Article
Energy & Fuels
S. Karthick Raja Namasivayam, Esther Haveela, K. Samra, R. S. Arvind Bharani, Sivaraj Sigamani, Ramachandran Srinivasan, M. Kavisri, Meivelu Moovendhan
Summary: The study investigated the enhanced cytotoxic effect of gold nanoparticle-loaded camptothecin on a breast cancer cell line. Camptothecin was isolated from Aspergillus niger biomass and loaded onto chemically synthesized gold nanoparticles, forming a nano-drug conjugate. The prepared nanoformulation showed significant anticancer activity against breast cancer cells.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Chemistry, Multidisciplinary
Maqusood Ahamed, Mohd Javed Akhtar, M. A. Majeed Khan, Hisham A. Alhadlaq
Summary: This study prepared pure ZnO nanoparticles, Mo-doped ZnO nanoparticles, and Mo-ZnO/reduced graphene oxide nanocomposites using a green and easy method with date palm fruit extract. The green synthesized Mo-ZnO/RGO nanocomposites exhibited enhanced anticancer activity and improved cytocompatibility compared to pure ZnO nanoparticles. The potential anticancer mechanism of Mo-ZnO/RGO nanocomposites was explored through oxidative stress and apoptosis. The findings suggest the potential of fruit-based facile preparation of ZnO-based nanocomposites for cancer therapy.
Article
Chemistry, Multidisciplinary
Menaka Priya Balaji, Rajakumar Govindasamy, Naiyf S. Alharbi, Shine Kadaikunnan, Muthu Thiruvengadam, Venkidasamy Baskar, Vijayarangan Devi Rajeswari
Summary: The synthesis of stable zinc oxide nanoparticles using the leaf part of Chamaecostus cuspidatus was successfully achieved. The nanoparticles were characterized in terms of size range, median particle size, and zeta potential. The cytotoxicity activity against various cell lines demonstrated a potential anti-tumor activity.
Article
Chemistry, Multidisciplinary
Sumaira Anjum, Khadija Nawaz, Bushra Ahmad, Christophe Hano, Bilal Haider Abbasi
Summary: This research focuses on the fabrication of bimetallic nanoparticles using plant extracts, specifically Manilkara zapota leaf extract. The study shows that the leaf extract is capable of bioreducing metal ions to produce core-shell Au-Ag and hybrid Au-ZnO and Ag-ZnO nanoparticles. The phytochemical profiling and spectroscopic analysis confirm the involvement of certain phytochemicals in the synthesis process. The synthesized bimetallic nanoparticles exhibit enhanced therapeutic efficacy compared to their monometallic components and show potential for various applications, including antibacterial, anticancer, and anti-aging treatments. Moreover, the biocompatibility of these nanoparticles towards brine shrimp larvae and human red blood cells suggests their environmental and biological safety.
Article
Chemistry, Multidisciplinary
Saima Maher, Shazia Nisar, Sania Muhammad Aslam, Farooq Saleem, Farida Behlil, Muhammad Imran, Mohammed A. Assiri, Arifa Nouroz, Nadra Naheed, Zarmina Azad Khan, Parveen Aslam
Summary: Cancer treatment development is hindered by chemotherapy side effects, drug resistance, and tumor metastasis, leading to a bleak outlook for cancer patients. In the past decade, nanoparticles have emerged as a promising technique for delivering medicine. Zinc oxide nanoparticles have shown potential in promoting cancer cell apoptosis and there is a urgent need for novel anti-cancer therapies.
