Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Chemistry, Medicinal
Seyed Ehsan Mousavi, Farhad Tondro Anamag, Sarvin Sanaie
Summary: A meta-analysis of seven studies suggests that cannabis consumption is associated with a lower risk of developing type 2 diabetes mellitus when compared to non-users.
PHYTOTHERAPY RESEARCH
(2023)
Review
Environmental Sciences
Shan Wu, Wenjing Du, Xiangbin Zhong, Junqi Lu, Fei Wen
Summary: The association between road traffic noise and type 2 diabetes (T2DM) is inconsistent. However, a meta-analysis of cohort studies suggests that increasing exposure to road traffic noise may be associated with a higher risk of T2DM. The analysis included 8 cohort studies with a total of 4,989,846 participants and 416,799 diabetes cases. Sensitivity analyses and assessment of publication bias were also conducted.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Geriatrics & Gerontology
Hongmei Wu, Yeqing Gu, Xuena Wang, Ge Meng, Sabina Rayamajhi, Amrish Thapa, Qing Zhang, Li Liu, Shunming Zhang, Tingjing Zhang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
Summary: In this study, relative handgrip strength was found to be inversely associated with incident type 2 diabetes, while absolute handgrip strength showed no significant association. Meta-analysis results further supported the superiority of relative handgrip strength in predicting T2DM.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Ioannis Avgerinos, Thomas Karagiannis, Panagiota Kakotrichi, Theodoros Michailidis, Aris Liakos, David R. Matthews, Apostolos Tsapas, Eleni Bekiari
Summary: Sotagliflozin demonstrates efficacy in reducing blood glucose, body weight, and systolic blood pressure in patients with type 2 diabetes, with beneficial effects on heart failure and myocardial infarction. Its overall safety profile is comparable with other sodium-glucose cotransporter-2 inhibitors.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yining Wang, Liming Yu, Zhiqiang Ye, Rui Lin, Antonia RuJia Sun, Lingna Liu, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Li Li, Yanzhi Liu
Summary: Through a systematic review and meta-analysis, it was found that there was no significant correlation between fracture risk and metformin application in type 2 diabetes mellitus patients. Further research is needed to make a definite conclusion due to the limited number of existing studies, providing clinical consensus with more evidence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ana-Catarina Pinho-Gomes, Georgia Morelli, Alexandra Jones, Mark Woodward
Summary: The study found a negative association between lactation and maternal risk of type 2 diabetes, particularly in women with gestational diabetes, with the protective effect increasing with longer duration of lactation.
DIABETES OBESITY & METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Wenting Xie, Fugui Su, Guizhong Wang, Zichong Peng, Yaomin Xu, Yi Zhang, Ningning Xu, Kaijian Hou, Zhuping Hu, Yan Chen, Rongping Chen
Summary: Berberine has glucose-lowering effects in type 2 diabetes and its efficacy is related to the baseline fasting plasma glucose and glycosylated hemoglobin levels of patients. Treatment with berberine does not increase the risk of adverse events or hypoglycemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Li Liu, Fang-Hong Shi, Hua Xu, Yue Wu, Zhi-Chun Gu, Hou-Wen Lin
Summary: Ertugliflozin is effective and well tolerated in patients with type 2 diabetes compared to placebo or other hypoglycemic agents, with the exception of an increased risk of genital mycotic infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Jielin Zhou, Yan Lin, Yong Liu, Keyang Chen
Summary: The study revealed a link between antibiotic exposure and an increased risk of type 2 diabetes mellitus, especially in individuals over the age of 50. This suggests that caution should be exercised by physicians when prescribing antibiotics to potentially reduce the risk of T2DM.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Leila Ismail, Huned Materwala, Juma Al Kaabi
Summary: Diabetes is a leading cause of severe health complications and death globally, with no cure available, requiring preventive measures. This systematic review identifies major risk factors for type 2 diabetes incidence/prevalence and analyzes their impact on the disease. Insights and recommendations are provided for better diagnosis and prognosis, targeting healthcare professionals, individuals, and government institutions.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Endocrinology & Metabolism
