Review
Thermodynamics
Daxiang Deng, Long Zeng, Wei Sun
Summary: This paper comprehensively reviews recent advancements in flow boiling enhancement and fabrication of enhanced microchannels. It emphasizes the flow boiling enhancement performance of these enhanced microchannels in microchannel heat sinks, while also discussing their advantages and disadvantages after summarizing the classification and manufacturing methods of enhanced microchannels.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Thermodynamics
Zengkun Zhan, Lixia Chen, Hongna Zhang, Chuandong Lin, Sining Li, Xiaobin Li, Fengchen Li
Summary: This research proposes a new technique for heat transfer enhancement using viscoelastic fluid pulsating laminar flow (VPL flow). Numerical studies and flow performance analysis show that VPL flow significantly improves the overall heat transfer performance, with optimal enhancement achieved at pulsation frequencies close to the characteristic frequency of the viscoelastic fluid flow.
APPLIED THERMAL ENGINEERING
(2022)
Article
Thermodynamics
Haiping Wen, Zhixuan Liang, Qingyi Luo, Chili Wu, Changhong Wang
Summary: In this study, the numerical simulation software ANSYS Fluent is used to optimize the microchannel heat sink structure with different types of ribs and secondary channels. The results show that the microchannel heat sink with front triangular ribs and secondary channel composite performs the best. It outperforms the conventional microchannel heat sink by up to 34% in terms of overall performance. Sensitivity analysis reveals the significant influence of relative rib width, flow rate, and relative secondary channel width on heat dissipation, pressure drop, and overall performance.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2023)
Article
Thermodynamics
D. D. Ma, Y. X. Tang, G. D. Xia
Summary: The sinusoidal wavy microchannels with secondary channels (SWSC) show better heat removal performance in flow boiling studies compared to conventional microchannels, thanks to increased bubble nucleation induced by enlarged surface area and continuous development of thin liquid film due to the introduction of secondary channels. However, the SWSC microchannels suffer from a higher pressure drop penalty.
APPLIED THERMAL ENGINEERING
(2021)
Article
Thermodynamics
G. Marseglia, M. G. De Giorgi, P. Pontes, R. Solipa, R. R. Souza, A. L. N. Moreira, A. S. Moita
Summary: This paper investigates the advantages and challenges of two-phase flows, specifically flow boiling of pure liquids and nanofluids, for cooling microchannel heat sinks. The study finds that even at low concentrations, the water-Au nanofluid exhibits superior cooling performance compared to other fluids, indicating that even small concentrations of nanoparticles can significantly impact heat transfer mechanisms.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2024)
Review
Thermodynamics
Hussam Sadique, Qasim Murtaza
Summary: This paper provides a comprehensive overview of heat transfer enhancement using microchannel heat sink (MCHS) through various techniques. The focus is on recent developments in cooling technologies, classification of flow channels, different methods for heat transfer enhancement, and geometric modifications in MCHS. Studies have shown that interrupting the boundary layer, inducing secondary flows, and chaotic advection in channels can promote heat transfer performance without significant changes in pumping power. Special emphasis is given to fractal shaped MCHS for reducing temperature non-uniformity with minimal pressure drop.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Review
Thermodynamics
Akash Dwivedi, Mohammad Mohsin Khan, Harveer Singh Pali
Summary: A novel framework has been employed to enhance heat transfer in heat exchangers through microchannels. The use of nanofluids as working fluids shows better thermal behavior. Flow disrupters and ceramic microchannels can also improve heat transfer performance.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Thermodynamics
Qifeng Zhu, Ruirui Su, Lingyun Hu, Junjie Chen, Jingwei Zeng, Hongwei Zhang, Haolei Sun, Sen Zhang, Dianwei Fu
Summary: A new design of microchannel heat sink with periodic gradual-expansion and sudden-constriction cross-sections was proposed to enhance heat transfer through improved fluid mixing. Numerical investigations showed that the new design exhibited significant improvement in heat transfer enhancement and overall performance.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2022)
Review
Thermodynamics
Shashank Singh, Anup Malik, Harlal Singh Mali
Summary: This article critically examines the research on modifications in geometry of channels for thermo-hydraulic performance enhancement and aims to determine the best channel configuration with optimal parameters. It explores various designs and their influencing parameters, as well as presents conclusions and potential recommendations for future research.
