FOXP transcription factors in vertebrate brain development, function, and disorders

Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes

(2019) Stephanie L. Hickey et al.   Cell Reports

Specification of diverse cell types during early neurogenesis of the mouse cerebellum

(2019) John W Wizeman et al.   eLife

FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

(2019) Ryan J Kast et al.   eLife

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression

(2019) Marissa Co et al.   CEREBRAL CORTEX

OUP accepted manuscript

(2018)   CEREBRAL CORTEX

Whole genome sequencing identifies a de novo 2.1 Mb balanced paracentric inversion disrupting FOXP1 and leading to severe intellectual disability

(2018) M.-L. Vuillaume et al.   CLINICA CHIMICA ACTA

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders

(2018) Sara B Estruch et al.   HUMAN MOLECULAR GENETICS

Mapping the distribution of language related genes FoxP1 , FoxP2 , and CntnaP2 in the brains of vocal learning bat species

(2018) Pedro M. Rodenas-Cuadrado et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Phonological working memory and FOXP2

(2018) Katrin Schulze et al.   NEUROPSYCHOLOGIA

Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain

(2018) Lucia Fong et al.   NEUROSCIENCE

FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

(2018) Zachary Daniel Burkett et al.   eLife

Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release

(2018) Jon-Ruben van Rhijn et al.   Brain Structure & Function

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Differential effects of Foxp2 disruption in distinct motor circuits

(2018) Catherine A. French et al.   MOLECULAR PSYCHIATRY

A De Novo FOXP1 Truncating Mutation in a Patient Originally Diagnosed as C Syndrome

(2018) Roser Urreizti et al.   Scientific Reports

Three Japanese patients with 3p13 microdeletions involving FOXP1

(2018) Keiko Yamamoto-Shimojima et al.   BRAIN & DEVELOPMENT

Neocerebellar Crus I Abnormalities Associated with a Speech and Language Disorder Due to a Mutation in FOXP2

(2018) G. P. D. Argyropoulos et al.   CEREBELLUM

Altered social behavior in mice carrying a cortical Foxp2 deletion

(2018) Vera P Medvedeva et al.   HUMAN MOLECULAR GENETICS

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity

(2018) Bradley P. Coe et al.   NATURE GENETICS

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Vocal cord immobility as a cause of aphonia in a child with 3p13p12 deletion syndrome encompassing FOXP1 gene

(2018) Hatice Mutlu-Albayrak et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Foxp1 regulation of neonatal vocalizations via cortical development

(2017) Noriyoshi Usui et al.   GENES & DEVELOPMENT

Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization

(2017) Henning Fröhlich et al.   HUMAN MOLECULAR GENETICS

Equivalent missense variant in the FOXP2 and FOXP1 transcription factors causes distinct neurodevelopmental disorders

(2017) Elliot Sollis et al.   HUMAN MUTATION

FOXP1 -related intellectual disability syndrome: a recognisable entity

(2017) Ilse Meerschaut et al.   JOURNAL OF MEDICAL GENETICS

Loss of Intercalated Cells (ITCs) in the Mouse Amygdala ofTshz1Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes

(2017) Jeffrey Kuerbitz et al.   JOURNAL OF NEUROSCIENCE

Foxp1 in Forebrain Pyramidal Neurons Controls Gene Expression Required for Spatial Learning and Synaptic Plasticity

(2017) Daniel J. Araujo et al.   JOURNAL OF NEUROSCIENCE

The familial co-aggregation of ASD and ADHD: a register-based cohort study

(2017) L Ghirardi et al.   MOLECULAR PSYCHIATRY

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Control of Huntington’s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2

(2017) Lea J. Hachigian et al.   Cell Reports

Prospective investigation of FOXP1 syndrome

(2017) Paige M. Siper et al.   Molecular Autism

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System

(2017) Ezequiel Mendoza et al.   Frontiers in Molecular Neuroscience

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression

(2017) Luca Braccioli et al.   Stem Cell Reports

Animal Models of Speech and Vocal Communication Deficits Associated With Psychiatric Disorders

(2016) Genevieve Konopka et al.   BIOLOGICAL PSYCHIATRY

Exome sequencing in mostly consanguineous Arab families with neurologic disease provides a high potential molecular diagnosis rate

(2016) Wu-Lin Charng et al.   BMC Medical Genomics

Genoarchitecture of the extended amygdala in zebra finch, and expression of FoxP2 in cell corridors of different genetic profile

