Editorial Material
Orthopedics
Latika Gupta, Aurelie Najm, Koroush Kabir, Diederik De Cock
Summary: BMC Musculoskeletal Disorders launched a Collection on digital health to explore the impact of digital technologies on musculoskeletal medicine. This editorial summarizes the findings and focuses on key topics such as digital tools for diagnosis and evaluation of diseases and advances in health record analysis. It also discusses the acceptability and validity of these digital advances. Overall, this editorial and the papers in this collection provide insights into the future and challenges of digital health in musculoskeletal care.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Psychology, Clinical
Helga Ask, Rosa Cheesman, Eshim S. Jami, Daniel F. Levey, Kirstin L. Purves, Heike Weber
Summary: Anxiety disorders are common worldwide and often have early onset, with long-lasting consequences. While research on the genetics of anxiety has lagged behind other psychiatric disorders, progress is being made, offering opportunities for future research and potentially new therapeutic approaches. Investigations into gene-environment interactions and causal associations with related traits and disorders are expected to expand, with a focus on larger sample sizes and studies among young individuals.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Gianluca Ricco, Elisa Andrini, Giambattista Siepe, Cristina Mosconi, Valentina Ambrosini, Claudio Ricci, Riccardo Casadei, Davide Campana, Giuseppe Lamberti
Summary: Merkel cell carcinoma is a skin neuroendocrine tumor, with increasing incidence and potentially curable with multimodal treatment. The optimal management of non-metastatic MCC remains unclear, but promising new treatments like immune checkpoint inhibitors are being explored. Current treatment recommendations focus on localized MCC, with analysis needed for the advantages and disadvantages of different treatment modalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Almir Bitencourt, Isaac Daimiel Naranjo, Roberto Lo Gullo, Carolina Rossi Saccarelli, Katja Pinker
Summary: Advancements in imaging analysis and AI technology have opened up various potential applications in breast imaging, such as breast cancer risk prediction, lesion detection and classification, and radiogenomics. The use of AI tools in breast imaging presents an unprecedented opportunity to extract clinical value from imaging data.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Maryam Hina, Chetna Chauhan, Puneet Kaur, Sascha Kraus, Amandeep Dhir
Summary: The literature on the circular economy business model (CEBM) has been growing rapidly in recent years. However, there has been a lack of critical analysis of the existing literature. This systematic literature review (SLR) aims to critically analyze and evaluate the prior findings on CEBM, identify research gaps, and propose future research agendas. Through analyzing 126 studies, the paper provides a comprehensive assessment of the drivers and barriers of CEBM and presents a conceptual framework based on actor-network theory for further investigation. The study also offers theoretical and practical implications for overcoming barriers and addressing challenges in CEBM implementation.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Business
Maryam Hina, Chetna Chauhan, Rajat Sharma, Amandeep Dhir
Summary: This study conducted a systematic literature review to determine the current state of research on the relationship between the circular economy business model (CEBM) and sustainability. The findings highlight the linkages between CEBM and the pillars of sustainability, including the environmental, social, and economic dimensions. Research gaps within each theme are identified, providing opportunities for future research.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2023)
Review
Parasitology
Santanu Sasidharan, Prakash Saudagar
Summary: Leishmaniasis is a zoonotic disease caused by parasite-infected sandfly bites, with clinical manifestation depending on the parasite species. The review thoroughly examines the past, present, and future of the disease, highlighting the urgent need for new therapeutics and reassessment of measures.
PARASITOLOGY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Zuzanna Swierczewska, Milosz Lewandowski, Agnieszka Surowiecka, Wioletta Baranska-Rybak
Summary: Interest in the microbiome of cutaneous diseases, especially the gut-brain-skin axis, has increased recently. The link between the commensals and the host in the pathogenesis of hidradenitis suppurativa is yet to be established. Studies consistently show increased abundance of specific bacterial species and a loss of commensal species in HS lesions. The role of gut and blood microbiome in HS is not fully understood, but there is a link to an increased risk of developing Crohn's disease and ulcerative colitis. Lifestyle, dietary approaches, and probiotics show promise as adjuvant therapy for HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Computer Science, Software Engineering
Davide Taibi, Josef Spillner, Konrad Wawruch
Summary: Serverless systems are gaining popularity and adoption among many companies, offering a platform for efficient development and deployment of applications without the need to manage underlying infrastructure. However, they also come with new challenges that researchers need to address in the future.
Article
Physics, Multidisciplinary
Pablo Martinez Pancorbo, Huanhuan Zhang, Xingxing Yu, Ting-Hui Xiao, Keisuke Goda
Summary: The emergence of metal-free surface-enhanced Raman scattering (SERS) substrates has provided promising alternatives for reliable, high-sensitivity Raman spectroscopy. This perspective article reviews the theory of metal-free SERS, introduces promising substrates, clarifies challenges, provides potential solutions, and discusses unexploited applications.
