Review
Medicine, General & Internal
Jin Xu, Chunyu Zhong, Shu Huang, Xinyi Zeng, Shali Tan, Lei Shi, Yan Peng, Muhan Lu, Lianjun Ma, Xiaowei Tang
Summary: This meta-analysis of eight studies involving 248 patients found that POEM is effective and safe for treating sigmoid-type achalasia, with a high clinical success rate of 90.4%. Various esophageal parameters significantly improved post-POEM, with an adverse events rate of 13.0% and reflux rates of 41.5% and 12.5% for objective and symptomatic cases respectively.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Michael B. Ujiki, Vanessa N. VanDruff
Summary: Peroral endoscopic myotomy (POEM) is an innovative and minimally invasive treatment for achalasia. Studies worldwide have shown that POEM is safe and effective for different types of achalasia.
WORLD JOURNAL OF SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Monisha Sudarshan, Siva Raja, Saurav Adhikari, Sudish Murthy, Prashanthi Thota, Scott Gabbard, Monica Ray, Usman Ahmad, Mahdusudhan Sanaka
Summary: This study aimed to investigate the effectiveness of POEM in patients with type III achalasia. The results showed that POEM surgery can improve symptoms and esophageal function in patients, with long-lasting effects and fast postoperative recovery. The incidence of complications in patients was low. Therefore, POEM can be considered as a first-line treatment for this subtype of the disease.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Abbas E. Abbas
Summary: Achalasia is a foregut disease characterized by lack of identifiable etiology or cure.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Hiroki Sato, Yohei Nishikawa, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue
Summary: Screening and surveillance of POEM are crucial in detecting esophageal carcinoma. ESD is feasible for achalasia cases, but can be challenging on the POEM-line due to fibrosis. Surveillance endoscopy is recommended for specific high-risk cases and those with a history of esophageal carcinomas.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Zhao -Chao Zhang, Jia-Qi Xu, Xin-Yang Liu, Hai-Ting Pan, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Li -Li Ma, Jian-Wei Hu, Ming-Yan Cai, Wen-Zheng Qin, Quan-Lin Li, Ping-Hong Zhou
Summary: Salvage POEM is a promising treatment option for achalasia patients who have experienced myotomy failure, especially after a previous POEM failure, as it has a high rate of treatment success and clinical relief.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Eduardo Turiani Hourneaux de Moura, Jose Jukemura, Igor Braga Ribeiro, Galileu Ferreira Ayala Farias, Aureo Augusto de Almeida Delgado, Lara Meireles Azeredo Coutinho, Diogo Turiani Hourneaux de Moura, Rubens Antonio Aissar Sallum, Ary Nasi, Sergio A. Sanchez-Luna, Paulo Sakai, Eduardo Guimaraes Hourneaux de Moura
Summary: This study compared the efficacy and outcomes of POEM and LM-PF in the treatment of achalasia. The results showed no significant differences between the two groups in symptom improvement, but the rate of reflux esophagitis was higher in the POEM group. The POEM group had shorter anesthesia and procedure times, and improvement in all domains of quality of life.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Joseph R. Triggs, Amanda J. Krause, Dustin A. Carlson, Erica N. Donnan, Ryan A. J. Campagna, Anand S. Jain, Peter J. Kahrilas, Eric S. Hungness, John E. Pandolfino
Summary: BOM is a common adverse event after myotomy for achalasia, associated with post-treatment symptom severity, achalasia type, and treatment modality. Pretreatment type III achalasia, LHM as opposed to POEM, and an increased post-treatment integrated relaxation pressure are risk factors for BOM development.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Abdullah Ozgur Yeniova, In Kyung Yoo, Eunju Jeong, Joo Young Cho
Summary: Peroral endoscopic myotomy is considered as an effective treatment for achalasia patients. This study compared the safety and efficacy of POEM in treatment-naive patients and those with prior treatment failure. Results showed that POEM is safe and equally effective for both groups up to 6 months post treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Zuzana Vackova, Jan Mares, Jana Krajciova, Zuzana Rabekova, Lucie Zdrhova, Pavla Loudova, Julius Spicak, Petr Stirand, Tomas Hucl, Jan Martinek
Summary: More than 20% of achalasia patients show signs of partial recovery of esophageal peristalsis after POEM treatment. This recovery is mainly seen in patients with type II achalasia, but the clinical impact appears to be minimal.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Medicine, General & Internal
Lucille Queneherve, Blandine Vauquelin, Arthur Berger, Emmanuel Coron, Raphael Olivier
