Article
Medical Laboratory Technology
Ruixin Li, Zhihao Hu, Zhuoyin Wang, Tianyu Zhu, Guojun Wang, Bulang Gao, Jingtao Wang, Xiumei Deng
Summary: MiR-125a-5p can promote gastric cancer growth and invasion by upregulating the expression of EphA2, TAZ, and TEAD2, while also reversing the EMT process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Mirko Minini, Alice Senni, Xingkang He, Sara Proietti, Domenico Liguoro, Angela Catizone, Alessandro Giuliani, Rita Mancini, Andrea Fuso, Alessandra Cucina, Yihai Cao, Mariano Bizzarri
Summary: Myo-Inositol inhibits the PI3K/Akt pathway, particularly effective in triple-negative breast cancer cells, but not in hormone-responsive breast cancer cells unless estrogen effects are counteracted. This novel axis involving miR-125a-5p downregulating IP(6)K1 gene could be activated as a molecular target therapy in breast cancer, inhibiting metastasis and tumor progression.
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Article
Biochemistry & Molecular Biology
Fatemeh Ahmadpour, Somayeh Igder, Hossein Babaahmadi-Rezaei, Ehsan Khalili, Malek Kanani, Vahid Soleimani, Ghorban Mohammadzadeh
Summary: The promoter hypermethylation of miR-125a leads to its decreased expression in breast cancer, while overexpression of miR-125a can reduce autophagy. These findings provide a new therapeutic approach for the treatment of breast cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Article
Oncology
Fu-Long Li, Kun-Liang Guan
Summary: The Hippo signaling pathway is an important regulatory pathway that plays a vital role in animal development and tissue homeostasis. It regulates tissue growth and organ size and is associated with various diseases, particularly cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Bowen Zhu, V Mitheera, Megan Finch-Edmondson, Yaelim Lee, Yue Wan, Marius Sudol, Ramanuj DasGupta
Summary: The study identified miR-582-5p as a post-transcriptional regulator of the Hippo-YAP/TAZ signaling pathway in NSCLC cells, inhibiting YAP/TAZ signaling by targeting NCKAP1 and PIP5K1C. The findings highlight the potential therapeutic value of restoring miR-582-5p expression in the treatment of lung cancer driven by YAP/TAZ.
Article
Cell Biology
Jianing Tang, Yongwen Luo, Liang Xiao
Summary: This study identified USP26 as a deubiquitinating enzyme for TAZ in anaplastic thyroid cancer (ATC) and demonstrated its significant influence on cell proliferation, migration, and invasion in ATC. Depletion of USP26 resulted in decreased TAZ protein level and affected the expression of TAZ/TEAD target genes in ATC.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Su Jung Hwang, Bum Ju Ahn, Min-Wook Shin, Ye-Seul Song, Youngbin Choi, Goo Taeg Oh, Kyu-Won Kim, Hyo-Jong Lee
Summary: Ninj1 plays a critical role in maintaining vascular integrity, while miR-125a-5p acts as a novel regulator in inflammatory diseases and diabetic retinopathy.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Article
Medical Laboratory Technology
Wangzhen Shen, Jiawei Zhang, Yunfeng Pan, Yun Jin
Summary: In this study, it was found that lncRNA MIR4435-2HG promotes the development of neuroglioma by upregulating the TAZ gene, while miR-125a-5p can block this effect.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Oncology
Taruna Arora, Mohd Adnan Kausar, Shimaa Mohammed Aboelnaga, Sadaf Anwar, Malik Asif Hussain, Sadaf Sadaf, Simran Kaur, Alaa Abdulaziz Eisa, Vyas Murti Madhavrao Shingatgeri, Mohammad Zeeshan Najm, Abdulaziz A. Aloliqi
Summary: This review article discusses the impact of the hippo signaling pathway, miRNA biogenesis, and the crosslinks between miRNA and the hippo pathway on cancer. Understanding these processes can enhance the effectiveness of cancer treatment therapies.
Article
Oncology
Xia Zheng, Jie Shao, Jun Qian, Shenlin Liu
Summary: This study identified a novel circRNA, circRPS19, derived from ribosomal protein S19, as a potential therapeutic target for gastric cancer. CircRPS19 was upregulated in gastric cancer cells and promoted cancer progression by stabilizing HK2 protein through the miR-125a-5p/USP7 pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)