Article
Cell Biology
Chien-Kuo Han, Wei-Fang Lee, Chin-Jung Hsu, Yuan-Li Huang, Chih-Yang Lin, Chun-Hao Tsai, Chien-Chung Huang, Yi-Chin Fong, Min-Huan Wu, Ju-Fang Liu, Chih-Hsin Tang
Summary: DPP4 plays a crucial role in rheumatoid arthritis, with its expression levels closely associated with the development of inflammatory diseases. Increasing DPP4 expression can reduce levels of inflammatory cytokines.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Huan Yang, Qiong Zeng, Harold A. Silverman, Manojkumar Gunasekaran, Sam J. George, Alex Devarajan, Meghan E. Addorisio, Jianhua Li, Tea Tsaava, Vivek Shah, Timothy R. Billiar, Haichao Wang, Michael Brines, Ulf Andersson, Valentin A. Pavlov, Eric H. Chang, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Inflammation is initiated by molecular signatures of microbes and tissue injury, triggering the body's defensive response. Neuronal synthesis of HMGB1 is an important mediator of inflammation, with the release of HMGB1 by nociceptors playing a role in neurogenic inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia, Shengyong Luo
Summary: The study showed that QLY granules have significant therapeutic effects on adjuvant arthritis rats, which may be associated with downregulating the CXCL12/CXCR4-NF-kappa B signaling pathway. Further research on the use of QLY granules as a potential treatment for rheumatoid arthritis is warranted.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Susana Aidee Gonzalez-Chavez, Salma Marcela Lopez-Loeza, Samara Acosta-Jimenez, Ruben Cuevas-Martinez, Cesar Pacheco-Silva, Eduardo Chaparro-Barrera, Cesar Pacheco-Tena
Summary: Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) have the potential to delay the onset of the disease. Physical exercise (PE) has been shown to benefit RA patients, but its impact in reducing the risk of developing RA has not been extensively studied. This study investigated the effects of low-intensity PE on the joints of mice with pre-arthritic CIA. The results showed that PE reduced joint inflammation and damage, as well as down-regulated the expression of proinflammatory genes and proteins. Further research is needed to understand the underlying mechanisms of PE in preclinical arthritis and its role in reducing the risk of developing RA.
Article
Plant Sciences
Rafaela Cunha Matosinhos, Juliana Pantaleao Bezerra, Camila Helena Barros, Ana Catharina Fernandes Pereira Ferreira Bernardes, Grazielle Brandao Coelho, Marcela Carolina de Paula Michel Araujo, Rodrigo Dian de Oliveira Aguiar Soares, Daniela Sachs, Denia Antunes Saude-Guimaraes
Summary: The study demonstrated that coffee extracts prepared with water at 98 degrees C were more effective in exerting anti-gouty and anti-inflammatory activities. Caffeic and chlorogenic acids were found to decrease hypernociception, inhibit neutrophil migration, and reduce pro-inflammatory cytokines concentration, suggesting coffee as a potential candidate for acute gout therapy studies.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ana Catharina Fernandes Pereira Ferreira Bernardes, Rafaela Cunha Matosinhos, Marcela Carolina de Paula Michel Araujo, Camila Helena Barros, Rodrigo Dian de Oliveira Aguiar Soares, Daniela Caldeira Costa, Daniela Sachs, Denia Antunes Saude-Guimaraes
Summary: The study aimed to demonstrate the effects of sesquiterpene lactones isolated from Lychnophora trichocarpha and Lychnophora passerina on MSU crystal-induced arthritis in C57BL6 mice, as well as their inhibitory effects on neutrophil migration and pro-inflammatory cytokine release, and their evaluation on SOD and CAT activities in the cartilage of mice. Sesquiterpene lactones showed anti-inflammatory, antinociceptive, and antioxidant activities, suggesting potential anti-gout effects through inflammation, pain, and oxidative stress pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Jie Xiao, Chaoyi Liang, Lizeai Zhang, Jinling Li, Sijia Liu
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide and poses a major health concern with COVID-19. Rheumatoid arthritis (RA) patients may have a higher risk of infection and disease progression due to impaired immune systems, immunosuppressants, and comorbidities. The immune mechanisms and pathological interactions between COVID-19 and RA are reviewed, as the immune inflammation in COVID-19 resembles that of RA. The potential cardiovascular complications and challenges of treating RA patients with COVID-19 are also discussed.
