Article
Agriculture, Dairy & Animal Science
Maira S. D. Pavlak, Cristine Kaufmann, Cinthia Eyng, Paulo L. O. Carvalho, Paulo C. Pozza, Flavio M. Vieites, Nilton Rohloff Junior, Andre S. Avila, Clauber Polese, Ricardo Nunes
Summary: The objective of this study was to evaluate the behavior of zeolite against different types of corn in broiler chickens' diets. The results showed that there was a significant interaction between corn types and zeolite inclusion for feed conversion ratio. Corn with lower mycotoxin contamination caused a reduction in body weight gain and an increase in the relative weight of abdominal fat. The inclusion of zeolite improved the percentage of digestible nutrients.
Article
Pharmacology & Pharmacy
Vinicius Duarte, Adriano Olnei Mallmann, Diogo Liberalesso, Cristina Tonial Simoes, Luciane Tourem Gressler, Francieli Adriane Molossi, Ana Paula Frederico Rodrigues Loureiro Bracarense, Carlos Augusto Mallmann
Summary: The study demonstrated that deoxynivalenol (DON) can cause damage to broilers' intestinal tissues, but an antimycotoxins additive (AMA) showed efficacy in alleviating these harmful effects.
Article
Food Science & Technology
Ismail Zabiulla, Venkataramaiah Malathi, H. V. L. N. Swamy, Jaya Naik, Lane Pineda, Yanming Han
Summary: The experiment investigated the efficacy of a smectite-based clay binder in reducing the toxicological effects of aflatoxin B-1 in broiler chickens. The results showed that supplementation of this clay binder improved growth performance, reduced liver toxicity, and enhanced humoral immune response in broilers.
Article
Biochemistry & Molecular Biology
Marianna Miliaraki, Panagiotis Briassoulis, Stavroula Ilia, Kalliopi Michalakakou, Theodoros Karakonstantakis, Aikaterini Polonifi, Kalliopi Bastaki, Efrossini Briassouli, Konstantinos Vardas, Aikaterini Pistiki, Maria Theodorakopoulou, Theonymfi Tavladaki, Anna-Maria Spanaki, Eumorfia Kondili, Helen Dimitriou, Maria Venihaki, Sotirios Tsiodras, Dimitrios Georgopoulos, Marina Mantzourani, Serafeim Nanas, Apostolos Armaganidis, George L. Daikos, Ioannis Papassotiriou, George Briassoulis
Summary: Oxidative stress plays a crucial role in the pathophysiology of sepsis. This study investigates whether an imbalance between oxidants and antioxidants can serve as an independent discriminator and mortality predictor for septic patients. The results show that septic patients have elevated oxidant/antioxidant ratios, which are associated with severity of illness, inflammatory responses, and apoptosis-related factors.
Article
Food Science & Technology
Orranee Srinual, Tossapol Moonmanee, Chompunut Lumsangkul, Hien Van Doan, Montri Punyatong, Mongkol Yachai, Thanongsak Chaiyaso, Kittima Kongtong, Wanaporn Tapingkae
Summary: The study evaluated the efficacy of red yeast (Sporidiobolus pararoseus; RY) as a mycotoxin binder in broiler chickens. Results showed that RY supplementation effectively alleviated the toxicity induced by aflatoxin B1 and ochratoxin A, indicating its potential as a novel feed additive in the broiler industry.
Article
Biochemistry & Molecular Biology
Yumei Liu, Ruiqi Dong, Yuxiang Yang, Hui Xie, Yufeng Huang, Xiaoguang Chen, Dongmei Wang, Ziqiang Zhang
Summary: T-2 toxin, a common contaminant in food, induced kidney injury in rabbits, characterized by increased oxidative stress and inflammation. However, pretreatment with a low dose of SeMet effectively reversed these effects, suggesting a potential protective role of selenium against T-2 toxin-induced kidney damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Environmental Sciences
Weidong Hu, Zhengke He, Lin Du, Li Zhang, Jun Li, Yue Ma, Shicheng Bi
Summary: The aim of this study was to evaluate the effect of LPS exposure on OS-associated markers. The results showed that LPS treatment significantly increased the levels of oxygen radicals and their products, while significantly reducing the levels of antioxidants. Subgroup evaluation revealed that the jejunum and duodenum demonstrated stronger antioxidant capability. Overall, exposure to LPS induces significant OS in chickens.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agriculture, Dairy & Animal Science
Y. P. Chen, Y. F. Gu, H. R. Zhao, Y. M. Zhou
Summary: Squalene supplementation can enhance growth performance, improve oxidative status, and alleviate liver injury in diquat-challenged broilers.
Article
Agriculture, Dairy & Animal Science
Bemela Mawulom Tokofai, Kokou Idoh, Oyegunle Emmanuel Oke, Amegnona Agbonon
Summary: The study demonstrated that Vernonia amygdalina extract has hepatoprotective effects on poultry, reducing the adverse effects of carbon tetrachloride-induced liver damage. The aqueous extract at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels.
Article
Chemistry, Applied
Hongwei Guo, Juan Chang, Ping Wang, Qingqiang Yin, Chaoqi Liu, Silu Li, Qun Zhu, Mingfan Yang, Xiaofei Hu
Summary: This study focused on evaluating the detoxification of aflatoxin B-1 (AFB(1)) both in vitro and in broiler chickens using a triple-action compound mycotoxin detoxifier (CMD). The results showed that CMD efficiently removed AFB(1) in vitro and improved broiler production performance while reducing AFB(1) residues in the chickens.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Physiology
Tong Xing, Xiaona Pan, Lin Zhang, Feng Gao
Summary: Wooden breast syndrome in broiler chickens not only affects the pectoralis major muscle but also leads to liver injury, as evidenced by higher plasma enzymes and histopathological changes in the liver. This myopathy induces oxidative stress, mitochondrial dysfunction, and hepatic apoptosis, along with inflammatory responses in the liver. Additional assessment is needed to understand the systemic physiological disparities and metabolic changes associated with wooden breast myopathy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rehab E. Abdelrahman, Abdel Azeim A. Khalaf, Mohamed A. Elhady, Marwa A. Ibrahim, Eman Hassanen, Peter A. Noshy
Summary: The study showed that OTA exposure in broiler chickens resulted in suppressed immune responses, oxidative stress, and apoptotic effects in various organs, while QUE administration alleviated these immunotoxic effects by modulating the immune system, reducing oxidative stress, and inhibiting apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Emre Yilmaz, Mehmet Gul
Summary: This study evaluated the impact of cumin essential oil supplementation on gene expression related to antioxidant, apoptotic, detoxification, and heat shock mechanisms in heat-stressed broilers. The results showed that cumin essential oil had a dose-dependent positive effect on certain genes and downregulated these genes in the tissues of heat-stressed broilers.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ola A. A. Habotta, Xiaoyan Wang, Hamzah Othman, Abdulrahman A. Aljali, Mahmoud Gewaily, Mahmoud A. Dawood, Asmaa Khafaga, Amr I. I. Zaineldin, Rajeev K. Singla, Bairong Shen, Heba I. Ghamry, Eman Elhussieny, Amany El-Mleeh, Samah F. F. Ibrahim, Ahmed Abdeen
Summary: Selenium-enriched yeast (SeY) was found to significantly alleviate copper (Cu)-induced hepatic and renal damage, possibly through the activation of antioxidant molecules and reduction of inflammatory stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Rehab E. Abdelrahman, Abdel Azeim A. Khalaf, Mohamed A. Elhady, Marwa A. Ibrahim, Eman I. Hassanen, Peter A. Noshy
Summary: This study found that the flavonoid quercetin can protect broiler chickens against nephrotoxicity induced by the mycotoxin ochratoxin A. Exposure to ochratoxin A resulted in increased levels of certain blood markers and decreased renal antioxidants, while coadministration of quercetin mitigated these toxic effects.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Valeria Farkas, Gabor Csitari, Laszlo Menyhart, Nikoletta Such, Laszlo Pal, Ferenc Husveth, Mohamed Ali Rawash, Akos Mezolaki, Karoly Dublecz
Summary: The microbial communities in the gastrointestinal tract of chickens play a crucial role in gut homeostasis, metabolism, and health of the host. This study evaluated the microbial communities in different intestinal segments of broiler chickens with different growth rates and identified the influence of sampling place and body weight on microbiota composition.
