Article
Biochemistry & Molecular Biology
Jingbo Zhang, Xiang Qu, Junjun Li, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Yoshiki Sawa, Li Liu, Shigeru Miyagawa
Summary: Diabetic foot ulceration is a common complication, and transplantation of hUC-MSC tissue sheets can promote wound healing, improve collagen deposition, and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Junshuai Xue, Nianfeng Sun, Yang Liu
Summary: This study presents a novel and effective approach to accelerate diabetic skin wound healing. The researchers shaped human umbilical cord mesenchymal stem cells (hUC-MSCs) into spheres and combined them with nanopeptide hydrogels for transplantation into a mouse model. The results demonstrated that this approach significantly accelerated wound healing and promoted angiogenesis by inhibiting inflammation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Liping Teng, Maria Maqsood, Min Zhu, Yuting Zhou, Mingzhu Kang, Juan Zhou, Jinghua Chen
Summary: This study demonstrates that hucMSCs-exo can facilitate diabetic wound repair by inducing anti-inflammatory macrophages, promoting angiogenesis, and collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Fang Chen, Jianghui Qin, Pingli Wu, Wenshan Gao, Guoming Sun
Summary: This study introduces reversible boronic bonds to create an intelligent antioxidant hydrogel scaffold for efficient delivery of antioxidants to diabetic wounds. The hydrogel responds to changes in glucose levels, releasing more antioxidants as glucose level increases. The hydrogel shows good biocompatibility, biodegradability, and mechanical properties similar to skin tissue. In vitro and in vivo experiments demonstrate that the hydrogel effectively eliminates reactive oxygen species, reduces inflammation, promotes angiogenesis, and improves tissue remodeling during diabetic wound healing. This strategy offers new insight into glucose-responsive scaffolds and holds great potential for the treatment of chronic diabetic wounds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Dermatology
Mohammad Ali Nilforoushzadeh, Hamideh Afzali, Amir Raoofi, Maryam Nouri, Reza Naser, Omid Gholami, Davood Nasiry, Abdolreza Mohammadnia, Zahra Razzaghi, Alimohammad Alimohammadi, Zahra Safaie Naraghi, Aisan Peyrovan, Faeze Jahangiri, Ebrahim Khodaverdi Darian, Auob Rustamzadeh, Sona Zare
Summary: This study evaluated the effectiveness of using cell spray for the healing of diabetic wounds in rats through clinical, pathological, and biometric parameters. The results showed that the application of cell spray significantly accelerated the healing of diabetic wounds on Days 7, 14, and 21.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Engineering, Biomedical
Zixuan Zhou, Jingnan Xun, Chenghao Wu, Chao Ji, Shizhao Ji, Futing Shu, Yuxiang Wang, Hao Chen, Yongjun Zheng, Shichu Xiao
Summary: This study demonstrates that micronized amniotic membrane (mAM) can be used as a microcarrier to improve the proliferation efficiency of umbilical cord-derived mesenchymal stem cells (UC-MSC) in vitro and accelerate burn wound healing when used in combination with UC-MSC (mAM-MSC). Transcriptome sequencing revealed upregulation of genes related to growth factors, angiogenesis, and wound healing in mAM-MSC compared to traditional 2D-cultured MSC, which was confirmed by RT-qPCR. Gene ontology analysis showed enrichment of terms related to cell proliferation, angiogenesis, cytokine activity, and wound healing in mAM-MSC. In a burn wound model, topical application of mAM-MSC promoted faster wound healing, increased MSC survival, and enhanced neovascularization.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen
Summary: Emodin can improve diabetic wound healing by promoting extracellular matrix synthesis and granulation tissue formation, and promote the conversion of M1-like macrophages to M2-like macrophages by down-regulating the NF-xB signaling pathway. This study identified potential targets of emodin and revealed its role in fibroblast proliferation and ECM formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Jinghuang Chen, Xingfu Bao, Tian Meng, Jian Sun, Xiurong Yang
Summary: This study prepared a series of ZIF-67 with different morphologies and sizes, exhibiting remarkable antibacterial activity and promoting angiogenesis and cell proliferation. These single-component ZIF-67 nanostructures showed great potential for accelerating wound healing in diabetic patients and integrating with other complementary active ingredients for biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Multidisciplinary
