Article
Plant Sciences
Si Li, Estevao G. J. Macaringue, Donghui Zhou, Peng Shi, Weiwei Tang, Junbo Gong
Summary: This study aimed to develop and identify inhibitor substitutes from a library of kidney stone prescriptions in traditional Chinese medicines to prevent pathological kidney stone formation. Water- and n-butanol-soluble extracts from 20 kinds of herbs showed almost 100% inhibition percentage, with n-butanol extracts found to be more effective than the commercial drug citrate.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Dalielah Jappie, Allen Rodgers, Neil Ravenscroft, Dawn Webber, Mayur Danny Gohel
Summary: This study found that urinary glycosaminoglycans (GAGs) have an inhibitory effect on calcium oxalate (CaOx) stone formation, with higher concentrations and stronger inhibition in the black population. This may contribute to the lower occurrence rate of kidney stones in black individuals.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Iris H. Valido, Victor Fuentes-Cebrian, Roberto Boada, Oriol Vallcorba, Montserrat Resina-Gallego, Manuel Valiente, Montserrat Lopez-Mesas
Summary: Nephrolithiasis is a multifactorial disease that results in the formation of stones in the kidneys. The most common type of stones are calcium oxalate hydrate stones, which are associated with hypercalciuria and hyperoxaluria. By analyzing the composition and crystalline structures of calcium oxalate stones, distinctions can be made between dihydrated and monohydrated phases, improving diagnosis accuracy for patients.
Article
Biochemistry & Molecular Biology
Qing-Lin Ye, Da-Ming Wang, Xin Wang, Zhi-Qiang Zhang, Qi-Xing Tian, Shi-Yao Feng, Zhi-Hui Zhang, De-Xin Yu, De-Mao Ding, Dong-Dong Xie
Summary: The study found that the levels of Sirt1 expression are closely related to CaOx kidney stone formation, with downregulation of Sirt1 leading to increased cell injury and crystal deposition. Increasing Sirt1 expression in vitro or administering resveratrol in vivo can alleviate cell damage and reduce crystal deposition.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Crystallography
Yu-Chao Hsu, Li-Cheng Pan, Lie-Ding Shiau
Summary: A photomicroscopic growth apparatus was used to study the growth rates of calcium oxalate crystals in a new synthetic urine with and without inhibitors. The effects of various inhibitors on the growth rates of calcium oxalate indicated that the inhibition of growth rates increases in the order magnesium ions < citrate ions < chondroitin sulfate ions < phytate ions. The polymorphic forms of calcium oxalate crystals without inhibitors and with various inhibitors were examined using scanning electron microscopy.
Article
Genetics & Heredity
Yuqi Xia, Xiangjun Zhou, Zehua Ye, Weimin Yu, Jinzhuo Ning, Yuan Ruan, Run Yuan, Fangyou Lin, Peng Ye, Di Zheng, Ting Rao, Fan Cheng
Summary: This study identified potential ceRNAs and immune cell infiltration involvement in kidney stone pathogenesis, providing novel therapeutic targets for kidney stones. The ceRNA network includes specific molecules like NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR-139-5p, CCL7, and ROBO2, while immune cells like macrophages and mast cells play a role in the process.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Lei Li, Zehua Ye, Yuqi Xia, Bojun Li, Lijia Chen, Xinzhou Yan, Tianhui Yuan, Baofeng Song, Weimin Yu, Ting Rao, Fangyou Lin, Xiangjun Zhou, Fan Cheng
Summary: This study investigated the role and molecular mechanisms of YAP-ACSL4-mediated ferroptosis in calcium oxalate crystal-induced renal fibrosis. The results showed that inhibiting ferroptosis or ACSL4 can mitigate renal fibrosis induced by calcium oxalate crystals, and YAP regulates ferroptosis by enhancing ACSL4 expression. Therefore, targeting the YAP-ACSL4 axis and ferroptosis may hold promise as a potential therapeutic approach for preventing renal fibrosis in patients with kidney stones.