Article
Pharmacology & Pharmacy
Awatif M. E. Omran
Summary: This study successfully synthesized zinc oxide nanoparticles using Cyperus rotundus rhizome. The nanoparticles exhibited stability and showed potential applications in antioxidation, antibacterial properties, cytotoxicity, and photocatalysis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shaimaa A. Mousa, El-Sayed R. El-Sayed, Samar S. Mohamed, Mohamed A. Abo El-Seoud, Adel A. Elmehlawy, Dalia A. M. Abdou
Summary: This study identified a fungal endophyte, Aspergillus terreus, capable of synthesizing multiple types of nanoparticles. Characterization and evaluation of the nanoparticles showed promising antioxidant and antimicrobial activities, highlighting the potential of endophytic fungi as a platform for nanoparticle synthesis.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Kanika Dulta, Gozde Kosarsoy Agceli, Parveen Chauhan, Rohit Jasrotia, P. K. Chauhan
Summary: The synthesis of zinc oxide nanoparticles using rhizome extract of plant B. ciliata was reported in this study, characterized by various techniques showing antimicrobial and antioxidant properties, as well as remarkable selective cytotoxicity against human cervical cancer and colon cancer cell lines.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Chemistry, Physical
Seyyed Vahid Mousazad Goorabjavari, Fateme Golmohamadi, Saba Haririmonfared, Hosein Ahmadi, Soheil Golisani, Hadi Yari, Anwarul Hasan, Zehra Edis, Mahsa Ale-Ebrahim, Majid Sharifi, Behnam Rasti, Fahimeh Nemati, Mojtaba Falahati
Summary: In this study, inorganic zinc oxide nanoparticles (ZnO NPs) were synthesized and their interaction with human serum albumin (HSA) was found to be mediated by hydrophobic forces forming a static complex, with minimal impact on the melting temperature and secondary structure of HSA. Furthermore, ZnO NPs exhibited selective anticancer effects on leukemia cells while being safe against normal cells.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Medicine, Research & Experimental
Maryam Farokhcheh, Leilabeigom Hejazian, Zeinab Akbarnejad, Fereshteh Pourabdolhossein, Seyed Mohammad Hosseini, Tahereh Mohammad Mehraei, Nabiollah Soltanpour
Summary: The study demonstrated the neuroprotective effect of geraniol on zinc oxide nanoparticles-induced neurotoxicity, improving learning and memory impairments, reducing oxidative stress and bioaccumulation. Geraniol shows promising therapeutic potential for cognitive function improvement.
Review
Chemistry, Physical
Th Abhishek Singh, Anirudh Sharma, Neeraj Tejwan, Noyel Ghosh, Joydeep Das, Parames C. Sil
Summary: Zinc oxide nanoparticles (ZnONPs) have garnered significant interest in nanobiotechnology for their diverse biomedical applications, serving as antibacterial, antioxidant, and antidiabetic agents, as well as playing a role in bone and soft-tissue regeneration for tissue engineering. Their future perspectives and mechanisms of action are also being explored.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Nutan Rani, Kavita Rawat, Mona Saini, Sapna Yadav, Saima Syeda, Kalawati Saini, Anju Shrivastava
Summary: In this article, researchers developed ZnO nanoparticles using the leaf extract of Azadirachta indica and tested their cytotoxicity on cervical cancer cell lines. The results showed significant cytotoxicity of the biosynthesized ZnO nanoparticles against the cancer cells, indicating their potential as a treatment option for cervical cancer.
Article
Crystallography
Asif Kamal, Malka Saba, Khetab Ullah, Saeedah Musaed Almutairi, Bandar M. AlMunqedhi, Mohamed Ragab abdelGawwad
Summary: In recent years, nanotechnology has emerged as an important field for the synthesis of nanoparticles using biological processes. Mushroom extract is a prominent method in biological synthesis due to its abundance of biologically active compounds. In this study, Zinc Oxide nanoparticles (ZnO NPs) were successfully synthesized using Daedalea sp. mushroom extract. The nanoparticles exhibited irregular morphology, with an average size of 14.58 nm. Various analytical techniques confirmed the synthesis of ZnO NPs, which were then tested for biocompatibility, antifungal, antileishmanial, and antibacterial activities. The ZnO nanoparticles showed strong antibacterial effects against both gram-positive and gram-negative bacteria, as well as high antifungal activity against Aspergillus niger fungus.
Article
Environmental Sciences
Muhammad Imran Ghani, Sana Saleem, Shabir A. Rather, Muhammad Saad Rehmani, Saud Alamri, Vishnu D. Rajput, Hazem M. Kalaji, Noor Saleem, Tanveer Ali Sial, Mengyun Liu
Summary: The study demonstrates that foliar application of zinc oxide nanoparticles can significantly enhance the growth performance of cucumber and reduce the negative impacts of drought stress. Furthermore, the application of zinc oxide nanoparticles also improves photosynthetic pigments, photosynthesis, and PSII activity in plants, contributing to increased stress tolerance.