Eleonora Grespan, Annamaria Guolo, Elza Muscelli, Ele Ferrannini, Andrea Mari
Summary: This study uses a meta-analytic approach to quantify the impairment of the incretin effect (IE) in type 2 diabetes (T2D) and investigates the factors associated with this impairment. The results show that IE is significantly impaired in T2D patients and is influenced by age, glucose tolerance, BMI, and fasting GIP.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Rui Song, Weiting Hu, Rui Cheng, Yibo Zhao, Weiwei Qin, Xing Li, Yikun Zhu, Lu Gan, Jing Liu
Summary: This systematic review and meta-analysis revealed that circulating levels of CTRP9 were lower in patients with type 2 diabetes mellitus (T2DM), both with and without complications. However, further studies with larger sample sizes are needed to validate these findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Milad Davarpanah, Nafiseh Shokri-mashhadi, Rahele Ziaei, Parvane Saneei
Summary: Multiple epidemiologic studies have shown that circulating brain-derived neurotrophic factor (BDNF) levels are lower in patients with type 2 diabetes and other glycemic disorders compared to healthy controls. However, there is no significant correlation between BDNF concentrations and glycemic parameters such as fasting blood glucose, insulin resistance, and glycosylated hemoglobin. Further prospective investigations are needed to confirm these findings.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Milena Cioana, Jiawen Deng, Ajantha Nadarajah, Maggie Hou, Yuan Qiu, Sondra Song Jie Chen, Angelica Rivas, Laura Banfield, Parm Pal Toor, Fangwen Zhou, Ayla Guven, Haifa Alfaraidi, Ahlam Alotaibi, Lehana Thabane, M. Constantine Samaan
Summary: The findings of this systematic review and meta-analysis suggest that obesity is not a universal phenotype in children with T2D. Male participants had a higher risk of obesity compared to female participants, and Asian participants had the lowest prevalence of obesity while White participants had the highest prevalence.
Article
Multidisciplinary Sciences
Ben Hollis, Felix R. Day, Alexander S. Busch, Deborah J. Thompson, Ana Luiza G. Soares, Paul R. H. J. Timmers, Alex Kwong, Doug F. Easton, Peter K. Joshi, Nicholas J. Timpson, Ken K. Ong, John R. B. Perry
NATURE COMMUNICATIONS
(2020)
Article
Medicine, General & Internal
Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Stephen J. Sharp, Felix R. Day, Fumiaki Imamura, Thomas E. Gundersen, Luca A. Lotta, Ivonne Sluijs, Isobel D. Stewart, Rupal L. Shah, Yvonne T. van der Schouw, Eleanor Wheeler, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Christina C. Dahm, Niki Dimou, Douae El-Fatouhi, Paul W. Franks, Guy Fagherazzi, Sara Grioni, Jose Maria Huerta, Alicia K. Heath, Louise Hansen, Mazda Jenab, Paula Jakszyn, Rudolf Kaaks, Tilman Kuehn, Kay-Tee Khaw, Nasser Laouali, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Anja Olsen, Salvatore Panico, J. Ramon Quiros, Olov Rolandsson, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Annemieke M. W. Spijkerman, Tammy Y. N. Tong, Rosario Tumino, Konstantinos K. Tsilidis, John Danesh, Elio Riboli, Adam S. Butterworth, Claudia Langenberg, Nita G. Forouhi, Nicholas J. Wareham
Review
Endocrinology & Metabolism
Karan R. Chadda, Tuck Seng Cheng, Ken K. Ong
Summary: GLP-1 agonists show promising efficacy in treating children with obesity and/or T2DM, with positive effects on reducing HbA1c and body weight. Adverse effects mainly include gastrointestinal symptoms and minor hypoglycemic episodes.
Article
Medicine, General & Internal
Benjamin I. Perry, Stephen Burgess, Hannah J. Jones, Stan Zammit, Rachel Upthegrove, Amy M. Mason, Felix R. Day, Claudia Langenberg, Nicholas J. Wareham, Peter B. Jones, Golam M. Khandaker
Summary: Insulin resistance and cardiometabolic traits are unlikely to have a causal role in the pathogenesis of schizophrenia. However, inflammation is associated with both schizophrenia and insulin resistance, potentially explaining their common occurrence in clinical practice. Therapeutic interventions targeting inflammation may be beneficial for the prevention and treatment of both schizophrenia and comorbid insulin resistance, with further research needed to understand the underlying biological mechanisms.
