Review
Clinical Neurology
Zhiqing Tang, Kaiyue Han, Rongrong Wang, Yue Zhang, Hao Zhang
Summary: Excitatory rTMS over the ipsilesional hemisphere significantly improves upper limb motor function, hand strength, and hand dexterity in stroke patients. Both iTBS and HF-rTMS can significantly promote upper limb motor function and hand dexterity, with excitatory rTMS being most beneficial when applied within the first 3 months after stroke.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Afifa Safdar, Marie-Claire Smith, Winston D. Byblow, Cathy M. Stinear
Summary: This review assessed the application of rTMS protocols for improving upper limb motor performance after stroke. The majority of studies still follow the interhemispheric competition model and do not consider the bimodal balance recovery model. Future studies should select patients and apply rTMS protocols based on ipsilesional corticomotor function.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Neurosciences
Xiaofang Wu, Rui Wang, Qunqiang Wu, Chunhua Liao, Jianshe Zhang, Huiduo Jiao, Baolin Chen, Shuyan Wang, Rui Liu
Summary: Upper limb motor impairments after stroke severely impact the quality of life of patients and their families. Transcranial magnetic stimulation (TMS) has been shown to be effective in promoting upper limb motor recovery. This study investigated the combined effect of high frequency repetitive TMS and cervical nerve root magnetic stimulation on functional improvement in stroke patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Joyce L. Chen, Ashley Schipani, Clarissa Pedrini Schuch, Henry Lam, Walter Swardfager, Alexander Thiel, Jodi D. Edwards
Summary: Cathodal tDCS on contralesional M1 may enhance motor recovery post-stroke, but the effects are small and consistent. Further research with larger cohorts is necessary to explore potential sub-populations that may respond to this approach.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Daigo Sakamoto, Toyohiro Hamaguchi, Kai Murata, Hiroshi Ito, Yasuhide Nakayama, Masahiro Abo
Summary: Repetitive transcranial magnetic stimulation (rTMS) combined with intensive occupational therapy improves upper limb motor paralysis and activities of daily living after stroke. This study aims to predict treatment effects and determine exercises for occupational therapy based on the severity of paralysis. It provides valuable insights for practice planning after rTMS treatment.
Review
Multidisciplinary Sciences
Ze-Jian Chen, Yang-An Li, Nan Xia, Ming-Hui Gu, Jiang Xu, Xiao-Lin Huang
Summary: This meta-analysis evaluated the effects of rPMS for upper limb rehabilitation in stroke patients. The results showed that rPMS can improve motor impairment, proximal muscle strength, and activity limitation outcomes, but not muscle spasticity and distal strength.
Article
Clinical Neurology
Sybren Van Hoornweder, Laurens Vanderzande, Eva Bloemers, Stefanie Verstraelen, Siel Depestele, Koen Cuypers, Kim van Dun, Carolien Strouwen, Raf Meesen
Summary: The study found that transcranial direct current stimulation (tDCS) can improve upper limb function in stroke patients, but its effectiveness depends on multiple factors, with particularly promising results in chronic stroke patients.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Xiaoming Xi, Hujun Wang, Liang Han, Mengmeng Ding, Jinglu Li, Chenye Qiao, Linlin Zhang, Zongjian Liu, Shuyan Qie
Summary: A systematic review and meta-analysis showed that repetitive transcranial magnetic stimulation (rTMS) combined with task-oriented training (TOT) has a positive effect on upper limb function recovery in stroke patients. The neuro plasticizing effect of rTMS may translate into functional improvement by promoting neuro electrical signaling.
Review
Clinical Neurology
Francisco Jose Sanchez-Cuesta, Yeray Gonzalez-Zamorano, Aida Arroyo-Ferrer, Marcos Moreno-Verdu, Juan Pablo Romero-Munoz
Summary: rTMS interventions over M1 are effective for improving upper limb motor function in people with subacute and chronic stroke. Early interventions are widely recommended, but interventions in subacute or chronic phases are still useful.
NEUROREHABILITATION
(2023)
Article
Medicine, General & Internal
Ji Hye Kang, Min-Wook Kim, Kyoung Ha Park, Young-Ah Choi
Summary: The study showed that LF rTMS + MI combined with additional ES led to greater improvement in upper extremity motor function after stroke. The change in FMA scores was significantly higher in the experimental group compared to the control group.
