Article
Oncology
Satoru Yokoyama, Atsushi Takahashi, Ryota Kikuchi, Soshi Nishibu, Jennifer A. Lo, Miroslav Hejna, Wooyoung M. Moon, Shinichiro Kato, Yue Zhou, F. Stephen Hodi, Jun S. Song, Hiroaki Sakurai, David E. Fisher, Yoshihiro Hayakawa
Summary: This study identifies a novel SOX10/IRF4 pathway that regulates noncanonical induction of IRF1 independent of the JAK-STAT pathway and can be targeted to improve the efficacy of anti-PD-1 therapy in melanoma.
Article
Immunology
Bryan M. Rogers, Laura Smith, Zoltan Dezso, Xu Shi, Enrico DiGiammarino, Denny Nguyen, Sunantha Sethuraman, Pingping Zheng, Donghee Choi, Dong Zhang, Andrew Nguyen, Kathleen McGuire, Wei Liu, Namjin Chung, Debra T. Chao, Shiming Ye, Gabriel R. Starbeck-Miller
Summary: VISTA is considered an inhibitory protein that limits immune responses, but the effects of its agonism on immune cell biology are not yet clear. This study identified two novel VISTA antibodies that elicit transcriptional and functional changes in monocytes by agonizing VISTA. The research sheds light on previously unknown aspects of VISTA biology in myeloid cells and lays the foundation for future studies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Xiufang Yang, Huilan Du, Wenhui Bian, Qingxue Li, Hairu Sun
Summary: This study demonstrated that FOXD3-AS1 is upregulated in cervical cancer tissues and cells, promoting cell proliferation, migration, and invasion. High FOXD3-AS1 expression is associated with poor tumor differentiation, increased tumor size, and lymph node metastasis. FOXD3-AS1 directly targets miR-128-3p, leading to upregulation of LIMK1 expression in cervical cancer cells, thus facilitating cervical cancer progression.
Article
Developmental Biology
Manuel Rocha, Elaine Kushkowski, Ruby Schnirman, Clare Booth, Noor Singh, Alana Beadell, Victoria E. Prince
Summary: The neural crest (NC) is a transient multipotent cell population that migrates extensively to produce a remarkable array of vertebrate cell types. NC cell specification progresses in an anterior to posterior fashion, resulting in distinct, axial-restricted subpopulations. The homeodomain transcription factor Cdx4 plays a critical role in the development of posterior NC cells in zebrafish embryos, regulating the expression of key genes and influencing migratory behaviors.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D'Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Amelia Fasci, Leonardo Chieregato, Ana Paula Rebelo, Marta Giacomello, Antonio Rosato, Ildiko Szabo, Chiara Romualdi, Mauro Piacentini, Luigi Leanza
Summary: This article investigates the plasticity of melanoma and the role of Transglutaminase Type-2 (TG2) in regulating melanoma formation and invasiveness. The results suggest that TG2 expression can affect melanoma invasiveness and may contribute to unraveling the vulnerabilities of melanoma.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Rana S. Moubarak, Ana De Pablos-Aragoneses, Vanessa Ortiz-Barahona, Yixiao Gong, Michael Gowen, Igor Dolgalev, Sorin A. A. Shadaloey, Diana Argibay, Alcida Karz, Richard Von Itter, Eleazar Carmelo Vega-Saenz De Miera, Elena Sokolova, Farbod Darvishian, Aristotelis Tsirigos, Iman Osman, Eva Hernando
Summary: In this study, the researchers identified PHF8 as a previously unidentified prometastatic gene in melanoma. They found that PHF8 promotes cell invasion and is involved in the TGF beta signaling pathway, providing new insights into the epigenetic regulation of metastasis in cancer.
