Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

TSA restores hair follicle-inductive capacity of skin-derived precursors

(2019) Ling Guo et al.   Scientific Reports

Wanted, dead and alive; why a multidisciplinary approach is needed to unlock hair treatment potential

(2019) Yi Shan Lim et al.   EXPERIMENTAL DERMATOLOGY

Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues

(2019) Long Zhang et al.   Journal of Tissue Engineering and Regenerative Medicine

Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin

(2019) Yuzo Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Preparation of hair beads and hair follicle germs for regenerative medicine

(2019) Tatsuto Kageyama et al.   BIOMATERIALS

Use of extracellular matrix hydrogel from human placenta to restore hair-inductive potential of dermal papilla cells

(2019) Xinyu Zhang et al.   Regenerative Medicine

Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin

(2018) Sabrina Mai-Yi Fan et al.   BIOMATERIALS

Spontaneous hair follicle germ (HFG) formation in vitro, enabling the large-scale production of HFGs for regenerative medicine

(2018) Tatsuto Kageyama et al.   BIOMATERIALS

Establishment of an in vitro organoid model of dermal papilla of human hair follicle

(2018) Abhishak C. Gupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impact of substrate stiffness on dermal papilla aggregates in microgels

(2018) Justin J. Y. Tan et al.   Biomaterials Science

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

(2018) Alka Madaan et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

(2018) Dustin H. Marks et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Tissue engineering of human hair follicles using a biomimetic developmental approach

(2018) Hasan Erbil Abaci et al.   Nature Communications

Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells

(2017) Mingxing Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life is 3D: Boosting Spheroid Function for Tissue Engineering

(2017) Matthias W. Laschke et al.   TRENDS IN BIOTECHNOLOGY

Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid

(2017) Ekaterina Kalabusheva et al.   Stem Cells International

As a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells

(2017) Shun-E. Xiao et al.   Scientific Reports

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

(2016) H. Matsumura et al.   SCIENCE

Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

(2016) Xiaoxiao Wang et al.   Stem Cells Translational Medicine

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model

(2016) R. Takagi et al.   Science Advances

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

(2015) S. Harel et al.   Science Advances

Derivation of Hair-Inducing Cell from Human Pluripotent Stem Cells

(2015) Ksenia Gnedeva et al.   PLoS One

Induced Pluripotent Stem Cells for Regenerative Medicine

(2014) Karen K. Hirschi et al.   Annual Review of Biomedical Engineering

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

(2014) Waleed Rahmani et al.   DEVELOPMENTAL CELL

Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells

(2014) Ruifeng Yang et al.   Nature Communications

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

(2014) B. A. Morgan   Cold Spring Harbor Perspectives in Medicine

Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies

(2013) Saeed Abbasalizadeh et al.   BIOTECHNOLOGY ADVANCES

Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering

(2013) Manabu Ohyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth

(2013) C. A. Higgins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell dynamics in the hair follicle niche

(2013) Panteleimon Rompolas et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration

(2012) Yi-Ching Huang et al.   BIOMATERIALS

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop

(2012) W.-M. Woo et al.   GENES & DEVELOPMENT

Restoration of the intrinsic properties of human dermal papilla in vitro

(2012) Manabu Ohyama et al.   JOURNAL OF CELL SCIENCE

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling

(2012) Rachel Sennett et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

(2012) Koh-ei Toyoshima et al.   Nature Communications

Hair organ regeneration via the bioengineered hair follicular unit transplantation

(2012) Kyosuke Asakawa et al.   Scientific Reports

Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells

(2011) Ruka Shimizu et al.   EXPERIMENTAL DERMATOLOGY

De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro

(2011) Gerd Lindner et al.   JOURNAL OF BIOTECHNOLOGY

Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells

(2011) Luis A. Garza et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay

(2011) Bo Mi Kang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Modelling the hair follicle dermal papilla using spheroid cell cultures

(2010) Claire A. Higgins et al.   EXPERIMENTAL DERMATOLOGY

The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race

(2009) Elaine Fuchs   CELL

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization

(2009) Manabu Ohyama et al.   EXPERIMENTAL DERMATOLOGY

From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

(2009) Claire A. Higgins et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hair follicle neogenesis induced by cultured human scalp dermal papilla cells

(2009) Jizeng Qiao et al.   Regenerative Medicine

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties

(2008) M. Rendl et al.   GENES & DEVELOPMENT

Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential

(2007) K. J.L Fernandes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES