Article
Clinical Neurology
William O. Tatum, Lawrence J. Hirsch, Michael A. Gelfand, Emily K. Acton, W. Curt LaFrance, Robert B. Duckrow, David Chen, Andrew S. Blum, John Hixson, Joe Drazkowski, Selim Benbadis, Gregory D. Cascino
Summary: The study aimed to evaluate the quality of smartphone videos of neurologic events in adult epilepsy outpatients, finding that the majority of videos were suitable for clinical interpretation. Methods to improve video quality include encouraging patient interaction, adequate duration, and enlarged field of view during filming. While there were limitations in video quality, accuracy remained for the review of videos of epileptic seizures and psychogenic nonepileptic attacks.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Emergency Medicine
Asim Kalkan, Ahmet Demirel, Seref Emre Atis, Edip Burak Karaaslan, Mehmet Esat Ferhatlar, Mucahit Senturk
Summary: This study aimed to evaluate the utility of serum NRGN level in the differentiation of epilepsy and PNES patients. The results showed that the serum NRGN level was significantly higher in epilepsy patients compared to the control group, suggesting its potential as a biomarker for distinguishing epileptic seizure and PNES.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Ushtar Amin, Christopher T. Primiani, Stephanie MacIver, Angelica Rivera-Cruz, Alfred T. Frontera, Selim R. Benbadis
Summary: The study found that smartphone videos can be a useful adjunctive tool in diagnosing seizure-like events, with a 94% agreement in diagnosis compared to video-EEG monitoring.
Article
Physics, Multidisciplinary
Chloe Hinchliffe, Mahinda Yogarajah, Samia Elkommos, Hongying Tang, Daniel Abasolo
Summary: Psychogenic non-epileptic seizures (PNES) and epilepsy can be differentiated using entropy algorithms to analyze EEG signals. Machine learning can automate classification and reduce diagnosis costs. Combining multiple frequency bands improves the accuracy of diagnosing PNES from EEGs and ECGs.
Article
Behavioral Sciences
Tyler Burr, Yosefa Modiano, Prachi Raichur, Christopher Barton, Jeetendra Sah, Darren Farber, Dylan Brock, Samir Karia, Zulfi Haneef, Cemal Karakas
Summary: This study aimed to evaluate the diagnostic predictive value of video-EEG for differentiating PNEE from ES in children. Four child neurologists formulated a diagnostic impression based on videos alone and with additional clinical information. The results showed that the diagnostic accuracy by video alone was 74.5%, and providing clinical information significantly improved the accuracy.
EPILEPSY & BEHAVIOR
(2022)
Review
Cell Biology
Shinichi Kinoshita, Ryuta Koyama
Summary: Microglia in the epileptic brain exhibit different activation phenotypes, but their exact roles remain unclear.
NEURAL REGENERATION RESEARCH
(2021)
Article
Behavioral Sciences
Steven Lenio, Wesley T. Kerr, Meagan Watson, Sarah Baker, Chad Bush, Alex Rajic, Laura Strom
Summary: Dissociative seizures are a common neurological disorder that can be difficult to distinguish from epileptic seizures, but the DSLS score can accurately predict the diagnosis and play an important role in clinical decision making.
EPILEPSY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Amna A. Ajam, Colin Berkheimer, Bin Xing, Aadil Umerani, Shayaan Rasheed, Xuan V. Nguyen
Summary: This study analyzed survey data from radiology outpatients and found that patients' top concerns were the handling of patient concerns and complaints by medical staff, as well as the sensitivity to patient needs. When comparing radiology and non-radiology visits, patients had higher expectations regarding the helpfulness of registration desk personnel, the comfort of waiting areas, and the ease of obtaining an appointment at the desired time.
Review
Clinical Neurology
Lorenzo Ricci, Marilisa Boscarino, Giovanni Assenza, Mario Tombini, Jacopo Lanzone, Vincenzo Di Lazzaro, Sara Casciato, Alfredo D'Aniello, Alessandra Morano, Giancarlo Di Gennaro
Summary: Using home-video recordings (HVRs) to support physicians in the differential diagnosis of paroxysmal seizure-like episodes (PSLE) has shown consistent improvements in diagnostic and clinical decision-making, as well as reducing stress levels in families and improving quality of life. Training in performing good-quality videos is necessary and increases the diagnostic value of HVRs.
NEUROLOGICAL SCIENCES
(2021)
Article
Engineering, Mechanical
Yangyang Yu, Jiajia Li, Zhixuan Yuan, Yongchen Fan, Ying Wu
Summary: This paper investigates the mechanism of epileptic seizures after ischemic stroke by establishing a coupled network model of neurons and astrocytes. The disruption of ion concentration gradient is found to be an important reason for epileptic seizures after ischemic stroke. Furthermore, factors such as massive glutamate release, excessive receptor activation, and high extracellular potassium concentration also play a role in the propagation of epileptic seizures.
