Article
Biochemical Research Methods
Diana Horta, Marta Moreno-Torres, Maria Jose Ramirez-Lazaro, Sergio Lario, Julia Kuligowski, Juan Daniel Sanjuan-Herraez, Guillermo Quintas, Albert Villoria, Xavier Calvet
Summary: This study analyzed the plasma lipidomic profiles of quiescent UC and CD patients and found changes in lipids associated with fatigue and IBD. Dysregulation of lipid metabolism was linked to fatigue symptoms, with a focus on arachidonic acid and glycerophospholipid metabolisms and the sphingolipid pathway. Protein-metabolite interaction network revealed disease-associated hidden proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Spiro Khoury, Antoine Beauvais, Jenny Colas, Anais Saint-Martin Willer, Frederic Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny
Summary: Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) characterized by remodeling of the pulmonary venous system and venous obstruction. There is currently no effective medical therapy for PVOD and lung transplantation is the only available treatment option. Recent research suggests that PVOD patients exhibit lung lipointoxication, potentially playing a role in the development of the disease.
Article
Chemistry, Multidisciplinary
Lana Papafilippou, Anna Nicolaou, Alexandra C. Kendall, Dolores Camacho-Munoz, Marilena Hadjidemetriou
Summary: The spontaneous self-assembly of biomolecules around the surface of nanoparticles, known as the biomolecule corona, has been well studied in terms of protein composition but not lipid composition. In this study, targeted and untargeted lipidomics were used to analyze the adsorbed bioactive lipids on the surface of liposome nanoparticles after incubation with human plasma. The biomolecule corona was found to contain a diverse mixture of simple and complex lipid species, with certain lipids showing preferential binding to the nanoparticle surface. Proteomic analysis revealed the presence of apolipoproteins, suggesting a potential lipoprotein-mediated adsorption mechanism. This study highlights the importance of bridging proteomics with lipidomics to understand the interactions at the bio-nano interface.
Article
Endocrinology & Metabolism
Ruili Yin, Xiaojing Wang, Kun Li, Ke Yu, Longyan Yang
Summary: By studying the global lipidome in the plasma of Chinese adolescents, differences in lipid features were found between obese students and normal or overweight students. Eight significant metabolites were identified to be associated with obese adolescents, providing a basis for evaluating the risk and monitoring the development of obesity.
BMC ENDOCRINE DISORDERS
(2021)
Article
Biology
Jiahui Si, Jiachen Li, Canqing Yu, Yu Guo, Zheng Bian, Iona Millwood, Ling Yang, Robin Walters, Yiping Chen, Huaidong Du, Li Yin, Jianwei Chen, Junshi Chen, Zhengming Chen, Liming Li, Liming Liang, Jun Lv
Summary: The study found that healthy lifestyles were associated with reduced risk of coronary heart disease through the mediation of various lipid metabolites, including VLDL particles, HDL particles, and triglycerides. Lifestyle interventions and statins may have different effects on components of the lipid profile.
Article
Surgery
Ana Isabel Perez Zapata, Carolina Varela Rodriguez, Cristina Martin-Arriscado Arroba, Marta Duran Ballesteros, Mercedes Bernaldo de Quiros Fernandez, Nuria Amigo Grau, Eduardo Ferrero Herrero, Elias Rodriguez Cuellar
Summary: This study analyzed the changes in the molecular profile of lipoproteins in plasma after bariatric surgery in obese patients and found that bariatric surgery can decrease cardiovascular disease risk factors.
Article
Biochemistry & Molecular Biology
Aaron A. Mehus, Bret Rust, Joseph P. Idso, Benjamin Hanson, Huawei Zeng, Lin Yan, Michael R. Bukowski, Matthew J. Picklo
Summary: Time-restricted feeding (TRF) can prevent insulin resistance and hepatic steatosis caused by high-fat diet intake. TRF does not increase LCPUFA levels in the liver, but alters lipid composition and gene expression, reducing fatty acid synthesis and restoring diurnal gene signaling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Lidia Minguez-Alarcon, Sheryl L. Rifas-Shiman, Joanne E. Sordillo, Izzuddin M. Aris, Allison J. Wu, Marie-France Hivert, Emily Oken, Jorge E. Chavarro
Summary: This study investigated the differences in DXA-measured body composition between children and adolescents born by cesarean delivery and those born by vaginal delivery. The results showed that adolescents born by cesarean delivery had significantly higher measures of lean mass, fat mass, and central adiposity compared with those born by vaginal delivery. However, these associations did not remain after adjustment for the mothers' self-reported prepregnancy BMI.