Review
Immunology
Yuhan Chen, Xiuli Yi, Ningyue Sun, Weinan Guo, Chunying Li
Summary: This review introduces the epidemiology, clinical characteristics, and therapeutic innovations of melanoma, discusses the tumor microenvironment and functions of different types of infiltrating immune cells in melanoma, systematically summarizes the linkage between epigenetics and antitumor immunity in melanoma, and introduces the progress of clinical trials regarding epigenetics-based melanoma immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nour el Imane Issam Salah, Farida Marnissi, Abdelhakim Lakhdar, Mehdi Karkouri, Mohamed Elbelhadji, Abdallah Badou
Summary: This study analyzed the expression of a novel immune checkpoint, VISTA, in the rare and deadly tumor UM. The results showed that VISTA expression was associated with tumor aggressiveness, T cell exhaustion, and poor overall survival. VISTA may serve as a prognostic marker and a potential target for immunotherapy in UM patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guang-Liang Chen, Rui Li, Xiao-Xiang Chen, Juan Wang, Shan Cao, Rui Song, Ming-Chun Zhao, Li-Ming Li, Nicole Hannemmann, Georg Schett, Cheng Qian, Aline Bozec
Summary: Metastatic melanoma is a challenging disease, and understanding the molecular mechanisms behind its metastasis is crucial. The downregulation of AP-1 transcription factor member Fra-2 in melanoma cells is associated with a more aggressive phenotype both in vitro and in vivo. Further research revealed that the Fra-2-Fam212b axis plays a key role in promoting melanoma metastasis by affecting cell migration, invasion, cell cycle transition, and tissue angiogenesis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Anja Wessely, Theresa Steeb, Carola Berking, Markus Vincent Heppt
Summary: Early detection is crucial for the prognosis of cutaneous melanoma, and new therapies have significantly improved patient survival. The aggressiveness of melanoma is closely related to the embryonic origin of melanocytes and melanoma cells, as well as cellular plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Altaf A. Dar, James R. Miller, Stanley P. Leong, Kevin B. Kim, Wilson Liao, Liliana Soroceanu, Sean McAllister, Robert J. Debs, Dirk Schadendorf, Sancy A. Leachman, James E. Cleaver, Mohammed Kashani-Sabet
Summary: The activation of nuclear receptor coactivator 3 (NCOA3) contributes to melanoma development following exposure to ultraviolet light, while downregulation of NCOA3 expression can suppress melanoma proliferation and increase the sensitivity of melanoma cells to UV radiation.
Article
Multidisciplinary Sciences
Haijun Zhu, Mengshi Kang, Xinping Bai
Summary: The study confirmed that miR-10a-5p had lower expression in melanoma cells and high expression suppressed the proliferation, migration, and invasion abilities. It was also found that miR-10a-5p targeted LIN28B mRNA and decreased LIN28B protein expression. TCF21 upregulation led to decreased LIN28B expression and increased miR-10a-5p expression, revealing a potential regulatory relationship between TCF21 and miR-10a-5p in melanoma.
Article
Biochemistry & Molecular Biology
Gamze Kuser-Abali, Youfang Zhang, Pacman Szeto, Peinan Zhao, Samar Masoumi-Moghaddam, Clare G. Fedele, Isobel Leece, Cheng Huang, Jen G. Cheung, Malaka Ameratunga, Fumihito Noguchi, Miles C. Andrews, Nicholas C. Wong, Ralf B. Schittenhelm, Mark Shackleton
Summary: Cellular heterogeneity in melanoma is regulated by melanin pigment content and EZH2 protein. Conventional EZH2 methyltransferase inhibitors have no effect on low-pigmented melanoma cells (LPCs), but silencing or degradation of EZH2 inhibits LPC growth and induces high-pigmented melanoma cells (HPCs). The E2-conjugating enzyme UBE2L6 and E3 ligase UBR4 regulate EZH2 protein levels via ubiquitination in LPCs and are downregulated by UHRF1-mediated CpG methylation. Targeting UHRF1/UBE2L6/UBR4-mediated regulation of EZH2 may have therapeutic potential in melanoma.