NONLINEAR DYNAMICS
(2022)
Article
Engineering, Biomedical
Wenjuan Xiong, Ewan S. Nurse, Elisabeth Lambert, Mark J. Cook, Tatiana Kameneva
Summary: This study investigates the use of machine learning techniques for classification of psychogenic non-epileptic seizures (PNES) and epileptic seizures (ES) based on electroencephalography (EEG) and electrocardiography (ECG) data. The highest classification accuracy achieved was 87.83%, using the 15-0 minute preictal period of EEG and ECG data. Combining ECG data with EEG data improved the classification accuracy from 86.37% to 87.83%.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jinyu Fang, Yuan Ni, Jian Zhang
Summary: UGC short videos play a crucial role in sharing information and disseminating content in the era of new information technology. Accurately assessing their value is important for self-media platforms' development and cyberspace governance. This study proposes a method for assessing UGC short video value based on element mining and data analysis, involving text clustering, sentiment analysis, and the VIKOR model. The findings reveal the value dimensions, such as creators, platforms, and users, and offer insights into the value of short videos in different partitions.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Tianpeng Zhang, Fangjun Yu, Haiman Xu, Min Chen, Xun Chen, Lianxia Guo, Cui Zhou, Yuting Xu, Fei Wang, Jiandong Yu, Baojian Wu
Summary: Rev-erb alpha plays a crucial role in the circadian regulation of epileptic seizures, affecting seizure susceptibility, severity, and GABA signaling in the hippocampus. Furthermore, Rev-erb alpha regulates the expression of Slc6a1 and Slc6a11, influencing GABA clearance.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Eung Chang Kim, Jiaren Zhang, Andy Y. Tang, Eric C. Bolton, Justin S. Rhodes, Catherine A. Christian-Hinman, Hee Jung Chung
Summary: This study reveals that impaired axonal surface expression of K(v)7 channels in KCNQ2-related epileptic encephalopathy is associated with epileptic seizures, cognitive and behavioral deficits, and neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Roberto Rodriguez-Ortiz, Ataulfo Matinez-Torres
Summary: Epilepsy is a chronic neurological disorder affecting 50 million people worldwide, with zebrafish used to model the disease. Mutations in the activated HCN channel were generated and phenotypic characteristics related to epilepsy were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Adam M. Goodman, Jane B. Allendorfer, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: This study found that patients with delayed diagnosis of functional seizures had differences in neural activation and functional connectivity during processing of stressful experiences compared to those with early diagnosis. These differences were correlated with the duration of undiagnosed illness and not with psychiatric comorbidities. The findings suggest a potential mechanistic association between neuropathophysiology, response to stressful experiences, and functional neuroanatomy in functional seizures.
Article
Pharmacology & Pharmacy
Cheng Chen, Sean Hennessy, Colleen M. Brensinger, Ghadeer K. Dawwas, Emily K. Acton, Warren B. Bilker, Sophie P. Chung, Sascha Dublin, John R. Horn, Todd A. Miano, Thanh Phuong Pham Nguyen, Samantha E. Soprano, Charles E. Leonard
Summary: This study identifies skeletal muscle relaxant (SMR) drug-drug-drug interaction (3DI) signals associated with increased rates of unintentional traumatic injury. The findings suggest the need for further research on the effects of SMR drugs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Ghadeer K. Dawwas, Sean Hennessy, Colleen M. Brensinger, Emily K. Acton, Warren B. Bilker, Sophie Chung, Sascha Dublin, John R. Horn, Melanie M. Manis, Todd A. Miano, David W. Oslin, Thanh Phuong Pham Nguyen, Samantha E. Soprano, Douglas J. Wiebe, Charles E. Leonard
Summary: The concurrent use of muscle relaxants with other drugs may contribute to unintentional traumatic injury.
Article
Clinical Neurology
Adam M. Goodman, Pranav Kakulamarri, Rodolphe Nenert, Jane B. Allendorfer, Noah S. Philip, Stephen Correia, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: Traumatic brain injury (TBI) may trigger functional seizures (FS). Patients with FS often have more severe psychiatric comorbidities. TBI and psychopathology are associated with changes in neural network connectivity, but their effects on networks and their relationship with FS remain unclear.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Emily K. Acton, Allison W. Willis, Sean Hennessy
Summary: Pharmacoepidemiology plays an increasingly important role in informing clinical practice, drug regulation, and health policy. This article proposes a simple taxonomy to help researchers identify the most common biases in pharmacoepidemiology studies. By considering biases related to the study population, study design, and data source, researchers can plan, conduct, and evaluate pharmacoepidemiologic studies more effectively.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Clinical Neurology
Aurelie Hanin, Jorge Cespedes, Karim Dorgham, Yashwanth Pulluru, Margaret Gopaul, Guy Gorochov, David A. Hafler, Vincent Navarro, Nicolas Gaspard, Lawrence J. Hirsch
Summary: The study aims to investigate inflammation in patients with new-onset refractory status epilepticus (NORSE) by analyzing cytokines/chemokines in cerebrospinal fluid (CSF) and serum. Significant increase of pro-inflammatory cytokines/chemokines was observed in patients with SE compared to those without, and in patients with cNORSE compared to non-cryptogenic RSE. Elevated innate immunity cytokine/chemokine levels were associated with worse short- and long-term outcomes in patients with NORSE.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Christina Mueller, Adam M. Goodman, Jane B. Allendorfer, Rodolphe Nenert, Tyler E. Gaston, Leslie E. Grayson, Stephen Correia, Noah S. Philip, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: This study aimed to quantify changes in white matter morphology using neurite orientation dispersion and density imaging (NODDI) after neurobehavioral therapy (NBT) for functional seizures (FS). The results showed that patients with FS exhibited white matter plasticity in specific regions, which correlated with improvements in psychosocial functioning. NODDI could be considered for future assessments of interventions in patients with FS.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Margaret T. Gopaul, Aurelie Hanin, Jorge Cespedes, Yashwanth Pulluru, Karnig Kazazian, Andreas van Baalen, Teneille E. Gofton, Nicolas Gaspard, Lawrence J. Hirsch
Summary: The etiology of new-onset refractory status epilepticus (NORSE), including its subtype with prior fever known as FIRES (febrile infection-related epilepsy syndrome), remains uncertain. This study investigated the seasonality of NORSE cases and found that the incidence of NORSE is highest in the summer and lowest in the spring.
