Journal
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Volume 10, Issue 3, Pages 706-720Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-020-00736-1
Keywords
Nanoparticles; Electrospinning; Stem cells; Immunomodulation; Regenerative medicine
Funding
- 4NanoEARDRM project
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Presented work focuses on the development of biodegradable polymer nanoparticles loaded with antibiotics as drug delivery systems deposited on electrospun scaffolds for tissue engineering. The innovative ciprofloxacin-loaded poly(dl-lactide-co-glycolide) NPs ensure a continuous slow release and high local concentration at the site of action for an optimal therapy. The local delivery of antibiotics as an integrated part of electrospun scaffolds offers an effective, safe, and smart enhancement supporting tissue regeneration. Presented data provides solid scientific evidence for fulfilling the requirements of local nano antibiotic delivery systems with biodegradability and biocompatibility for a wide range of tissue engineering applications, including middle ear tissues (e.g., tympanic membranes) which are subject to bacterial infections. Further characterization of such systems, including in vivo studies, is required to ensure successful transfer from lab to clinical applications.
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