Article
Plant Sciences
Ruixia Bao, Qian Chen, Zheng Li, Dan Wang, Yuzheng Wu, Mengyang Liu, Yi Zhang, Tao Wang
Summary: The study isolated a compound named eurycomanol from E. longifolia, which was found to promote uric acid excretion through kidney and intestine, decrease hepatic purine synthesis, and maintain uric acid homeostasis. This suggests the potential of eurycomanol to be developed as a novel drug for the treatment of under-excretion type hyperuricemia.
Review
Endocrinology & Metabolism
Yongsheng Mei, Bingzi Dong, Zhuang Geng, Lili Xu
Summary: The article discusses the synthesis and metabolism of uric acid, the etiology of hyperuricemia, the relationship between hyperuricemia and kidney disease, and the treatment of gout and gouty nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Biqian Wei, Pengfei Ren, Ruzhen Yang, Yuan Gao, Qingjuan Tang, Changhu Xue, Yuming Wang
Summary: The hypouricemic effect of mannuronate oligosaccharide (MOS) was investigated in hyperuricemic mice. MOS significantly reduced serum uric acid levels, alleviated kidney inflammation, and promoted uric acid excretion by regulating protein levels. Furthermore, MOS modulated the gut microbiota, particularly reducing Tyzzerella levels. The study also highlighted the crucial role of gut microbiota in the hypouricemic effect of MOS.
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Medicine, General & Internal
Kaiqing Li, Yanchun Ma, Xue Xia, Huili Huang, Jianing Li, Xiaoxin Wang, Yang Gao, Shuxiang Zhang, Tong Fu, Ying Tong
Summary: Hyperuricemia nephropathy, also known as gouty nephropathy, refers to renal damage induced by hyperuricemia caused by excessive production of serum uric acid or low excretion of uric acid. The persistence of symptoms will lead to changes in renal tubular phenotype and accelerate the progress of renal fibrosis. The existence and progressive aggravation of symptoms will bring a heavy burden to patients, their families and society, affect their quality of life and reduce their well-being.
Article
Multidisciplinary Sciences
Dongming Chen, Chenlei Jiang, Hong Lu
Summary: In this study, the therapeutic potential of total flavonoids of Phellinus igniarius (TFPI) in uric acid nephropathy was evaluated. The results showed that TFPI can effectively reduce serum uric acid and creatinine levels, inhibit xanthine oxidase activity, and promote the expression of ABCG2 by targeting TLR4 receptor and NLRP3 inflammasome.
Article
Plant Sciences
Yoon-Young Sung, Heung Joo Yuk, Dong-Seon Kim
Summary: The study showed that SMS-E has anti-hyperuricemic effects by reducing XO activity and regulating renal urate transporters. Additionally, SMS-E also has the ability to reduce renal inflammation and serum IL-1 beta levels.
JOURNAL OF GINSENG RESEARCH
(2021)
Review
Urology & Nephrology
Kang Zhang, Long Tang, Shang-shang Jiang, Yue-fen Wang, Yuan Meng, Meng-di Wang, Fang-qiang Cui, Zhen Cai, Wen-jing Zhao
Summary: This systematic review and meta-analysis found that hyperuricemia and elevated serum uric acid (SUA) were both independently associated with an increased incidence of kidney failure events in IgA nephropathy (IgAN) patients.
Article
Plant Sciences
Guo-Yi Tang, Sha Li, Yu Xu, Cheng Zhang, Xiao-Yu Xu, Lin Xu, Ning Wang, Yibin Feng
Summary: This study analyzed the bioactive compound profiles of a renal herb formula (RHF) and evaluated its protective effects against hyperuricemic nephropathy. It was found that RHF improved kidney functions and inhibited apoptosis and inflammation in kidney residential cells through targeting specific pathways. RHF and its bioactive compounds have the potential to be developed into effective drugs for the treatment and management of hyperuricemic nephropathy.