(2016) Alba Vicario et al.   Brain Structure & Function

FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation

(2016) S.V. Precious et al.   EXPERIMENTAL NEUROLOGY

Ultrasonic vocalizations of adult maleFoxp2-mutant mice: behavioral contexts of arousal and emotion

(2016) S. Gaub et al.   GENES BRAIN AND BEHAVIOR

FOXP2variants in 14 individuals with developmental speech and language disorders broaden the mutational and clinical spectrum

(2016) Miriam S Reuter et al.   JOURNAL OF MEDICAL GENETICS

FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing

(2016) Iris Adam et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c

(2016) Yi-Chuan Chen et al.   NATURE NEUROSCIENCE

Knockout of Foxp2 disrupts vocal development in mice

(2016) Gregg A. Castellucci et al.   Scientific Reports

A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice

(2016) Jonathan Chabout et al.   Frontiers in Behavioral Neuroscience

Early neuroimaging markers of FOXP2 intragenic deletion

(2016) Frédérique J. Liégeois et al.   Scientific Reports

Foxp1/2/4 regulate endochondral ossification as a suppresser complex

(2015) Haixia Zhao et al.   DEVELOPMENTAL BIOLOGY

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

(2015) Daniel J. Araujo et al.   GENES & DEVELOPMENT

Identification and functional characterization ofde novo FOXP1variants provides novel insights into the etiology of neurodevelopmental disorder

(2015) Elliot Sollis et al.   HUMAN MOLECULAR GENETICS

Differential coexpression of FoxP1, FoxP2, and FoxP4 in the Zebra Finch (Taeniopygia guttata) song system

(2015) Ezequiel Mendoza et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning

(2015) J. B. Heston et al.   JOURNAL OF NEUROSCIENCE

Foxp1 Regulates Cortical Radial Migration and Neuronal Morphogenesis in Developing Cerebral Cortex

(2015) Xue Li et al.   PLoS One

Delineation of the 3p14.1p13 microdeletion associated with syndromic distal limb contractures

(2014) Julien Thevenon et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization

(2014) Cora Sin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cell Type-Specific Expression Analysis to Identify Putative Cellular Mechanisms for Neurogenetic Disorders

(2014) X. Xu et al.   JOURNAL OF NEUROSCIENCE

Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour

(2014) C Bacon et al.   MOLECULAR PSYCHIATRY

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Refining analyses of copy number variation identifies specific genes associated with developmental delay

(2014) Bradley P Coe et al.   NATURE GENETICS

Genotype to phenotype relationships in autism spectrum disorders

(2014) Jonathan Chang et al.   NATURE NEUROSCIENCE

Specific expression of FOXP2 in cerebellum improves ultrasonic vocalization in heterozygous but not in homozygous Foxp2 (R552H) knock-in pups

(2014) Eriko Fujita-Jimbo et al.   NEUROSCIENCE LETTERS

De novo TBR1 mutations in sporadic autism disrupt protein functions

(2014) Pelagia Deriziotis et al.   Nature Communications

FOXP1mutations cause intellectual disability and a recognizable phenotype

(2013) Anna K. Le Fevre et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Correlated Gene Expression and Target Specificity Demonstrate Excitatory Projection Neuron Diversity

(2013) Staci A. Sorensen et al.   CEREBRAL CORTEX

3p14.1 de novo microdeletion involving the FOXP1 gene in an adult patient with autism, severe speech delay and deficit of motor coordination

(2013) Orazio Palumbo et al.   GENE

FoxP2 Regulates Neurogenesis during Embryonic Cortical Development

(2013) D. Tsui et al.   JOURNAL OF NEUROSCIENCE

Engineered Deafness Reveals That Mouse Courtship Vocalizations Do Not Require Auditory Experience

(2013) E. J. Mahrt et al.   JOURNAL OF NEUROSCIENCE

Diminished FoxP2 Levels Affect Dopaminergic Modulation of Corticostriatal Signaling Important to Song Variability

(2013) Malavika Murugan et al.   NEURON

Mice do not require auditory input for the normal development of their ultrasonic vocalizations

(2012) Kurt Hammerschmidt et al.   BMC NEUROSCIENCE

Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

(2012) Michael E. Talkowski et al.   CELL

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

(2012) S. Li et al.   DEVELOPMENT

Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS

(2012) David L. Rousso et al.   NEURON

Foxp2 Mutations Impair Auditory-Motor Association Learning

(2012) Simone Kurt et al.   PLoS One

Of Mice, Birds, and Men: The Mouse Ultrasonic Song System Has Some Features Similar to Humans and Song-Learning Birds

