-AS1 facilitates malignant behavior in bladder cancer cells by sponging miR-3918 and regulating KIF20A expression.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abhishek Tyagi, Shih-Ying Wu, Sambad Sharma, Kerui Wu, Dan Zhao, Ravindra Deshpande, Ravi Singh, Wencheng Li, Umit Topaloglu, Jimmy Ruiz, Kounosuke Watabe
Summary: Smoking is associated with increased risk of lung cancer brain metastasis. Chronic nicotine exposure recruits specific cells, secretes specific genes, and enhances the metastatic capacity of tumor cells in the brain.
Article
Medicine, Research & Experimental
Katerina-Marina Pilala, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Petros Barbarigos, Panagiotis Levis, Georgios Kotronopoulos, Konstantinos Stravodimos, Andreas Scorilas, Margaritis Avgeris
Summary: Bladder cancer (BlCa) is characterized by heterogeneous molecular landscape and lacks personalized treatment. In this study, we investigated the epigenetic regulation of the miR-143/145 cluster in BlCa. We found that the methylation of MIR145 core promoter was associated with disease progression and poor survival in BlCa patients. Combining MIR145 core promoter methylation with established disease markers improved risk stratification and prediction of treatment outcome. Our findings highlight the importance of personalized risk stratification and management in BlCa.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Lanlan Wan, Dongsheng Gu, Xin Jin
Summary: The study demonstrates that NCK1-AS1 is highly expressed in LSCC cells and is associated with the development and malignant behaviors of LSCC. NCK1-AS1 upregulates the expression of NCK1 by interacting with miR-137, thereby promoting the proliferation, invasion, and migration of LSCC cells.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoming Yang, Xiaosong Wei, Chengzhi Yi, Yang Yang, Zhiwei Fang, Yuanheng Dai, Yufeng Guo, Dongkui Song
Summary: Bladder cancer (BC) is the most common malignant tumor in the genitourinary system. This study found that HAND2-AS1 is downregulated in BC tissues and its overexpression inhibited malignant behaviors of BC cells. Further investigation revealed that HAND2-AS1 acts as a suppressor in BC development through the modulation of miR-17-5p/KLF9 axis.
DNA AND CELL BIOLOGY
(2022)
Article
Medicine, General & Internal
Meng Xia, Li-Jun Duan, Bi-Nan Lu, Yu-Zhou Pang, Zong-Ran Pang
Summary: This study revealed that knockdown of lncRNA AFAP1-AS1 inhibits the stemness of cervical cancer cells by upregulating miR-27b-3p to suppress VEGF-C signaling pathway.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Bin Zhang, Juncheng Wang, Lei Du, Lufei Shao, Yourui Zou, Haibo Liu, Jinfang Liu
Summary: Knockdown of NCK1-AS1 attenuates the development of atherosclerosis by regulating the miR-1197/COX10 axis, suggesting that this lncRNA might be a potential therapeutic target for AS.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Cell Biology
Jin Hu, Haohao Huang, Zihan Xi, Shenghui Ma, Jie Ming, Fang Dong, Hui Guo, Huiqiong Zhang, Ende Zhao, Guojie Yao, Liu Yang, Feng Zhang, Wuping Zheng, Hengyu Chen, Tao Huang, Lei Li
Summary: In this study, the researchers investigated the functional role of a novel long noncoding RNA SEAS1 in breast cancer progression. They found that SEAS1 was downregulated in TNBC tissues and its knockdown increased the proliferation, migration, and invasion of TNBC cell lines. They also discovered that SEAS1 acted as a sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor inhibitor. Additionally, they demonstrated that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. Their findings suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Lei Du, Yongli Gao
Summary: The study revealed that PGM5-AS1 upregulates GDF10 gene expression by competitively binding to miR-587, thus inhibiting proliferation and accelerating apoptosis of PCa cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: Cancer-associated fibroblasts (CAF) promote cancer stemness and chemoresistance in urothelial bladder cancer (UBC) by overexpressing miR-146a-5p. MiR-146a-5p also enhances UBC stemness and chemoresistance by targeting ARID1A and PRKAA2 mRNA in UBC cells. Elevated levels of exosomal miR-146a-5p in UBC patients' serum are associated with tumor stage and relapse risk.
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)