Article
Biotechnology & Applied Microbiology
Nengdang Jiang, Xiaoyue Chen, Zhixia Fan, Shilei Sun, Huoyong Jiang, Yunxiu Zhao, Yijun Dai
Summary: Ensifer adhaerens CGMCC 6315 contains two nitrile hydratases, CnhA and PnhA, which are upregulated in relation to nitrogen metabolism. The NtrC protein is also upregulated during nutrient deprivation and negatively regulates polysaccharide synthesis. A Delta ntrC mutant strain showed enhanced acetamiprid degradation and expression of cnhA and pnhA compared to the wild-type strain. Inoculation with the Delta ntrC strain improved soybean seed germination. This study highlights the importance of NtrC in regulating nitrile hydratase expression and its potential for pesticide pollution remediation.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
Article
Biochemistry & Molecular Biology
Md. Akibul Hasan Bakky, Ngoc Tuan Tran, Ming Zhang, Yongsheng Zhang, Huifen Liang, Yilei Wang, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Summary: This study characterized the polysaccharide from Gracilaria lemaneiformis and investigated its fermentation by rabbitfish intestinal microbes. The study found that the polysaccharide was mainly composed of galactose and anhydrogalactose, and it enhanced the production of short-chain fatty acids and altered the gut microbiota. The findings suggest that the polysaccharide has prebiotic potential and could be used as a functional feed additive in aquaculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Bilal Muhammad Khan, Li-Xin Zheng, Wajid Khan, Aftab Ali Shah, Yang Liu, Kit-Leong Cheong
Summary: This study filled the gap in the physical and chemical characterization of Gracilaria blodgettii polysaccharides, revealing its antioxidant potential and potential applications in the functional food industry.
Article
Plant Sciences
Meenakshi Bhardwaj, Sugumar Mani, R. Malarvizhi, Veeresh Kumar Sali, Hannah R. Vasanthi
Summary: The study showed that a sulfated polysaccharide extracted from marine algae has significant immunomodulatory effects in experimental rats, reducing systemic inflammation and possessing antioxidant and anti-inflammatory potential.
Article
Biochemistry & Molecular Biology
Ana S. Luis, Arnaud Basle, Dominic P. Byrne, Gareth S. A. Wright, James A. London, Chunsheng Jin, Niclas G. Karlsson, Gunnar C. Hansson, Patrick A. Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A. Yates, Eric C. Martens, Alan Cartmell
Summary: This study uses structural biology to uncover how sulfatases from the human gut microbiota recognize sulfated glycans. The data reveals that carbohydrate sulfatases are highly selective for the glycan component of their substrate.
NATURE CHEMICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mary Shamya Arokiarajan, Rajasekar Thirunavukkarasu, Jerrine Joseph, Obluchinskaya Ekaterina, Wilson Aruni
Summary: Marine ecosystem associated organisms are a rich source of bioactive compounds, particularly polysaccharides, which have gained significant interest in the biomedical field. Seaweeds are particularly noted for their natural bioactive sulfated polysaccharides, with a wide range of therapeutic applications including antitumor and immunomodulatory properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Zhiping Fan, Ping Cheng, Pan Zhang, Guangming Zhang, Jun Han
Summary: The exceptional network assembly of natural polysaccharides/proteins-based hydrogels offers favorable biological characteristics and tunable physical properties making them ideal candidates for food and biomedical applications. Rheological analysis provides quantitative insights into the assembled network, crucial for determining hydrogel properties and their suitability for food or biomedical use.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Horticulture
Hillary Righini, Roberta Roberti, Silvia Cetrullo, Flavio Flamigni, Antera Martel Quintana, Ornella Francioso, Veronica Panichi, Stefano Cianchetta, Stefania Galletti
Summary: The study demonstrated that seed priming with Jania adhaerens water-soluble polysaccharides (JA WSPs) can protect tomato plants from soil-borne pathogens and promote plant growth. Results showed that WSPs increased seedling emergence, reduced disease severity, and enhanced plant development.
