Journal
GENES
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/genes11010072
Keywords
satellite DNA; genome architecture; chromosome restructuring; Robertsonian translocations; satellite DNA transcription
Categories
Funding
- Science and Technology Foundation (FCT) from Portugal [SFRH/BD/147488/2019, UID/MULTI/04046/2019]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/147488/2019] Funding Source: FCT
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Repetitive DNA is a major organizational component of eukaryotic genomes, being intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs (satDNAs) can be found clustered in specific heterochromatin-rich chromosomal regions, building vital structures like functional centromeres and also dispersed within euchromatin. Interestingly, despite their association to critical chromosomal structures, satDNAs are widely variable among species due to their high turnover rates. This dynamic behavior has been associated with genome plasticity and chromosome rearrangements, leading to the reshaping of genomes. Here we present the current knowledge regarding satDNAs in the light of new genomic technologies, and the challenges in the study of these sequences. Furthermore, we discuss how these sequences, together with other repeats, influence genome architecture, impacting its evolution and association with disease.
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