APPLIED THERMAL ENGINEERING
(2023)
Article
Engineering, Environmental
Chaomeng Chen, Li Yi, Minqiang Pan
Summary: This study achieved a balance between heat transfer performance and flow performance of microchannel heat sinks through the establishment of an optimization objective function based on a complex network structure. The experimental results validated that the comprehensive performance of the optimized structure was better than the initial design structure, and the optimized structure with fewer fractal levels performed better.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Thermodynamics
Majid Khan, S. Z. Shuja, B. S. Yilbas, H. Al-Qahtani
Summary: The design configuration of microchannel heat sinks is crucial for enhancing heat transfer efficiency. This study focuses on the innovative design of a 3D microchannel with turbulators and evaluates its thermal performance under various conditions. The findings suggest that the microchannel with turbulators located at 75% of the channel length with a pitch of 0.75 mm exhibits the highest thermal performance.
CASE STUDIES IN THERMAL ENGINEERING
(2022)
Article
Thermodynamics
Seyedali Sabzpoushan, Moslem Sabouri
Summary: This study proposes a simple cost-effective concept to improve the hydrothermal performance of liquid-cooled microchannel heat sinks. By using parallel microchannels with interdigitated cavities and lateral passages, the heat sink performance is improved with the formation of secondary flow. 3D numerical simulations show that the proposed configurations have significant improvements in hotspot area, hotspot temperature, average Nusselt number, and Coefficient of Performance.
APPLIED THERMAL ENGINEERING
(2023)
Article
Thermodynamics
Anurag Maheswari, Yogesh K. Prajapati
Summary: In the present study, a three-dimensional numerical simulation was conducted to investigate the thermohydraulic performance of a novel design of double-layer microchannel heat sinks. The modified heat sink with an intermediate rectangular fin and different hole shapes significantly enhanced the heat transfer rate by approximately 45-60% compared to the conventional design. However, higher pressure drops were observed due to flow restrictions. Among all the cases considered, heat sinks with circular and triangular holes showed superior thermal performance with a marginal difference of approximately 2-5%. The improved heat transfer rate in the modified heat sink was attributed to better fluid mixing and thinner boundary layers facilitated by the fins with holes. Optimization analysis identified a heat sink with a hole radius of 0.286 mm and 15 holes as the superior configuration, achieving a maximum heat transfer rate approximately 51-64% higher than the conventional design.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Haoyu Zhou, Jungbae Lee, Minsoo Kang, Hakgae Kim, Hyoungsoon Lee, Jung Bin In
Summary: In this study, an all-laser fabrication method is proposed to fabricate a microfluidic heat sink for silicon devices. The microchannels are engraved on a silicon wafer using lasers, and inlet/outlet holes are drilled on a quartz glass cover. The heat generated by the device is successfully removed by the fabricated microfluidic channel.
MATERIALS & DESIGN
(2022)
Article
Thermodynamics
X. L. Wu, C. Y. Li, J. L. Yang, Y. Liu, X. H. Han
Summary: Two-phase microchannel heat sink has attracted extensive attention due to its small size, high heat transfer efficiency, good temperature uniformity, and low working fluid charge. The heat transfer performance of the heat sink is influenced by heat flux and mass flow rate, and dry-out phenomenon can occur if the mass flow rate is not reasonable. A study was conducted to explore the influence of mass flow rate and heat flux on the flow boiling heat transfer performance and flow regimes of a two-phase microchannel heat sink using R245fa as the working fluid. The results showed that dry-out became more severe with higher heat flux and no dry-out was observed within certain ranges of mass flow rate and heat flux.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Materials Science, Multidisciplinary
Meng Zhang, Qingqing Chen, Yunpeng He, Yuzhe Hong, Daxin Li, Zhihua Yang, Dechang Jia, Delong Cai, Zibo Niu, Jingyi Guan, Bingzhu Wang
Summary: The study compared the oxidation behavior and mechanism of SiBCN monoliths with SiC and SiC-BN monoliths, revealing that SiBCN monoliths had better oxidation resistance due to the positive role of BN(C) phase during oxidation. At different temperatures, SiC and SiC-BN monoliths showed different levels of oxidation damage, with SiC-BN monoliths exhibiting more cracks and bubbles compared to SiC and SiBCN monoliths.
