Journal
GENES
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/genes10121008
Keywords
hypoxia; non-coding RNA; microRNA; hypoxia-inducible factor; gastrointestinal cancer
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017R1C1B2012268, 2018M3A9H3023077, 2019R1A2C1083892, 2019R1I1A2A01060951]
- KRIBB Research Initiative Program
- National Research Foundation of Korea [2019R1I1A2A01060951, 2018M3A9H3023077] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Hypoxia-inducible factors (HIFs) are transcription factors that play central roles in cellular responses against hypoxia. In most cancers, HIFs are closely associated with tumorigenesis by regulating cell survival, angiogenesis, metastasis, and adaptation to the hypoxic tumor microenvironment. Recently, non-coding RNAs (ncRNAs) have been reported to play critical roles in the hypoxic response in various cancers. Here, we review the roles of hypoxia-response ncRNAs in gastrointestinal cancer, with a particular focus on microRNAs and long ncRNAs, and discuss the functional relationships and regulatory mechanisms between HIFs and ncRNAs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available