TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens

Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells

(2019) Zhitao Gao et al.   Journal of Genetics and Genomics

Preclinical Models in Chimeric Antigen Receptor–Engineered T-Cell Therapy

(2018) Elizabeth Louise Siegler et al.   HUMAN GENE THERAPY

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination

(2018) Yasushi Akahori et al.   BLOOD

Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

(2018) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients

(2016) R Oostvogels et al.   BONE MARROW TRANSPLANTATION

Targeting Alpha-Fetoprotein (AFP)–MHC Complex with CAR T-Cell Therapy for Liver Cancer

(2016) Hong Liu et al.   CLINICAL CANCER RESEARCH

Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

(2016) S Rafiq et al.   LEUKEMIA

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

(2016) Christian B. Schiller et al.   Oncotarget

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

(2016) Marieke Griffioen et al.   Frontiers in Immunology

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity

(2016) Marcela V Maus et al.   Molecular Therapy-Oncolytics

Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources

(2015) John Patton et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential

(2015) Q Zhao et al.   LEUKEMIA

Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H

(2014) Y Inaguma et al.   GENE THERAPY

Target Antigen Density Governs the Efficacy of Anti–CD20-CD28-CD3 ζ Chimeric Antigen Receptor–Modified Effector CD8+T Cells

(2014) Keisuke Watanabe et al.   JOURNAL OF IMMUNOLOGY

Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds

(2014) Ravit Oren et al.   JOURNAL OF IMMUNOLOGY

Minor histocompatibility antigens: past, present, and future

(2014) Eric Spierings   TISSUE ANTIGENS

Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor

(2014) Ge Zhang et al.   Scientific Reports

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma

(2012) P C Schuberth et al.   GENE THERAPY

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

(2012) P. Meij et al.   HAEMATOLOGICA

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

(2012) Elena Provasi et al.   NATURE MEDICINE

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

(2012) Jennifer D. Stone et al.   OncoImmunology

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens

(2010) E. H. Warren et al.   BLOOD

Mathematical Modeling of Chimeric TCR Triggering Predicts the Magnitude of Target Lysis and Its Impairment by TCR Downmodulation

(2010) S. E. James et al.   JOURNAL OF IMMUNOLOGY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

(2010) M. M. van Loenen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR

(2009) S. Okamoto et al.   CANCER RESEARCH

Steric Hindrance and Fast Dissociation Explain the Lack of Immunogenicity of the Minor Histocompatibility HA-1Arg Null Allele

(2009) E. Spierings et al.   JOURNAL OF IMMUNOLOGY

Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA

(2008) T. Kawase et al.   BLOOD

Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation

(2008) Hiroki Torikai et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY