Article
Biochemistry & Molecular Biology
An Yang, Xin Liu, Ping Liu, Yunzhang Feng, Hongbo Liu, Shen Gao, Limin Huo, Xinyan Han, Jurong Wang, Wei Kong
Summary: The study demonstrated that UCA1 promotes cell proliferation and inhibits apoptosis in gastric cancer cells by sponging miR-145 to upregulate MYO6 expression. Targeting the UCA1/miR-145/MYO6 axis may offer a potential therapeutic strategy for gastric cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jing-Jin Yang, Wei-Xia Peng, Mei-Biao Zhang
Summary: This study investigated the role of lncRNA KCNQ1OT1 in osteogenic differentiation of bone marrow mesenchymal stem cells. The results showed that KCNQ1OT1 can upregulate the expression of RICTOR by inhibiting miR-205-5p, thus promoting osteogenesis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Yibo Hu, Li Lei, Ling Jiang, Hongliang Zeng, Yushan Zhang, Chuhan Fu, Haoran Guo, Yumeng Dong, Yujie Ouyang, Xiaolin Zhang, Jinhua Huang, Qinghai Zeng, Jing Chen
Summary: This study reveals that long non-coding RNA UCA1 is highly expressed in psoriatic keratinocytes and positively regulates keratinocyte-driven inflammation and psoriasis development by binding to METTL14, and activating HIF-1 alpha and NF-kappa B signaling pathway. These findings provide new insights into the molecular mechanisms of keratinocyte-driven inflammation in psoriasis.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yunpeng Sun, Xue Shan, Jiantao Guo, Xuguang Liu, Dashi Ma
Summary: Abnormal levels of CHI3L1 and lnc TUG1 are closely associated with the progression of myocardial fibrosis. This study investigated the role of CHI3L1 in regulating myocardial fibrosis and found that CHI3L1 upregulates the expression of lnc TUG1. The interaction between lnc TUG1 and miR-495-3p/ETS1 axis was also examined.
Article
Biology
Mingyu Zhang, Bowen Zhang, Xiaohan Wang, Jiahang Song, Ming Tong, Zheng Dong, Jiaonan Xu, Meng Liu, Yuan Jiang, Ning Wang, Ying Wang, Zhimin Du, Yanyan Liu, Rong Zhang, Chaoqian Xu
Summary: In this study, a novel long non-coding RNA called CFAR was found to be a profibrotic factor in the heart, promoting cardiac fibrosis through the miR-449a-5p/LOXL3/mTOR axis. CFAR may serve as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Oncology
Wen Chen, Qunjun He, Jingjing Liu, Ni Li, Kai Xiao, Honghui Chen
Summary: This study reveals that PLAGL2 enhances Snail expression and promotes gastric cancer progression and metastasis through the UCA1/miR-145-5p/YTHDF1 axis, suggesting that PLAGL2 may serve as a therapeutic target for gastric cancer treatment.
Article
Oncology
Heng-Heng Yuan, Xin-Chen Zhang, Xiao-Li Wei, Wen-Jie Zhang, Xiao-Xue Du, Peng Huang, Hao Chen, Lu Bai, Hong-Feng Zhang, Yu Han
Summary: This study elucidates the detailed role of UCA1 in cetuximab resistance in colorectal cancer (CRC) and its underlying molecular mechanism. UCA1 decreases CRC cell sensitivity to cetuximab by suppressing apoptosis and activating the HGF/c-MET pathway. This discovery provides evidence for UCA1 as a predictor and therapeutic target for cetuximab resistance.
Article
Cardiac & Cardiovascular Systems
Chengnan Tian, Shuo Hu, Junjian Yu, Wentong Li, Peijun Li, Huanlei Huang
Summary: This study revealed that PVT1 promotes cardiac fibrosis by increasing HCN1 expression through sponging miR-145. These findings suggest that targeting PVT1 may be a potential therapeutic option for cardiac fibrosis and cardiac diseases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Oncology
Zhichao Jin, Baoxinzi Liu, Bofan Lin, Ran Yang, Cunen Wu, Weiwei Xue, Xi Zou, Jun Qian
Summary: The long non-coding RNA RP9 pseudogene (RP9P) promotes colorectal cancer progression by regulating the miR-133a-3p/FOXQ1 axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yuan Chi, He Xin, Zhaoyu Liu
Summary: This study revealed that under hypoxic conditions, exosomes secreted by PSCs deliver lncRNA UCA1 into pancreatic cancer cells, leading to resistance to Gem through recruitment of EZH2 and regulation of histone methylation level in the SOCS3 gene region.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yuan Yao, Shaoshan Chen, Na Lu, Yue Yin, Zhiwen Liu
Summary: The study revealed that in oral squamous cell carcinoma, lncRNA JPX promotes cell proliferation, migration, and invasion through the miR-944/CDH2 axis, providing a new direction for potential targeted treatment.
Article
Medicine, Research & Experimental
Yunpeng Luan, Yanmei Li, Lina Zhu, Shuangqing Zheng, Dechang Mao, Zhuxue Chen, Yong Cao
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Oncology
Yun-Peng Luan, Qi-Feng Li, Shi-Guo Wu, De-Chang Mao, Yan-Yun Deng, Rong-Wang Chen
MOLECULAR MEDICINE REPORTS
(2018)
Article
Biology
Yunpeng Luan, Dechang Mao, Aiwei Guo, Yong Cao, Jielong Zhou, Fei Xiang, Zhi Xiong
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Biology
Yunpeng Luan, Yanmei Li, Xiaoguan Yue, Yong Cao, Fei Xiang, Dechang Mao, Zhi Xiong
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Biology
Yanmei Li, Yunpeng Luan, Xiaoguang Yue, Fei Xiang, Dechang Mao, Yong Cao, Zhi Xiong
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Biology
Yong Cao, Fei Dai, Yanmei Li, Lu Jia, Yunpeng Luan, Youjie Zhao
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Biotechnology & Applied Microbiology
S. H. Li, H. B. Yin, M. R. Ren, M. J. Wu, X. L. Huang, J. J. Li, Y. P. Luan, Y. L. Wu
BIOTECHNIC & HISTOCHEMISTRY
(2019)
Article
Biology
Yunqi Luan, Yunpeng Luan, Youjie Zhao, Fei Xiong, Yanmei Li, Lili Liu, Yong Cao, Fei Dai
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Public, Environmental & Occupational Health
Junjia Lu, Dechang Mao, Xiang Li, Yunqiang Ma, Yunqi Luan, Yong Cao, Yunpeng Luan
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)