Article
Nutrition & Dietetics
Tuck Seng Cheng, Stephen J. Sharp, Soren Brage, Pauline M. Emmett, Nita G. Forouhi, Ken K. Ong
Summary: This study found that in childhood, total energy intake and protein intake may be potential modifiable determinants of puberty timing. Higher total energy intake in boys was associated with earlier voice breaking, while in girls higher total energy intake was associated with earlier B2, PHV, and menarche. Higher protein intake in girls was also associated with earlier B2, PHV, and menarche.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Summary: The study identifies loss-of-function alleles in the GIGYF1 gene associated with six-fold higher susceptibility to both LOY and Type 2 Diabetes, as well as adverse metabolic health. This highlights a potential direct connection between clonal mosaicism and metabolic health.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Tuck Seng Cheng, Felix R. Day, John R. B. Perry, Jian'an Luan, Claudia Langenberg, Nita G. Forouhi, Nicholas J. Wareham, Ken K. Ong
Summary: This study found that dietary and plasma phospholipid fatty acids were associated with puberty timing in girls but not in boys. Specifically, the intake of polyunsaturated fatty acids and certain fatty acids were linked to earlier puberty traits in girls. The findings suggest that dietary and endogenous metabolic pathways affecting plasma dihomo-gamma-linolenic acid may influence the timing of puberty in girls.
Article
Multidisciplinary Sciences
B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Goncalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, X. Dai, E. G. Bochukova, R. C. Trembath, H. C. Martin, A. P. Coll, D. H. Rowitch, N. J. Wareham, D. A. van Heel, N. Timpson, R. B. Simerly, K. K. Ong, R. D. Cone, C. Langenberg, J. R. B. Perry, G. S. Yeo, S. O'Rahilly
Summary: MC3R regulates the timing of sexual maturation, linear growth rate, and accrual of lean mass, while MC4R controls appetite, food intake, and energy expenditure. Loss of MC3R leads to delayed puberty, reduced linear growth, and decreased lean mass, while loss of MC4R results in delayed sexual maturation and insensitivity of reproductive cycle length to nutritional perturbation.
Article
Endocrinology & Metabolism
Tuck Seng Cheng, Nasloon Ali, Iffat Elbarazi, Rami H. Al-Rifai, Fatma Al-Maskari, Tom Loney, Luai A. Ahmed
Summary: The study found that in the Mutaba'ah Study in the United Arab Emirates, many pregnant women were overweight or obese before pregnancy, and most of them had excessive or inadequate gestational weight gain. Factors such as higher parity, lower maternal education, infertility treatment, and maternal active smoking were associated with higher prepregnancy BMI. Additionally, women with higher parity were less likely to experience excessive gestational weight gain when they were normal weight before pregnancy, and higher maternal education was negatively associated with inadequate gestational weight gain among women with normal weight and overweight.
OBESITY SCIENCE & PRACTICE
(2022)
Review
Obstetrics & Gynecology
Tuck Seng Cheng, Ken K. Ong, Frank M. Biro
Summary: This article discusses early puberty in girls, including the possible mechanisms such as endocrine-disrupting chemicals and obesity, as well as the potential health impacts on women. The second paper will focus on clinical management and public health prevention.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Tuck Seng Cheng, Ken K. Ong, Frank M. Biro
Summary: This article discusses the public health implications of early puberty, including its effects on mental health, risky behaviors, cardiometabolic health, and hormone-related cancers such as breast cancer. It also provides recommendations for clinical management and public health considerations.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2022)
Article
Genetics & Heredity
Nicola Pirastu, Ciara McDonnell, Eryk K. Grzeszkowiak, Ninon Mounier, Fumiaki K. Imamura, Jordi R. Merino, Felix Day, Jie Zheng, Nele F. Taba, Maria Pina Concas, Linda Repetto, Katherine Kentistou, Antonietta Robino, Tonu Esko, Peter Joshi, Krista Fischer, Ken Ong, Tom Gaunt, Zoltan Kutalik, John R. B. Perry, James Wilson
Summary: Diet is a crucial factor in human health, and using Mendelian randomization, this study provides evidence of causal associations between specific eating patterns and obesity, blood lipid status, and several other risk factors and health outcomes.
Review
Endocrinology & Metabolism
Duaa Olwi, Felix Day, Ken Ong
Summary: This study systematically reviewed the evidence on the effect of rhGH on pubertal timing. The results showed significant differences in the effects of rhGH on pubertal timing among different clinical indications. Only children with idiopathic short stature showed earlier pubertal timing with rhGH treatment.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Tuck Seng Cheng, Soren Brage, Esther M. F. van Sluijs, Ken K. Ong
Summary: This study examines the association between physical activity and puberty timing in boys and girls. The findings suggest that higher levels of physical activity are associated with a lower risk of early puberty, particularly in girls. These findings are important for understanding the relationship between puberty timing and physical activity.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)