Article
Multidisciplinary Sciences
Carrie T. Chan
Summary: This study aims to investigate the association between BMI and the incidence of PSF among pediatric patients with AIS. The results show that there is no significant association between underweight, overweight, or obese BMI categories and incident PSF.
Article
Health Care Sciences & Services
Wenyan Ding, Shaohang Xu, Baojin Zhou, Ruo Zhou, Peng Liu, Xiangyi Hui, Yun Long, Longxiang Su
Summary: This study investigates the changes in lipidomics that can predict sepsis after cardiac surgery. The results reveal characteristic lipidomic changes in the plasma of septic patients before and after surgery, and suggest two cholesterol esters and two amides as promising signatures for sepsis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Ulf Riserus, Joel Kullberg, Lars Johansson, Hakan Ahlstrom, Jan W. Eriksson, Jan Oscarsson
Summary: The study investigated plasma metabolomic profiles related to visceral adipose tissue volume, liver and pancreas fat percentages in obese individuals. Metabolic associations were shared between liver PDFF and VAT adipose tissue, but not with pancreatic PDFF, indicating distinct metabolic profiles for different ectopic fat depots. The addition of specific metabolites improved the prediction of liver steatosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Ana Laura de la Garza, Alejandra Mayela Martinez-Tamez, Anael Mellado-Negrete, Sofia Arjonilla-Becerra, Gloria Itzel Pena-Vazquez, Luis Martin Marin-Obispo, Carmen Hernandez-Brenes
Summary: This study aimed to evaluate shifts in gut microbiota and correlate these with serum fatty acid profiles in male Wistar rats fed a cafeteria diet. The cafeteria diet induced an obese phenotype accompanied by impaired serum fatty acids, and the obesity metabotype may be mediated by gut dysbiosis caused by specific fatty acids in the cafeteria diet. There is a certain correlation between gut microbiota associated with obesity and serum fatty acids.
Article
Biochemistry & Molecular Biology
Neven Zarkovic, Biserka Orehovec, Bruno Barsic, Marko Tarle, Marta Kmet, Ivica Luksic, Franz Tatzber, Willibald Wonisch, Elzbieta Skrzydlewska, Wojciech Luczaj
Summary: This study analyzed the differences in plasma phospholipid profiles between deceased COVID-19 patients, recovered patients, and healthy individuals. The findings showed increased levels of certain phospholipids in the plasma of recovered patients and most deceased patients, but significantly decreased levels in a subgroup of deceased patients. Additionally, these deceased patients exhibited abnormal levels of CRP and LDH, suggesting other underlying disorders. Furthermore, a decrease in autoantibodies against oxidative modifications of low-density lipoprotein (oLAb) was observed in all subjects, especially deceased patients, indicating systemic oxidative stress and altered immune system.
Article
Biochemistry & Molecular Biology
Jonathan R. Lindner, Brian P. Davidson, Zifeng Song, Claudia S. Maier, Jessica Minnier, Jan Frederick Stevens, Maros Ferencik, Sahar Taqui, J. Todd Belcik, Federico Moccetti, Michael Layoun, Paul Spellman, Mitchell S. Turker, Hagai Tavori, Sergio Fazio, Jacob Raber, Gerd Bobe
Summary: Coronary microvascular dysfunction (MVD) is a syndrome characterized by abnormal vascular tone regulation during metabolic demand. A study on non-elderly symptomatic subjects with MVD showed specific lipidomic profiles in plasma, including lower concentrations of long-carbon chain triacylglycerols and diacylglycerols, and higher concentrations of short-chain triacylglycerols. These findings suggest potential for better characterization and treatment of MVD.