Article
Biochemistry & Molecular Biology
Paula Calvo, Antonia Costa-Bauza, Felix Grases
Summary: This study evaluated the effect of phytate on the crystallization of calcium oxalate, hydroxyapatite and brushite in artificial urine. The results showed that all lower InsPs seemed to inhibit the crystallization of calcium salts, especially InsP6 and InsP5 for calcium oxalate, and InsP5 and InsP4 for brushite. However, phytate had weak effects on the crystallization of hydroxyapatite in vitro, indicating a different mechanism for its in vivo crystallization.
Article
Geochemistry & Geophysics
Yu Tian, Guilin Han, Jie Zeng, Qian Zhang, Lifang Xu, Ke Liu, Chunlei Xiao, Lulin Ma, Ye Zhao
Summary: By measuring the mineral compositions and major trace element concentrations of kidney stone samples, it was found that calcium oxalate monohydrate and calcium oxalate dihydrate are the main mineral components, with calcium being the most abundant element. Principal component analysis revealed complex relationships among elements in kidney stones, indicating a special preference for oxalates by calcium during the crystallization process.
Article
Pharmacology & Pharmacy
Bornika Chattaraj, Arijit Nandi, Anwesha Das, Amit Sharma, Yadu Nandan Dey, Dharmendra Kumar, R. Mogana
Summary: The decoction of Enhydra fluctuans is used traditionally for kidney stones and urinary problems, but there is a lack of scientific studies on its influence on urinary stone formation. This study investigated the effect of the aqueous extract of Enhydra fluctuans on calcium oxalate crystallisation and examined its metabolites' interactions with proteins involved in renal stone formation. The results showed that the extract inhibited calcium oxalate crystallisation and certain metabolites had modulatory effects on proteins associated with renal stone formation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Bo Li, Yin Tang, Liang Zhou, Xi Jin, Yu Liu, Hong Li, Yan Huang, Kunjie Wang
Summary: This study revealed an association between calcium oxalate and abdominal aortic calcification, establishing a connection between kidney stones and AAC after eliminating confounding factors.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Avinav Bharati, Susama Rani Mandal, Arun Kumar Gupta, Amlesh Seth, Raju Sharma, Ashu S. Bhalla, Chandan J. Das, Sabyasachi Chatterjee, Pratik Kumar
Summary: The developed dual energy CT based method in this study can effectively characterize renal stones in patients, especially differentiating sub types of calcium stones. Through the study of 50 patients, it was found that the method could differentiate different types of stones with high sensitivity, providing important guidance for treatment decisions.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Review
Health Care Sciences & Services
Kyriaki Stamatelou, David S. Goldfarb
Summary: In the past two decades, there have been no major breakthroughs in the understanding and therapy of kidney stones, which remains a challenging disease for patients, physicians, and healthcare systems. Epidemiological studies play a crucial role in identifying global changes in the prevalence and burden of kidney stones and modifiable risk factors. The expanding knowledge of kidney stone epidemiology significantly enhances the modern management of the disease.
Review
Urology & Nephrology
Xiaopeng Zheng, Wei Zhu, Guohua Zeng
Summary: The purpose of this paper is to assist patients with calcium oxalate stones in accessing prevention and treatment options through dietary management. Typical cases from our hospital and other hospitals were selected for case review, and a literature review was conducted through PubMed search to provide comprehensive analysis and suggestions.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Geochemistry & Geophysics
Yu Tian, Guilin Han, Rui Qu, Chunlei Xiao
Summary: This study investigated the element content in kidney stone samples from patients in Beijing. It found that calcium is higher in inorganic components compared to organic components. Carbonate apatite stones have a higher element content, especially magnesium. Principal component analysis identified co-precipitation processes of specific elements. This research provides important reference for patient intake of elements.
