Journal
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
Volume 24, Issue 2, Pages 465-474Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JBHI.2019.2933046
Keywords
Seizure prediction; EEG; common spatial patterns; convolutional neural network
Categories
Funding
- National Natural Science Foundation of China [61572231]
- National Key R&D Program of China [2017YFE0112000]
- Shanghai Municipal Science and Technology Major Project [2017SHZDZX01]
- EPSRC [EP/H009744/1] Funding Source: UKRI
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Epilepsy seizure prediction paves the way of timely warning for patients to take more active and effective intervention measures. Compared to seizure detection that only identifies the inter-ictal state and the ictal state, far fewer researches have been conducted on seizure prediction because the high similarity makes it challenging to distinguish between the pre-ictal state and the inter-ictal state. In this paper, a novel solution on seizure prediction is proposed using common spatial pattern (CSP) and convolutional neural network (CNN). Firstly, artificial pre-ictal EEG signals based on the original ones are generated by combining the segmented pre-ictal signals to solve the trial imbalance problem between the two states. Secondly, a feature extractor employing wavelet packet decomposition and CSP is designed to extract the distinguishing features in both the time domain and the frequency domain. It can improve overall accuracy while reducing the training time. Finally, a shallow CNN is applied to discriminate between the pre-ictal state and the inter-ictal state. Our proposed solution is evaluated on 23 patients' data from Boston Children's Hospital-MIT scalp EEG dataset by employing a leave-one-out cross-validation, and it achieves a sensitivity of 92.2% and false prediction rate of 0.12/h. Experimental result demonstrates that the proposed approach outperforms most state-of-the-art methods.
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