Article
Anatomy & Morphology
Simona Coviello, Yaiza Gramuntell, Patrycja Klimczak, Emilio Varea, Jose Miguel Blasco-Ibanez, Carlos Crespo, Antonio Gutierrez, Juan Nacher
Summary: This study provides evidence for the presence of immature neurons in the human brain and defines their characteristics and lineage, which is important for understanding brain development and function.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Marco Ghibaudi, Nicole Marchetti, Elena Vergnano, Chiara La Rosa, Bruno Benedetti, Sebastien Couillard-Despres, Stefano Farioli-Vecchioli, Luca Bonfanti
Summary: The recent discovery of cortical immature neurons (cINs) in the piriform cortex raises questions about their maintenance or reduction throughout the lifespan. Unlike most brain structural plasticity forms, which decline with age due to stem cell depletion, all cINs are produced during embryogenesis and retain their immaturity until they fully mature and integrate into neural circuits. This study analyzed the abundance, maturation stage, and expression of markers of maturity/immaturity in cINs in the mouse piriform cortex from postnatal to advanced ages. The results show that while the number of cINs decreases with age, a small population of highly immature cINs persists in advanced ages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Cui Li, Yu Zheng, Yufang Zheng, Zhiheng Xu
Summary: Mutations in the WDR60 gene have been linked to short-rib polydactyly syndromes, affecting embryonic development and the migration of newborn neurons during brain development. WDR60 plays a crucial role in controlling microtubule organization, with potential implications for understanding the pathogenesis of SRPS.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Marco Ghibaudi, Alessia Amenta, Miriam Agosti, Marco Riva, Jean-Marie Graic, Francesco Bifari, Luca Bonfanti
Summary: Recently, a population of immature neurons generated prenatally, retaining immaturity for long periods and finally integrating in adult circuits has been described in the cerebral cortex. Comparative studies revealed differences in occurrence/rate of different forms of neurogenic plasticity across mammals, with gyrencephalic species having more immature neurons. To extend experimentation to large-brained mammals, including humans, it is important to detect cell markers of neurogenic plasticity in brain tissues obtained through different procedures. However, the variability in fixation methods and antibody specificity makes comparison difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Marco Ghibaudi, Luca Bonfanti
Summary: Undifferentiated neurons may exist in the neural networks of the adult mammalian brain, not only in small stem cell niches from embryonic germinal layers but also in various parenchymal brain regions. However, our understanding of these young neurons is not yet clear, and further mapping and research are needed.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Xiao Liu, Shang-Kun Dai, Pei-Pei Liu, Chang-Mei Liu
Summary: This study demonstrates the important role of Arid1a in regulating the proliferation and differentiation of neural stem/progenitor cells during cortical development, and suggests potential gene candidates for understanding the pathological mechanisms and developing interventions for neurodevelopmental disorders caused by Arid1a mutations. Rescue experiments successfully restored the neurogenic defects in Arid1a knockout neural stem/progenitor cells.
CELL PROLIFERATION
(2021)
Article
Cell & Tissue Engineering
Johannes Voelker, Jonas Engert, Christine Voelker, Linda Bieniussa, Philipp Schendzielorz, Rudolf Hagen, Kristen Rak
Summary: This study found a postnatal neural stem cell niche in all subnuclei of rat CN, but with significant differences in potential. These results may be beneficial for the development of new regenerative strategies for hearing loss.
STEM CELLS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Andre Steinecke, McLean M. Bolton, Hiroki Taniguchi
Summary: Interregional neuronal communication plays a crucial role in cortical circuit assembly. The cholinergic system regulates inhibitory axonal ramification in the developing neocortex by signaling through nicotinic acetylcholine receptors and T-type voltage-dependent calcium channels. Proper levels of subcortical cholinergic neuron activity are necessary for the normal development of chandelier cell axonal arbors.
