Review
Cell Biology
Bohan Zhang, Alexandre Trapp, Csaba Kerepesi, Vadim N. Gladyshev
Summary: There are interventions proposed to reverse aging rather than just slow it down, but the criteria for achieving rejuvenation are still controversial. A key prerequisite for a rejuvenation intervention is a significant reduction in biological age, which can be assessed by biomarkers such as epigenetic clocks.
Article
Cell Biology
Chantel L. Martin, Cavin K. Ward-Caviness, Radhika Dhingra, Tarek M. Zikry, Sandro Galea, Derek E. Wildman, Karestan C. Koenen, Monica Uddin, Allison E. Aiello
Summary: Living in adverse neighborhood environments may accelerate epigenetic aging, while positive neighborhood attributes could buffer these effects.
Article
Public, Environmental & Occupational Health
Jingwei Li, Li Tian, Wei Ouyang
Summary: This study examines the impact of built environment on elderly health in high-density Chinese cities and reveals that neighborhood-built environment is closely related to elderly health, with physical activity and social interaction playing a mediating role. The impacts of built environment variables on elderly health vary among different age and gender groups.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Rashida Brown, Elleni M. Hailu, Belinda L. Needham, Ana Diez Roux, Teresa E. Seeman, Jue Lin, Mahasin S. Mujahid
Summary: The study found that changes in neighborhood socioeconomic and social conditions were associated with changes in leukocyte telomere length, with improvement in neighborhood socioeconomic status linked to slower telomere attrition, while increases in safety and overall neighborhood social environment score were associated with more pronounced telomere attrition. This suggests that broader social and socioeconomic contexts should be considered in relation to biological aging. Future research should further explore psychosocial mechanisms underlying these associations using longitudinal study designs.
Article
Cell Biology
Xiao Dong, Shixiang Sun, Lei Zhang, Seungsoo Kim, Zhidong Tu, Cristina Montagna, Alexander Y. Maslov, Yousin Suh, Tao Wang, Judith Campisi, Jan Vijg
Summary: Telomere attrition has been identified as a biomarker and cause of aging, affecting gene expression in subtelomeric regions. Analysis of gene expression data from the GTEx RNA sequencing database reveals spatial relationships between telomeres and gene expression in aging, with more upregulated genes than downregulated genes in subtelomeric regions.
Article
Public, Environmental & Occupational Health
Jaap Goudsmit, Anita Huiberdina Johanna van den Biggelaar, Wouter Koudstaal, Albert Hofman, Wayne Chester Koff, Theodore Schenkelberg, Galit Alter, Michael Joseph Mina, Julia Wei Wu
Summary: The Human Immunomics Initiative focuses on studying immunity and predictability of vaccine responsiveness in aging populations by differentiating between chronological, biological, and immune age, utilizing existing large-scale population cohorts for research. The goal is to enhance vaccine effectiveness in aging populations by relating vaccine responsiveness to biological and immune age.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Criminology & Penology
Young-An Kim, Joonggon Kim
Summary: The study examines the relationship between physical and social environmental features and neighborhood crime in a large Korean city. It finds that incorporating physical and social environmental features based on the theoretical framework of criminal opportunities and social disorganization is useful for understanding the spatial patterns of crime in the Korean context.
CRIME & DELINQUENCY
(2022)
Article
Public, Environmental & Occupational Health
Lilian G. Perez, Joan S. Tucker, Eric R. Pedersen, Wendy M. Troxel, Anthony Rodriguez, Caislin L. Firth, Rachana Seelam, Regina A. Shih, Elizabeth J. D. 'Amico
Summary: This study examines the relationship between changes in perceived and objective neighborhood social environment variables during adolescence and alcohol and marijuana use in emerging adulthood. The results show that increasing perceived disorganization is associated with more severe alcohol consequences and increased marijuana use in social activities. Decreasing objective neighborhood SES is associated with fewer alcohol consequences and more socialization with peers drinking alcohol. Unexpectedly, both decreasing and increasing perceived social cohesion are associated with fewer alcohol consequences. Increasing perceived social cohesion is associated with lower solitary alcohol use.
Review
Nursing
Pamela Jackson, Mirjam-Colette Kempf, Burel R. Goodin, Bertha A. Hidalgo, Edwin N. Aroke
Summary: This study aimed to describe the evidence on the relationship between neighborhood environmental characteristics and epigenetic age. The results showed a relationship between neighborhood characteristics and epigenetic age, whether the characteristic of interest was socioeconomic or physical. However, the findings varied based on measurement methods, and there was a lack of investigations on physical characteristics, indicating a need for more attention.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Man-Kit Lei, Mark T. Berg, Ronald L. Simons, Steven R. H. Beach
Summary: Research suggests that neighborhood disadvantage is associated with accelerated biological aging among Black Americans, regardless of age or gender. Decreasing neighborhood disadvantage can promote healthy aging, particularly among Black Americans.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Health Care Sciences & Services
Philippa Clarke, Anam M. Khan, Neil Kamdar, Kristian Seiler, Kenzie Latham-Mintus, Mark D. Peterson, Michelle A. Meade, Joshua R. Ehrlich
Summary: This study examined the relationship between neighborhood characteristics and incident type 2 diabetes mellitus among adults aging with vision impairment. The results showed that living in neighborhoods with greater intersection density and high-speed roads increased the risk of T2DM for older adults with VI. On the other hand, living in neighborhoods with broadband internet access, optical stores, supermarkets, and gyms/fitness centers reduced the risk of T2DM for both younger and older adults with VI.
