Article
Biochemistry & Molecular Biology
Jeongho Park, Hyun-Ouk Kim, Kwang-Hyun Park, Myung-Bok Wie, Sun-Eun Choi, Jang-Hyuk Yun
Summary: Angiogenesis plays a crucial role in various diseases, and the Ulmus davidiana extract U60E can alleviate symptoms by inhibiting VEGF-induced angiogenesis.
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Neurosciences
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju
Summary: This study investigated the biological effects of EPC-derived MVs on BMECs, showing that EPC-MVs can enhance BMEC viability, proliferation, migration, and tube formation. These results suggest the proangiogenic effect of EPC-derived MVs on BMECs, which holds potential applications in cell-free therapy for brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Katharina Sommer, Heike Jakob, Theresa Lettenmeier, Dirk Henrich, Jasmina Sterz, Ingo Marzi, Johannes Frank
Summary: Chronic non-healing wounds in diabetic patients with additional peripheral vascular disease pose challenges in modern medicine. This study investigated the effects of 11,12 epoxyeicosatrienoic acid (EET) in a combined model of hyperglycemia and ischemia in mice. The results showed that EET treatment improved wound healing by resolving inflammation, promoting neovascularization, and increasing expression of TGF-beta and SDF-1 alpha.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Antonio Rampino, Tiziana Annese, Silvia Torretta, Roberto Tamma, Rosa Maria Falcone, Domenico Ribatti
Summary: VEGF plays a controversial role in schizophrenia, with high levels potentially predicting better response to antipsychotic drugs, while low levels might indicate resistance to therapy.
NEUROSCIENCE LETTERS
(2021)
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Review
Biochemistry & Molecular Biology
Akiyoshi Uemura, Yoko Fukushima
Summary: Rho GTPases, especially RhoJ, play essential roles in regulating cell migration and junctions in vascular endothelial cells, affecting vascular formation and permeability. RhoJ, enriched in angiogenic ECs, induces actin depolymerization by competing with Cdc42 for common effector proteins, thus influencing cytoskeletal rearrangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anh-Nhung Le, Seong-Soon Park, Minh-Xuan Le, Unn Hwa Lee, Byung Kyun Ko, Hye Ryeong Lim, Ri Yu, Seong Hee Choi, Byung Ju Lee, Soo-Youn Ham, Chang Man Ha, Jeong Woo Park
Summary: Deficiency of DRG2 induces senescence and dysfunction of endothelial cells, leading to impaired angiogenesis and reduced blood flow. DRG2 deficiency upregulates arginase 2 and reactive oxygen species generation in endothelial cells. These findings highlight the significant role of DRG2 in endothelial cell senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Tomohiro Shiiya, Masanori Hirashima
Summary: During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. This review discusses the chemotactic factors, LEC-extracellular matrix interactions, and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels, providing insights into the molecular mechanisms underlying physiological lymphatic vascular development and lymphangiogenesis associated with pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Giovanna Azzarito, Lisa Kurmann, Brigitte Leeners, Raghvendra K. Dubey
Summary: miR193a-3p inhibits vascular endothelial cell growth and breast cancer cell-driven angiogenesis by altering the secretome and downregulating pro-growth signals and proangiogenic proteins.
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Oncology
Xin Li, Xinyu Su, Chen Yan, Yuanyuan Ma, Heng Li, Jianhong Xia, Hongliang Li, Qian Jiang, Liqing Zhou, Zhengyun Zou
Summary: This study discusses the role of VEGF in radiotherapy resistance of ESCC. It found that serum VEGF levels were related to clinical response, and knocking down VEGF expression improved the sensitivity of ESCC cells to radiation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)