(2012) Gustavo Arriaga et al.   PLoS One

Analysis of two language-related genes in autism

(2012) Claudio Toma et al.   PSYCHIATRIC GENETICS

FOXP2 promotes the nuclear translocation of POT1, but FOXP2(R553H), mutation related to speech-language disorder, partially prevents it

(2011) Yuko Tanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imaging genetics of FOXP2 in dyslexia

(2011) Arndt Wilcke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Endophenotypes of FOXP2: Dysfunction within the human articulatory network

(2011) F. Liégeois et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder

(2011) Jillian P. Casey et al.   HUMAN GENETICS

FoxP2 expression in the cerebellum and inferior olive: Development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex

(2011) Hirofumi Fujita et al.   JOURNAL OF COMPARATIVE NEUROLOGY

An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning

(2011) C A French et al.   MOLECULAR PSYCHIATRY

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Association study of the CNS patterning genes and autism in Han Chinese in Taiwan

(2011) Yi-Ling Chien et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

(2011) Y. Sakai et al.   Science Translational Medicine

Foxp2 Regulates Gene Networks Implicated in Neurite Outgrowth in the Developing Brain

(2011) Sonja C. Vernes et al.   PLoS Genetics

De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment

(2010) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An extended Family with a Dominantly Inherited Speech Disorder

(2010) J. A. Hurst et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Chiari I malformation, delayed gross motor skills, severe speech delay and epileptiform discharges in a child with FOXP1 haploinsufficiency

(2010) Christopher W Carr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Knockdown of FoxP2 alters spine density in Area X of the zebra finch

(2010) S. B. Schulz et al.   GENES BRAIN AND BEHAVIOR

The structure of innate vocalizations in Foxp2-deficient mouse pups

(2010) S. Gaub et al.   GENES BRAIN AND BEHAVIOR

Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits

(2010) Denise Horn et al.   HUMAN MUTATION

Foxp1/2/4-NuRD Interactions Regulate Gene Expression and Epithelial Injury Response in the Lung via Regulation of Interleukin-6

(2010) Ann L. Chokas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Foxp4 is essential in maintenance of purkinje cell dendritic arborization in the mouse cerebellum

(2010) W.Y. Tam et al.   NEUROSCIENCE

Foxp1 and Lhx1 Coordinate Motor Neuron Migration with Axon Trajectory Choice by Gating Reelin Signalling

(2010) Elena Palmesino et al.   PLOS BIOLOGY

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development

(2009) X. Feng et al.   BLOOD

Modified sound-evoked brainstem potentials in Foxp2 mutant mice

(2009) Simone Kurt et al.   BRAIN RESEARCH

A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice

(2009) Wolfgang Enard et al.   CELL

Detailed Expression Pattern of Foxp1 and Its Possible Roles in Neurons of the Spinal Cord during Embryogenesis

(2009) Yoshihiro Morikawa et al.   DEVELOPMENTAL NEUROSCIENCE

Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia

(2009) Sonja C Vernes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis

(2009) Mitchel J. Pariani et al.   European Journal of Medical Genetics

Characterization of Foxp2-expressing cells in the developing spinal cord

(2009) Y. Morikawa et al.   NEUROSCIENCE

The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex

(2009) T. Hisaoka et al.   NEUROSCIENCE

Molecular characterization of the intercalated cell masses of the amygdala: implications for the relationship with the striatum

(2009) T. Kaoru et al.   NEUROSCIENCE

Foxp2 Inhibits Nkx2.1-Mediated Transcription of SP-C via Interactions with the Nkx2.1 Homeodomain

(2008) Beiyun Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1

(2008) Jeremy S. Dasen et al.   CELL

Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits

(2008) Matthias Groszer et al.   CURRENT BIOLOGY

Expression ofFOXP2in the developing monkey forebrain: Comparison with the expression of the genesFOXP1,PBX3, andMEIS2

(2008) Kaoru Takahashi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Conservation and diversity of Foxp2 expression in muroid rodents: Functional implications

(2008) Polly Campbell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Birdsong Decreases Protein Levels of FoxP2, a Molecule Required for Human Speech

(2008) Julie E. Miller et al.   JOURNAL OF NEUROPHYSIOLOGY

Expression ofFoxp4in the developing and adult rat forebrain

(2008) Kaoru Takahashi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons

(2008) David L. Rousso et al.   NEURON

Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells

(2008) E. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders

(2008) Fabrice Laroche et al.   PSYCHIATRIC GENETICS