Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

(2019) Kenta Tsutsumi et al.   Nature Communications

Upregulation of AcrEF in Quinolone Resistance Development in Escherichia coli When AcrAB-TolC Function Is Impaired

(2018) Chuan-Zhen Zhang et al.   Microbial Drug Resistance

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

(2017) Xuan Wang-Kan et al.   mBio

Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump

(2017) Anthony W. P. Fitzpatrick et al.   Nature Microbiology

Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

(2017) Venkata Krishnan Ramaswamy et al.   Scientific Reports

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria

(2016) Yinhu Wang et al.   CURRENT DRUG TARGETS

Opening the Channel: the Two Functional Interfaces of Pseudomonas aeruginosa OpmH with the Triclosan Efflux Pump TriABC

(2016) Abigail T. Ntreh et al.   JOURNAL OF BACTERIOLOGY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC

(2016) Hyeongseop Jeong et al.   STRUCTURE

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

(2016) Michelle M. C. Buckner et al.   mBio

Tripartite assembly of RND multidrug efflux pumps

(2016) Laetitia Daury et al.   Nature Communications

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

(2016) Dilay Hazal Ayhan et al.   PLOS BIOLOGY

Computational prediction of protein interfaces: A review of data driven methods

(2015) Li C. Xue et al.   FEBS LETTERS

MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium

(2015) Saemee Song et al.   INFECTION AND IMMUNITY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies

(2015) Martyn F. Symmons et al.   Frontiers in Microbiology

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance

(2014) Jessica MA Blair et al.   Future Microbiology

Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

(2014) Jessica M. A. Blair et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Genetic assessment of the role of AcrB β-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump ofEscherichia coli

(2014) Jon W. Weeks et al.   MOLECULAR MICROBIOLOGY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

AcrB, AcrD, and MdtABC Multidrug Efflux Systems Are Involved in Enterobactin Export in Escherichia coli

(2014) Tsukasa Horiyama et al.   PLoS One

Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success

(2014) Liam S. Redgrave et al.   TRENDS IN MICROBIOLOGY

MacA, a Periplasmic Membrane Fusion Protein of the Macrolide Transporter MacAB-TolC, Binds Lipopolysaccharide Core Specifically and with High Affinity

(2013) S. Lu et al.   JOURNAL OF BACTERIOLOGY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Membrane Fusion Proteins of Type I Secretion System and Tripartite Efflux Pumps Share a Binding Motif for TolC in Gram-Negative Bacteria

(2012) Minho Lee et al.   PLoS One

Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

(2011) Matthew E Wand et al.   BMC MICROBIOLOGY

Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC

(2011) Elena B. Tikhonova et al.   CHEMISTRY & BIOLOGY

AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium

(2011) Seiji Yamasaki et al.   JOURNAL OF ANTIBIOTICS

The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter

(2011) Sita D. Modali et al.   MOLECULAR MICROBIOLOGY

Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli

(2011) Chih-Chia Su et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium

(2010) Tsukasa Horiyama et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli

(2010) N. G. Coldham et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems

(2010) F. De Angelis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Only for substrate antibiotics are a functional AcrAB-TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium

(2009) V. Ricci et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium

(2009) J. M. A. Blair et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The C-Terminal Domain of AcrA Is Essential for the Assembly and Function of the Multidrug Efflux Pump AcrAB-TolC

(2009) Q. Ge et al.   JOURNAL OF BACTERIOLOGY

Crystal Structure of the Periplasmic Component of a Tripartite Macrolide-Specific Efflux Pump

(2009) Soohwan Yum et al.   JOURNAL OF MOLECULAR BIOLOGY

The assembled structure of a complete tripartite bacterial multidrug efflux pump

(2009) M. F. Symmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and functional diversity of bacterial membrane fusion proteins

(2008) Helen I. Zgurskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS