Article
Veterinary Sciences
Matthew J. Atherton, Antonia Rotolo, Kumudhini P. Haran, Nicola J. Mason
Summary: This case report demonstrates the development of CRS in a canine patient following CAR-T therapy, with increased levels of key cytokines associated with human CRS. Dogs serve as a valuable model to study the pathophysiology of CRS and to identify potential therapeutics for this life-threatening condition.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pathology
Luisa Vera Muscatello, Francesca Gobbo, Giancarlo Avallone, Micaela Innao, Cinzia Benazzi, Giulia D'Annunzio, Donatella Romaniello, Massimo Orioles, Mattia Lauriola, Giuseppe Sarli
Summary: Immunohistochemistry was performed on 168 canine tumors to evaluate PDL1 immunopositivity. The study found that PDL1 was expressed in some canine tumors, with a high prevalence in melanomas.
VETERINARY PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiwon Yang, Jing Jiao, Kyle M. Draheim, Guoxiang Yang, Hongyuan Yang, Li-Chin Yao, Leonard D. Shultz, Dale L. Greiner, Deepa Rajagopal, Sandrine Vessillier, Curtis C. Maier, Sunish Mohanan, Danying Cai, Mingshan Cheng, Michael A. Brehm, James G. Keck
Summary: Immuno-oncology (IO)-based therapies have been successful in treating cancer, but may lead to severe adverse events like cytokine release syndrome (CRS). Currently, there is a lack of in vivo models to evaluate dose-response relationships and safety issues. This study tested an in vivo PBMC humanized mouse model using a specific T-cell engager (BiTE) to assess treatment efficacy and cytokine release. The results show that this model accurately predicts tumor control and cytokine release, and captures variability among donors. The PBMC humanized mouse model is a reliable platform to identify effective treatments and complications.
Article
Medicine, General & Internal
Haya S. Raef, Cesar Piedra-Mora, Neil B. Wong, Diana Junyue Ma, Clement N. David, Nicholas A. Robinson, Ramon M. Almela, Jillian M. Richmond
Summary: Analysis of gene expression in dogs with pemphigus revealed increased T and B cell signatures and upregulation of specific chemokines/cytokines in lesions, mirroring patterns seen in human pemphigus. Direct comparison identified five conserved differentially expressed genes between canine and human pemphigus datasets, expanding understanding of the disease and potentially aiding in the development of biomarkers for prognosis and treatment response.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Jhalak Dholakia, Alexander C. Cohen, Charles A. Leath, Elizabeth T. Evans, Ronald D. Alvarez, Premal H. Thaker
Summary: Cytokine therapy has the potential to enhance cancer treatment by modulating the immune system. Recent development of novel delivery systems aims to overcome systemic toxicities and administration challenges associated with unmodified cytokine therapy, thus increasing therapeutic activity. Expanding research in these systems may advance immune oncology and represent the next frontier of cytokine-based immuno-oncology.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Clinical Neurology
Christine A. Eckhardt, Haoqi Sun, Preeti Malik, Syed Quadri, Marcos Santana Firme, Daniel K. Jones, Meike van Sleuwen, Aayushee Jain, Ziwei Fan, Jin Jing, Wendong Ge, Husain H. Danish, Caron A. Jacobson, Daniel B. Rubin, Eyal Y. Kimchi, Sydney S. Cash, Matthew J. Frigault, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover
Summary: This study developed an automated, physiologic metric, known as the EEG immune effector cell-associated neurotoxicity syndrome score, to detect the presence and severity of neurotoxicity among patients undergoing chimeric antigen receptor-T cell therapy. The score showed high criterion, construct, and predictive validity, making it a reliable method for assessing neurotoxicity in these patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Erik D. Hanson, Lauren C. Bates, Elizabeth P. Harrell, David B. Bartlett, Jordan T. Lee, Chad W. Wagoner, Mohamdod S. Alzer, Dean J. Amatuli, Brian C. Jensen, Allison M. Deal, Hyman B. Muss, Kirsten A. Nyrop, Claudio L. Battaglini
Summary: Exercise may attenuate immunosenescence and improve immune cell response in older breast cancer survivors, although deficits in certain cell types like MAIT and CD3(+) are observed at baseline. Acute exercise leads to mobilization of immune cells, with trends towards improvement in BCS post-exercise, suggesting potential benefits of exercise training in rescuing immune dysfunction associated with aging and cancer.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Endocrinology & Metabolism
Amy Qiang, Chad Slawson, Patrick E. Fields
Summary: O-GlcNAcylation is a crucial post-translational modification that plays a key role in maintaining normal cellular function, while aberrant O-GlcNAcylation has been associated with various pathological conditions. Although its role in immune cell growth is not fully understood, its impact on inflammation responses associated with diabetes and obesity has been highlighted.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Druszczynska, Magdalena Godkowicz, Jakub Kulesza, Sebastian Wawrocki, Marek Fol
Summary: Cytokine receptors play a critical role in regulating immune response against mycobacteria by recognizing and binding specific cytokines and activating intracellular signaling pathways. Mutations in cytokine receptor genes may lead to increased susceptibility to mycobacteria and impaired immune surveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Mary-Keara Boss
Summary: Canine translational models of radiation research serve as a valuable bridge between rodent and human studies, providing important clinical results for human cancer patients.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
S. Bi, J. Zhang, L. Zhang, K. Huang, J. Li, L. Cao
Summary: A recent study found that yeast cell wall product (YP) can enhance the immune responses in chickens immunized with NDV vaccine. The study investigated the cell-mediated immune responses elicited by NDV and YP in commercial broilers. The results showed that YP increased the concentration of certain immune factors in the blood and promoted lymphocyte proliferation. The study also found upregulated gene expression in the spleen and jejunum.
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Yue Xi, Wei Wang, Hua Wang, Xiaolin Wang, Jie Zhang, Jing Zhao, Guixiang Wang, Jingang Gui, Xin Ni
Summary: Immunologic dysfunction is an important mechanism underlying JORRP, and this study found impaired HPV-specific T-cell response in JORRP patients. The patients showed a Th2-biased cytokine profile, increased memory T cells, and reduced naive T cells in circulation. T cells from JORRP patients exhibited a greater activation profile upon HPV6/11 antigens stimulation, with a higher number of IL-10- and IL-4-secreting cells. Additionally, JORRP patients had reduced cell proliferation, increased apoptosis, and a higher percentage of differentiated T cells expressing the replicative senescent cell marker CD57 in response to HPV6/11 antigen stimulation.
CLINICAL IMMUNOLOGY
(2022)
Article
Mathematics, Applied
Odelaisy Leon-Triana, Soukaina Sabir, Gabriel F. Calvo, Juan Belmonte-Beitia, Salvador Chulian, Alvaro Martinez-Rubio, Maria Rosa, Antonio Perez-Martinez, Manuel Ramirez-Orellana, Victor M. Perez-Garcia
Summary: Immunotherapies, particularly the use of CAR T cells to treat B-cell malignancies, have shown significant success in targeting cancer cells. A mathematical model describing the time response of leukaemias to CAR T cell injection accounts for various biological processes and predicts the dynamics of different compartments post-injection, emphasizing the potential role of competition between leukaemic and CAR T cells in cancer relapses.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Multidisciplinary Sciences
Maciej Parys, Spela Bavcar, Richard J. Mellanby, David Argyle, Takanori Kitamura
Summary: Immunotherapy is a standard approach in cancer treatment, but only a small fraction of patients respond to it. To improve efficacy and identify responsive patient sub-populations, research is needed in novel strategies and the use of animal models. Mouse models are currently used, but dogs, with their naturally occurring cancers and intact immune systems, can serve as translational models for cancer immunotherapy research.