Article
Multidisciplinary Sciences
Hyungsoo Kim, Yongmei Feng, Rabi Murad, Joanna Pozniak, Carl Pelz, Yeqing Chen, Bhavik Dalal, Rosalie Sears, Eduard Sergienko, Michael Jackson, Eytan Ruppin, Meenhard Herlyn, Curtis Harris, Jean-Christophe Marine, Victoria Klepsch, Gottfried Baier, Ze'ev A. Ronai
Summary: The orphan nuclear receptor NR2F6 has a tumor-intrinsic function in regulating antitumor immunity. It plays a role in tumor development and the abundance of CD8(+) T cells. Blocking NR2F6 enhances the efficacy of PD-1 therapy and could be a promising anticancer treatment strategy.
Article
Dermatology
J. Kim, H. Choi
Summary: The study found that several mucin proteins are expressed in human skin cells, among which MUCL1 has the highest expression and a clear negative correlation with melanin production in epidermal melanocytes. The research revealed a novel mechanism of mucin regulation with diagnostic and preventive roles of MUCL1 in cutaneous melanoma, suggesting an association between MUCL1, threonine, melanogenesis, and metastasis-related genes in melanoma cells.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
Yuling Wang, Vijaya Ramachandran, Dawen Sui, Kejing Xu, Lauren E. Haydu, Shenying Fang, Jennifer L. McQuade, Sarah B. Fisher, Anthony Lucci, Emily Z. Keung, Jennifer Wargo, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey E. Lee
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Russell G. Witt, Brandon Cope, Yi-Ju Chiang, Timothy Newhook, Heather Lillemoe, Ching-Wei D. Tzeng, Iris B. Chen, Sarah B. Fisher, Anthony Lucci, Jennifer A. Wargo, Jeffrey E. Lee, Merrick Ross, Jeffrey E. Gershenwald, Justine Robinson, Emily Z. Keung
Summary: After an opioid education initiative for patients undergoing lymphadenectomy for cutaneous malignancy, there were significant improvements in prescribing practices, with non-opioid analgesics utilization more than doubling and a 60% reduction in median oral morphine equivalents prescribed.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Letter
Dermatology
J. Trinidad, C. K. Gabel, J. J. Han, L. Bonomo, A. Cartron, S. Chand, W. Coburn, S. Daveluy, M. Davis, K. L. DeNiro, L. M. Guggina, K. Hennessy, M. Hoffman, K. Katz, J. J. Keller, S. J. Kim, S. Konda, E. Lake, F. N. Lincoln, J. A. Lo, A. Markova, E. K. Marvin, R. G. Micheletti, S. Newman, F. N. U. Nutan, C. V. Nguyen, V. Pahalyants, J. Patel, S. Rahnama-Moghadam, P. V. Rambhatla, M. Riegert, R. E. Reingold, D. B. Robinson, R. Rrapi, J. C. Sartori-Valinotti, L. Seminario-Vidal, Z. Sharif-Sidi, J. Smogorzewski, N. Spaccarelli, J. R. Stewart, S. D. Tuttle, M. N. Ulrich, K. A. Wanat, F. Di Xia, B. Kaffenberger, D. Kroshinsky
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
ChuanLiang Cui, Bin Lian, XiaoShi Zhang, Di Wu, Ke Li, Lu Si, Yue Yang, Hui Tian, Li Zhou, ZhiHong Chi, XiNan Sheng, Yan Kong, LiLi Mao, Xuan Wang, Xue Bai, XieQiao Yan, SiMing Li, Jie Dai, BiXia Tang, Xiaoting Wei, Jeffrey E. Gershenwald, Charles M. Balch, Jun Guo
Summary: Based on a study of 1814 MuM patients, researchers have proposed a staging system for mucosal melanoma that incorporates all anatomical primary tumor sites and can be used to guide the design of clinical trials.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Edmund K. Bartlett, Douglas Grossman, Susan M. Swetter, Sancy A. Leachman, Clara Curiel-Lewandrowski, Stephen W. Dusza, Jeffrey E. Gershenwald, John M. Kirkwood, Amy L. Tin, Andrew J. Vickers, Michael A. Marchetti
ANNALS OF SURGICAL ONCOLOGY
(2022)
Correction
Oncology
Alexander C. J. van Akkooi, Tina J. Hieken, Elizabeth M. Burton, Charlotte Ariyan, Paolo A. Ascierto, Salvatore V. M. A. Asero, Christian U. Blank, Matthew S. Block, Genevieve M. Boland, Corrado Caraco, Sydney Chng, B. Scott Davidson, Joao Pedreira Duprat Neto, Mark B. Faries, Jeffrey E. Gershenwald, Dirk J. Grunhagen, David E. Gyorki, Dale Han, Andrew J. Hayes, Winan J. van Houdt, Giorgos C. Karakousis, Willem M. C. Klop, Georgina V. Long, Michael C. Lowe, Alexander M. Menzies, Roger Olofsson Bagge, Thomas E. Pennington, Piotr Rutkowski, Robyn P. M. Saw, Richard A. Scolyer, Kerwin F. Shannon, Vernon K. Sondak, Hussein Tawbi, Alessandro A. E. Testori, Mike T. Tetzlaff, John F. Thompson, Jonathan S. Zager, Charlotte L. Zuur, Jennifer A. Wargo, Andrew J. Spillane, Merrick I. Ross
