Article
Cell Biology
Wangyue Jia, Zhaoyan Wang, Ceshu Gao, Jian Wu, Qiong Wu
Summary: The endothelial-to-mesenchymal transition (EndMT) is a significant process in idiopathic pulmonary fibrosis (IPF) where galectin-3 plays a crucial role. Inhibition of galectin-3 can alleviate the pathogenesis of IPF and transition of endothelial cells. The study suggests potential therapeutic targets for vascular remodeling in IPF.
CELL DEATH & DISEASE
(2021)
Review
Geriatrics & Gerontology
Li-Ping Jiang, Xiao-Hua Yu, Jin-Zhi Chen, Mi Hu, Yang-Kai Zhang, Hui-Ling Lin, Wan-Ying Tang, Ping-Ping He, Xin-Ping Ouyang
Summary: Atherosclerosis, the main pathological basis of cardiovascular diseases, involves plaque formation in blood vessels and HDAC3 has been found to play critical roles in regulating vascular function, cell migration, foam cell formation, and more in the disease process.
Article
Food Science & Technology
Hongxia Li, Lin Xiao, Hui He, Hongmei Zeng, Jingjing Liu, Chunjie Jiang, Guibin Mei, Jiasheng Yu, Hao Chen, Ping Yao, Yuhan Tang
Summary: This study investigates the anti-atherosclerotic properties of quercetin by modulating the Gal-3-NLRP3 pathway, showing promising effects in reducing atherosclerotic lesions. The findings suggest a potential strategy for the prevention and treatment of atherosclerosis using naturally-occurring quercetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Yi He, Salvador Alejo, Jessica D. Johnson, Sridharan Jayamohan, Gangadhara R. Sareddy
Summary: This study found that overexpression of RCN3 is associated with poor survival rates in glioblastoma patients. Reduction in RCN3 expression can decrease proliferation and self-renewal of glioma stem cells and alter the expression of genes related to translation, ribosome, stem cell differentiation, and extracellular matrix.
Review
Pharmacology & Pharmacy
Yi-Sheng He, Yu-Qian Hu, Kun Xiang, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Gui-Hong Wang, Hai-Feng Pan
Summary: Galectins are a protein family that plays important roles in physiological and pathological processes, including inflammation and autoimmune diseases. Recent studies have shown that galectins are involved in the occurrence and development of autoimmune diseases, providing potential therapeutic targets.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Grazyna Sygitowicz, Agata Maciejak-Jastrzebska, Dariusz Sitkiewicz
Summary: Galectin-3 plays a key role in chronic inflammation and is involved in various cardiovascular diseases. Its potential utility as a biomarker is discussed, along with its role in myocardial fibrosis and inflammation.
Article
Multidisciplinary Sciences
Xing Chen, Chunyu Yu, Xinhua Liu, Beibei Liu, Xiaodi Wu, Jiajing Wu, Dong Yan, Lulu Han, Zifan Tang, Xinyi Yuan, Jianqiu Wang, Yue Wang, Shumeng Liu, Lin Shan, Yongfeng Shang
Summary: This study reveals that the carbohydrate binding protein galectin-3 acts as a sensor for lipopolysaccharide (LPS) and regulates the mTORC1 signaling pathway and glucose metabolism, playing a crucial role in diabetes and cancer.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Emily Capone, Stefano Iacobelli, Gianluca Sala
Summary: LGALS3BP, a secreted protein expressed in most human cells, has been identified as a potential therapeutic target for cancer treatment. Studies have shown that LGALS3BP plays a significant role in cancer, potentially impacting prognosis and functionality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Cynthia Buelck, Elisabeth E. L. Nystroem, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
Summary: The metalloproteases meprin alpha and meprin beta are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease. They form covalently linked heterodimers in the colon, and the major intestinal substrate for these heterodimers is galectin-3. The cleavage of galectin-3 by meprin alpha/beta heterodimers may play a key role in colon host-microbiome homeostasis.
Review
Biochemistry & Molecular Biology
Hiroki Tomizawa, Yoshiyuki Yamada, Misaki Arima, Yui Miyabe, Mineyo Fukuchi, Haruka Hikichi, Rossana C. N. Melo, Takechiyo Yamada, Shigeharu Ueki
Summary: Galectin-10 is an abundant cytoplasmic protein in human eosinophils and has been identified as a potential biomarker in eosinophilic diseases. It is released through extracellular trap cell death, indicating a close relationship between eosinophils and Galectin-10. This review highlights the functional roles of Galectin-10 in immunity and its potential as a biomarker in eosinophilic diseases.
Review
Physiology
Fengyun Wang, Lixin Zhou, Amity Eliaz, Chang Hu, Xinhua Qiang, Li Ke, Glenn Chertow, Isaac Eliaz, Zhiyong Peng
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with high morbidity and mortality. Galectin-3 (Gal3), a protein with proinflammatory and profibrotic properties, has been implicated in the development and progression of both AKI and CKD. Elevated Gal3 levels in the serum of AKI and CKD patients and its association with CKD progression have been observed. Gal3 is also associated with AKI incidence in critically ill patients, and blocking Gal3 has shown promising results in reducing AKI incidence and mortality in animal models.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Manju Kandel, Stephen Tong, Susan P. Walker, Ping Cannon, Tuong-Vi Nguyen, Teresa M. MacDonald, Natalie J. Hannan, Tu'uhevaha J. Kaitu'u-Lino, Lucy A. Bartho
Summary: Preeclampsia is a pregnancy disease associated with high mortality rates for mothers and infants. This study found reduced levels of galectin-3 protein and LGALS3 mRNA expression in the placenta of women with early-onset preeclampsia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Diego D. Santos, Gisela R. S. Sasso, Nycole M. Belote, Rafael Andre da Silva, Izabella Lice, Rebeca D. Correia-Silva, Fernanda T. Borges, Adriana A. F. Carbonel, Cristiane D. Gil
Summary: The role of galectin-3 in liver was evaluated using an acute model of cisplatin-induced toxicity. Treatment with modified citrus pectin (MCP) was used to inhibit galectin-3. The study showed that reducing the levels of galectin-3 in hepatocytes promotes cell death and increases oxidative stress.
Article
Biochemistry & Molecular Biology
R. J. Slack, R. Mills, A. C. Mackinnon
Summary: Galectin-3, a beta-galactoside-binding mammalian lectin, plays a crucial role in regulating cellular signaling by prolonging retention time or retarding lateral movement of cell surface receptors in the plasma membrane. It is involved in various cellular functions such as diffusion, compartmentalization, endocytosis, and the functionality of membrane receptors, and has been shown to be pro-fibrotic in multiple models of organ fibrosis. Additionally, there has been a significant increase in scientific literature investigating the role of Galectin-3 in fibrotic diseases and the clinical development of new Galectin-3 inhibitors over the past decade.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Clinical Neurology
Sergi Borrego-Ecija, Agnes Perez-Millan, Anna Antonell, Laura Fort-Aznar, Elif Kaya-Tilki, Alberto Leon-Halcon, Albert Llado, Laura Molina-Porcel, Mircea Balasa, Jordi Junca-Parella, Javier Vitorica, Jose Luis Venero, Tomas Deierborg, Antonio Boza-Serrano, Raquel Sanchez-Valle
Summary: Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD), and Gal-3 levels were found to be significantly increased in FTD patients, particularly in brain tissue and cerebrospinal fluid (CSF). Gal-3 shows potential as a diagnostic marker for FTD, especially in cases with MAPT mutations, and its levels correlate with markers of neuronal injury.
ALZHEIMERS & DEMENTIA
(2023)
