Journal
BMC PULMONARY MEDICINE
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12890-019-1029-x
Keywords
Circulating tumor cells; Non-small cell lung cancer; Prognosis; Meta-analysis
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Funding
- National Natural Science Foundations of China (NSFC) [81572285]
- National Natural Science Foundation of Chongqing City [cstc2018jcyjAX0592]
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Background: Our study aimed to verify the prognostic value of circulating tumor cells (CTCs) prior to initial treatment on survival of non-small cell lung cancer (NSCLC) by using meta-analysis and system review of published studies. Materials and methods: The PubMed, EMBASE and Cochrane Library were searched, respectively, to identify all studies that addressed the issues of CTCs prior to initial treatment and progression-free survival (PFS) and overall survival (OS). Finally, ten citations were included for analysis and assessment of publication bias by using review manager 5.3 statistical software and STATA 15.0. Results: Randomized model analyzing multivariate Cox Proportional Hazards Regression indicated that higher abundance of CTCs significantly predicts poorer prognosis of lung cancer cases basing both on PFS (Z = 2.31, P = 0.02) and OS of advanced cases (Z = 2.44, P = 0.01), and systematic study aslo indicated the similar results. Conclusion: High CTCs prior to initial treatment can predict shorter PFS and OS in NSCLC, and further studies are warranted in the future.
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