Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Liqing Qiu, Jing Yue, Lingyu Ding, Zihao Yin, Ke Zhang, Hongfang Zhang
Summary: In this review, the impact of cancer-associated fibroblasts (CAFs) on esophageal squamous cell carcinoma (ESCC) is highlighted, including the induction of chemoresistance, radioresistance, migration, invasion, and immune escape. The origin of CAFs and the influence of ESCC cells on CAF activation are also discussed. Furthermore, the clinical prospects and future trends of CAFs-targeted therapies in ESCC are emphasized. A better understanding of the molecular biology of CAFs may contribute to the development of novel anti-ESCC strategies.
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Oncology
Tong Liu, Peilong Li, Juan Li, Qiuchen Qi, Zhaowei Sun, Shuang Shi, Yan Xie, Shibiao Liu, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Cancer-cell-released exosomal miRNAs play a significant role in tumor microenvironment communication, with miR-320b identified as closely associated with lymphangiogenesis and lymphatic metastasis in ESCC patients. Through transfer by exosomes, miR-320b activates the AKT pathway in HLECs independently of VEGF-C, affecting tube formation, migration, and EMT progression in ESCC cells. Furthermore, METTL3 positively regulates pri-miR-320b maturation through an m6A-dependent mechanism.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng, Xiaozhi Zhang
Summary: The study demonstrated that SOCS6 can enhance the radiosensitivity of HPV+ ESCC and ESCC cells, reduce their stemness through ubiquitylation and degradation of c-Kit. Thus, SOCS6 could be a potential target for overcoming radioresistance in ESCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pathology
Guorui Sun, Yanru Yang, Jin Liu, Zizhao Gao, Tianqi Xu, Jia Chai, Junpeng Xu, Zhenge Fan, Tian Xiao, Qingge Jia, Mingyang Li
Summary: This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Polymer Science
Jun Yeon Park, Myoung-Sook Shin
Summary: Polysaccharide PLE-II isolated from persimmon leaves significantly inhibits the expression of angiogenesis-related factors (such as VEGF and MMP-9) in HUVECs by regulating the PI3K/AKT, p38, JNK, and NF-kappa B p65 signaling pathways.
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yun-Zhu Zeng, Yong-Qu Zhang, Xue-Qiong Lin, Jiong-Yu Chen, Fan Zhang, Jian-Ling Zhu, Xiao-Long Wei
Summary: In patients with ESCC, high levels of the co-expression of VEGF-C and survivin were significantly correlated with tumor staging, lymph node metastasis, differentiation, as well as worse disease-free survival and overall survival. The combined detection of VEGF-C and survivin could serve as a feasible and effective marker to predict the prognosis and survival of ESCC patients.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Long Zhang, Jinchen Shao, Zhichao Liu, Jie Pan, Bin Li, Yang Yang, Yi He, Yuchen Han, Zhigang Li
Summary: PNI is associated with lymphovascular invasion and advanced tumor invasion in ESCC patients, and although not an independent prognostic indicator, patients with PNI positivity should be considered for adjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma, Rong-Quan He
Summary: This study revealed that UBE2C mRNA and protein levels were highly expressed in ESCC and may play different roles in different stages of the disease. UBE2C mainly influences the biological function of esophageal cancer through synergistic effects with genes such as CDK1, PTTG1, and SKP2. Additionally, a potential UBE2C-related ceRNA network (HCP5/has-miR-139-5p/UBE2C) was constructed for ESCC.
Article
Cell Biology
Huishan Zeng, Huiru Yang, Yifan Song, Dong Fang, Liang Chen, Zhijun Zhao, Chaojie Wang, Songqiang Xie
Summary: The CDK7/9 inhibitor SNS-032 has shown promising anti-tumor activity against ESCC by inhibiting cell growth, increasing sensitivity to cisplatin, inducing apoptosis, and reducing migration and invasion abilities. It also significantly inhibited tumor growth and metastasis in in vivo models, suggesting its potential as a therapeutic agent for ESCC patients, including those with metastasis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Cell Biology
Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee, Chao Cheng
Summary: The study revealed significant differences in the microbiota composition between patients with ESCC and those with PN esophagus, with the former showing reduced microbial diversity and decreased abundances of specific taxa. Functional analysis indicated altered nitrate reductase and nitrite reductase functions in the microbiota of ESCC patients. These findings suggest that specific microbes and microbiota may influence the development of ESCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jiangfen Li, Yufang Xie, Xueli Wang, Feng Li, Shugang Li, Man Li, Hao Peng, Lan Yang, Chunxia Liu, Lijuan Pang, Hong Zou, Jin Zhao, Yan Qi, Yuwen Cao, Jianming Hu
Article
Oncology
Jiangfen Li, Yufang Xie, Xueli Wang, Chenhao Jiang, Xin Yuan, Anzhi Zhang, Lan Yang, Chunxia Liu, Hong Zou, Feng Li, Jianming Hu