Article
Chemistry, Analytical
Junjun Lei, Gaokun Zheng, Zhen Yao, Zhigang Huang
Summary: In this study, the authors analyze the outer acoustic streaming flows generated over a fluid-solid interface using theoretical and numerical methods. They explore the differences between symmetric and asymmetric acoustic resonances and find that in symmetric resonances, the limiting velocities always drive fluids from the acoustic pressure node towards adjacent antinodes. However, in asymmetric resonances, the outer acoustic streaming is spatially separated from the acoustic radiation force and is independent of the shift in acoustic pressure. These findings have implications for acoustics streaming flow control and particle manipulation in microfluidics applications.
Article
Engineering, Electrical & Electronic
Qin Lin, Feiyan Cai, Junjun Lei, Qingying Luo, Fei Li, Jiaqian Wang, Xiangxiang Xia, Jinping Wang, Junhao Li, Hairong Zheng
Summary: Numerical demonstration of enhanced Rayleigh streaming in a resonant cylindrical shell showed similarities with classical Rayleigh streaming in a rigid cavity, but with significantly higher velocity. The enhancement of the streaming originates from resonant excitation of non-leaky circumferential modes intrinsic to the shell, making it potentially useful for applications such as particle manipulation and liquid mixing.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Reza Rasouli, Maryam Tabrizian
Summary: 3D cell spheroid culture provides a faithful recreation of cell growth environment compared to 2D culture, with a new boundary-driven acoustic microstreaming tool that accelerates spheroid production, showing versatility in producing different types of spheroids.
Article
Chemistry, Analytical
Sintayehu Assefa Endaylalu, Wei-Hsin Tien
Summary: This study investigated the mixing performance in a Y-junction microchannel with acoustic streaming through numerical simulation. Acoustic streaming significantly increased vorticity and improved mixing performance, with further enhancements achieved at lower inlet velocities, sharper vertex angles, and higher oscillation amplitudes. Integration of triangular structures both at the junction and sidewall regions led to the best mixing index results.
Article
Nanoscience & Nanotechnology
Liqiang Li, Kun Jia, Ke-ji Yang
Summary: This study experimentally and numerically investigates the buildup of acoustic and streaming fields in microfluidics using surface acoustic waves (SAWs). The results show that the buildup time of the acoustic field is N times the acoustic period, while the buildup of the streaming field is an acoustic momentum diffusion process. The geometric shape of the microchannel determines the characteristic size of the flow.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Acoustics
Yuwen Li, Wei Tan, Zhifang Liu, Shuoshuo Mu, Guorui Zhu
Summary: This paper presents experimental investigations on acoustic streaming in viscoelastic fluids for the first time. The addition of polyethylene oxide (PEO) polymer significantly alters the flow characteristics in the microchannel, resulting in two modes of acousto-elastic flow: positive mode and negative mode. The viscoelastic fluids exhibit mixing hysteresis features at low flow rates and flow pattern degeneration at high flow rates. The degeneration of flow pattern is further summarized as time fluctuation and spatial disturbance range reduction. The positive mode in acousto-elastic flow can enhance the mixing of viscoelastic fluids in micromixers, while the negative mode provides a potential method for particle/cell manipulation in viscoelastic body fluids such as saliva by suppressing unstable flow.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Citsabehsan Devendran, David J. Collins, Adrian Neild
Summary: Surface acoustic wave (SAW) micromanipulation offers modularity, easy integration into microfluidic devices and a high degree of flexibility. However, reducing the threshold for manipulating smaller particles is a major challenge. The novel excitation configuration based on diffractive-acoustic SAW (DASAW) actuation shows promise in reducing the critical minimum particle size that can be manipulated, with the ability to tune the streaming magnitude by changing the channel height.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Chemistry, Analytical
Sungryul Park, Sangwook Lee, Hyun Soo Kim, Hong Jin Choi, Ok Chan Jeong, Ruixian Lin, Younghak Cho, Min-Ho Lee
Summary: The article introduces a simple on-chip acoustofluidic method to align ellipsoidal cells and focus them into a single stream. By generating acoustic standing waves in a microchannel, the method successfully aligns and focuses a population of Euglena gracilis cells. This method is important for the application of flow cytometry.