Article
Materials Science, Ceramics
Meng Zhang, Daxin Li, Yuanyi Zhou, Zhihua Yang, Dechang Jia, Delong Cai, Zibo Niu
Summary: Different coatings were applied to SiC fibers to fabricate SiCf/SiBCN composites, with C/ZrB2 coatings showing desirable comprehensive mechanical properties. However, ZrB2/BN and C/ZrB2/BN composite coatings were not effective for reinforcing the SiBCN matrix.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Article
Cell Biology
Liru Wang, Mu Su, Mengyan Zhang, Hongyan Zhao, Hongli Wang, Jie Xing, Chenyu Guo, Dianshuang Zhou, Wenhui Xue, Haibo Lu, Yan Zhang
Summary: This study developed a series of prognostic prediction models for colon cancer patients after surgery, with LNR identified as the most important clinical factor affecting survival time.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Ceramics
Meng Zhang, Junnan Hou, Daxin Li, Bin Liang, Zibo Niu, Qian Zhang, Zhihua Yang, Dechang Jia, Delong Cai, Xiaoming Duan, Peigang He, Yu Zhou
Summary: This study investigated the phase composition, microstructural evolution, mechanical properties, thermophysical properties, and thermal shock resistance of Mo-SiBCN metal-ceramic composites with different sintering additives. The competition of reaction products between Mo and SiBCN was detected, with the increase in SiBCN content leading to a decrease in bulk density, elastic modulus, and bending strength, but an increase and subsequent decrease in hardness. The addition of sintering additives significantly improved the bending strength and hardness of the composites. The residual bending strength after thermal shock varied with SiBCN content, showing both increases and decreases.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jie Xing, Ruiyang Zhai, Cong Wang, Honghao Liu, Jiaqi Zeng, Dianshuang Zhou, Mengyan Zhang, Liru Wang, Qiong Wu, Yue Gu, Yan Zhang
Summary: DNA methylation is increasingly recognized for its potential as a biomarker in diseases. The latest version of DiseaseMeth has expanded disease coverage, added more samples, and updated tools for better analysis, facilitating further research on the role of methylation in diseases.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Materials Science, Ceramics
Meng Zhang, Daxin Li, Yuzhe Hong, Zibo Niu, Zhihua Yang, Dechang Jia, Yu Zhou
Summary: SiBCN, SiC, and SiC-BN ceramics/composites were prepared using mechanical alloying combined with hot-pressing sintering method. The oxidation kinetics of SiBCN, SiC, and SiC-BN were analyzed by calculating the thickness of the oxide layers. The results showed that the BN(C) phase in SiBCN can slow down the generation rate of gases.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Article
Genetics & Heredity
Mengyan Zhang, Jiyun Zhao, Huili Dong, Wenhui Xue, Jie Xing, Ting Liu, Xiuwen Yu, Yue Gu, Baoqing Sun, Haibo Lu, Yan Zhang
Summary: Tumor heterogeneity poses challenges for cancer diagnosis and treatment. This study proposes a computational method to quantify the specificity of GPCRs DNA methylation and identifies specific GPCRs DNA methylation biomarkers. Potential drugs were discovered through predicting drug sensitivities. Specific biomarkers were validated in various cancers.
Article
Biochemistry & Molecular Biology
Mengyan Zhang, Te Ma, Cong Wang, Jiyun Zhao, Jie Xing, Honghao Liu, Mu Su, Ruiyang Zhai, Ting Liu, Baoqing Sun, Yan Zhang
Summary: This study proposed a classification framework for luminal breast cancer based on DNA methylation profiles and transcriptomes. The identified immune subgroups showed significant differences in DNA methylation levels, immune microenvironment, and pathology features. In addition, a subgroup in luminal breast cancer was found to benefit from immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Guanggong Zong, Jinjiang Zhou, Mengyan Zhang, Yanqiu Ma, Yang Zhao, Xiaoyan He, Jianxiu Hao, Fangfang Wang
Summary: Core-shell composites with strong weather resistance, mechanical strength and creep resistance can be prepared using co-extrusion technology. The trapezoidal mortise and tenon structure had the best interface bonding, bending properties and creep resistance among the three types tested, which effectively improved the dimensional stability of the co-extruded composite after water absorption.