Article
Environmental Sciences
Nguyen Thuy Lan Chi, Geetha Royapuram Veeraragavan, Kathirvel Brindhadevi, Arunachalam Chinnathambi, Saleh H. Salmen, Sulaiman Ali Alharbi, Ramakrishnan Krishnan, Arivalagan Pugazhendhi
Summary: The purpose of this study was to assess the bio-fabrication possibilities of metal-tolerant Aspergillus niger biomass filtrate and the anticancer potential of synthesized silver nanoparticles. The results showed that A. niger has the ability to reduce nitrate and efficiently fabricate AgNPs. These AgNPs, capped and stabilized with various functional groups, exhibited in-vitro anticancer potential when tested against the HeLa cell line.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vahid Pouresmaeil, Ali Hakem Al Abudi, Ammar Hossein Mahimid, Mohammad Sarafraz Yazdi, Ali Es-haghi
Summary: This study investigates the relationship between serum selenium and copper levels with inflammatory cytokines and oxidative stress in patients with type 2 diabetes mellitus (T2DM). The results show that increased levels of copper and selenium are associated with higher levels of markers of oxidative stress and inflammatory cytokines, indicating their importance in the development of T2DM.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Polymer Science
Mohammdamin Bozorgi Kasgari, Mohammad Hossein Hazrati, Majid Tabasi Moghaddam, Attiye Sadeghi Kowsarkhizi, Mohsen Zareian, Ehsan Karimi, Ehsan Oskoueian
Summary: Salmonella infection is a global public health issue. This study found that microencapsulated phenolic compounds from Teucrium polium leaves can improve the growth and health status of mice challenged by Salmonella enteritidis infection.
Article
Biochemistry & Molecular Biology
Vahideh Haeri, Ehsan Karimi, Ehsan Oskoueian
Summary: In this study, kaempferol was encapsulated into nanoliposomal structures and the health-promoting effects of nanoliposome-loaded kaempferol were evaluated in mice challenged by cadmium-induced toxicity. The findings showed that dietary supplementation with nanoliposome-loaded kaempferol could alleviate the toxicity of cadmium in mice.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Farzaneh Sadeghzadeh, Atefeh Sadat Ziaratnia, Masoud Homayouni Tabrizi, Ghazal Hosseini Torshizi, Maitham Alhajamee, Davoud Khademi
Summary: This study aimed to develop a PLGA-based nanosystem modified with PEG, chitosan, and folic acid for the delivery of colchicine to cancer cells. The fabricated nanosystem showed antioxidant effects and induced apoptosis in HT-29 cancer cells. The use of PPCF-NPs system for colchicine delivery can selectively target cancer cells and induce apoptosis.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Biochemistry & Molecular Biology
Kimia Firouzabadi, Ehsan Karimi, Masoud Homayouni Tabrizi
Summary: Flavonoid compounds have shown effective cancer suppression, and nanocarriers have been used to improve their properties and transmission. In this study, polyethylene glycol-modified albumin nanoparticles were synthesized and loaded with naringenin, followed by binding of folic acid to the nanoparticle surface. The nanoparticles exhibited desirable physicochemical properties and demonstrated significant effects on the apoptosis mechanism.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Amin Farhadi, Masoud Homayouni Tabrizi, Soroush Sadeghi, Danial Vala, Tina Khosravi
Summary: The aim of this study was to enhance the treatment effectiveness by loading Chrysin (CHY) on solid lipid nanoparticles (SLNs) and decorating them with folate-bound chitosan. The synthesized CHY-SCF-NPs showed increased size, change in surface charge, and demonstrated potent anti-cancer properties, making them a promising candidate for pancreatic cancer treatment.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Biochemical Research Methods
Helia Ghafaripour, Masoud Homayouni Tabrizi, Ehsan Karimi, Niloofar Barati Naeeni
Summary: The present study aimed to investigate the anticancer effects of lawsone encapsulated in folic acid (FA) and chitosan (CS) modified polylactic-co-glycolic acid (PLGA) nanoparticles against Panc-1 cells. The nanoparticles were characterized in terms of shape/size and zeta potential index, and the lawsone entrapment efficacy was evaluated. Apoptosis induction, cell cycle arrest, and gene expression were assessed to study the anticancer mechanisms. The nanoparticles exhibited antioxidative and antibacterial activities. The findings suggest that lawsone-loaded PLGA-FA-CS nanoparticles hold great potential in pancreatic cancer treatment.