Article
Chemistry, Multidisciplinary
Sumit Mohanty, Aniruddha Paul, Pedro M. Matos, Jiena Zhang, Jakub Sikorski, Sarthak Misra
Summary: The unique pumping mechanism of cephalopods has been mimicked in an untethered microrobot called CeFlowBot, utilizing an array of vibrating bubbles to enhance propulsion. Functionalized with magnetic layers, CeFlowBots can be steered under combined magnetic and acoustic fields to navigate remote environments and perform targeted manipulation, making them useful for clinical applications such as targeted drug delivery. Additionally, an ultrasound imaging system is employed to visualize the motion of CeFlowBots in hard-to-reach environments inaccessible to optical cameras.
Article
Chemistry, Analytical
Hanlin Wang, Joe Boardman, Xiaoyan Zhang, Chao Sun, Meng Cai, Jun Wei, Zhiqiang Dong, Mingqian Feng, Dongfang Liang, Sheng Hu, Yu Qian, Shuang Dong, Yongqing Fu, Hamdi Torun, Aled Clayton, Zhenlin Wu, Zhihua Xie, Xin Yang
Summary: An enhanced tilted-angle (ETA) acoustofluidic device is developed for cell mechanophenotyping, which can distinguish and identify different cell types based on their acoustic contrast factors. The device uses an interdigital transducer and introduces a 5-degree inclination angle to manipulate cells according to their mechanical properties. The methodology is demonstrated by distinguishing lung and breast cancer cells from leukocytes.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Fatima Alshehhi, Waqas Waheed, Abdulla Al-Ali, Eiyad Abu-Nada, Anas Alazzam
Summary: In this study, the motion of a microparticle in a microchannel under the influence of a standing surface acoustic wave (SSAW) was simulated using the Immersed Boundary-Lattice Boltzmann Method (IB-LBM). The microparticles were found to move towards the pressure node locations when the SSAW was applied. The transient response of the particles was affected by their geometric parameters, such as radius, density, and compressibility.
Article
Engineering, Electrical & Electronic
Jun Long Han, Hong Hu, Qing Yun Huang, Yu Lin Lei
Summary: In this study, an acoustofluidic platform based on standing surface acoustic waves (SSAWs) was established to analyze the influence of droplet contact angle on particle separation. Experimental results demonstrated the importance of reducing the contact angle for achieving better particle separation efficiency.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Nanoscience & Nanotechnology
Adem Ozcelik, Zeynep Aslan
Summary: A simple and low-cost microfluidic pumping device utilizing 3D printing and acoustofluidics technology has been developed, offering controllable and continuous flow rates for on-chip sample processing and analysis. The device achieves a maximum flow rate of around 12 μL/min and allows for control of pumping direction by frequency tuning, providing a promising solution for portable, affordable, and reliable fluid manipulation in on-chip applications.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Engineering, Multidisciplinary
D. A. Gubaidullin, P. P. Osipov, A. . A. . Abdyushev
Summary: By simulating the quadrupole hyperbolic resonator, this study investigated the formation of acoustic fields and their influence on particle distribution in complex-shaped acoustofluidic devices, revealing that the effects of the acoustic field on particle distribution depend on the phase shifts of the boundary oscillations.