Review
Clinical Neurology
Gengbin Chen, Tuo Lin, Manfeng Wu, Guiyuan Cai, Qian Ding, Jiayue Xu, Wanqi Li, Cheng Wu, Hongying Chen, Yue Lan
Summary: This updated meta-analysis provides robust evidence of the efficacy of rTMS treatment in improving upper extremity and fine function during various phases of stroke.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Taotao Wang, Zhonghua Liu, Jianxiong Gu, Jizhi Tan, Tian Hu
Summary: This study compared the rehabilitation effects of soft robot gloves and repetitive transcranial magnetic stimulation (rTMS) in patients with severe upper limb motor dysfunction after a stroke. The results showed that there was no significant difference in FMA-UE score improvement between the soft robot glove group and the rTMS group, but the improvement was significantly better than the conventional treatment group. There was no significant difference in MBI score improvement among the three treatment groups.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Qiuwen Gong, Rubing Yan, Han Chen, Xia Duan, Xiaoyu Wu, Xin Zhang, Yi Zhou, Zhou Feng, Ya Chen, Jianbo Liu, Peng Xu, Jing Qiu, Hongliang Liu, Jingming Hou
Summary: This study found that cerebellar transcranial direct current stimulation (tDCS) therapy can effectively and safely promote the recovery of upper limb motor function in stroke patients through a randomized trial.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Nan Chen, Xiao Qiu, Yan Hua, Jian Hu, Yulong Bai
Summary: This study aimed to observe the efficacy and explore the possible neurophysiological mechanism of applying sequential inhibitory and facilitatory rTMS for upper limb motor dysfunction post-stroke. The results showed that this therapy significantly promoted motor recovery in the patient, possibly by enhancing excitability in the ipsilesional hemisphere, restoring interhemispheric balance, and inducing cortical reorganization through neuroplasticity.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, General & Internal
Onika Banduni, Megha Saini, Neha Singh, Debasish Nath, S. Senthil Kumaran, Nand Kumar, M. V. Padma Srivastava, Amit Mehndiratta
Summary: Upper extremity motor impairment is common in stroke patients, and traditional rehabilitation methods have limitations. Virtual reality and rTMS provide technology-driven solutions for better post-stroke upper limb motor improvement. Interactive games in a VR environment can provide novel and motivating customized training, while rTMS can facilitate neuroplasticity and promote recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Theresia J. M. Roelofs, Milou Straathof, Annette van der Toorn, Willem M. Otte, Roger A. H. Adan, Rick M. Dijkhuizen
Summary: Eating disorders and obesity are major health issues in Western Society, requiring an understanding of the neural mechanisms underlying their development. The study found that food intake and sucrose tasting can influence functional network organization, potentially explaining specific patterns in feeding behavior.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Psychology, Clinical
Theresia J. M. Roelofs, Mieneke C. M. Luijendijk, Annette van der Toorn, Guido Camps, Paul A. M. Smeets, Rick M. Dijkhuizen, Roger A. H. Adan
Summary: This study used high-field fMRI to investigate how oro-sensory stimulation and gastric distention affect brain activation in rats, revealing unique responses to sucrose tasting and extensive activation induced by gastric distention. The findings align with human experiments, demonstrating the translational value of the approach and offering new insights into the processing of sensory signals leading to satiation.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Neurosciences
Josine E. G. Vaes, Caren M. van Kammen, Chloe Trayford, Annette van Der Toorn, Torben Ruhwedel, Manon J. N. L. Benders, Rick M. Dijkhuizen, Wiebke Moebius, Sabine H. van Rijt, Cora H. Nijboer
Summary: The study suggests that intranasal delivery of MSCs shows promising therapeutic potential in improving neurodevelopmental outcomes in infants with encephalopathy of prematurity. MSCs can enhance oligodendrocyte maturation and alleviate brain inflammation, thereby ameliorating neurodevelopmental abnormalities caused by diffuse white matter injury.
Article
Critical Care Medicine
Michel R. T. Sinke, Willem M. Otte, Anu E. Meerwaldt, Bart A. A. Franx, Mohamed H. M. Ali, Fazle Rakib, Annette van der Toorn, Caroline L. van Heijningen, Christel Smeele, Tariq Ahmed, Erwin L. A. Blezer, Rick M. Dijkhuizen
Summary: This study aimed to characterize structural and functional changes in gray and white matter regions using MRI techniques after mild and moderate TBI. Results showed increased diffusivities and reduced fractional anisotropy in certain brain regions after moderate TBI, which normalized over time with recovery of sensorimotor function. Additionally, multiple imaging markers, particularly diffusion parameters, were found to accurately distinguish between control brains and different grades of TBI-affected brains.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Neurosciences
Milou Straathof, Anu E. Meerwaldt, Henk M. De Feyter, Robin A. de Graaf, Rick M. Dijkhuizen
Summary: Brain metabolism plays a crucial role in cerebrovascular and neurodegenerative diseases, and current clinical tools like PET and MRS have limitations. Deuterium metabolic imaging (DMI) is highlighted as a promising technique for assessing brain metabolism, providing more detailed information than traditional methods. With improvements in resolution, DMI has the potential to become a valuable noninvasive tool for mapping glucose uptake and its downstream metabolites in healthy and diseased brains.
