Review
Biochemistry & Molecular Biology
Bailey H. Duhon, Thien T. Phan, Shannon L. Taylor, Rachelle L. Crescenzi, Joseph M. Rutkowski
Summary: Lymphedema and lipedema are complex diseases with unique aspects of their underlying pathophysiology and genetics. Despite some shared features, much more research has been done on lymphedema, leading to the discovery of genetic markers. Further work is needed on lipedema research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ankita Poojari, Kapil Dev, Atefeh Rabiee
Summary: Lipedema is a fat and fascia disorder primarily affecting women. The mechanisms underlying this condition and its treatment options are not well understood. This review explores the morphological phenotype of lipedema fat, its pathophysiology, and potential biomarkers, while emphasizing the importance of technological interventions in the future.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rachelle Crescenzi, Paula M. C. Donahue, Maria Garza, Niral J. Patel, Chelsea Lee, Kelsey Guerreso, Greg Hall, Yu Luo, Sheau-Chiann Chen, Karen L. Herbst, Michael Pridmore, Aaron W. Aday, Joshua A. Beckman, Manus J. Donahue
Summary: 3T MR lymphangiography can distinguish lipedema from obesity or lymphedema. This study used MRI technology to identify characteristic features in patients with lipedema.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Alexandre C. Amato, Juliana L. Amato, Daniel A. Benitti
Summary: This study aimed to examine the coexistence of lipedema symptoms and attention-deficit/hyperactivity disorder (ADHD). Lipedema is a medical condition characterized by abnormal fat accumulation and inflammation in the legs and buttocks, often accompanied by swelling and pain. ADHD is a common disorder that affects attention and behavior control, impacting social, academic, and occupational functioning. The study used a screening questionnaire and self-report scale to assess ADHD prevalence in a group of women with or without lipedema symptoms.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Endocrinology & Metabolism
Ludovica Verde, Elisabetta Camajani, Giuseppe Annunziata, Antoanstefan Sojat, Ljiljana V. Marina, Annamaria Colao, Massimiliano Caprio, Giovanna Muscogiuri, Luigi Barrea
Summary: This review provides an overview of the current evidence on the efficacy, anti-inflammatory properties, and safety of very low-calorie ketogenic diet (VLCKD) as a potential treatment for lymphedema.
CURRENT OBESITY REPORTS
(2023)
Article
Medicine, General & Internal
Alexandre Campos Moraes Amato, Daniel Augusto Benitti
Summary: Lipedema is a chronic progressive disease with various available treatments, including liposuction surgery. Each patient may have different treatment objectives, highlighting the importance of understanding individual patient needs to provide the most effective therapy for a better quality of life. In selected cases, non-surgical treatment of lipedema can be feasible and meet selected clinical objectives.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Surgery
Alexandre Campos Moraes Amato, Dumitriu Zunino Saucedo, Keller da Silva Santos, Daniel Augusto Benitti
Summary: Lipedema is a disease characterized by abnormal fat deposition in the limbs, with high prevalence and genetic characteristics. Ultrasound evaluation of dermis and subcutaneous tissue thickness can be used as a distinguishing feature for diagnosing lipedema in the lower limbs, with specific cutoff values for diagnosis.
Article
Endocrinology & Metabolism
Arin K. Greene, Christopher L. Sudduth
Summary: This study found significant differences in BMI and cellulitis history between patients with obesity-induced lymphedema and obesity without lymphedema, while patients with lipedema were associated with BMI. Patients with higher BMI were more likely to develop lower extremity lymphedema, and severely obese patients needed to lose weight before considering surgical treatment.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Kevin J. Donohoe, Brett J. Carroll, David K. V. Chung, Elizabeth H. Dibble, Emilia Diego, Francesco Giammarile, Frederick D. Grant, Stephen Y. Lai, Hannah Linden, Megan E. Miller, Neeta Pandit-Taskar, Nicholas E. Tawa Jr, Sergi Vidal-Sicart
Summary: Expert representatives from 11 professional societies have developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The complete findings and discussions of the study group, including example clinical scenarios, have been published and are available online. The AUC document includes scenarios for scintigraphy in various cancers and lymphatic flow mapping in lymphedema, as well as considerations for pediatric cases. It aims to assist healthcare practitioners in using lymphoscintigraphy.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Isabel Forner-Cordero, Angeles Forner-Cordero, Gyozo Szolnoky
Summary: Lipedema is a chronic disease characterized by abnormal fat deposition in lower limbs and common symptoms of easy bruising and pain. Despite its impact on quality of life, there is limited understanding of the disease. The management goals are multimodal, focusing on improving quality of life through compression garments, physical therapy, diet and psychological counseling.