Review
Geriatrics & Gerontology
Jie Xiao, Chaoyi Liang, Lizeai Zhang, Jinling Li, Sijia Liu
Summary: This article reviews the immune mechanisms and pathological interactions between COVID-19 and RA, highlighting the similarities in immune inflammation. The potential mechanisms leading to cardiovascular complications and challenges in treating RA patients with COVID-19 are also discussed. Additionally, the use of antirheumatic drugs as potential treatment options for COVID-19 is explored, given the similar proinflammatory cytokines induced in both diseases.
Review
Biochemistry & Molecular Biology
Carla Felice, Arianna Dal Buono, Roberto Gabbiadini, Marcello Rattazzi, Alessandro Armuzzi
Summary: Spondyloarthritis and inflammatory bowel diseases are chronic immune disorders of the joints and the gut that often coexist in the same patient. The pathogenesis of both disorders involves genetic predisposition, environmental triggers, microbiome features, immune cell trafficking, and soluble factors such as cytokines. However, different cytokines may be involved in the tissue damage process, making it challenging to find an efficacious therapeutic plan that targets both inflammatory manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nobuaki Kikyo
Summary: Rheumatoid arthritis (RA) is an example of a disease with circadian fluctuations in severity. RA patients experience stiffness, pain, and swelling in the morning, which becomes less severe in the afternoon. This is due to higher levels of pro-inflammatory hormones and cytokines in the morning and insufficient anti-inflammatory cortisol levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Zibin Jiang, Jin-Wen Chen, Joanne Haughan, Darko Stefanovski, Lawrence R. Soma, Mary A. Robinson
Summary: Extracorporeal shockwave therapy (ESWT) is a treatment for musculoskeletal injuries in equine athletes, and changes in white blood cell gene transcripts may serve as biomarkers for assessing its effects.
DRUG TESTING AND ANALYSIS
(2022)
Article
Health Care Sciences & Services
Amanda J. Eakin, Tahanver Ahmed, Cathy M. McGeough, Stephen Drain, H. Denis Alexander, Gary D. Wright, Philip Gardiner, Dawn Small, Anthony J. Bjourson, David S. Gibson
Summary: This study investigates the relationship between disease activity in rheumatoid arthritis (RA) and the numbers and phenotypes of circulating regulatory T cells (Tregs) and monocytes. It also explores the potential sialic acid link between Tregs and monocytes and the effects of sialic acid on Treg activation and cytokine release.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Medicinal
Hassan Maleki, Hediyeh Azadi, Yaser Yousefpoor, Mahtab Doostan, Maryam Doostan, Mohammad Hosein Farzaei
Summary: This study formulated ginger extract into nanoemulsion to enhance its therapeutic benefits against rheumatoid arthritis. The ginger-loaded nanoemulsion demonstrated high antioxidant activities and increased skin permeability. In anti-arthritic evaluations, it showed significant improvement in arthritic symptoms, including a decline in paw edema and reduction of inflammatory cytokines.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Rheumatology
Melek Yalcin Mutlu, Koray Tascilar, Georg Schett
Summary: The use of biologic disease modifying antirheumatic drugs (bDMARDs) has greatly improved patient outcomes in inflammatory arthritis. However, not all patients achieve remission, and some may have resistance to single cytokine inhibition by bDMARDs. In these cases, the simultaneous or sequential inhibition of multiple cytokines may be considered. Although there have been challenges in the past with combination therapies, advancements in understanding inflammatory pathways and the safety of bDMARDs make new biologic treatment combinations possible. This review discusses the rationale and current evidence for the use of combination bDMARDs in inflammatory arthritis.