Summary: This mini-review focuses on the risk factors associated with per oral endoscopic myotomy (POEM) failure for the treatment of achalasia. The study identifies risk factors including pre-, intra-, and post-procedural factors. Pre-procedural factors such as pre-treatment Eckardt score, previous treatments, and esophageal morphology are discussed. In addition, the study highlights the association of mucosal injury during POEM and post-POEM GERD with POEM failure.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Hong Jin, Bin Wang, Zhong-qing Zheng, Li-li Zhang, Qiu-yu Chen, Chun Shan Zhao, Bang-mao Wang, Wei Zhao
Summary: The study found that POEM therapy can effectively relieve symptoms in achalasia patients, even those who had previously undergone pneumatic dilation. There may be differences in fibrosis levels and complications between patients who underwent POEM after pneumatic dilation and those who did not. Longer follow-up studies with larger cohorts are needed to evaluate the long-term outcomes and complications of POEM.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Jun Nakamura, Hiroki Sato, Manabu Onimaru, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hikichi Takuto, Haruhiro Inoue
Summary: This retrospective study analyzed the characteristics and efficacy of peroral endoscopic myotomy (POEM) in patients with esophageal motility disorders (EMDs) who had previous gastric surgery. The results showed that patients with gastric surgery often presented severe disease manifestations, with gastric cancer being the main surgical indication. POEM was found to be safe and effective in these patients, although it increased the incidence of reflux esophagitis.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Madhusudhan R. Sanaka, Rajat Garg, Pravallika Chadalavada, Prashanthi N. Thota, Scott Gabbard, Malav P. Parikh, George Khoudari, Sudish Murthy, Siva Raja
Summary: The study suggests that POEM is safe and highly effective for achalasia patients with sigmoid esophagus and those without sigmoid esophagus in western population. Treatment success rates and complications were similar between the two groups, indicating that POEM should be considered as the treatment of choice for advanced achalasia with sigmoid esophagus.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
David Friedel, Stavros N. Stavropoulos
Summary: Peroral endoscopic myotomy (POEM) is a minimally invasive procedure for treating esophageal achalasia. It has proven to be a superior alternative to laparoscopic Heller myotomy, especially for type III achalasia. However, there are concerns regarding the development of gastroesophageal reflux disease (GERD) after POEM, which requires further refinement of the technique and post-procedural care.
MINERVA GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Woohyung Lee, Dae Wook Hwang, Ho-Seong Han, In Woong Han, Jin Seok Heo, Michiaki Unno, Masaharu Ishida, Hiroshi Tajima, Nobuyuki Nishizawa, Kohei Nakata, Yasuji Seyama, Yoshiya Isikawa, Ho Kyoung Hwang, Jin-Young Jang, Taeho Hong, Joon Seong Park, Hee Joon Kim, Chi-Young Jeong, Ippei Matsumoto, Hiroki Yamaue, Manabu Kawai, Masayuki Ohtsuka, Shugo Mizuno, Mitsuhiro Asakuma, Yuji Soejima, Teijiro Hirashita, Masayuki Sho, Yutaka Takeda, Jeong-Ik Park, Yong Hoon Kim, Hwa Jung Kim, Masakazu Yamamoto, Itaru Endo, Masafumi Nakamura, Yoo-Seok Yoon
Summary: The study aimed to evaluate the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. By comparing the data of postoperative infectious complications in different groups, the study found that spleen preservation could lower the risk of infectious complications, but the risk may vary according to the surgeon's experience.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Da Hyun Jung, Ji Hyun Youn, Bo Mi Moon, Ji Hye Lee, Hyun-Seung Ryu, Joon Sung Kim, Hyuk Lee, Gwang Ha Kim, Jun Chul Park
Summary: This study explored the hemostatic effects and mechanisms of two hemostatic powders in a porcine upper gastrointestinal hemorrhage model, demonstrating their ability to improve initial hemostasis effectively, with additional ulcer-healing effects from EGF.
Article
Gastroenterology & Hepatology
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
Summary: Abdominal obesity is associated with an increased risk of developing Crohn's disease, but not ulcerative colitis, according to a population-based cohort study in Korea.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Yuna Kim, Sung Hwan Yoo, Jaeyoung Chun, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study found that exposing patients to virtual reality (VR) prior to endoscopic procedures can reduce their anxiety levels, leading to less discomfort and incomplete procedures, as well as decreased use of sedative medication. The proportion of patients with high anxiety significantly decreased in the VR group compared to the control group, and patients in the VR group reported higher satisfaction with sedation.