Article
Urology & Nephrology
Zhi Bo Zhao, Julian Marschner, Takamasa Iwakura, Chenyu Li, Manga Motrapu, Meisi Kuang, Bastian Popper, Andreas Linkermann, Jan Klocke, Philipp D. Enghard, Yoshiharu Muto, Benjamin Humphreys, Helena Erlandsson Harris, Paola Romagnani, Hans-Joachim Anders
Summary: Late diagnosis is a challenge for AKI treatment, but targeting AKI-CKD transition may improve outcomes. HMGB1, a nuclear regulator of transcription and a driver of necroinflammation, modulates AKI-CKD transition. Preemptive HMGB1 antagonism can attenuate AKI-CKD transition in a model of persistent kidney hypoxia.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Engineering, Biomedical
Elita Montanari, Hanna Krupke, Jean-Christophe Leroux
Summary: Currently, there is a lack of sustained release formulations for highly dosed small hydrophilic drugs. In this study, parenteral lipid spherulites were developed to entrapped and release large amounts of such drugs in a sustained manner. The spherulites demonstrated higher loading efficiency compared to liposomes and showed promising results in increasing the systemic exposure of the drug. PE spherulites were found to be a promising lipid platform for the extravascular administration of highly dosed small hydrophilic drugs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chao Han, Pengxuan Ren, Medina Mamtimin, Linus Kruk, Edita Sarukhanyan, Chenyu Li, Hans-Joachim Anders, Thomas Dandekar, Irena Krueger, Margitta Elvers, Silvia Goebel, Kristin Adler, Goetz Muench, Thomas Gudermann, Attila Braun, Elmina Mammadova-Bach
Summary: This study analyzed the collagen- and CRP-binding surfaces of GPVI monomers and dimers using computational modeling and bioinformatics, and compared them with other mammalian GPVI isoforms. Experimental results show that the EA-20 antibody inhibits platelet adhesion and aggregation in response to collagen and CRP, but not to fibrin, and prevents thrombus formation in whole blood. Therefore, the blockade of this minimal collagen-binding epitope of GPVI with the EA-20 antibody could represent a new anti-thrombotic approach.
Article
Biochemistry & Molecular Biology
Andrea Ribeiro, Feiyue Liu, Matthias Srebrzynski, Simone Rother, Karina Adamowicz, Marta Wadowska, Stefanie Steiger, Hans-Joachim Anders, Christoph Schmaderer, Joanna Koziel, Maciej Lech
Summary: In this study, the impact of uremic toxin indoxyl sulfate on macrophages and tubular epithelial cells and its role in modulating the response to lipopolysaccharide (LPS) were investigated. Indoxyl sulfate, which accumulates in the blood of patients with chronic kidney disease (CKD), was found to induce low-grade inflammation and modulate macrophage function. Additionally, it was shown to enhance the inflammatory response associated with LPS and contribute to the senescence of tubular epithelial cells during injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Paola Romagnani, A. Richard Kitching, Nelson Leung, Hans-Joachim Anders
Summary: Glomerulonephritis (GN) is a diverse group of immune-mediated disorders, which cannot be properly classified or treated based on histological patterns alone. To overcome this problem, a new classification system is proposed that considers disease category, immunological activity, and chronicity, which will guide the therapeutic approach.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Hans-Joachim Anders, Gema M. Fernandez-Juarez, Augusto Vaglio, Paola Romagnani, Juergen Floege
Summary: The management of immune-mediated kidney diseases focuses on controlling the underlying immune disease process and the non-immune mechanisms of chronic kidney disease (CKD) progression. Non-pharmacological interventions, such as reducing salt intake and regular physical activity, along with approved drug interventions, can help attenuate CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Hans-Joachim Anders
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Oncology
Linus Kruk, Medina Mamtimin, Attila Braun, Hans-Joachim Anders, Joachim Andrassy, Thomas Gudermann, Elmina Mammadova-Bach
Summary: Inflammation plays a crucial role in the progression and metastasis of renal cell carcinoma by regulating the interaction between tumor cells and the tumor microenvironment. This review summarizes recent research on the role of inflammation in RCC tumors and discusses potential inflammatory pathways as therapeutic targets.