Article
Genetics & Heredity
Liang Zhang, Zhengbin Han, Hongjuan He, Ximeijia Zhang, Mengyan Zhang, Boran Li, Qiong Wu
Summary: Meg8-DMR, the first maternal methylated DMR discovered in the Dlk1-Dio3 domain, plays a role in regulating microRNA expression. Deletion of Meg8-DMR enhances migration and invasion in MLTC-1 cells. However, its biological function in mouse development remains unknown. This study used CRISPR/Cas9 to generate genomic deletions of Meg8-DMR in mice and found that it regulates microRNA expression without affecting embryonic development.
Article
Genetics & Heredity
Honghao Liu, Haijun Che, Mengyan Zhang, Jinyue Lv, Chengjie Pu, Jiawei Wu, Yan Zhang, Yue Gu
Summary: In this study, the role of cuproptosis in lung adenocarcinoma (LUAD) was evaluated, and a cuproptosis-related score (CuS) was constructed to predict aggressiveness and prognosis in LUAD for precise treatment. CuS had a better predictive performance than cuproptosis genes, possibly due to the synergy of SLC family genes, and patients with high CuS had a poor prognosis. Functional enrichment analysis revealed the correlation between CuS and immune and mitochondrial pathways in multiple datasets. Furthermore, potential drugs targeting high-CuS patients, including AZD3759, a targeted drug for LUAD, were predicted. In conclusion, cuproptosis is involved in LUAD aggressiveness, and CuS can accurately predict the prognosis of patients, providing a basis for precise treatment of patients with high CuS in LUAD.
Article
Biology
Mengyan Zhang, Xingda Zhang, Te Ma, Cong Wang, Jiyun Zhao, Yue Gu, Yan Zhang
Summary: A CMBR method was developed to identify subgroups in HR+ breast cancer based on computational functional networks and DNA methylation, providing valuable insights into personalized treatment strategies and management options.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biology
Cong Wang, Mengyan Zhang, Jiyun Zhao, Bin Li, Xingjun Xiao, Yan Zhang
Summary: Cancer drug response prediction based on genomic information is crucial in personalized medicine. The proposed method, MOICVAE, utilizes integrated omics data to enhance drug sensitivity prediction and fill in missing cancer-drug associations. MOICVAE achieved impressive results on benchmark datasets and demonstrated superior performance over state-of-the-art methods. It not only improved accuracy in drug sensitivity prediction but also provided valuable insights for treatment options and tumor characteristics.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Zhengjie Deng, Shuctian He, Mengyan Zhang, Yizhen Wang
Summary: This paper proposes a method to transfer user's posture to a 3D model, by capturing skeleton information using Kinect and applying a series of transformations on the skeleton. The feasibility and effectiveness of this method have been demonstrated through experiments, and it can be applied to other types of models as well.
2022 INTERNATIONAL CONFERENCE ON VIRTUAL REALITY, HUMAN-COMPUTER INTERACTION AND ARTIFICIAL INTELLIGENCE, VRHCIAI
(2022)
Article
Medicine, Research & Experimental
Yihan Wang, Yan Zhang, Yan Huang, Chuangeng Chen, Xingda Zhang, Ying Xing, Yue Gu, Mengyan Zhang, Li Cai, Shouping Xu, Baoqing Sun
Summary: In breast cancer, high intratumor DNA methylation heterogeneity may lead to drug resistance, metastasis, and poor prognosis. The analysis of differential epialleles between tumor core and periphery regions reveals a correlation between intratumor methylation heterogeneity and hypoxic microenvironment, which could provide guidance for developing effective treatment schemes for breast cancer patients.