Review
Pharmacology & Pharmacy
Mehwish Jabeen, Melody Dutot, Roxane Fagon, Bernard Verrier, Claire Monge
Summary: Natural marine sulfated polysaccharides with promising antiviral activity could be a safe alternative to synthetic broad-spectrum antiviral drugs.
Review
Chemistry, Applied
Wenjing Lu, Zhifeng Yang, Juan Chen, Di Wang, Yu Zhang
Summary: This review highlights the antiviral mechanisms of sulfated polysaccharides, suggesting that they may interfere with various steps in the virus life cycle or enhance host immune response. Additionally, the antiviral activity of sulfated polysaccharides is influenced by factors such as degree of substitution, substitution position, molecular weight, and spatial conformation, providing insights for the development of novel therapeutic agents.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Nofar Yehuda, Yury Turkulets, Ilan Shalish, Ariel Kushmaro, Shoshana (Malis) Arad
Summary: The cell-wall sulfated polysaccharide of the red microalga Porphyridium sp. can complex with metal ions to produce novel materials with high antimicrobial activity, especially against Candida albicans. The Cu2O-polysaccharide complex exhibited covalent binding of copper, increased viscosity and conductivity, and showed inhibitory effects against various bacteria and fungi. The complex's antimicrobial properties were attributed to needle-like structures on the surface, indicating potential biotechnological applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Zhiping Fan, Ping Cheng, Lixia Chu, Jun Han
Summary: Natural polysaccharide-based hydrogels have excellent biocompatibility and soft physical properties, making them promising candidates for food and biomedical applications. In this study, a new gel system composed of pectin and salecan was designed and prepared. Structural and rheological analysis revealed the potential advantages of these pectin-salecan hydrogels in various food and biomedical fields.
Article
Food Science & Technology
Min Huang, Alicia Hui Ping Theng, Dongying Yang, Hongshun Yang
Summary: This study found that varying concentrations of kappa-carrageenan affect the rheological properties of a model cake flour system, leading to increased firmness, higher resistance towards deformation, and delayed starch gelatinisation. The results highlight the potential application of carrageenan-containing materials in bakery products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Lindauro C. Pereira Junior, Fernando G. Nascimento, Samara R. B. D. Oliveira, Glauber C. Lima, Francisco Diego S. Chagas, Venicios G. Sombra, Judith P. A. Feitosa, Eliane M. Soriano, Marcellus H. L. P. Souza, Guilherme J. Zocolo, Lorena M. A. Silva, Regina C. M. de Paula, Renan O. S. Damasceno, Ana Lucia P. Freitas
Summary: The study isolated and characterized a polysaccharide from the marine alga Acanthophora spicifera, which exhibited protective potential against chemically-induced gastric mucosa injury. The sulfated polysaccharide showed promising gastroprotective effects by preventing lipid peroxidation and enhancing the defense mechanisms of the gastric mucosa.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Mingyue Shen, Xianxiang Chen, Lixin Huang, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The sulfated polysaccharide (SMP) from Mesona chinensis Benth exhibits immunomodulatory effects by inducing various immune responses and improving antioxidant capacity. The SMP can be used as functional foods for its beneficial effects on immune regulation and overall health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Anil Kumar Patel, Akash Pralhad Vadrale, Reeta Rani Singhania, Philippe Michaud, Ashok Pandey, Shu-Jen Chen, Chiu-Wen Chen, Cheng-Di Dong
Summary: In recent years, algal polysaccharides have been extensively studied for pharmaceutical, nutraceutical, and biomedical applications due to their promising bioactive properties. They are also increasingly being used in industrial and dietary sectors. The marine algae contain a variety of polysaccharides that have a significant impact on the global economy. In the pharmaceutical and biomedicine industries, alginates, fucoidans, ulvans, carrageenans, and chitin are becoming increasingly important.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Masoud Hamidi, Oseweuba Valentine Okoro, Giuseppe Ianiri, Hafez Jafari, Khodabakhsh Rashidi, Saeed Ghasemi, Raffaello Castoria, Davide Palmieri, Cedric Delattre, Guillaume Pierre, Mahta Mirzaei, Lei Nie, Hadi Samadian, Amin Shavandi