Article
Biology
Kerlijne Moorkens, Jo L. M. R. Leroy, Jusal Quanico, Geert Baggerman, Waleed F. A. Marei
Summary: This study investigated the changes in lipid metabolism in the oviduct of mice fed an obesogenic diet. The results showed that the obesogenic diet led to an increase in the overall lipid levels and differential regulation of specific lipids in the oviductal epithelium. These lipidomic changes may impact reproductive events in the oviduct, such as fertilization and early embryo development.
Article
Nutrition & Dietetics
Wangxing Yang, Na Han, Mingyuan Jiao, Xinlei Chang, Jue Liu, Qianling Zhou, Hai-Jun Wang
Summary: This study aimed to describe the diet quality of pregnant women and investigate the relationship between maternal diet and the prevalence of low birth weight and small for gestational age. The results showed that inadequate intake of fruits and dairy products during the second trimester was associated with an increased risk of low birth weight and small for gestational age. Sufficient consumption of fruits and dairy products during pregnancy is recommended to prevent these adverse outcomes.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Zheying Zhang, Wenyan Fan, Qingzu Gao, Yifei Han, Jingyu Ma, Wuji Gao, Yuhan Hu, Huifang Zhu, Rui Yang, Haijun Wang, Baoshun Du, Zuoyang Zhang, Jiateng Zhong
Summary: We report a circRNA named hsa_Circ_0000826 (Circ_0000826) that is significantly downregulated in colorectal cancer (CRC) tissues and is associated with a poor prognosis in patients. Silencing Circ_0000826 promotes CRC cell proliferation, while overexpression of Circ_0000826 inhibits CRC cell proliferation. Furthermore, Circ_0000826 can bind to AUF1 and competitively inhibit its binding to c-MYC 30-UTR, leading to decreased c-MYC expression and cell proliferation.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Orthopedics
Zijie Xu, Yifan Song, Ronghui Deng, Jing Ye, Xinjie Wang, Haijun Wang, Jia-Kuo Yu
Summary: The study compares the values and relationship of tibial tubercle lateralization measurements between CT and MRI. The results suggest that the values measured by MRI may underestimate tibial tubercle lateralization compared to CT, but the values in the other modality can be estimated using regression equations. Therefore, an additional CT scan for tibial tubercle lateralization evaluation may not be necessary.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Oceanography
Lingchunzi Li, Jing Wang, Haijun Wang, Xin Jin, Lijing Du
Summary: Driven by globalization and the COVID-19 outbreak, the Belt and Road Initiative (BRI) is more important than ever in the post-pandemic era. To improve crossborder transportation and promote economic recovery, we design an intermodal hub-and-spoke network based on the BRI. Our research shows that rail subsidies are positively correlated with construction subsidies, but may not affect the choice of hubs.
OCEAN & COASTAL MANAGEMENT
(2023)
Article
Obstetrics & Gynecology
Yuelong Ji, Jinhui Xu, Tao Su, Lizi Lin, Shuang Zhou, Heling Bao, Zheng Liu, Shusheng Luo, Xiangrong Xu, Na Han, Hai-Jun Wang
Summary: This study investigated the effect of LT4 treatment on fetal growth and birth weight among pregnant women with mild subclinical hypothyroidism and TPOAb(-). The results showed that LT4 treatment was associated with decreased fetal head circumference in this population.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Crystallography
Lijuan Zhang, Xiaolong Jiang, Jing Chen, Chuanchao Zhang, Lianghong Yan, Haijun Wang, Xiaoyu Luan, Wei Liao, Xiaodong Jiang, Yong Jiang
Summary: In this paper, single-layer SiO2 sol-gel antireflection films pretreated by triple-frequency laser with different parameters are characterized by macroscopical parameters such as transmittance, refractive index, and thickness. The law of surface modification and the defect removal mechanism of the SiO2 sol-gel antireflection film by laser conditioning are obtained. It is found that laser conditioning can reduce the thickness of the film, introduce densification, and eliminate micro-defects, which is the main reason for improving the laser damage resistance of films.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqi Wang, Chengbin Duan, Shun Yao, Jinping Chen, Shaolin Zhang, Zongming Wang, Bin Hu, Zhigang Mao, Haijun Wang, Yonghong Zhu, Wenli Chen