Review
Biochemistry & Molecular Biology
Chongxu Shi, Elmina Mammadova-Bach, Cong Li, Dong Liu, Hans-Joachim Anders
Summary: Cholesterol crystal (CC) embolism is a complication of advanced atherosclerotic plaques primarily induced by interventional and surgical procedures. Prophylaxis through plaque stabilization and avoiding unnecessary catheter interventions is the main approach to CC embolism. Platelet inhibitors and anticoagulants may reduce the risk of vascular occlusions and tissue ischemia in case CC embolism occurs. Given the unmet medical need, effective treatment strategies for CC embolism are urgently needed.
Article
Cell Biology
Zhi Luo, David Klein Cerrejon, Simon Romer, Nicole Zoratto, Jean-Christophe Leroux
Summary: Biopharmaceuticals, such as proteins and peptides, have greatly improved the treatment of various diseases. However, most of these drugs need to be administered parenterally due to their large size and instability. In this study, a novel technology was developed to enhance drug absorption by combining noninvasive stretching of the buccal mucosa with permeation enhancers. The engineered suction patch achieved significantly higher bioavailability in dogs compared to a commercial tablet formulation of a peptide drug. Additionally, a first-in-human study confirmed the acceptability of this dosage form, supporting its clinical translatability.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Yu Hu, Hao Tang, Nan Xu, Xiaowo Kang, Weijun Wu, Chuhan Shen, Junsheng Lin, Yinyin Bao, Xingyu Jiang, Zhi Luo
Summary: This study introduces a novel 3D printable wound dressing that is composed of three commonly used non-toxic compounds. The material exhibits tunable degradation kinetics and high flexibility, making it a promising option for personalized wound care.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Cell Biology
Ajinath Kale, Vishwadeep Shelke, Yutian Lei, Anil Bhanudas Gaikwad, Hans-Joachim Anders
Summary: This article reviews the unique chemistry, pharmacology, and toxicity profile of the novel calcineurin inhibitor (CNI) Voclosporin and summarizes its efficacy and safety data in the treatment of active lupus nephritis. The article also discusses possible options for implementing Voclosporin in the management of lupus nephritis, including patient stratification, combination therapy, sequential therapy, and alternative options.
Article
Chemistry, Multidisciplinary
Safira Noor Anindita, Riccardo Conti, Doris Zauchner, Nevena Paunovic, Wanwan Qiu, Marina Green Buzhor, Adva Krivitsky, Zhi Luo, Ralph Muller, Hansjorg Grutzmacher, Xiao-Hua Qin, Jean-Christophe Leroux, Yinyin Bao
Summary: We report a 3D printing approach for high-resolution manufacturing of structurally complex and mechanically strong PEG hydrogels via heat-assisted digital light processing. By using PEG macromonomer melts and post-printing swelling, high-fidelity 3D hydrogels with complex structures were achieved. The use of a dual-macromonomer resin containing a PEG-based macrophotoinitiator enabled the production of all-PEG hydrogel constructs with compressive toughness up to 1.3 MJ m(-3). This study highlights the potential of heat-assisted DLP of PEG photopolymers for hydrogel fabrication, contributing to the development of 3D tissue-like constructs for regenerative medicine.
Review
Immunology
Hans-Joachim Anders, A. Richard Kitching, Nelson Leung, Paola Romagnani
Summary: 'Glomerulonephritis' (GN) refers to a group of immune-mediated disorders characterized by inflammation of the kidney's filtration units. Current classification is based on histopathological lesion patterns, but these patterns do not align well with the diverse pathological mechanisms and do not guide optimal therapy. Instead, a proposed immunopathogenesis-based classification groups GN disorders into five categories, allowing for more targeted and effective treatments.
NATURE REVIEWS IMMUNOLOGY
(2023)