Article
Oncology
Friedrich Anger, Anna Doering, Jacob van Dam, Johan Friso Lock, Ingo Klein, Max Bittrich, Christoph-Thomas Germer, Armin Wiegering, Volker Kunzmann, Casper van Eijck, Stefan Loeb
Summary: The new definition of borderline resectability for PDAC according to international consensus criteria takes into account anatomical, biological, and conditional dimensions. CA19-9 as an independent prognostic risk factor for OS in BR-B patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Seth Quinn, Warqaa Akram, Scarlett Hao, Michael D. Honaker
Summary: This study compares outcomes in older patients undergoing emergent surgical treatment for acute diverticulitis. The results show that mortality is higher in older patients undergoing Hartmann procedure, while morbidity is lower in patients aged 80 years and above undergoing primary anastomosis with diverting loop ileostomy. Readmission rates vary depending on the procedure performed. Age should be carefully considered in emergency diverticulitis surgery.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Oncology
L. Vigano, B. Branciforte, V. Laurenti, G. Costa, F. Procopio, M. Cimino, D. Del Fabbro, L. Di Tommaso, G. Torzilli
Summary: The study found that the replacement HGP is associated with an increased risk of local recurrence. In these patients, a wide surgical margin should be pursued, because R1vasc and R0min resections could be insufficient. R1par resection is inadequate, independently of the HGP.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Carsten Nieder, Nicolaus H. Andratschke, Anca L. Grosu
Summary: Biologically younger, fully independent octogenarians can tolerate most oncological treatments, while increasing frailty decreases eligibility for certain treatments such as chemotherapy and surgery. Most brain metastases are part of widespread cancer dissemination, often with compromised performance status. Multidisciplinary assessment is crucial in this vulnerable patient population, where age, frailty, comorbidity, and additional deficits from brain metastases or their treatment can lead to immobilization, hospitalization, and termination of systemic anticancer treatment. Successful treatments (surgery, radiosurgery, systemic therapy) and best supportive care are discussed, highlighting the limitations of prognostic scores developed for all-comers rather than octogenarians. Survival after radiosurgery was found to be more encouraging than after whole-brain radiotherapy in retrospective studies. Prospective research focusing on octogenarians is needed to optimize outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kenichiro Kakutani, Yoshitada Sakai, Zhongying Zhang, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Kohei Kuroshima, Naotoshi Kumagai, Yoshiaki Hiranaka, Shinya Hayashi, Yuichi Hoshino, Hitomi Hara, Ryosuke Kuroda
Summary: This study aimed to reveal the prognosis of patients with symptomatic spinal metastases (SSM) after spine surgery. The results showed that spine surgery significantly improved the performance status (PS), activities of daily living (ADL), ambulation, and survival of SSM patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Zhehuang Li, Liangyu Guo, Bairu Guo, Peng Zhang, Jiaqiang Wang, Xin Wang, Weitao Yao
Summary: This study compared the predictive performance of seven commonly used prognostic scoring systems for surgically treated spine metastases and found that none of the scoring systems could perform optimally at all time points and for all pathology types. The reference survival times provided in the original study need to be updated, and it is important to be aware of the underestimation for current patients.
Article
Critical Care Medicine
Burak Sercan Ercin, Burak Ergun Tatar, Pedro C. Cavadas
Summary: This study presents technical modifications for monitoring medial femoral condyle (MFC) free flap in hand reconstruction and compares different monitoring methods. The selection of monitors based on the defect area positively affects the postoperative prognosis of the flap.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Oncology
Se Ik Kim, Bo Ram Choi, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Chel Hun Choi, Maria Lee
Summary: Preoperative cervical conization may reduce the recurrence rate of disease in patients with early cervical cancer, particularly those undergoing minimally invasive surgery.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Chao Chen, Da Wang, Xiaoxu Ge, Jian Wang, Yuhuai Huang, Tianyi Ling, Tian Jin, Jinhua Yang, Fengping Wang, Weihong Wu, Lifeng Sun
Summary: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis, while the scoring system developed in this study is effective for prediction of OS of patients after surgery.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Miguel Esperanca-Martins, Diogo Roque, Tiago Barroso, Andre Abrunhosa-Branquinho, Diogo Belo, Nuno Simas, Luis Costa
Summary: The prevalence of metastatic spine disease is increasing and requires a multidisciplinary approach for optimal clinical outcomes. We reviewed recent data and proposed an updated algorithmic approach to personalized management. A flowchart-based approach provides evidence-based decision-making in a context of uncertainty and urgency.
Article
Oncology
Eran Nizri, Yaniv Berger, Eraan Green, Matan Kyzer, Asaf Aizic, Nadav Nevo, Fabian Gerstenhaber, Joseph M. Klausner, Mordechai Gutman, Guy Lahat, Aviad Hoffman, Ravit Geva
Summary: This study found that patients with visceral peritoneal colorectal metastases (VPCMs) who also had lymph node metastases (LNMs) may be more prone to systemic recurrence, indicating a potential need for adjuvant treatment.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Masaoki Ito, Yoshihiro Miyata, Kei Kushitani, Daisuke Ueda, Yukio Takeshima, Morihito Okada
Summary: This study evaluated the prognostic impact of EGFR and KRAS mutations on the recurrence of resected IASLC grade 2 and 3 lung adenocarcinoma patients and found that positive EGFR and KRAS mutations were risk factors for recurrence in these patients. Therefore, the statuses of EGFR and KRAS mutations should be evaluated simultaneously when assessing the risk of recurrence.
Article
Oncology
Jamila Laoukili, Alexander Constantinides, Emma C. E. Wassenaar, Sjoerd G. Elias, Danielle A. E. Raats, Susanne J. van Schelven, Jonathan van Wettum, Richard Volckmann, Jan Koster, Alwin D. R. Huitema, Simon W. Nienhuijs, Ignace H. J. T. de Hingh, Rene J. Wiezer, Helma M. U. van Grevenstein, Inne H. M. Borel Rinkes, Djamila Boerma, Onno Kranenburg
Summary: This study identifies the resistance of peritoneal metastases in colorectal cancer to oxaliplatin and links it to the specific molecular subtype and high reducing capacity. Inhibiting the reducing capacity may be an effective strategy to overcome oxaliplatin resistance in peritoneal metastases.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Holly G. Prigerson, Martin Viola, Paul K. Maciejewski, Francesca Falzarano
Summary: This study investigated the relationship between advance care planning (ACP) activities and the likelihood of receiving value-concordant end-of-life care. It found that for patients who prioritize comfort, engaging in end-of-life discussions with physicians and completing Do-Not-Resuscitate (DNR) orders can improve the odds of receiving value-concordant care. However, for patients who prioritize life-extension, ACP does not appear to improve the odds of receiving value-concordant care.
Article
Oncology
Laurence Gau, Mathieu Ribeiro, Bruno Pereira, Karine Poirot, Aurelien Dupre, Denis Pezet, Johan Gagniere
Summary: This meta-analysis confirms that both overall survival (OS) and recurrence-free survival (RFS) are impaired following liver surgery for CRLM in BRAF-mutated patients. The risks of hepatic and extrahepatic recurrences are significantly higher in BRAF-mutated patients, who often have right-sided colon primary tumors, primary positive lymph nodes, and multiple CRLM.