Summary: Monitoring postoperative biochemical levels in acromegaly patients, especially those in developing countries, is a challenge. In this study, a mobile and low-cost method using MobileNetv2-based transfer learning algorithm was established to predict biochemical remission. The algorithm showed high accuracy in predicting biochemical remission in both the training and validation cohorts.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Qiang Feng, Chao-Qun Fan, Jing-Jing Wang, Huan Wang, Dong-Ming Wu, George P. Nassis, Mei Wang, Hai-Jun Wang
Summary: This study found that exposure to green space and engaging in sufficient physical activity are protective factors against low muscle strength in Chinese adults. The combination of increased green space exposure and physical activity may have a greater effect on improving muscle strength. Therefore, incorporating green spaces into city design and built environments is recommended.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pediatrics
Yunfei Xing, Jiangao Fan, Hai-Jun Wang, Hui Wang
Summary: This study compared the clinical features of children with metabolic-associated fatty liver disease (MAFLD) and nonalcoholic fatty liver disease (NAFLD), and found that most clinical features were similar between the two groups, with over 75% of children with NAFLD also being diagnosed with MAFLD. However, approximately 19% of children with NAFLD could not be categorized as MAFLD.
Correction
Automation & Control Systems
Pengfei Yin, Zhonghua Liu, Di Wu, Hua Huo, Haijun Wang, Kaibing Zhang
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Environmental Sciences
Shuang Zhou, Tiantian Li, Na Han, Kai Zhang, Yi Zhang, Qin Li, Yuelong Ji, Jue Liu, Hui Wang, Jianlin Hu, Ting Liu, Hein Raat, Haijun Wang
Summary: This study examined the effects of prenatal exposure to PM2.5 on childhood growth, specifically on BMI Z-scores in the first three years. The results showed that prenatal exposure to PM2.5 and its constituents were associated with higher BMI Z-scores in children. The study highlights the importance of developing public health policies to control harmful PM2.5 constituents for the promotion of child health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Jinlang Lyu, Zhongshang Wan, Zheng Liu, Shuang Zhou, Xiangxian Feng, Aiyu Gao, Yi Lin, Fang Zhang, Haijun Wang
Summary: In addition to genetic factors and energy-related behaviors, psycho-cultural factors are important in the development of obesity. Improving body image has been suggested as an effective method for managing body weight. This study aimed to evaluate the effects of a multifaceted intervention on the body image of children and explore whether body image played a mediating role in changes in adiposity indicators.
Article
Clinical Neurology
Sijie Chen, Longsheng Huang, Guihua Liu, Jie Kang, Qinfang Qian, Jingrong Wang, Rong Wang, Lizhen Zheng, Haijun Wang, Ping Ou
Summary: Acupuncture can improve symptoms of autism spectrum disorder (ASD), and the improvement of the serotonin system may be one of the main regulatory mechanisms of acupuncture for treating ASD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Public, Environmental & Occupational Health
Zheng Liu, Zhi-Han Yue, Li-Ming Wen, Jinfeng Zhao, Shuang Zhou, Ai-Yu Gao, Fang Zhang, Hai-Jun Wang
Summary: This study aimed to assess the time-specific intervention effects on school-aged children's physical activity. The findings showed that the intervention led to an increase in moderate-to-vigorous physical activity within in-school periods but did not improve out-of-school physical activity. The results suggest the need to tailor intervention components to specific periods of a day to improve school-aged children's overall pattern of physical activity.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqi Wang, Chengbin Duan, Shun Yao, Jinping Chen, Shaolin Zhang, Zongming Wang, Bin Hu, Zhigang Mao, Haijun Wang, Yonghong Zhu, Wenli Chen
Summary: This study presents a mobile and low-cost method to predict biochemical remission in acromegaly patients after surgery. The results show that the MobileNetv2-based transfer learning algorithm can accurately predict the likelihood of biochemical remission in acromegaly patients, providing a potential solution for those who live in remote areas or regions with limited medical resources.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)