DISABILITY AND HEALTH JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Zhibin Liang, Antonio Currais, David Soriano-Castell, David Schubert, Pamela Maher
Summary: Mitochondria, as the primary source of energy production in the brain, become inefficient and dysfunctional with age and in neurological disorders. Natural products are utilized as potential neuroprotective agents to restore mitochondrial function, highlighting both the value and challenges in the discovery and development of future neurotherapeutics.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Digne Tembely, Auberi Henry, Laetitia Vanalderwiert, Kevin Toussaint, Amar Bennasroune, Sebastien Blaise, Herve Sartelet, Stephane Jaisson, Celine Gales, Laurent Martiny, Laurent Duca, Beatrice Romier-Crouzet, Pascal Maurice
Summary: The incidence of cardiovascular diseases is increasing due to the aging population, which has a major influence on the vascular tree. Aging leads to changes in the morphology and function of the arterial wall, as well as remodeling of the vascular extracellular matrix. The release of elastin-derived peptides (EDPs) from elastin degradation products is a characteristic feature of aged conduit arteries. These EDPs not only affect the mechanical properties of arteries but also modulate the development and progression of various vascular and metabolic diseases. The elastin receptor complex (ERC), which contains elastin-binding protein, protective protein/cathepsin A, and neuraminidase-1 (NEU1), plays a crucial role in mediating the biological effects of these peptides. This review provides an overview of the consequences of aging on the vasculature and the release of EDPs, discusses the composition and signaling pathways of the ERC, and explores the pharmacological strategies targeting ERC activation. Additionally, it highlights the emerging regulatory functions of the ERC through desialylation of membrane glycoproteins by NEU1 and its potential implication in receptor transactivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Pamela Jackson, Antoinette L. Spector, Larissa J. Strath, Lisa H. Antoine, Peng Li, Burel R. Goodin, Bertha A. Hidalgo, Mirjam-Colette Kempf, Cesar E. Gonzalez, Alana C. Jones, Thomas C. Foster, Jessica A. Peterson, Tammie Quinn, Zhiguang Huo, Roger Fillingim, Yenisel Cruz-Almeida, Edwin N. Aroke
Summary: The study aimed to examine the relationship between neighborhood deprivation and pain severity in knee osteoarthritis (KOA) and the influence of epigenetic age acceleration (EpAA) on that relationship. The results showed a positive correlation between neighborhood deprivation, EpAA, and pain severity. Epigenetic age acceleration acted as a mediator between neighborhood deprivation and pain severity, suggesting that it may play a role in the well-documented relationship between neighborhood of residence and age-related diseases.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Eun Young Choi, Elizabeth M. Zelinski, Jennifer Ailshire
Summary: This study aims to examine the relationship between neighborhood social environment and self-perceptions of aging (SPA), and how age may moderate this relationship. The results show that social cohesion has a significant impact on SPA, while the percentage of older adults in the neighborhood and perceived disorder have a negative impact on SPA. These findings provide important insights for promoting favorable perceptions of aging, especially for middle-aged residents.
INNOVATION IN AGING
(2023)
Article
Environmental Sciences
Eun Jung Kim, Jiyeong Kim, Hyunjung Kim
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Green & Sustainable Science & Technology
Eun Jung Kim, Hyunjung Kim
Article
Environmental Sciences
Eun Jung Kim, Jiyeong Kim, Hyunjung Kim
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Green & Sustainable Science & Technology
Wonjun Cho, Minho Kim, Hyunjung Kim, Youngsang Kwon
Article
Computer Science, Interdisciplinary Applications
Seongyong Kim, Seula Park, Hyunjung Kim, Kiyun Yu
Summary: This paper introduces a novel method for extracting indoor structures from complex floor plans, by processing building elements into vectorized form and unifying various plan formats into a consistent style using conditional generative adversarial networks. The experimental results show that the proposed model performs comparably to existing methods in detecting and recognizing rooms, with superior performance in one-to-one matches.
JOURNAL OF COMPUTING IN CIVIL ENGINEERING
(2021)
Article
Green & Sustainable Science & Technology
Hyunjung Kim, Eun Jung Kim
Summary: This study evaluates the increase in visitors to tourism zones in Japan through quantitative methods and regression modeling. The results show that regions with narrow tourism zones in the same prefectures experienced a significant increase in visitors, with subsidies having a positive impact on visitor numbers. Implications on tourism policies, urban and regional development, and community development can be drawn from this study.
Article
Chemistry, Multidisciplinary
Hyunjung Kim
Summary: This study proposes a new technology for automatically extracting accurate indoor spatial information from floor plan images using deep learning, and evaluates its effectiveness through an assessment framework.
APPLIED SCIENCES-BASEL
(2021)
Article
Computer Science, Information Systems
Hyunjung Kim, Seongyong Kim, Kiyun Yu
Summary: Automatic floor plan analysis has gained increased attention in recent research, and this study aimed to build a framework using CNN for analyzing floor plans of complex buildings. By dividing the floor plan into normalized patches, the proposed CNN model can process varied scales or high-resolution inputs, detecting building objects per patch and assembling them into one result. The framework exhibited similar performance to existing studies in detection rate and recognition accuracy, despite the complexity of the data used.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2021)