INTERNATIONAL ANGIOLOGY
(2021)
Article
Medicine, Research & Experimental
Laurence M. Black, Seth Winfree, Suraj D. Khochare, Malgorzata M. Kamocka, Amie M. Traylor, Stephanie K. Esman, Shehnaz Khan, Abolfazl Zarjou, Anupam Agarwal, Tarek M. El-Achkar
Summary: Lymphangiogenesis (LA) is a process that occurs in response to tissue injury, with unclear roles in disease progression. The study focuses on the distribution and spatial dynamics of LA in the context of acute kidney injury. The lymphatic system is crucial in physiology and has been identified as a key player in disease progression.
LABORATORY INVESTIGATION
(2021)
Article
Immunology
Philipp Kruppa, Sabrina Gohlke, Kamila Lapinski, Francisco Garcia-Carrizo, George A. Soultoukis, Manfred Infanger, Tim J. Schulz, Mojtaba Ghods
Summary: This study found that subcutaneous adipose tissue (SAT) in lipedema patients exhibits features such as adipocyte hypertrophy, immune cell recruitment, and fibrosis, which are associated with the disease stage. These findings contribute to a better understanding of the development of lipedema.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Song Jin, Changlian Zhang, Min Gao, Ting Wang, Lanbo Li, Guoren Yang, Yang Ou, YunJie Li, Sheng Li
Summary: The study validated the use of noninvasive reflectance LSCM for diagnosing lymphedema, showing potential for clinical adoption as a supporting diagnostic method.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Oncology
Jie Deng, Mary S. Dietrich, Kenneth J. Niermann, Robert J. Sinard, Anthony J. Cmelak, Sheila H. Ridner, Jill Gilbert, Barbara A. Murphy
Summary: A tool for assessing symptoms of head and neck lymphedema and fibrosis was developed and pilot tested in medical settings. The tool was found to effectively capture patients' symptoms and medical conditions, but some participants found it burdensome due to length, leading to item reduction and refinement. Further rigorous psychometric testing is ongoing to validate the strength and internal validity of the tool.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Medicine, Research & Experimental
L. Keith, C. A. Seo, C. Rowsemitt, M. Pfeffer, M. Wahi, M. Staggs, J. Dudek, B. Gower, M. Carmody
Summary: This paper discusses the clinical features of lipedema (LI), the potential effectiveness of a ketogenic diet (KD) in alleviating these features, and the improved understanding of optimal nutritional management for LI patients.