Article
Agriculture, Dairy & Animal Science
Wageha A. Awad, Daniel Ruhnau, Ana Gavrau, Karoly Dublecz, Michael Hess
Summary: Betaine, a component of poultry diets, has various effects on nutritional physiology. Natural and synthetic betaine have different effects on intestinal barrier and tissue. Adding natural betaine has a positive effect on performance and does not negatively affect gut paracellular permeability.
Article
Agriculture, Dairy & Animal Science
Nikoletta Such, Akos Mezolaki, Mohamed Ali Rawash, Kesete Goitom Tewelde, Laszlo Pal, Laszlo Wagner, Kornel Schermann, Judit Poor, Karoly Dublecz
Summary: Ammonia emission is a significant air quality issue worldwide, mainly related to animal production, with the European Union accounting for about 80-90%. The release of ammonia from manure is primarily due to nitrogen excreted through urine. There are various nutritional methods to decrease nitrogen excretion, such as feeding low protein diets supplemented with crystalline amino acids. Feed additives, including exogenous enzymes, pro- and prebiotics, can also modify nitrogen excretion and composition. However, there is limited information on how modified microbiota affects nitrogen ratio and ureolytic activity. This study evaluated the effects of different cereal grains, soluble fiber fractions, and probiotic and symbiotic treatments on ammonia release and nitrogen composition in broiler excreta.
Article
Agronomy
Mohamed Ali Rawash, Valeria Farkas, Nikoletta Such, Akos Mezolaki, Laszlo Menyhart, Laszlo Pal, Gabor Csitari, Karoly Dublecz
Summary: Barley and oats are viable alternatives to corn and wheat in poultry nutrition. They contain beneficial fiber and beta-glucans, which affect gut function and microbiota. However, the inclusion rates and presence of exogenous glucanase need to be carefully considered.
Article
Environmental Sciences
Karoly Dublecz, Ilona Anna Geicsnek-Koltay, Nikoletta Such, Zsuzsanna Benedek, Akos Kovacs, Adam Bartos, Judit Poor, Laszlo Pal
Summary: This trial evaluated the effects of different nutritional treatments on the N balance parameters of fattening pigs. The results showed that feeding low-protein diets reduced N excretion and urinary pH significantly compared to the control diet. Sugar beet pulp increased the fecal N excretion and urinary pH, while reducing N digestibility and the TAN ratio. Benzoic acid did not reduce urinary pH. The measured N excretion, retention, and TAN excretion values were more favorable than those in the guidelines or emission inventory.
Article
Agriculture, Dairy & Animal Science
Patrik Strifler, Boglarka Horvath, Nikoletta Such, Valeria Farkas, Laszlo Wagner, Karoly Dublecz, Laszlo Pal
Summary: Feeding low-protein diets can reduce ammonia emissions in broiler chicken production without compromising production traits and carcass composition.
Article
Agriculture, Dairy & Animal Science
Patrik Traj, Csilla Sebok, Mate Mackei, Agnes Kemeny, Orsolya Farkas, Akos Kakonyi, Laszlo Kovacs, Zsuzsanna Neogrady, Akos Jerzsele, Gabor Matis
Summary: The inadequate use of antibiotics has led to the emergence of resistant microbes, posing a major threat in human and veterinary medicine. Natural alternatives to antibiotics are being explored to improve farm animal productivity. This study investigates the anti-inflammatory and antioxidant activity of luteolin, a phytochemical found in vegetables, in a chicken hepatic cell culture. The results demonstrate that luteolin has anti-inflammatory and antioxidant effects, making it a potential alternative to antibiotics for improving animal health and productivity.
Article
Microbiology
Andras Fodor, Tibor Vellai, Claudia Hess, Laszlo Makrai, Karoly Dublecz, Laszlo Pal, Andor Molnar, Michael G. Klein, Eustachio Tarasco, Sandor Jozsa, Petra Ganas, Michael Hess
Summary: Entomopathogenic bacteria are symbionts of entomopathogenic nematodes that produce antimicrobial peptides with broad-spectrum activity. These peptides can neutralize various pathogens. In a feeding experiment with broiler cockerels, a feed supplement containing these peptides showed gastrointestinal activity, reducing the number of Clostridium perfringens units in the lower jejunum. No adverse effects were observed, indicating the safety of this supplement.