Article
Neurosciences
Julia Boonzaier, Milou Straathof, Dirk Jan Ardesch, Annette van Der Toorn, Gerard van Vliet, Caroline L. van Heijningen, Willem M. Otte, Rick M. Dijkhuizen
Summary: This study successfully applied an MRI-compatible bilateral tDCS setup and found that bilateral tDCS can locally modulate neuronal activity and connectivity, potentially indicating therapeutic potential.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Pavel Yanev, Geralda A. F. van Tilborg, Annette van der Toorn, Xiangmei Kong, Ann M. Stowe, Rick M. Dijkhuizen
Summary: In this study, a slow-releasing hydrogel loaded with pro-angiogenic factors was injected into the stroke lesion of rats to promote recovery. The hydrogel showed prolonged release of the factors and resulted in significant sensorimotor recovery and increased vascularization in the perilesional cortex. This method supports brain tissue regeneration and functional recovery in the chronic phase post-stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Clinical Neurology
Aladdin Taha, Joaquim Bobi, Ruben Dammers, Rick M. Dijkhuizen, Antje Y. Dreyer, Adriaan C. G. M. van Es, Fabienne Ferrara, Matthew J. Gounis, Bjoern Nitzsche, Simon Platt, Michael H. Stoffel, Victor Volovici, Gregory J. del Zoppo, Dirk J. Duncker, Diederik W. J. Dippel, Johannes Boltze, Heleen M. M. van Beusekom
Summary: Translation of acute ischemic stroke research to the clinical setting remains limited, with only one drug successfully completing the path from experimental study to clinical practice. Large gyrencephalic animal models, such as dogs, swine, sheep, and nonhuman primates, have been recommended to improve the selection of experimental treatments before testing in clinical studies. This review discusses the characteristics of these animal models and aims to facilitate the selection of appropriate models for studying acute ischemic stroke.
Article
Clinical Neurology
Bart A. A. Franx, Annette Van der Toorn, Caroline Van Heijningen, Denis Vivien, Thomas Bonnard, Rick M. Dijkhuizen
Summary: Molecular MRI can detect vascular inflammation after acute ischemic stroke, providing complementary information for treatment decision-making. In the study, it was found that VCAM-1 expression significantly increased at 6 hours post-recanalization and declined after 24 hours, but remained elevated in lesion borderzones.
Article
Clinical Neurology
Eduardo Candelario-Jalil, Rick M. Dijkhuizen, Tim Magnus
Summary: The role of neuroinflammation in ischemic stroke pathology and its interactions with central nervous system and peripheral immune responses are critically discussed. Neuroinflammation is associated with blood-brain barrier breakdown, neuronal injury, and worse neurological outcomes during acute phase of stroke.
Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Noa van der Knaap, Bart A. A. Franx, Charles B. L. M. Majoie, Aad van der Lugt, Rick M. Dijkhuizen
Summary: The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel. However, successful recanalization does not always result in favorable clinical outcome. Post-recanalization perfusion deficits (PRPDs), constituted by cerebral hypo- or hyperperfusion, may contribute to lagging patient recovery rates, but its clinical significance remains unclear.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Jord J. T. Vink, Eline C. C. van Lieshout, Willem M. M. Otte, Ruben P. A. van Eijk, Mirjam Kouwenhoven, Sebastiaan F. W. Neggers, H. Bart van der Worp, Johanna M. A. Visser-Meily, Rick M. M. Dijkhuizen
Summary: Inhibitory repetitive transcranial magnetic stimulation treatment started within 3 weeks after stroke onset promotes upper limb motor recovery, reduces disability and dependence, and leads to earlier discharge from the rehabilitation center.
Article
Endocrinology & Metabolism
Bart A. A. Franx, Geralda A. F. Van Tilborg, Aladdin Taha, Joaquim Bobi, Annette Van der Toorn, Caroline L. Van Heijningen, Heleen M. M. Van Beusekom, Ona Wu, Rick M. Dijkhuizen, CONTRAST Consortium
Summary: In this study, we investigated the effects of recanalization on disease outcome after experimental cerebral ischemia-reperfusion. We found that recanalization resulted in acute-to-subacute lesion volume reductions, particularly in females. Post-ischemic hyperperfusion developed differently in males and females, and had varying effects on disease outcome, depending on the perfusion parameter used.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)