Article
Pharmacology & Pharmacy
Jian Yang, Ya-rong Lin, Bo -jun Xiong, Ze-hong Chen, Yu-fei Luo, Ying Xu, Yan-ping Su, Hui-hui Huang, Chang-xi Yu
Summary: Koumine, an alkaloid, has therapeutic effects against rheumatoid arthritis (RA) and may restore the homeostasis of Th subsets and cytokines by inhibiting T cell activation, subsequently regulating the polarization of Th subsets and the downstream imbalance of pro/anti-inflammatory cytokines in RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Rheumatology
Jaiber Gutierrez-Sanchez, Viviana Parra-Izquierdo, Cristian Florez-Sarmiento, Diego Alejandro Jaimes, Juliette De Avila, Juan Manuel Bello-Gualtero, Alejandro Ramos-Casallas, Lorena Chila-Moreno, Cesar Pacheco-Tena, Adriana Beltran-Ostos, Philippe Chalem-Choueka, Wilson Bautista-Molano, Consuelo Romero-Sanchez
Summary: The application of IBD screening criteria in patients with spondyloarthritis (SpA) can provide an opportunity for timely referral to gastroenterology.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Alejandro Ramos-Casallas, Juliette De Avila, Andrea Chaparro-Sanabria, Philippe Chalem Choueka, Juan Manuel Bello-Gualtero, Lorena Chila-Moreno, Cesar Pacheco-Tena, Wilson Bautista-Molano, Consuelo Romero-Sanchez
Summary: This study aimed to establish the association between Porphyromonas gingivalis (P. gingivalis) infection, body mass index (BMI), joint involvement, and serum adipokines in first-degree relatives (FDR) of patients with rheumatoid arthritis (RA). The results showed that leptin levels were associated with BMI >25 and radiographic damage in FDR. Additionally, the presence of P. gingivalis was related to FDR, low levels of adipsin, resistin, and adiponectin. Adipokines may play a role in the pathogenesis of RA in FDR.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Article
Clinical Neurology
Fernando Guevara-Villazon, Cesar Pacheco-Tena, Antonio Anchondo-Lopez, Luis Alberto Ordonez-Solorio, Benjamin Contreras Martinez, Arturo Munoz-Cobos, Arturo Luevano-Gonzalez, Susana Aidee Gonzalez-Chavez
Summary: The study aimed to analyze the differential transcriptome expression in hypertrophic ligaments flavum (HLF) compared to normal ligaments. Through a case-control study, 15 patients with hypertrophy of LF and 15 controls were analyzed. Histological alterations and dysregulated genes associated with signaling pathways in HLF were identified. The results suggest that abnormal processes in hypertrophied LF are mediated by the interaction of specific pathways, which may have therapeutic potential that needs further confirmation.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Diana Marcela Castillo, Gloria Ines Lafaurie, Consuelo Romero-Sanchez, Nathaly Andrea Delgadillo, Yormaris Castillo, Wilson Bautista-Molano, Cesar Pacheco-Tena, Juan Manuel Bello-Gualtero, Philippe Chalem-Choueka, Jaime E. Castellanos
Summary: This study found that antibodies against arginine-gingipain A (RgpA) and the double positivity of RgpA and peptidyl arginine deiminase (PPAD) may serve as biomarkers for rheumatoid arthritis (RA), improving its diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Susana Aidee Gonzalez-Chavez, Salma Marcela Lopez-Loeza, Samara Acosta-Jimenez, Ruben Cuevas-Martinez, Cesar Pacheco-Silva, Eduardo Chaparro-Barrera, Cesar Pacheco-Tena
Summary: Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) have the potential to delay the onset of the disease. Physical exercise (PE) has been shown to benefit RA patients, but its impact in reducing the risk of developing RA has not been extensively studied. This study investigated the effects of low-intensity PE on the joints of mice with pre-arthritic CIA. The results showed that PE reduced joint inflammation and damage, as well as down-regulated the expression of proinflammatory genes and proteins. Further research is needed to understand the underlying mechanisms of PE in preclinical arthritis and its role in reducing the risk of developing RA.
Article
Medicine, General & Internal
Consuelo Romero-Sanchez, Juliette De Avila, Alejandro Ramos-Casallas, Lorena Chila-Moreno, Nathaly Andrea Delgadillo, Philippe Chalem-Choueka, Cesar Pacheco-Tena, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano
Summary: This study aimed to investigate the association between adipokine profile and disease activity, body mass index, and periodontal infection in early rheumatoid arthritis (RA) patients. The results showed that high levels of leptin were associated with greater clinical activity in RA patients who were overweight and had periodontal infection. This suggests a potential pathological mechanism involving adipokines in the relationship between RA, overweight, and periodontal infection.