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Edmund K. Bartlett, Douglas Grossman, Susan M. Swetter, Sancy A. Leachman, Clara Curiel-Lewandrowski, Stephen W. Dusza, Jeffrey E. Gershenwald, John M. Kirkwood, Amy L. Tin, Andrew J. Vickers, Michael A. Marchetti
Summary: This study provides the first estimates of clinically significant treatment thresholds based on the risk of recurrence for patients with primary cutaneous melanoma, representing an early step towards individualizing treatment recommendations.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
ChuanLiang Cui, Bin Lian, XiaoShi Zhang, Di Wu, Ke Li, Lu Si, Yue Yang, Hui Tian, Li Zhou, ZhiHong Chi, XiNan Sheng, Yan Kong, LiLi Mao, Xuan Wang, Xue Bai, XieQiao Yan, SiMing Li, Jie Dai, BiXia Tang, Xiaoting Wei, Jeffrey E. Gershenwald, Charles M. Balch, Jun Guo
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Claudia Capparelli, Timothy J. Purwin, McKenna Glasheen, Signe Caksa, Manoela Tiago, Nicole Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W. Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, Andrew E. Aplin
Summary: Cellular plasticity plays a crucial role in tumor heterogeneity and phenotype switching. SOX10 is involved in the phenotypic switching of cutaneous melanoma, and cIAP1/2 inhibitors can selectively induce cell death in SOX10-deficient cells.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Andrew W. Hahn, Ashley Menk, Dayana B. Rivadeneira, Ryan C. Augustin, Mingchu Xu, Jun Li, Xiaogang Wu, Aditya K. Mishra, Tuba N. Gide, Camelia Quek, Yan Zang, Christine N. Spencer, Alexander M. Menzies, Carrie R. Daniel, Courtney W. Hudgens, Theodore Nowicki, Lauren E. Haydu, M. A. Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M. Burton, Jared Malke, Julie M. Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E. Woodman, Y. N. Vashisht Gopal, Renato Guerrieri, Grant M. Fischer, Jian Wang, Khalida M. Wani, John F. Thompson, Jeffrey E. Lee, Patrick Hwu, Nadim Ajami, Jeffrey E. Gershenwald, Georgina Long, Richard A. Scolyer, Michael T. Tetzlaff, Alexander J. Lazar, Dirk Schadendorf, Jennifer A. Wargo, John M. Kirkwood, Ralph J. DeBerardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S. Wilmott, Weiyi Peng, Michael A. Davies, Greg M. Delgoffe, Yana G. Najjar, Jennifer L. McQuade
Summary: This study investigated the association between body mass index (BMI) and tumor or microbiome characteristics in patients with metastatic melanoma. The findings suggest that the host metabolic phenotype influences melanoma metabolism and may explain the improved outcomes observed in overweight/obese patients treated with immune checkpoint inhibitors and targeted therapies.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Merve Hasanov, Denai R. Milton, Alicia Bea Davies, Elizabeth Sirmans, Chantal Saberian, Eliza L. Posada, Sylvia Opusunju, Jeffrey E. Gershenwald, Carlos A. Torres-Cabala, Elizabeth M. Burton, Rivka R. Colen, Jason T. Huse, Isabella C. Glitza Oliva, Caroline Chung, Mary Frances McAleer, Susan L. McGovern, Debra N. Yeboa, Betty Y. S. Kim, Sujit S. Prabhu, Ian E. McCutcheon, Jeffrey S. Weinberg, Frederick F. Lang, Hussein A. Tawbi, Jing Li, Lauren E. Haydu, Michael A. Davies, Sherise D. Ferguson
Summary: This study evaluates changes in clinical features and overall survival (OS) for patients with melanoma brain metastasis (MBM). The treatment options for MBM have significantly changed in the last decade, leading to improved OS. Factors associated with survival in MBM patients include patient age, primary tumor Breslow thickness, prior immunotherapy, leptomeningeal disease, symptomatic MBMs, and whole brain radiation therapy in the current era.