Article
Agriculture, Multidisciplinary
Longjun Shu, Meifeng Yang, Naixin Liu, Yixiang Liu, Huiling Sun, Siyu Wang, Yue Zhang, Yilin Li, Xinwang Yang, Ying Wang
Summary: This study optimized a plant-derived peptide RDP1-M3 for anti-hyperuricemia, showing enhanced efficacy in alleviating hyperuricemia and inhibiting XOD in mice, as well as influencing the expression of various proteins related to uric acid metabolism in vivo.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Peng Liu, Guijie Ma, Yang Wang, Lifan Wang, Ping Li
Summary: Excess serum uric acid aggravates metabolic diseases and traditional Chinese medicine can treat gouty nephropathy by regulating NF-kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Rubin-Garcia, Facundo Vitelli-Storelli, Laura Alvarez-Alvarez, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Alvaro Hernaez, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Luis Serra-Majem, Naomi Cano-Ibanez, Josep A. Tur, Alba Marcos-Delgado, Anna Tresserra-Rimbau, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Zenaida Vazquez-Ruiz, Nancy Babio, Rocio Barragan, Olga Castaner-Nino, Cristina Razquin, Lucas Tojal-Sierra, Enrique Gomez-Gracia, Sandra Gonzalez-Palacios, Marga Morey, Antonio Garcia-Rios, Sara Castro-Barquero, Maria Rosa Bernal-Lopez, Jose Manuel Santos-Lozano, Miguel Ruiz-Canela, Antoni Castro-Salomo, Eva Cristina Pascual-Castello, Veronica Moldon, Vanessa Bullon-Vela, Carolina Sorto-Sanchez, Juan Carlos Cenoz-Osinaga, Liliana Gutierrez, Maira Mengual, Rosa Maria Lamuela-Raventos, Vicente Martin-Sanchez
Summary: This study found an inverse association between the intake of certain subclasses of polyphenols and serum uric acid levels and hyperuricemia in individuals with metabolic syndrome. Further research is needed to confirm these findings.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Food Science & Technology
Ming Chen, Jing Luo, Hongwu Ji, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu
Summary: This study demonstrates the anti-hyperuricemia effect of carnosine and reveals its mechanism, providing scientific evidence for the application of carnosine in hyperuricemia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cardiac & Cardiovascular Systems
Woohyeun Kim, Tae Hwa Go, Dong Oh Kang, Jieun Lee, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dae Ryong Kang, Jang-Young Kim, Eung Ju Kim
Summary: The study investigated the association between uric acid and incident hypertension with a focus on age and sex differences. It found that younger women are at the highest risk of developing uric acid-related incident hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsien Chang, Yi-Fen Chiang, Hsin-Yuan Chen, Yun-Ju Huang, Kai-Lee Wang, Yong-Han Hong, Mohamed Ali, Tzong-Ming Shieh, Shih-Min Hsia
Summary: Chrysin effectively reduces uric acid levels in hyperuricemia-induced rats by inhibiting xanthine oxidase activity and regulating the expression of uric acid transporter proteins. It also demonstrates anti-oxidative and anti-inflammatory effects by modulating various inflammatory pathways in both kidney and serum, suggesting potential new treatments for gout.
Article
Biochemistry & Molecular Biology
Gensheng Zhang, Huirong Han, Zhengbing Zhuge, Fang Dong, Shan Jiang, Wenwen Wang, Drielle D. Guimaraes, Tomas A. Schiffer, En Yin Lai, Lucas Rannier Ribeiro Antonino Carvalho, Ricardo Barbosa Lucena, Valdir A. Braga, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: Boosting the nitrate-nitrite-NO pathway shows therapeutic potential in ameliorating renal and cardiovascular dysfunction induced by renal ischemia-reperfusion injury, reducing oxidative stress and injuries.