Article
Biotechnology & Applied Microbiology
Norma Angelica Bolivar-Jacobo, Raul Alberto Reyes-Villagrana, Gerardo Pavel Espino-Solis, Ana Luisa Renteria-Monterrubio, Martha Maria Arevalos-Sanchez, Rogelio Sanchez-Vega, Eduardo Santellano-Estrada, David Chavez-Flores, America Chavez-Martinez
Summary: Ultrasound can be used to increase the biomass and fermentation products of probiotics. The effects of high-intensity ultrasounds on the growth and fermentative profile of Lactobacillus acidophilus and helveticus were studied. The ultrasound amplitude influenced the enzyme activity, protein concentration, and organic acid concentration of the probiotics.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Carolina Alvarado-Gonzalez, Herlinda Clement, Lourdes Ballinas-Casarrubias, Angelica Escarcega-Avila, Ivan Arenas-Sosa, Karla Sofia Lopez-Contreras, Fernando Zamudio, Gerardo Corzo, Gerardo Pavel Espino-Solis
Summary: This manuscript describes the ecosystem of Chihuahua, Mexico and the composition of venoms from two scorpion species. The study identified three new venom fractions, one of which displayed antimicrobial activity. This research provides an opportunity to discover potential molecules for biomedical and biotechnological applications.
Article
Sport Sciences
Estefania Quintana-Mendias, Judith M. Rodriguez-Villalobos, Argel Gastelum-Arellanez, Natanael Cervantes, Claudia E. Carrasco-Legleu, Gerardo Pavel Espino-Solis
Summary: Physical exercise has a systemic impact on the immune system, particularly on Natural Killer cells. This study examined the acute effects of moderate- and high-intensity exercise on immunological markers in healthy women. The results showed that exercise increased the percentage of Natural Killer cells and also had an impact on cytokine levels.
Article
Rheumatology
Alfonso Gastelum-Strozzi, Diana Elsa Flores-Alvarado, Virginia Pascual-Ramos, Everardo Alvarez-Hernandez, Cesar Francisco Pacheco-Tena, Guillermo Arturo Guaracha-Basanez, Conrado Garcia Garcia, Susana Aidee Gonzalez-Chavez, Jose Francisco Moctezuma-Rios, Amaranta Manrique de Lara, Jorge Antonio Esquivel-Valerio, Irazu Contreras-Yanez, Dionicio Angel Galarza-Delgado, Janitzia Vazquez-Mellado, Ingris Pelaez-Ballestas, Greta Cristina Reyes-Cordero
Summary: This study analyzed the relationship between COVID-19 cases and deaths in Mexico and vaccine acceptance among patients with rheumatic and musculoskeletal diseases (RMDs). The results showed that overall vaccine acceptance was high, but differences were observed based on specific diagnoses, with rheumatoid arthritis (RA) patients showing decreased acceptance during the peak of the epidemic curve, while systemic lupus erythematosus (SLE) patients became more accepting. These findings have important implications for updating clinical practice recommendations.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Monica Guadalupe Matuz-Flores, Jesus Alfredo Rosas-Rodriguez, Orlando Tortoledo-Ortiz, Salvador Munoz-Barrios, Gloria Esther Martinez-Bonilla, Jorge Hernandez-Bello, Christian Johana Banos-Hernandez, Cesar Pacheco-Tena, Gabriela Athziri Sanchez-Zuno, Beatriz Panduro-Espinoza, Jose Francisco Munoz-Valle
Summary: This study found that the polymorphisms of the PADI4 gene are associated with the risk and progression of RA. The GTG haplotype is related to RA susceptibility and is associated with higher PADI4 mRNA expression and PAD4 enzymatic activity in RA patients.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Rosa Isela Ruvalcaba-Ontiveros, Susana Aidee Gonzalez-Chavez, Anel Rocio Carrasco-Hernandez, Salma Marcela Lopez-Loeza, Ivonne Castellanos-Ponce, Gregorio Vazquez-Olvera, Miguel Angel Neri-Flores, Gerardo Pavel Espino-Solis, Jose Alberto Duarte-Moller, Cesar Pacheco-Tena, Hilda Esperanza Esparza-Ponce
Summary: This study presents the therapeutic effect of silica-gold nanostructures (SGNs) in a collagen-induced arthritis (CIA) mouse model. The results show that SGNs can alleviate arthritis lesions, reduce the expression of inflammatory genes, and decrease the levels of inflammatory factors in the serum.
BIOMATERIALS SCIENCE
(2022)