Journal
CANCER MANAGEMENT AND RESEARCH
Volume 11, Issue -, Pages 10327-10335Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S231971
Keywords
microRNA-199a; target genes; carcinoma; biomarker; regulatory mechanisms
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Funding
- Natural Science Foundation of China [31572270]
- Key Scientific Research Projects of Henan Higher Education [19A180019]
- National Fostering Science Foundation Project of Henan Normal University [2016PL21]
- Postdoctoral research grant in Henan Province [001803040]
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microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.
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