Article
Clinical Neurology
Markus Leitinger, Nicolas Gaspard, Lawrence J. Hirsch, Sandor Beniczky, Peter W. Kaplan, Khalil Husari, Eugen Trinka
Summary: The proposed standardized approach of a diagnostic IV ASM trial further refines the ACNS and Salzburg diagnostic criteria for NCSE.
Article
Clinical Neurology
Milena Gandy, Rosa Michaelis, Jayne Acraman, Kirsten A. A. Donald, Michael Fitzpatrick, W. Curt LaFrance, Seth A. A. Margolis, Avani C. C. Modi, Markus Reuber, Venus Tang, Zoe Thayer, Kirsten Verity, Janelle L. L. Wagner, Jo Wilmshurst, Sarah Whittaker, Heidi M. M. Munger Clary
Summary: Mental health comorbidities in patients with seizures are often poorly managed, and the report aims to address these gaps in care by providing education and guidance on integrating mental health management into routine seizure care. It describes eight services from different regions that met the inclusion criteria and showcases their core operations, outcomes, and implementation factors. The report also offers practical tips for building successful psychological care services within seizure settings. Future work is needed to further establish the evidence base in this area and examine both psychological and pharmacological care models.
Article
Clinical Neurology
Christina Mueller, Adam M. Goodman, Rodolphe Nenert, Jane B. Allendorfer, Noah S. Philip, Stephen Correia, Robert A. Oster, William Curt LaFrance Jr, Jerzy P. Szaflarski
Summary: The study aimed to evaluate the repeatability of neurite orientation dispersion and density imaging in healthy controls (HCs) and traumatic brain injury (TBI) patients. The results showed that NDI and ODI exhibited excellent repeatability in both groups, with some group differences observed. However, F-ISO had relatively poor repeatability and few group differences were found. These findings suggest that the NDI and ODI metrics can be used to assess the effects of interventions, but caution is advised when interpreting F-ISO changes over time.
JOURNAL OF NEUROIMAGING
(2023)
Review
Clinical Neurology
Aurelie Hanin, Jorge Cespedes, Anita Huttner, David Strelnikov, Margaret Gopaul, Marcello DiStasio, Annamaria Vezzani, Lawrence J. Hirsch, Eleonora Aronica
Summary: New-Onset Refractory Status Epilepticus (NORSE) is a severe form of status epilepticus and its subtype with a preceding febrile illness, known as FIRES, remains largely unexplained. Understanding the pathophysiological mechanisms and long-term consequences of cryptogenic NORSE is crucial for improving patient management and preventing secondary neuronal injury and drug-resistant post-NORSE epilepsy. Neuropathological evaluations have been helpful in identifying the etiologies of some previously unknown cases. This study summarizes the findings of neuropathology studies in NORSE patients, highlighting cases where neuropathology findings aided in diagnosis or treatment selection.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
W. Curt LaFrance, Roberta Tedesco, Grayson L. Baird, Jeff Wincze, Krista Tocco, Jordan Anderson
Summary: The study retrospectively examined the clinical outcomes of outpatients with FND treated with the Neuro-Behavioral Therapy (NBT) approach. The results showed positive effects of NBT in improving clinical symptoms and functional assessments, indicating its feasibility as a treatment method for FND.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Meeting Abstract
Clinical Neurology
D. Ertan, S. Aybek, W. C. LaFrance, K. Kanemoto, A. Tarrada, L. Maillard, W. El-Hage, C. Hingray
Article
Clinical Neurology
T. A. Milligan, A. Yun, W. C. LaFrance, G. Baslet, B. Tolchin, J. Szaflarski, V. S. S. Wong, S. Plioplys, B. A. Dworetzky
Summary: This study surveyed neurology residency program directors and recent graduates about the education provided on functional seizures (FS) during residency. The results revealed a gap in education regarding the diagnosis and management of FS, highlighting the need for standardized training in this area.
EPILEPSY & BEHAVIOR REPORTS
(2022)