Article
Biochemistry & Molecular Biology
Yuan-Yuan Zhang, Jie Zhang, Wen-Xuan Zhang, Yue Wang, Ying-Hong Wang, Qing-Yun Yang, Song Wu
Summary: A simple, rapid, accurate, and selective quantitative method based on H-1 nuclear magnetic resonance (qNMR) was successfully established and developed for assessing the purity of dipotassium glycyrrhizinate (KG). The method was validated for reliability, specificity, linearity, and showed consistent results with HPLC coupled with ultraviolet detection, making it a useful and practical protocol for the determination of KG and glycyrrhizin analogs.
Review
Urology & Nephrology
Mattias Carlstrom
Summary: Nitric oxide plays crucial roles in regulating kidney, cardiovascular, and metabolic functions. Reduced bioactivity of NO due to oxidative stress is considered important. Understanding NO biology and developing novel approaches to restoring NO homeostasis offer potential therapeutic applications for kidney, cardiovascular, and metabolic disorders.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Airlla Laana de Medeiros Cavalcanti, Patricia Keytth Lins Rocha, Zhengbing Zhuge, Marcelo F. Montenegro, Luciano Leite Paulo, Leonidas das Gracas Mendes-Junior, Maria Claudia Rodrigues Brandao, Petronio F. Athayde-Filho, Jon O. Lundberg, Eddie Weitsberg, Mattias Carlstrom, Valdir de Andrade Braga
Summary: This study investigates the cardiovascular effects of the new organic nitrate NDIBP, and finds that it has a blood pressure-lowering effect without inducing tolerance. These effects may be mediated through the activation of the NO-sGC-cGMP signaling pathway and positive modulation of K+ channels in vascular smooth muscle.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yue Wang, Jing Feng, Song Wu, Huihui Shao, Wenxuan Zhang, Kun Zhang, Hanyilan Zhang, Qingyun Yang
Summary: A new method using derivatization high-performance liquid chromatography with ultraviolet detection was developed and validated for the quantitative analysis of genotoxic impurities in a novel drug. The method was found to be reliable and practical through optimization and validation of key experimental parameters.
Article
Biochemistry & Molecular Biology
Xuechen Li, Zhengbing Zhuge, Lucas Rannier R. A. Carvalho, Valdir A. Braga, Ricardo Barbosa Lucena, Shuijie Li, Tomas A. Schiffer, Huirong Han, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: The study indicates that treatment with inorganic nitrate and nitrite can attenuate the development of kidney fibrosis by targeting oxidative stress and lipid metabolism. Mechanisms include modulation of AMPK and AKT-PGC1α pathways.
Article
Biochemistry & Molecular Biology
Sophia K. Heuser, Anthea LoBue, Junjie Li, Zhengbing Zhuge, Francesca Leo, Tatsiana Suvorava, Annika Olsson, Rebekka Schneckmann, Drielle D. Guimaraes Braga, Tanu Srivrastava, Lidia Montero, Oliver J. Schmitz, Joachim P. Schmitt, Maria Grandoch, Eddie Weitzberg, Jon O. Lundberg, John Pernow, Malte Kelm, Mattias Carlstrom, Miriam M. Cortese-Krott
Summary: Under normal homeostatic conditions, lack of EC Arg1 expression may result in down-regulation of eNOS expression, but NO bioavailability and vascular endothelial function remain preserved.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Agustina Heredia-Martinez, Guillermo Rosa-Diez, Jorge R. Ferraris, Anna-Karin Sohlenius-Sternbeck, Carina Nihlen, Annika Olsson, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom, Rafael T. Krmar
Summary: Nitric oxide plays a crucial role in cardiovascular and renal function, and dietary intake of inorganic nitrate, such as concentrated beetroot juice, can increase plasma nitrate and nitrite levels in both hemodialysis patients and healthy volunteers.