Jiahui He, Zhenlong Li, Jiaxin Wang, Tongyang Li, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a multifunctional hydrogel with antibacterial, antioxidant, self-healing, and conductive properties. The hydrogel is capable of releasing nitric oxide (NO) under near-infrared (NIR) laser irradiation, which promotes the healing of diabetic wounds.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Fatma Kubra Tombulturk, Zeynep Gizem Todurga-Seven, Onder Huseyinbas, Sibel Ozyazgan, Turgut Ulutin, Gonul Kanigur-Sultuybek
Summary: The research found that topical application of metformin accelerates wound healing by suppressing NF-kappa B p65 activity and diminishing the expression of MMP2 and MMP9. Diabetic wounds treated with metformin healed even faster than those in the control group that mimicked standard wound healing.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Zhichao Hao, Gen Liu, Lin Ren, Jiangchen Liu, Chuanzi Liu, Tao Yang, Xiangnan Wu, Xinchun Zhang, Ling Yang, Juan Xia, Weichang Li
Summary: Developing an effective treatment strategy for diabetic wound healing is a major challenge in clinical practice due to multidrug-resistant bacterial infections, angiopathy, and oxidative damage. This study designed a self-healing hydrogel with interpenetrating networks formed by multiple-dynamic bond cross-linking. The hydrogel showed excellent autonomous healing mediated by reversible breakage of Schiff bonds and reinforced by other noncovalent interactions. Incorporation of cathelicidin LL-37 in the hydrogel significantly promoted diabetic wound healing by various mechanisms. Therefore, this study provides an effective and safe strategy for diabetic wound treatment in clinical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yuanmeng He, Kaiyue Liu, Shen Guo, Rong Chang, Chen Zhang, Fangxia Guan, Minghao Yao
Summary: A multifunctional hydrogel (OGF) based on oxidized dextran, gallic acid-grafted gelatin, and Ferric ion showed excellent antibacterial ability and promoted the healing of infected wounds in diabetic patients.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Ning Li, Aiyan Zhan, Yiguo Jiang, Hongzhuo Liu
Summary: The designed MMP-responsive hydrogel loaded with deferoxamine promoted angiogenesis and accelerated wound healing in diabetic foot ulcers by increasing the expression of hypoxia-inducible factor-1 alpha.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Kaan Kaltalioglu
Summary: This study found that sinapic acid, a phytochemical, has the potential to promote wound healing in individuals with diabetes. By using sinapic acid-loaded gels, the researchers observed improved re-epithelialization and angiogenesis, increased collagen content, and decreased oxidative damage in diabetic wounds. These findings suggest that topical application of sinapic acid can be an effective approach for promoting diabetic wound healing, especially at low doses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Xin Huang, Hang Yin, Xin-Xing Wan, Bing Fu, Bei Tang, Jun Lei
Summary: The cumulative incidence of PPD at six weeks postpartum was 12.05%. Plasma 5-HT level at delivery was negatively correlated with EPDS scores at delivery and six weeks postpartum, but the changes in 5-HT were not associated with EPDS scores at six weeks postpartum. Plasma 5-HT is not a suitable biomarker for diagnosing PPD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Environmental Sciences
Chi Peng, Kai Zhang, Meie Wang, Xinxing Wan, Weiping Chen
Summary: Heavy metal concentrations in urban soils are likely to increase due to urbanization and emissions. The accumulation rates of heavy metals in urban soils varied among cities and were influenced by soil parent material and anthropogenic sources. Cd and Cu accumulation rates were similar across the three cities, while Zn and Pb accumulation rates were higher in Shanghai. Although urbanization led to elevated concentrations of Cd, Cu, Zn, and Pb in residential soils, the overall health risks for residents were negligible.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yufang Luo, Fang Liang, Xinxing Wan, Shengping Liu, Lanfang Fu, Jiake Mo, Xubiao Meng, Zhaohui Mo
Summary: The study found that hyaluronic acid, when combined with human umbilical cord blood-derived endothelial colony forming cells and human umbilical-derived mesenchymal stem cells, can promote angiogenesis and improve severe limb ischemia. This positive effect may be associated with activation of the CD44/miR-139-5p pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Guowu Gan, Ren Zhang, Beibei Lu, Yufang Luo, Shuai Chen, Huaxiang Lei, Yijun Li, Zhiyu Cai, Xiaojing Huang