IET NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Somayeh Khezri, Sara Karimian, Ehsan Yousefi, Ali Es-haghi
Summary: This study aims to evaluate the cytotoxic and antioxidant effects of walnut oil nanoemulsion on CT26 colon cancer cells. The results showed that the nanoemulsion has the ability to scavenge free radicals and is toxic to both CT26 colon cancer cells and HUVEC normal cells. The findings suggest that the walnut oil nanoemulsion has potential anticancer properties.
MICRO & NANO LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Hussein Ajel Alhadidi, Masoud Homayouni Tabrizi, Maryam Ghobeh
Summary: In this study, nanoparticles modified with chitosan and folic acid were designed to optimize the effects of arctiin on cancer cells. The synthesized nanoparticles showed good antioxidant and anti-inflammatory properties, indicating that modifying the surface of nanoparticles can enhance the bioavailability, stability, and effectiveness of medicinal compounds in therapy.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Mahshad Mollaei, Masoud Homayouni Tabrizi, Ali Es-haghi
Summary: Kaempferol was utilized as an efficient anti-breast cancer compound by improving its cellular uptake and aqueous solubility with the help of human serum albumin and folate-linked chitosan polymer. The synthesized nano-transporters selectively induced apoptotic death in human MCF-7 breast cancer cells and have the potential to be used as a selective anti-breast cancer compound.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Chemistry, Physical
Masoud Homayouni Tabrizi, Mozhgan Soltani, Ali Es-haghi
Summary: In this study, FC was loaded into SLN coated with FA-bound CS and exhibited significant growth and proliferation inhibitory effects in multiple human cancer cells. The FC-SLN-CS-FA formulation induced apoptotic cell death and downregulated genes associated with cell survival. Furthermore, FC-SLN-CS-FA demonstrated antioxidant properties and significantly inhibited angiogenesis. These findings suggest that FC-SLN-CS-FA nanoparticles have the potential to be an efficient anticancer agent.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Hoda Zarharan, Mahlasadat Bagherian, Ali Shah Rokhi, Romina Ramezani Bajgiran, Ehsan Yousefi, Pedram Heravian, Mitra Niazi Khazrabig, Ali Es-haghi, Mohammad Ehsan Taghavizadeh Yazdi
Summary: A novel nanocomposite Se-Au-CS was prepared and characterized, and its antioxidant and anti-angiogenesis effects were evaluated. The study demonstrated successful synthesis of Se and Au nanoparticles, and showed that Se-Au-CS exhibited effective anti-angiogenesis effects. These findings suggest the potential application of Se-Au-CS in cancer treatment.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Sogand Sanei, Mohammadamin Bozorgi Kasgari, Fatemeh Abedinzadeh, Atena Poor Sasan, Saeid Hassani, Ehsan Karimi, Ehsan Oskoueian, Mohammad Faseleh Jahromi
Summary: This study designed and evaluated microcapsules loaded with bioactive compounds from date seeds for their inhibitory effects on mold-contaminated diets. The developed microcapsules were spherical and homogeneous, with a size of 2.58 μm and acceptable PDI of 0.21. HPLC analysis confirmed the presence of xylose, fructose, mannose, glucose, and galactose as the main phytochemicals in the microcapsules. In vivo analysis demonstrated that mice receiving date seed microcapsules showed significant improvements in weight gain, feed intake, liver enzymes, and lipid peroxidation compared to mice receiving mycotoxin-contaminated diets. Moreover, the encapsulated bioactive compounds up-regulated the expression of GPx, SOD, IFN-γ, and IL-2 genes while down-regulating the iNOS gene. Overall, these findings suggest that the novel microcapsules loaded with date seed extracts have promising potential as mycotoxin inhibitors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Elena Rahimi, Farzaneh Asefi, Ahmadreza Afzalinia, Somayeh Khezri, Hadi Zare-Zardini, Adel Ghorani-Azam, Ali Es-haghi, Mohammad Ehsan Taghavizadeh Yazdi
Summary: In this study, a novel nanocomposite (CuO-Ag2O-NCs) based on chitosan coated copper/silver oxide nanoparticles was synthesized and evaluated for its effect on breast cancer. The results showed that CuO-Ag2O-NCs exhibited significant inhibitory effect on the growth of breast cancer cells and induced apoptosis. It also had lower toxicity on normal cells. The study suggests that CuO-Ag2O-NCs have potential as a treatment strategy for breast cancer.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