Review
Environmental Sciences
Yachana Mishra, Vijay Mishra, Aditi Chattaraj, Alaa A. A. Aljabali, Mohamed El-Tanani, Marzieh Ramezani Farani, Yun Suk Huh, Angel Serrano-Aroca, Murtaza M. Tambuwala
Summary: Water treatment plays a crucial role in addressing global water shortages. Carbon nanotubes (CNTs) show great potential in environmental applications due to their unique physical and chemical characteristics. The utilization of functionalized CNTs and nanocomposites can effectively eliminate contaminants, although their high costs still limit their widespread implementation in water treatment.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Marko Magdi Abdou Sidrak, Maria Silvia De Feo, Ferdinando Corica, Joana Gorica, Miriam Conte, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: Cancer is the leading cause of death globally, followed by heart disease and stroke. Precision medicine has emerged, tailoring diagnostic examinations and therapeutic procedures to individual patients. FAPI is a new tracer used in assessing and treating multiple cancer types. This review collected literature on FAPI theranostics, finding that it shows good tolerability and has potential for future applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Taylor B. Smallwood, Richard J. Clark
Summary: Animal venoms are complex mixtures of bioactive molecules, with disulfide-rich peptides being a major component. The study of venom-derived drugs has led to advancements in treating diseases such as type 2 diabetes and chronic pain. New techniques are expanding the pipeline of venom-derived peptides, offering potential for therapeutic applications and increased understanding of molecular targets.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Harun Norshidah, Ramachandran Vignesh, Ngit Shin Lai
Summary: Approximately 100-400 million people in tropical and subtropical regions are affected by dengue infections, with recent scientific breakthroughs providing new insights into antiviral drugs and vaccines. The search for specific dengue inhibitors is expanding, and a safer and more effective vaccine candidate is progressing through clinical trials. Disease monitoring and vector control will be crucial until effective antiviral therapy and licensed vaccines become available.
Review
Biochemistry & Molecular Biology
Melek P. Khalily, Medine Soydan
Summary: Peptides are increasingly being used in medicine as innovative drugs, imaging agents, theragnostic, and as components of sophisticated drugs. The development of peptide drugs has made significant progress in the last decade, thanks to advancements in chemical synthesis strategies, computational biology, recombinant technology, and chemical biology. Peptides and peptide mimics have been extensively studied in various therapeutic areas, with oncology, metabolism, and endocrinology being the most common medical indications. This review summarizes the current and emerging use of peptides for the diagnosis and treatment of different diseases.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Anesthesiology
Jo Nijs, Astrid Lahousse, Cesar Fontaine-de-las-Penas, Pascal Madeleine, Christel Fontaine, Tomohiko Nishigami, Christine Desmedt, Marian Vanhoeij, Kenza Mostaqim, Antonio I. Cuesta-Vargas, Eleni Kapreli, Paraskevi Bilika, Andrea Polli, Laurence Leysen, Omer Elma, Eva Roose, Emma Rheel, Sevilay Tumkaya Yilmaz, Liesbet De Baets, Eva Huyamans, Ali Turk, Ismail Saracoglu
Summary: Pain after cancer is often underestimated and undertreated. Precision medicine offers a way to classify patients into different subgroups based on their individual characteristics and tailor treatment accordingly. The application of precision medicine to post-cancer pain is an emerging issue, particularly in identifying and treating nociplastic pain. The 2021 IASP clinical criteria provide a framework for classifying and treating nociplastic pain in cancer patients, and the CANPPHE Network aims to implement and improve this approach through a diagnostic manual and case illustrations.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Rinske M. Bults, Johanna M. van Dongen, Raymond W. J. G. Ostelo, Jo Nijs, Doeke Keizer, C. Paul van Wilgen
Summary: This study examined the effectiveness of a primary care multidisciplinary treatment for chronic pain and found no significant differences compared to treatment as usual. However, there were statistically significant effects on patients' illness perceptions in favor of the intervention group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Eva Huysmans, Lisa Goudman, Iris Coppieters, Anneleen Malfliet, Wouter Van Bogaert, Jo Nijs, Maarten Moens, Ronald Buyl, Kelly Ickmans, Koen Putman
Summary: This cross-sectional study investigated the relationship between demographics, pain intensity, and cognitions, and healthcare use in individuals undergoing surgery for lumbar radiculopathy. The results showed that healthcare use was associated with variables such as sex, pain catastrophizing, pain magnification, and leg pain intensity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Silvia Di-Bonaventura, Josue Fernandez-Carnero, Luis Matesanz-Garcia, Alberto Arribas-Romano, Andrea Polli, Raul Ferrer-Pena
Summary: The main objective of this review was to examine the impact of different physiotherapy interventions on BDNF levels and analyze their effects on pain levels. The results showed that rTMS and EIMS interventions were more effective in reducing pain intensity and increasing BDNF levels compared to other physical therapies in chronic myofascial pain patients.
Article
Anesthesiology
Thomas Bilterys, Eveline Van Looveren, Anneleen Malfliet, Jo Nijs, Mira Meeus, Lieven Danneels, Kelly Ickmans, Barbara Cagnie, Dorien Goubert, Maarten Moens, Liesbet De Baets, Wouter Munneke, Olivier Mairesse
Summary: This study aimed to evaluate the relationship and conformity between self-reported and objectively measured sleep parameters. The findings suggest a discrepancy between subjective and objective sleep parameters in people with chronic spinal pain and comorbid insomnia, with participants tending to underestimate total sleep time and overestimate sleep onset latency.
