Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue
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Title
Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-01-29
DOI
10.3389/fphar.2019.01632
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Note: Only part of the references are listed.- Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes
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- Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity
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- Genetic Inhibition of Na + -Ca 2+ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate
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- The “Funny” Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells
- (2012) Yael Yaniv et al. MOLECULES
- The funny current has a major pacemaking role in the sinus node
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- Competing Oscillators in Cardiac Pacemaking
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- Dietary fish oil reduces pacemaker current and heart rate in rabbit
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- Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?
- (2009) Norbert Nagy et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- What keeps us ticking: a funny current, a calcium clock, or both?
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- Combined pharmacological block of IKr and IKs increases short-term QT interval variability and provokes torsades de pointes
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