Review
Biochemistry & Molecular Biology
Luca Bonfanti, Christine J. Charvet
Summary: Plasticity, especially neurogenesis, is a promising target for treating and preventing various diseases; different types of plasticity vary with age, brain region, and species; plasticity decreases with age, but comparisons between different forms of plasticity across species are still lacking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Simona Coviello, Bruno Benedetti, Dominika Jakubecova, Maria Belles, Patrycja Klimczak, Yaiza Gramuntell, Sebastien Couillard-Despres, Juan Nacher
Summary: The study showed that targeted PSA enzymatic depletion in the piriform cortex of rodents accelerates the final development of immature neurons, leading to increased NeuN expression, more cells carrying an axon initial segment (AIS), and an increased number of dendrites and dendritic spines. These findings demonstrate the crucial role of PSA in the development of immature neurons outside of neurogenic niches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anjali Gour, Kevin M. Boergens, Natalie Heike, Yunfeng Hua, Philip Laserstein, Kun Song, Moritz Helmstaedter
Summary: The study quantifies the circuit patterns of synaptogenesis for inhibitory interneurons in the developing mouse somatosensory cortex, revealing different developmental profiles and time courses for synaptic innervation of cell bodies, apical dendrites, and axon initial segments. Apical dendrites are innervated early and specifically, while axons innervating cell bodies gradually acquire specificity over time.
Review
Genetics & Heredity
Baptiste Libe-Philippot, Pierre Vanderhaeghen
Summary: The human cerebral cortex has unique developmental features, including prolonged patterns of neuronal generation and maturation, specific gene regulatory networks, and newly emerged molecular characteristics. These features are closely related to neurodevelopmental disorders, highlighting the connections between human neural development, evolution, and diseases.
ANNUAL REVIEW OF GENETICS, VOL 55
(2021)
Review
Anatomy & Morphology
Luca Bonfanti, Chiara La Rosa, Marco Ghibaudi, Chet C. Sherwood
Summary: Different animal species have varying degrees of neuronal plasticity. Non-mammalian vertebrates generally have adult neurogenesis, while mammals have reduced capacity for it. Comparative studies show differences in neural stem cell niches between mammalian species, with a trend of reduction from small-brained to large-brained species. However, large-brained mammals have large amounts of non-dividing immature neurons, potentially compensating for reduced adult neurogenesis in mammals.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Multidisciplinary Sciences
Guilherme Shigueto Vilar Higa, Jose Francis-Oliveira, Estevao Carlos-Lima, Alicia Moraes Tamais, Fernando da Silva Borges, Alexandre Hiroaki Kihara, Iane Carvalho Shieh, Henning Ulrich, Silvana Chiavegatto, Roberto De Pasquale
Summary: The prefrontal cortex (PFC) plays important roles in establishing behavioral patterns during early life. Serotonin (5-HT) is a significant factor in modulating brain activity. 5-HT is crucial for synaptic changes induced by theta-burst stimulation (TBS) during the third postnatal week. Activation of specific 5-HT receptors can lead to long-term depression (LTD) or long-term potentiation (LTP) when combined with TBS. Early-life chronic stress impairs 5-HT-dependent synaptic plasticity in the PFC.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Shawn F. Sorrells, Mercedes F. Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E. Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J. Huang, Jose Manuel Garcia-Verdugo, Michael C. Oldham, Zhengang Yang, Arturo Alvarez-Buylla
Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Matteo Piumatti, Ottavia Palazzo, Chiara La Rosa, Paola Crociara, Roberta Parolisi, Federico Luzzati, Frederic Levy, Luca Bonfanti
JOURNAL OF NEUROSCIENCE
(2018)
Article
Anatomy & Morphology
Chiara La Rosa, Roberta Parolisi, Ottavia Palazzo, Frederic Levy, Maryse Meurisse, Luca Bonfanti
BRAIN STRUCTURE & FUNCTION
(2018)
Editorial Material
Cell Biology
Ottavia Palazzo, Chiara La Rosa, Matteo Piumatti, Luca Bonfanti
NEURAL REGENERATION RESEARCH
(2018)
Review
Medicine, General & Internal
Chiara La Rosa, Marco Ghibaudi, Luca Bonfanti
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Biology
Chiara La Rosa, Francesca Cavallo, Alessandra Pecora, Matteo Chincarini, Ugo Ala, Chris G. Faulkes, Juan Nacher, Bruno Cozzi, Chet C. Sherwood, Irmgard Amrein, Luca Bonfanti
Article
Veterinary Sciences
Chiara La Rosa, Luca Bonfanti
FRONTIERS IN VETERINARY SCIENCE
(2018)