Summary: This study characterized and evaluated the biological properties of exopolysaccharides (EPS) produced by the yeast Papiliotrema terrestris PT22AV. The EPS showed potential antibacterial activity and wound healing capacity, making it a promising material for skin wound healing.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Environmental Sciences
Olfa Baccari, Mohamed Barkallah, Jihen Elleuch, Nourelhouda Ben Ayed, Amel Chtourou, Hela Karray-Hakim, Adenene Hammami, Philippe Michaud, Imen Fendri, Slim Abdelkafi
Summary: Parachlamydia acanthamoebae, a potential respiratory pathogen, was detected using a TaqMan-PCR assay that showed good accuracy and reproducibility. This diagnostic tool can be used for large-scale screening and during outbreaks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Hamadou Bakari, Djomdi, Zieba Falama Ruben, Djoulde Darnan Roger, Delattre Cedric, Pierre Guillaume, Dubessay Pascal, Michaud Philippe, Christophe Gwendoline
Summary: Sorghum, a cereal species with great genetic and phenotypic diversity, is cultivated worldwide for its seeds, fodder, sugar, and fiber. It is a versatile plant that can be used for various food, energy, and industrial purposes. With the increasing world population and decrease in biomass resources due to climate change, there is a need to reevaluate the potential of the entire value chain of sorghum.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Biochemical Research Methods
Olfa Baccari, Mohamed Barkallah, Jihen Elleuch, Nourelhouda Ben Ayed, Amel Chtourou, Hela Karray-Hakim, Adenene Hammami, Philippe Michaud, Imen Fendri, Slim Abdelkafi
Summary: This study developed a new duplex probe-based q-PCR assay for simultaneous detection and quantification of Parachlamydia acanthamoebae and Simkania negevensis. The assay showed high accuracy and sensitivity in detecting these bacteria in water and clinical samples.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Polymer Science
Anouar Mouhoub, Safae Er Raouan, Amine Guendouz, Zainab El Alaoui-Talibi, Saad Ibnsouda Koraichi, Soumya El Abed, Gedric Delattre, Cherkaoui El Modafar
Summary: This study aimed to develop biodegradable films using chitosan and essential oils to protect against biofilm formation on food-grade surfaces. The results showed that the chitosan film with added essential oils had strong antiadhesion activity, effectively preventing microbial attachment and biofilm development. Therefore, this film has potential for use as an active coating and packaging material in the food industry.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Medicinal
Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Pascal Dubessay, Philippe Michaud, Guillaume Pierre, Cedric Delattre, Cherkaoui El Modafar
Summary: The study investigated the ability of alginates extracted from two Moroccan brown seaweeds and their derivatives to induce phenolic metabolism in tomato seedlings. Elicitation was done by foliar spraying the seaweed alginates on tomato seedlings and evaluating their effects on PAL activity, polyphenol, and lignin production. It was found that low-molecular-weight alginates were more effective in inducing natural defenses in tomato seedlings compared to the alginate polymers. These findings suggest that low-molecular-weight alginates may have potential as a stimulant for plant natural defenses.
Article
Polymer Science
Gwendoline Christophe, Xiaoyang Hou, Emmanuel Petit, Mounir Traikia, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Cedric Delattre, Philippe Michaud, Guillaume Pierre, Pascal Dubessay
Summary: This study identified Peteryoungia rosettifformans as a wild producer of an exopolysaccharide related to glucuronan. Structural and biochemical analyses revealed that the polysaccharide had a molecular mass of 1.85 x 10(5) Da and was partially O-acetylated at C-2 and/or C-3 positions. The concentration of Mg2+ ions in the cultivation medium was found to impact the structure of the polysaccharide.