YONSEI MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Da Hyun Jung, Chan Hyuk Park, Soo In Choi, Hye Rim Kim, Myeongjee Lee, Hee Seok Moon, Jun Chul Park
Summary: This study demonstrates that polysaccharide hemostatic powder (PHP) is an effective initial treatment for peptic ulcer bleeding (PUB) and is not inferior to conventional treatments. Further research is needed to confirm the re-bleeding rate of PHP.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Orthopedics
C. W. Jang, M. Bang, J. H. Park, H. E. Cho
Summary: This study aims to summarize changes in recommendations for injection treatments for knee osteoarthritis (OA) in clinical practice guidelines (CPGs) and assess their impact on public interest. The findings show that while CPGs have shifted their recommendations, public interest and YouTube videos have not responded accordingly.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Surgery
So Young Han, Hong Jin Yoon, Jie-Hyun Kim, Hye Sun Lee, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
Summary: By analyzing the characteristics of patients with early gastric cancer who underwent ESD, we developed a nomogram to predict the risk of non-CR. This nomogram includes endoscopic features, radiologic findings, and pathology results, and it showed good predictive performance in the external validation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Neurosciences
Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Cho
Summary: Appropriate early rehabilitation is important for stroke patients, but the best strategy is currently unclear. This study investigates the effects of early exposure to environmental enrichment on stroke rehabilitation and identifies the mechanisms by which it improves outcomes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, Yuna Kim, Jaeyoung Chun, Kyungdo Han, Min-Chan Park, Ryul Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study aimed to assess whether the presence of immune-mediated inflammatory diseases (IMIDs) confers a higher risk of depression and anxiety in patients with type 2 diabetes (T2DM). The results showed that the existence of gut, joint, and skin IMIDs was associated with a higher risk of depression and anxiety. Patients with multiple IMIDs had a higher risk than those with only one.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Sang Jo Han, Su Jung Baik, Young Hoon Yoon, Jie Hyun Kim, Hye Sun Lee, Soyoung Jeon, Hyojin Park
Summary: This study aimed to compare the risk of metabolic syndrome and fatty liver diseases between gastric cancer survivors and non-cancer subjects. The results showed that gastric cancer survivors who underwent surgical treatment had lower risks of metabolic syndrome, fatty liver by ultrasonography, and metabolic dysfunction-associated fatty liver disease (MAFLD) than non-cancer subjects. However, there were no significant differences in the risks between non-surgical gastric cancer survivors and non-cancer subjects.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Yuna Kim, Yoo Jin Bae, Jie-Hyun Kim, Hyunki Kim, Su-Jin Shin, Da Hyun Jung, Hyojin Park
Summary: Trastuzumab-resistant gastric cancer cells exhibit an epithelial-mesenchymal transition (EMT)-like phenotype, and trastuzumab resistance is promoted by the Wnt/beta-catenin signaling pathway. The Wnt/beta-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Review
Medicine, General & Internal
Hyo-Joon Yang, Seung In Seo, Jin Lee, Cheal Wung Huh, Joon Sung Kim, Jun Chul Park, Hyunki Kim, Hakdong Shin, Cheol Min Shin, Chan Hyuk Park, Sang Kil Lee
Summary: Significant translational research advances have been made in the upper gastrointestinal (GI) research field in recent years. Endoscopic evaluation is a reasonable option for acquiring upper GI tissue for research purposes with minimal risk. The optimal number of biopsy samples and sample storage is crucial and might influence results. Few reports have been published on methods for sample collection from endoscopic biopsies. This review provides a protocol for collecting study samples for upper GI research, including microbiome, DNA, RNA, protein, single-cell RNA sequencing, and organoid culture, through a comprehensive literature review. Different methods and sample sizes are recommended for different types of analysis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Jun Kyu Hwang, Eun Kyung Park, Kyu-Won Shim, Dong-Seok Kim
Summary: This study aimed to analyze the effect of foramen magnum decompression with C1 laminectomy (C1L) for Chiari malformation type 1 (CM-1) in terms of improving clinical symptoms, expanding posterior fossa volume, and decreasing syrinx volume. The results showed that C1L can effectively increase posterior fossa volume, and combining C1L with duraplasty can result in a faster decrease in syrinx volume.
YONSEI MEDICAL JOURNAL
(2023)
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