Article
Physiology
Gianluigi Pironti, Stefano Gastaldello, Dilson E. Rassier, Johanna T. Lanner, Mattias Carlstrom, Lars H. Lund, Hakan Westerblad, Takashi Yamada, Daniel C. Andersson
Summary: This study used a mouse model of rheumatoid arthritis (RA) to find evidence of impaired cardiac contractile function associated with reduced Ca2+ sensitivity, increased expression of PAD2, and citrullination of alpha-actin, which was triggered by TNF-alpha. This provides molecular and physiological evidence for acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.
Article
Chemistry, Medicinal
Tong Qin, Xuefeng Gao, Lei Lei, Wenxuan Zhang, Jing Feng, Xing Wang, Zhufang Shen, Zhenming Liu, Yi Huan, Song Wu, Jie Xia, Liangren Zhang
Summary: In this study, 52 derivatives were designed and synthesized to evaluate their FXR transactivation activity. Twelve FXR agonists showed superior or comparable activity to XJ034, and two compounds had over 9-fold activity and were as potent as OCA. The lead compound, adamantan-1-yl(4-(2-amino-5-chlorophenyl)piperazin-1-yl)methanone (10a, EC50: 1.05 mu M), exhibited better efficacy in improving NAFLD in a mouse model compared to XJ034.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Tong Qin, Xuefeng Gao, Lei Lei, Jing Feng, Wenxuan Zhang, Yuhua Hu, Zhufang Shen, Zhenming Liu, Yi Huan, Song Wu, Jie Xia, Liangren Zhang
Summary: In this study, a novel potential drug target for nonalcoholic fatty liver disease (NAFLD) named Farnesoid X receptor (FXR) agonist was discovered through the development of a multi-stage computational workflow. The compound identified as the representative showed potent FXR agonistic activity in HEK293T cells and demonstrated positive effects on hypercholesterolemia, hepatic steatosis, hyperglycemia, and insulin resistance (IR) in high-fat-diet induced obese (DIO) mice.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pediatrics
Daniel N. Roberts, Paula Vallen, Maria Cronhjort, Tobias Alfven, Gabriel Sandblom, Susanna Tonroth-Horsefield, Boye L. Jensen, Per-Arne Lonnqvist, Robert Frithiof, Mattias Carlstrom, Rafael T. Krmar
Summary: This study aimed to assess the post-operative plasma-sodium concentration in children with acute appendicitis and provide a physiological explanation for plasma-sodium levels over time. The findings suggest that the use of moderately hypotonic fluid therapy after correction of extracellular fluid deficit is not necessarily associated with post-operative hyponatremia.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhengbing Zhuge, Sarah McCann Haworth, Carina Nihlen, Lucas Rannier R. A. Carvalho, Sophia K. Heuser, Andrei L. Kleschyov, Josefine Nasiell, Miriam M. Cortese-Krott, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstroem
Summary: This study aimed to investigate the effects of a lack of endothelial nitric oxide synthase (eNOS) in red blood cells (RBCs) on vascular endothelial function. Results showed that RBCs lacking eNOS induced endothelial dysfunction and vascular oxidative stress, similar to RBCs from patients with preeclampsia. This suggests that RBC-derived nitric oxide (NO) bioactivity plays a crucial role in protecting the endothelium from oxidative stress.
Article
Physiology
Rafael T. Krmar, Stephanie Franzen, Leif Karlsson, Helin Strandberg, Susanna Tornroth-Horsefield, Jesper K. Andresen, Boye L. Jensen, Mattias Carlstrom, Robert Frithiof
Summary: Perioperative hyponatremia is a serious electrolyte disorder caused by the non-osmotic release of arginine vasopressin and is associated with various types of surgery. By using a controlled hypotensive hemorrhage pig model, the effect of bleeding on plasma sodium was investigated. The results showed that all pigs developed hyponatremia after bleeding and were unable to excrete net-free water.
PHYSIOLOGICAL REPORTS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
G. Pironti, S. Gastaldello, D. Rassier, M. Carlstrom, L. H. Lund, H. Westerblad, T. Yamada, D. Andersson
EUROPEAN JOURNAL OF HEART FAILURE
(2021)