APPLIED MATHEMATICAL MODELLING
(2021)
Article
Acoustics
Erfan Taatizadeh, Arash Dalili, Pamela Ines Rellstab-Sanchez, Hamed Tahmooressi, Adithya Ravishankara, Nishat Tasnim, Homayoun Najjaran, Isaac T. S. Li, Mina Hoorfar
Summary: Acoustofluidics is an effective and novel method for cellular and particle separation and purification, offering advantages over traditional approaches. This study utilized two-dimensional numerical simulations to optimize platform design for improved separation efficiency and reproducible experimental outcomes.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Engineering, Multidisciplinary
Junjun Lei, Feng Cheng, Kemin Li, Zhongning Guo
APPLIED MATHEMATICAL MODELLING
(2020)
Article
Physics, Applied
Junjun Lei, Feng Cheng, Kemin Li, Zhongning Guo
APPLIED PHYSICS LETTERS
(2020)
Article
Physics, Applied
Junjun Lei, Feng Cheng, Kemin Li, Guotian Liu, Yongjun Zhang, Zhongning Guo, Yongkang Zhang
APPLIED PHYSICS LETTERS
(2020)
Article
Acoustics
Guannan Yang, Wei Lin, Haiqi Lai, Jin Tong, Junjun Lei, Maodan Yuan, Yu Zhang, Chengqiang Cui
Summary: This study synthesized Cu nanoparticles under ultrasonic treatment and found that the particle size decreased exponentially with increasing ultrasonic power. A quantitative model was proposed to describe the influence of ultrasonic power on the size distribution of metal nanoparticles, revealing a relational expression that fit well with the experimental results. This research provides a new experimental basis and theoretical method for understanding the mechanism of ultrasonic-induced size refinement of metal nanoparticles.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Qin Lin, Feiyan Cai, Junjun Lei, Qingying Luo, Fei Li, Jiaqian Wang, Xiangxiang Xia, Jinping Wang, Junhao Li, Hairong Zheng
Summary: Numerical demonstration of enhanced Rayleigh streaming in a resonant cylindrical shell showed similarities with classical Rayleigh streaming in a rigid cavity, but with significantly higher velocity. The enhancement of the streaming originates from resonant excitation of non-leaky circumferential modes intrinsic to the shell, making it potentially useful for applications such as particle manipulation and liquid mixing.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Mechanics
Zhigang Huang, Luming Ge, Weixun Wei, Yu Deng, Junjun Lei
Summary: DEP-FFF is a promising method for fractionating particles with potential applications in biomedical, chemical, and environmental engineering. Particle deformation plays a critical role in the fractionation accuracy and viability of bioparticles.
Review
Chemistry, Analytical
Guotian Liu, Junjun Lei, Feng Cheng, Kemin Li, Xuanrong Ji, Zhigang Huang, Zhongning Guo
Summary: This review provides a comprehensive overview of ultrasonic particle manipulation (UPM) and its application in the field of microfluidics, with a focus on the design and operation mechanism of glass capillaries. The study also demonstrates the potential advantages and future prospects of glass capillaries in UPM.
Article
Chemistry, Analytical
Junjun Lei, Gaokun Zheng, Zhen Yao, Zhigang Huang
Summary: In this study, the authors analyze the outer acoustic streaming flows generated over a fluid-solid interface using theoretical and numerical methods. They explore the differences between symmetric and asymmetric acoustic resonances and find that in symmetric resonances, the limiting velocities always drive fluids from the acoustic pressure node towards adjacent antinodes. However, in asymmetric resonances, the outer acoustic streaming is spatially separated from the acoustic radiation force and is independent of the shift in acoustic pressure. These findings have implications for acoustics streaming flow control and particle manipulation in microfluidics applications.
Article
Physics, Applied
Junjun Lei, Feng Cheng, Gaokun Zheng, Li Lin
Summary: We report on a wave-driven microfluidic ultrasonic shaker that can stably trap and oscillate microparticles in water in a microchannel. The trapped microparticles can be perturbed and oscillated by two standing waves of different frequencies. The oscillating frequency of the trapped microparticles is determined by the frequency difference between the two sound waves, and the shaking amplitude scales inversely to the frequency difference.
PHYSICAL REVIEW APPLIED
(2022)
Article
Physics, Applied
Junjun Lei, Gaokun Zheng, Feng Cheng, Kemin Li
Summary: In this study, an acoustofluidics framework based on an equilateral triangular channel design was established to generate vertically asymmetric acoustic pressure profiles, resulting in unidirectional acoustic radiation force and drag force for rapid agglomeration and sedimentation of microparticles.
APPLIED PHYSICS LETTERS
(2023)
Article
Ecology
Fengshi Tian, Junjun Lei, Xin Zheng, Yanfu Yin
Summary: The appropriate planning of infrastructure is crucial for protecting lives and property. Fire stations play a vital role in a city's infrastructure, and their precise location is important for reducing emergency response times and minimizing casualties.
Meeting Abstract
Psychiatry
Junjun Lei
PSYCHIATRIA DANUBINA
(2022)
Article
Physics, Applied
Junjun Lei, Feng Cheng, Guotian Liu, Kemin Li, Zhongning Guo
APPLIED PHYSICS LETTERS
(2020)
Article
Veterinary Sciences
Jun Jun Lei, Yuan Yuan Hu, Fang Liu, Shu Wei Yan, Ruo Dan Liu, Shao Rong Long, Peng Jiang, Jing Cui, Zhong Quan Wang
VETERINARY RESEARCH
(2020)