Editorial Material
Orthopedics
Jo Nijs, Anneleen Malfliet, Tomohiko Nishigami
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2023)
Editorial Material
Orthopedics
Jo Nijs, Astrid Lahousse
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2023)
Review
Medicine, General & Internal
Arne Wyns, Jolien Hendrix, Astrid Lahousse, Elke De Bruyne, Jo Nijs, Lode Godderis, Andrea Polli
Summary: Stress has negative impacts on physical and mental health, especially for patients with chronic pain who experience stress intolerance. This paper summarizes the role of the autonomic nervous system and hypothalamus-pituitary-adrenal axis in stress intolerance based on clinical and preclinical studies. The (epi)genetic mechanisms influencing these stress systems are also explored. Understanding the connection between stress, HPA axis, ANS, and chronic health conditions like chronic pain is crucial for improving public health and well-being.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cesar Fernandez-de-las-Penas, Stella Fuensalida-Novo, Jo Nijs, Annalie Basson, Gustavo Plaza-Manzano, Juan A. Valera-Calero, Lars Arendt-Nielsen, Ana I. de-la-Llave-Rincon
Summary: In 2021, the IASP proposed a grading system for classifying patients with carpal tunnel syndrome (CTS) into different pain phenotypes. The presence of a nociplastic or mixed-type pain phenotype in CTS patients may explain the lack of clinical effectiveness of selective treatments targeting the carpal tunnel area. Therefore, identifying the predominant pain phenotype in CTS patients is important for achieving better treatment outcomes.
Article
Biology
Cesar Fernandez-de-las-Penas, Jo Nijs, Barbara Cagnie, Robert D. Gerwin, Gustavo Plaza-Manzano, Juan A. Valera-Calero, Lars Arendt-Nielsen
Summary: Myofascial pain syndrome involves the presence of myofascial trigger points (TrPs), which can cause referred pain. The classification of TrPs as primary or secondary phenomena and their relationship to central or peripheral nervous system disorders is controversial. The International Association for the Study of Pain (IASP) proposed a clinical criteria and grading system in 2021 to classify patients based on nociceptive, neuropathic, or nociplastic pain phenotypes. While myofascial TrP pain is traditionally categorized as nociceptive, evidence suggests it may also be present in patients with predominantly nociplastic pain. Successful clinical treatment outcomes may be achieved by accurately classifying myofascial TrP pain into these phenotypes.
Article
Rehabilitation
Anthe Foubert, Evert Cleenders, Marijke Sligchers, Lisette Heystee, Mira Meeus, Peter Vaes, Jo Nijs, Nathalie A. Roussel
Summary: This prospective cohort study aimed to determine the associations between baseline psychological factors, PPTs, and CPM in (S)ALBP and disability after 3 months. Multiple linear regression analysis showed no significant associations between baseline factors and disability at follow-up.
JOURNAL OF MANUAL & MANIPULATIVE THERAPY
(2023)
Review
Rehabilitation
Adrian Escriche-Escuder, Jo Nijs, Karin G. Silbernagel, C. Paul van Wilgen, Melanie L. Plinsinga, Jose Casana, Antonio I. Cuesta-Vargas
Summary: This scoping review examined the effects and content of pain neuroscience education for patients with persistent painful tendinopathies. The findings suggest that the use of pain neuroscience education in conjunction with other interventions can improve various outcomes. However, due to limited knowledge of tendon pain and a lack of well-designed trials on pain neuroscience education in tendinopathy, further research is needed.
PHYSICAL THERAPY IN SPORT
(2023)
Editorial Material
Orthopedics
Jo Nijs, Liesbet De Baets, Paul Hodges
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2023)
Article
Microbiology
Cesar Fernandez-de-las-Penas, Carlos Guijarro, Juan Torres-Macho, Oscar J. Pellicer-Valero, Ana Franco-Moreno, Jo Nijs, Maria Velasco-Arribas
Summary: This study investigates the association between serological biomarkers and hospitalization treatments with sensitization-associated symptoms in COVID-19 survivors with post-COVID pain. The findings suggest that these symptoms are not associated with serological biomarkers at hospital admission and treatments received during hospitalization.
Article
Medicine, General & Internal
Iris Coppieters, Jo Nijs, Mira Meeus, Margot De Kooning, Emma Rheel, Eva Huysmans, Roselien Pas, Wouter Van Bogaert, Ives Hubloue, Kelly Ickmans
Summary: This study aimed to investigate the role of serotonergic and noradrenergic descending pathways in cognitive functioning in chronic whiplash-associated disorders (CWAD). The results showed that a single dose of Atomoxetine improved selective attention, while Citalopram had no significant effect. Exercise improved selective attention without medication intake, but worsened cognitive performance after taking Citalopram or Atomoxetine.
CLINICS AND PRACTICE
(2023)