Summary: The present study suggests that chronic apical periodontitis (CAP) may influence atherosclerosis by altering the abundance and diversity of gut microbiota. Lachnospiraceae and Ruminococcaceae were found to be positively correlated with serum TMAO levels, while serum TMAO levels were positively associated with atherosclerotic lesions.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Environmental Sciences
Chi Peng, Yalei He, Kai Zhang, Yan Zhang, Xinxing Wan, Meie Wang, Weiping Chen
Summary: Predicting temporal changes in PAH concentrations in urban soils is crucial for managing health risks. This study found that PAH concentrations in residential areas of metropolitan cities increase with building age, indicating an increasing health risk over time.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Endocrinology & Metabolism
Keke Zhang, Xinxing Wan, Md Asaduzzaman Khan, Xiaoying Sun, Xuan Yi, Zhouqi Wang, Ke Chen, Lin Peng
Summary: This study analyzed the differential expression of circular RNAs (circRNAs) in peripheral blood from patients with early type 2 diabetic nephropathy (ET2DN), type 2 diabetes mellitus (T2DM) and controls. The results identified hsa_circ_0001831 and hsa_circ_0000867 as potential novel diagnostic biomarkers for ET2DN.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Zi Guo, Xinxing Wan, Yufang Luo, Fang Liang, Siwei Jiang, Xiuhong Yuan, Zhaohui Mo
Summary: This study found that the expression levels of UHRF1 were significantly decreased in endothelial colony-forming cells derived from peripheral blood of participants with type 2 diabetes and in endothelial cells treated with high glucose, palmitate or hydrogen peroxide. Silencing of UHRF1 led to decreased migration ability and increased apoptosis and ROS production in endothelial cells, which might be related to impaired KEAP1/NRF2/haeme oxygenase-1 pathway. Mechanistically, UHRF1 is closely implicated in epigenetic regulation of chromatin modification status at KEAP1 genomic locus via histone acetylation. NRF2 down-regulation in turn inhibits UHRF1 protein level, which might be due to increased ROS generation. Conclusion: Diabetes-induced oxidative stress can mediate down-regulation of UHRF1, which enhances ROS production by regulating KEAP1/p-NRF2 pathway through histone acetylation and might also form a self-perpetuating feedback loop with KEAP1/p-NRF2 to further promote oxidative stress-induced apoptosis of endothelial cells in diabetes.
Article
Biochemistry & Molecular Biology
Fang Liang, Yu-fang Luo, Zi Guo, Qiang Qian, Xu-Biao Meng, Zhao-Hui Mo
Summary: This study investigated the role of miR-139-5p in diabetes-induced impairment of BMSCs, and found that it can mediate the impairment of BMSCs through the HOXA9/c-Fos pathway. Therefore, miR-139-5p/HOXA9 may be an important therapeutic target in treating diabetic BMSCs and diabetic complications in the future.
Article
Cell Biology
Yi-Fu He, Xi-Min Hu, Md. Asaduzzaman Khan, Bo-Yao Yu, Yi-Cun Sheng, Xian-Zhong Xiao, Xin-Xing Wan, Si-Pin Tan, Kun Xiong
Summary: Sepsis-induced brain injury increases the risk of mortality in septic patients. This study found that HSF1 alleviates sepsis-induced brain injury by inhibiting pyroptosis through the NLRP3-dependent pathway, suggesting HSF1 as a potential molecular target for treating brain injury in sepsis.
MEDIATORS OF INFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Xin-yu Chen, Ying-hong Dai, Xin-xing Wan, Xi-min Hu, Wen-juan Zhao, Xiao-xia Ban, Hao Wan, Kun Huang, Qi Zhang, Kun Xiong
Summary: Cell death is a fundamental process in human disease and the discovery of ZBP1's role in necroptosis provides important insights into the regulation of cell death and potential therapeutic options.
Article
Endocrinology & Metabolism
Xiaoying Sun, Xinxing Wan, Md Asaduzzaman Khan, Keke Zhang, Xuan Yi, Zhouqi Wang, Ke Chen
Summary: This study analyzed the differential expression of circRNAs in human BAT and WAT, and identified new biomarkers for BAT.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Urology & Nephrology
Sounak Ghosh Roy, Zhigui Li, Zi Guo, Kelly Tran Long, Sonja Rehrl, Xin Tian, Ke Dong, Whitney Besse
Summary: DNAJB11-kidney disease is a phenotype on the spectrum of ADPKD, with a PC1-dependent pathomechanism. The absence of UPR in multiple models suggests that alternative mechanisms, which may be cyst-dependent, explain renal failure in the absence of kidney enlargement.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
