Review
Rheumatology
Alice Courties, Francis Berenbaum, Jeremie Sellam
Summary: Vagus nerve stimulation (VNS) has shown promising effects in treating refractory epilepsy and various musculoskeletal diseases, particularly in dampening inflammatory responses in rheumatoid arthritis patients. Further studies and randomized controlled trials are needed to fully evaluate its efficacy.
Article
Immunology
Linlin Zhang, Sangsu Bang, Qianru He, Megumi Matsuda, Xin Luo, Yong-Hui Jiang, Ru-Rong Ji
Summary: Excessive inflammation is linked to autism spectrum disorder (ASD), and mutations of the synaptic scaffolding protein SHANK3 are involved in ASD. In this study, it was found that Shank3 deficiency aggravates hypothermia, systemic inflammation, and sepsis mortality induced by lipopolysaccharide (LPS) in mice. Shank3 regulates body temperature, inflammation, and sepsis in vagal sensory neurons.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Alice Courties, Camille Deprouw, Emmanuel Maheu, Eric Gibert, Jacques-Eric Gottenberg, Julien Champey, Beatrice Banneville, Camille Chesnel, Gerard Amarenco, Alexandra Rousseau, Francis Berenbaum, Jeremie Sellam
Summary: This open-label pilot study examined the efficacy and tolerance of transcutaneous auricular VNS (taVNS) on erosive hand osteoarthritis (EHOA) symptoms. The results showed that taVNS significantly reduced hand pain and improved the functional index, with no serious adverse events reported.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Emily Allen, Pott Pongpaopattanakul, Reshma A. Chauhan, Kieran E. Brack, G. Andre Ng
Summary: This study aimed to investigate the effects of electrical stimulation of the vagus nerve at varying parameters on NO release and cardiac electrophysiology using the isolated innervated rabbit heart preparation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Yaoyu Pu, Yunfei Tan, Youge Qu, Lijia Chang, Siming Wang, Yan Wei, Xingming Wang, Kenji Hashimoto
Summary: The study suggests that FMT from Chrna7 KO mice can induce depression-like phenotypes in ABX-treated mice, primarily through affecting gut microbiota composition and neural pathways.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Chemistry, Medicinal
Moein Ala, Mehdi Ghasemi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: Sumatriptan, a medication for migraine and cluster headaches, has been shown to possess anti-inflammatory properties and can protect against various inflammatory conditions by modulating inflammatory markers.
DRUG DEVELOPMENT RESEARCH
(2021)
Review
Behavioral Sciences
Yue Wang, Gaofeng Zhan, Ziwen Cai, Bo Jiao, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Immunology
Ningcen Li, Yi Guo, Yinan Gong, Yue Zhang, Wen Fan, Kaifang Yao, Zhihan Chen, Baomin Dou, Xiaowei Lin, Bo Chen, Zelin Chen, Zhifang Xu, Zhongxi Lyu
Summary: Acupuncture exhibits strong anti-inflammatory effects in multiple biological systems by regulating various immune cell populations and functions.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Lavoisier Akoolo, Vitomir Djokic, Sandra C. Rocha, Luis Ulloa, Nikhat Parveen
Summary: The study aimed to investigate whether electroacupuncture can alleviate symptoms of Lyme arthritis in mice by stimulating the sciatic-vagal network. The results showed that electroacupuncture had a lasting anti-inflammatory effect, reducing arthritis symptoms without affecting spirochete colonization. Therefore, electroacupuncture could be a promising therapeutic approach for patients with long-term Lyme disease manifestations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Chia-En Wong, Chi-Chen Huang, Ming-Tsung Chuang, Po-Hsuan Lee, Liang-Yi Chen, Hao-Hsiang Hsu, Chih-Yuan Huang, Liang-Chao Wang, Jung-Shun Lee
Summary: This study introduced the parameter of carotid-jugular angle (CJA) to predict the nerve origin in neck peripheral nerve sheath tumours (PNSTs). The results showed that CJA was associated with different nerve origins and could serve as a predictor for specific nerve origins. The findings provide evidence for surgical treatment and patient counselling.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Physiology
Michael Cremin, Sierra Schreiber, Kaitlin Murray, Emmy Xue Yun Tay, Colin Reardon
Summary: It is increasingly recognized that the nervous and immune systems have bidirectional communication and play a role in regulating immunological outcomes in various organs, including the lung. However, there are limitations in applying neural stimulation as a therapeutic for lung inflammation, especially for inflammation caused by novel pathogens. Better understanding of neuroanatomy and systematic evaluation of stimulation parameters using immune activation in lung tissues are needed to overcome these limitations. The communication between the nervous and immune systems has great potential in developing targeted therapeutics if specific challenges can be overcome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Soo Youn Song, Ye Won Jung, WonKyo Shin, Mia Park, Geon Woo Lee, Soohwa Jeong, Sukjeong An, Kyoungmin Kim, Young Bok Ko, Ki Hwan Lee, Byung Hun Kang, Mina Lee, Heon Jong Yoo
Summary: Endometriosis, a common gynecologic disease, often leads to various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. Inflammatory responses, nervous system sensitization, and altered distribution of nerve fibers may contribute to chronic pain in these patients. Understanding these mechanisms is crucial in guiding treatment decisions for endometriosis-related pain symptoms.
Review
Clinical Neurology
Jorge A. Ramos-Castaneda, Carlos Federico Barreto-Cortes, Diego Losada-Floriano, Sandra Milena Sanabria-Barrera, Federico A. Silva-Sieger, Ronald G. Garcia
Summary: This systematic review summarizes the scientific evidence on the safety and efficacy of Vagus Nerve Stimulation (VNS) on upper limb motor recovery after stroke. The results demonstrate that VNS, together with physical rehabilitation, significantly improves upper limb motor function in stroke patients and is a safe intervention.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Josh McGovern, Stephen Leadbitter, Gillian Miller, Adam Hounat, Irvine Kamande, Ross D. D. Dolan, Paul G. G. Horgan, David K. K. Chang, Nigel B. B. Jamieson, Donald C. C. McMillan
Summary: In this study, high vagal nerve activity, as measured by HRV, was not significantly associated with TNM stage, co-morbidity, systemic inflammation, or survival in patients undergoing potentially curative surgery for colorectal cancer (CRC). These findings suggest that HRV may not be a relevant factor in the treatment and survival of CRC.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Yumo Li, Binbin Wu, Cong Hu, Jie Hu, Qingquan Lian, Jun Li, Daqing Ma
Summary: This study found that Dexmedetomidine plays a role in protecting the lungs by increasing vagal nerve tone. The indirect anti-inflammatory effects and direct cytoprotective effects of Dexmedetomidine are likely achieved through increased vagal nerve tone and activation of alpha 2-adrenoceptors, respectively.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)