Article
Chemistry, Multidisciplinary
Ali Forouhar, Nasser Hamdami, Gholamreza Djelveh, Christine Gardarin, Guillaume Pierre, Alina Violeta Ursu, Philippe Michaud
Summary: Ultrasound pretreatment and microwave-assisted extraction (MAE) techniques were used to extract pectin from watermelon rind. The study found that ultrasonic pretreatment changed the morphology and increased the porosity of the raw powder, facilitating the extraction process. The highest extraction yield of pectin was achieved with 5 minutes of extraction at 500 W ultrasonic pretreatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Hana Derbel, Jihen Elleuch, Wael Mahfoudh, Philippe Michaud, Imen Fendri, Slim Abdelkafi
Summary: Bioactive peptides extracted from microalgae have gained significant attention recently due to their promising properties. In this study, proteins from the marine microalga Rhodomonas sp. were hydrolyzed into peptides using alcalase and pepsin. The biological activities of the protein preparations were evaluated and it was found that the crude protein exhibited higher antioxidant and anti-inflammatory activities compared to the peptides obtained after hydrolysis.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Medicinal
Latifa Tounsi, Hajer Ben Hlima, Faiez Hentati, Ons Hentati, Hana Derbel, Philippe Michaud, Slim Abdelkafi
Summary: This review provides a detailed overview of optimizing culture media elements and physical parameters to improve the large-scale production of phycobiliproteins. It also explores the main features of phycobiliproteins and examines their potential for biotechnological uses in various fields, with a focus on health and nutritional claims.
Article
Environmental Sciences
Aziza Safaa Chenine, Zakaria Boual, Mohamed Didi Ould Elhadj, Noura Addoun, Reguia Mahfoudi, Aicha Khemili, Hakim Belkhalfa, Khaldoun Bachari, Imen Fendri, Cherkaoui El Modafar, Zainab Alaoui Talibi, Pascal Dubessay, Cedric Delattre, Guillaume Pierre, Philippe Michaud, Jihen Elleuch, Slim Abdelkafi
Summary: This study investigates the impact of partial acid hydrolysis on the antihyperglycemic activity of a polysaccharide derived from Plantago ciliata seeds. The results demonstrate that the resulting oligosaccharides exhibit significant inhibitory effects on alpha-amylase and alpha-D-glucosidase enzymes and act as non-competitive inhibitors. Additionally, these oligosaccharides show resistance to digestion, suggesting their potential as a natural and healthy drug for reducing blood sugar levels.
EURO-MEDITERRANEAN JOURNAL FOR ENVIRONMENTAL INTEGRATION
(2023)
Review
Green & Sustainable Science & Technology
Ilyes Dammak, Mariem Fersi, Ridha Hachicha, Slim Abdelkafi
Summary: Microalgae cultivation in municipal wastewater offers potential for pollution removal and biomass utilization, promoting environmental sustainability. However, scaling these systems to industrial levels presents challenges in maintaining consistent control over multiple influencing factors. The use of native microalgal consortiums appears to be a promising strategy, but further exploration of their potential is necessary.
Article
Biochemistry & Molecular Biology
Ines Schmidt-Morgenroth, Philippe Michaud, Fabrizio Gasparini, Alexandre Avrameas
Summary: Mild cognitive impairment (MCI) is characterized by a decline in cognitive function and is an underlying condition of Alzheimer's disease (AD). Neuroinflammation has been investigated as a mechanism contributing to the progression of MCI to AD. Understanding this mechanism could help in the diagnosis and treatment of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Farah Hadjkacem, Jihen Elleuch, Meriem Aitouguinane, Fatma Zohra Chakou, Alina Violeta Ursu, Pascal Dubessay, Nathalie Bourgougnon, Mounir Traikia, Didier Le Cerf, Zainab El Alaoui-Talibi, Cherkaoui El Modafar, Zakaria Boual, Mohamed Didi Ould El Hadj, Cedric Delattre, Gwendoline Christophe, Philippe Michaud, Imen Fendri, Slim Abdelkafi, Guillaume Pierre
Summary: This study evaluates the biological and biotechnological potentials of two water soluble polysaccharides (alginate and fucoidan) extracted from a Tunisian brown macroalgae. The polysaccharides showed significant anti-inflammatory, anticoagulant, antihyperglycemic, and antiviral activities, as well as the ability to activate the natural defenses of tomato seedlings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)