Editorial Material
Oncology
Jeffrey E. Gershenwald
Summary: The prognostic significance of primary cutaneous melanoma tumor mitotic rate (TMR) has been of interest in the clinical field worldwide for many years. Is there a way to utilize the findings from Patuzzo et al. and other studies to enhance the classification and staging of melanoma, as well as develop clinical tools that incorporate TMR for improved risk and prognostic assessment?
Article
Oncology
Elliot A. Asare, Sarah B. Fisher, Yi-Ju Chiang, Lauren E. Haydu, Sameer H. Patel, Emily Z. Keung, Anthony Lucci, Jennifer Wargo, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey. E. Lee
Summary: Adrenectomy in patients with metastatic melanoma is associated with prolonged survival, especially when done selectively. Factors such as immune checkpoint blockade therapy and selection for surgery were found to be strongly associated with improved survival after adrenal metastasis diagnosis.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Correction
Multidisciplinary Sciences
Rodabe N. Amaria, Michael Postow, Elizabeth M. Burton, Michael T. Tetzlaff, Merrick I. Ross, Carlos Torres-Cabala, Isabella C. Glitza, Fei Duan, Denai R. Milton, Klaus Busam, Lauren Simpson, Jennifer L. McQuade, Michael K. Wong, Jeffrey E. Gershenwald, Jeffrey E. Lee, Ryan P. Goepfert, Emily Z. Keung, Sarah B. Fisher, Allison Betof-Warner, Alexander N. Shoushtari, Margaret Callahan, Daniel Coit, Edmund K. Bartlett, Danielle Bello, Parisa Momtaz, Courtney Nicholas, Aidi Gu, Xuejun Zhang, Brinda Rao Korivi, Madhavi Patnana, Sapna P. Patel, Adi Diab, Anthony Lucci, Victor G. Prieto, Michael A. Davies, James P. Allison, Padmanee Sharma, Jennifer A. Wargo, Charlotte Ariyan, Hussein A. Tawbi
Article
Oncology
Arthur R. Wolin, Melanie Y. Vincent, Taylor Hotz, Stephen C. Purdy, Sheera R. Rosenbaum, Connor J. Hughes, Jessica Y. Hsu, Michael U. J. Oliphant, Brock Armstrong, Veronica Wessells, Marileila Varella-Garcia, Matthew D. Galbraith, Angela Pierce, Dong Wang, Sujatha Venkataraman, Etienne Danis, Bethany Veo, Natalie Serkova, Joaquin M. Espinosa, Daniel L. Gustafson, Rajeev Vibhakar, Heide L. Ford
Summary: The study reveals that the highly expressed EYA2 gene in Group 3 Medulloblastoma (MB) is correlated with MYC gene and has a significant impact on MB growth and patient prognosis. Inhibition of EYA2 tyrosine phosphatase activity shows promising results in reducing MYC expression, providing a novel therapeutic avenue for this deadly disease.