MEDICAL HYPOTHESES
(2021)
Article
Oncology
Yen-Chun Ho, Meng -Ling Wu, Pei-Yu Gung, Chung-Huang Chen, Cheng-Chin Kuo, Shaw-Fang Yet
Article
Multidisciplinary Sciences
Yen-Chun Ho, Meng-Ling Wu, Chen-Hsuan Su, Chung-Huang Chen, Hua-Hui Ho, Guan-Lin Lee, Wei-Shiang Lin, Wen-Yu Lin, Yu-Juei Hsu, Cheng-Chin Kuo, Kenneth K. Wu, Shaw-Fang Yet
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Yan-Liang Lai, Chen-Yu Lin, Wei-Cheng Jiang, Yen-Chun Ho, Chung-Huang Chen, Shaw-Fang Yet
Article
Cardiac & Cardiovascular Systems
Chung-Huang Chen, Yen-Chun Ho, Hua-Hui Ho, Il-Chi Chang, Kathrin H. Kirsch, Yung-Jen Chuang, Matthew D. Layne, Shaw-Fang Yet
CARDIOVASCULAR RESEARCH
(2013)
Article
Cell Biology
Meng-Ling Wu, Chung-Huang Chen, Yung-Tsang Lin, Yuan-Jyun Jheng, Yen-Chun Ho, Liang-Tung Yang, Linyi Chen, Matthew D. Layne, Shaw-Fang Yet
CELL COMMUNICATION AND SIGNALING
(2014)
Article
Cell Biology
Chung-Huang Chen, Yen-Chun Ho, Hua-Hui Ho, Li-Yu Liang, Wei-Cheng Jiang, Guan-Lin Lee, Jen-Kuang Lee, Yu-Juei Hsu, Cheng-Chin Kuo, Kenneth K. Wu, Shaw-Fang Yet
Article
Developmental Biology
Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma, Lijuan Chen, Greggory Myers, Sally Camper, Debbie Mustacich, Marlys Witte, Dongwon Choi, Young-Kwon Hong, Hong Chen, Gaurav Varshney, James Douglas Engel, Shusheng Wang, Tae-Hoon Kim, Kim-Chew Lim, R. Sathish Srinivasan
Article
Biochemistry & Molecular Biology
Chen-Mei Chen, Meng-Ling Wu, Yen-Chun Ho, Pei-Yu Gung, Ming-Hsien Tsai, Alexander N. Orekhov, Igor A. Sobenin, Pinpin Lin, Shaw-Fang Yet
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Xin Geng, Keisuke Yanagida, Racheal G. Akwii, Dongwon Choi, Lijuan Chen, YenChun Ho, Boksik Cha, Md. Riaj Mahamud, Karen Berman de Ruiz, Hirotake Ichise, Hong Chen, Joshua Wythe, Constantinos M. Mikelis, Timothy Hla, R. Sathish Srinivasan
Article
Developmental Biology
Boksik Cha, Yen-Chun Ho, Xin Geng, Md Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J. Randolph, Xinwei Cao, Hong Chen, R. Sathish Srinivasan
Article
Medicine, Research & Experimental
Yuji Kondo, Jason L. Larabee, Liang Gao, Huiping Shi, Bojing Shao, Christopher M. Hoover, J. Michael McDaniel, Yen-Chun Ho, Robert Silasi-Mansat, Stephanie A. Archer-Hartmann, Parastoo Azadi, R. Sathish Srinivasan, Alireza R. Rezaie, Alain Borczuk, Jeffrey C. Laurence, Florea Lupu, Jasimuddin Ahamed, Rodger P. McEver, James F. Papin, Zhongxin Yu, Lijun Xia
Summary: The study found that the C-type lectin receptor L-SIGN acts as a receptor for SARS-CoV-2 infection, predominantly expressed in human liver sinusoidal endothelial cells (LSECs) and lymph node lymphatic endothelial cells. These endothelial cells showed increased levels of clotting factors after SARS-CoV-2 infection, potentially contributing to COVID-19-associated coagulopathy.
Article
Hematology
Md Riaj Mahamud, Xin Geng, Lijuan Chen, Zoheb Ahmed, Yenchun Ho, Rajanarayanan Sathishkumar Srinivasan
Summary: The study aims to determine whether platelets can regulate blood/lymph separation independently of LVVs. The results demonstrate that GATA2 promotes blood/lymph separation through platelets.
Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yen-Chun Ho, Xin Geng, Anna O'Donnell, Jaime Ibarrola, Amaya Fernandez-Celis, Rohan Varshney, Kumar Subramani, Zheila J. Azartash-Namin, Jang Kim, Robert Silasi, Jill Wylie-Sears, Zahra Alvandi, Lijuan Chen, Boksik Cha, Hong Chen, Lijun Xia, Bin Zhou, Florea Lupu, Harold M. Burkhart, Elena Aikawa, Lorin E. Olson, Jasimuddin Ahamed, Natalia Lopez-Andres, Joyce Bischoff, Katherine E. Yutzey, R. Sathish Srinivasan
Summary: PROX1 and FOXC2 are involved in the development and disease of cardiac valves. Deletion of PROX1 leads to thickening and myxomatous degeneration of valves, while abnormal expression of FOXC2 and PDGF-B is related to valve prolapse and valve insufficiency. Pharmacological inhibition of PDGF-B signaling can partially correct valve defects.
CIRCULATION RESEARCH
(2023)