Article
Veterinary Sciences
Patricia Hatala, Andrea Lajos, Mate Mackei, Csilla Sebok, Patrik Traj, Julia Voroshazi, Zsuzsanna Neogrady, Gabor Matis
Summary: Feline idiopathic cystitis (FIC) is a common urinary tract disorder in domestic cats. This study established a cell culture model of feline uroepithelial cells to investigate the effects of stress-induced norepinephrine on the development of the disease. The results showed that acute exposure to norepinephrine increased the metabolic activity, induced inflammation, triggered oxidative stress, and decreased barrier integrity of the cultured cells.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mate Mackei, Csilla Sebok, Julia Vorohazi, Patrik Traj, Fruzsina Mackei, Barnabas Olah, Hedvig Febel, Zsuzsanna Neogrady, Gabor Matis
Summary: Excessive use of azole fungicides in agriculture poses a potential threat to honeybees and other pollinator insects. This study investigated the acute sublethal effects of tebuconazole on the redox homeostasis and fatty acid composition in honeybee brains. The results showed that tebuconazole disrupted antioxidant capacity, increased lipid peroxidation, and altered fatty acid profiles in the brain.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Nikoletta Such, Kornel Schermann, Laszlo Pal, Laszlo Menyhart, Valeria Farkas, Gabor Csitari, Brigitta Kiss, Kesete Goitom Tewelde, Karoly Dublecz
Summary: This article examines the effects of parent flock age and hatching time on broiler chicken production traits and gut bacteriota. It is concluded that the live weight of day-old chickens is crucial for growth rate, while different parent flocks have no impact on gut bacteriota composition. However, hatching time does modify the bacterium composition of the ceca at day 11.
Article
Infectious Diseases
Andras Fodor, Claudia Hess, Petra Ganas, Zsofia Boros, Janos Kiss, Laszlo Makrai, Karoly Dublecz, Laszlo Pal, Laszlo Fodor, Anna Sebestyen, Michael G. Klein, Eustachio Tarasco, Manjusha M. Kulkarni, Bradford S. Mcgwire, Tibor Vellai, Michael Hess
Summary: Anti-microbial peptides have a great potential in combating multidrug resistance. The symbiotic complex of entomopathogenic nematodes and entomopathogenic bacteria releases non-ribosomal templated anti-microbial peptides that may serve as potential drug candidates. Comparative anti-microbial bioassays revealed that Xenorhabdus budapestensis and X. szentirmaii are excellent sources of efficient non-ribosomal templated anti-microbial peptides, which can antagonize certain pathogens.
Article
Agriculture, Dairy & Animal Science
Zsuzsanna Benedek, Karoly Dublecz, Ilona Anna Koltay, Gabor Fitos, Vanda Kisanna Varhelyi, Marianna Magyar, Bela Pirko, Nora Hegedusne Baranyai
Summary: There is a lack of information in Hungary about pig production technologies and changes since 2005, as well as the number of pigs kept in different categories. Our research team conducted a survey of pig farms to assess housing and manure management technologies in 2005 and 2015. The survey resulted in a database of practices in Hungarian pig production and a tool for farmers to calculate ammonia emissions.
Article
Veterinary Sciences
Jennifer Bencze-Nagy, Patrik Strifler, Boglarka Horvath, Nikoletta Such, Valeria Farkas, Karoly Dublecz, Laszlo Pal
Summary: The study aimed to investigate the health protective effects of dietary milk thistle seed, oil, and seed cake in ducks fed diets contaminated with deoxynivalenol and zearalenone. The results showed that milk thistle oil had a stronger positive effect on histopathology parameters compared to milk thistle seed and seed cake. All treatments were equally effective in reducing solitary cell death and infiltration of lympho- and histiocytes in the liver, as well as preventing lymphocyte depletion in the spleen and bursa of Fabricius. Overall, the applied milk thistle supplements were proven effective in preventing histopathological changes caused by deoxynivalenol and zearalenone.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Mate Mackei, Rebeka Talaber, Linda Muller, Agnes Sterczer, Hedvig Febel, Zsuzsanna Neogrady, Gabor Matis
Summary: The intestinal microbiome of dogs can be influenced by lactulose and psyllium husk, which enhance the synthesis of VFAs. Lactulose significantly increased total VFA concentration, while psyllium showed effects only on day 15, suggesting slightly different effects of these prebiotics.
VETERINARY SCIENCES
(2022)